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1. 发明申请

US20080038207A1 Method and device for decreasing contamination 有权
公开(公告)号：US20080038207A1
公开(公告)日：2008-02-14
申请号：US11827031
申请日：2007-07-10
申请人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
发明人： David Edwards , Mark Gabrielson , Robert Clarke , Wesley Dehaan , Matthew Brande , Jonathan Man
IPC分类号： A61K31/70 , A01N37/18
CPC分类号： A61B5/097 , G01N33/497
摘要： Methods and devices to determine rate of particle production and the size range for the particles produced for an individual are described herein. The device (10) contains a mouthpiece (12), a filter (14), a low resistance one-way valve (16), a particle counter (20) and a computer (30). Optionally, the device also contains a gas flow meter (22). The data obtained using the device can be used to determine if a formulation for reducing particle exhalation should be administered to an individual. This device is particularly useful prior to and/or following entry in a cleanroom to ensure that the cleanroom standards are maintained. The device can also be used to identify animals and humans who have an enhanced propensity to exhale aerosols (referred to herein as “over producers”, “super-producers”, or “superspreaders”). Formulations to reduce particle production are also described herein. The formulation is administered in an amount sufficient to alter biophysical properties in the mucosal linings of the body. When applied to mucosal lining fluids, the formulation alters the physical properties such as the gel characteristics at the air/liquid interface, surface elasticity, surface viscosity, surface tension and bulk viscoelasticity of the mucosal lining. The formulation is administered in an effective amount to minimize ambient contamination due to particle formation during breathing, coughing, sneezing, or talking, which is particularly important in cleanroom applications. In one embodiment, the formulation for administration is a non-surfactant solution. In one embodiment, the formulations are conductive formulations containing conductive agents, such as salts, ionic surfactants, or other substances that are in an ionized state or easily ionized in an aqueous or organic solvent environment. Preferably the formulation is administered in the form of an aerosol.

2. 发明申请

US20060249144A1 Ultrasonic Aerosol Generator 审中-公开
标题翻译：超声波气溶胶发生器
公开(公告)号：US20060249144A1
公开(公告)日：2006-11-09
申请号：US11381952
申请日：2006-05-05
申请人： Wesley DeHaan , Wiwik Watanabe
发明人： Wesley DeHaan , Wiwik Watanabe
IPC分类号： A61M11/00
CPC分类号： B05B17/0615 , A61M15/0085
摘要： An ultrasonic aerosol generator for delivering a liquid formulation in an aerosolized form at a high output rate of greater than 0.5 mL/minute, preferably greater than 1.0 mL/minute, and with diameters in a respirable size range, methods of using this device and kits including the device are described herein. The ultrasonic aerosol generator (10) contains at least (a) a liquid reservoir/aerosolization chamber (11), (b) a piezoelectric engine (12), (c) a relief aperture (13), and (d) an aerosol delivery element (20). Preferably the aerosolized particles that are delivered to the user through the aerosol delivery element have an average aerodynamic diameter of between 1 and 20 μm, more preferably between 1 and 10 μm, and most preferably between 1 and 5 μm. Optionally, the ultrasonic aerosol generator is designed to deliver more than one formulation simultaneously, preferably a low cost and/or stable formulation is administered simultaneously with a more expensive and/or labile formulation. In the preferred embodiment, the ultrasonic aerosol generator is a hand-held device designed for a single user.
摘要翻译：一种用于以大于0.5mL /分钟，优选大于1.0mL /分钟的高输出速率和具有可呼吸尺寸范围的直径的雾化形式的液体制剂输送超声波气雾发生器，使用该装置和试剂盒的方法包括本文所述的装置。超声波气溶胶发生器（10）至少包含（a）液体储存器/雾化室（11），（b）压电发动机（12），（c）释放孔（13），和（d）元件（20）。优选地，通过气溶胶输送元件输送给使用者的雾化颗粒的平均空气动力学直径为1至20μm，更优选为1至10μm，最优选为1至5μm。任选地，超声气溶胶发生器被设计成同时递送多于一种制剂，优选地，与更昂贵和/或不稳定的制剂同时施用低成本和/或稳定的制剂。在优选实施例中，超声波气溶胶发生器是为单个用户设计的手持式装置。

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