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1. 发明授权

US06562298B1 Structure for determination of item of interest in a sample 有权
标题翻译：用于确定样品中感兴趣项目的结构
公开(公告)号：US06562298B1
公开(公告)日：2003-05-13
申请号：US09298711
申请日：1999-04-23
申请人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
发明人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
IPC分类号： G01N3504
CPC分类号： G01N35/0092 , G01N35/025 , G01N35/04 , G01N2035/00534 , G01N2035/00752 , G01N2035/0465 , G01N2035/0467 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent.
摘要翻译：所公开的实施例涉及确定样品中的感兴趣物品。一个实施例涉及包括处理路径的结构。处理路径包括包括执行处理步骤的处理步骤执行通道的处理通道，以及避免处理步骤的处理步骤回避通道。第一原动机与工艺路径可操作地连接，用于沿着处理路径移动容纳样品的容器。第一移液系统与用于将样品引入容器的过程路径可操作地相关联。第二移液系统与用于将试剂引入容器的过程路径可操作地相关联。一种装置与工艺路径可操作地连接，并且与该容器选择性地接合，用于将样品和试剂混合在容器中。第二原动机与工艺路径可操作地连接，用于将容器选择性地定位在所选择的一个工艺步骤性能车道和工艺步骤回避车道中。读取器可操作地与处理路径连接，用于基于样品和试剂之间的反应来确定样品中的感兴趣物品。

2. 发明授权

US5856194A Method for determination of item of interest in a sample 失效
标题翻译：测定样品中感兴趣物品的方法
公开(公告)号：US5856194A
公开(公告)日：1999-01-05
申请号：US715780
申请日：1996-09-19
申请人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
发明人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
IPC分类号： G01N33/483 , G01N33/49 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/04
CPC分类号： G01N35/0092 , G01N35/04 , G01N2035/00534 , G01N2035/00752 , G01N2035/0465 , G01N2035/0467 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： The embodiments disclosed relate to determination of an item of interest in a sample. In one method, a process path comprising a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided is provided. A container holding the sample is moved along the process path. The sample is introduced to the container. A reagent is introduced to the container. The sample and the reagent are mixed in the container. The container is selectively positioned in a selected one of the process step performance lane and the process step avoidance lane. The item of interest in the sample is determined based upon a reaction between the sample and the reagent.
摘要翻译：所公开的实施例涉及确定样品中的感兴趣物品。在一种方法中，提供了一种处理路径，其包括包括执行处理步骤的处理步骤执行通道的处理通道，以及避免处理步骤的处理步骤回避通道。保持样品的容器沿着处理路径移动。将样品引入容器。将试剂引入容器。样品和试剂在容器中混合。容器选择性地定位在所选择的一个工艺步骤性能车道和工艺步骤回避车道中。基于样品和试剂之间的反应确定样品中的目标物。

3. 发明授权

US06588625B2 Sample handling system 有权
公开(公告)号：US06588625B2
公开(公告)日：2003-07-08
申请号：US09840960
申请日：2001-04-24
申请人： Robert P. Luoma, II , David C. Arnquist , James D. Hause
发明人： Robert P. Luoma, II , David C. Arnquist , James D. Hause
IPC分类号： G07F1100
CPC分类号： G01N35/0095 , B01L9/00 , G01N35/00732 , G01N35/0092 , G01N35/0099 , G01N35/025 , G01N35/026 , G01N35/04 , G01N2035/00326 , G01N2035/00752 , G01N2035/00801 , G01N2035/0093 , G01N2035/0465
摘要： A sample handling system includes a loading rack for receiving carriers with a plurality of test tubes holding samples. A robotic device transports a carrier with the samples to a positioner that moves the tubes within the carrier into an aspiration position. After aspiration, the robotic device returns the carrier to the loading rack. The system provides for handling of stat samples and automatic retesting of samples.

4. 发明授权

US08449839B2 Liquid waste management system 失效
标题翻译：液体废物管理系统
公开(公告)号：US08449839B2
公开(公告)日：2013-05-28
申请号：US11644086
申请日：2006-12-22
申请人： Ganesh Rajagopal , James W. Whitt , GeDon G. Berryman , Daniel H. Lains , Brian L. Ochranek , Gregory A. Blackwell , Robert P. Luoma, II , Jack F. Ramsey
发明人： Ganesh Rajagopal , James W. Whitt , GeDon G. Berryman , Daniel H. Lains , Brian L. Ochranek , Gregory A. Blackwell , Robert P. Luoma, II , Jack F. Ramsey
IPC分类号： B01L3/02
CPC分类号： G01N35/00 , B01L9/52 , G01N35/1004 , G01N2035/0496
摘要： A system for removing liquid waste from an automated diagnostic instrument. The system comprises (a) an accumulator having at least one inlet for waste liquids and at least one outlet for waste liquids; (b) a vacuum sub-system connected to the accumulator, the vacuum sub-system comprising a vacuum pump; and (c) a drain portion for removing waste liquids comprising a peristaltic pump having spring-loaded rollers. The liquid waste from the automated diagnostic instrument is moved by a pressure differential created by the vacuum pump and the peristaltic pump having spring-loaded rollers.
摘要翻译：用于从自动诊断仪器中清除液体废物的系统。该系统包括（a）具有至少一个废液入口和至少一个废液出口的蓄能器; （b）连接到蓄能器的真空子系统，所述真空子系统包括真空泵; 和（c）用于除去包括具有弹簧加载辊的蠕动泵的废液的排出部分。来自自动诊断仪器的液体废物由真空泵和具有弹簧加载辊的蠕动泵产生的压力差移动。

5. 发明授权

US10456786B2 Septums and related methods 有权
公开(公告)号：US10456786B2
公开(公告)日：2019-10-29
申请号：US13796553
申请日：2013-03-12
申请人： Robert P. Luoma, II
发明人： Robert P. Luoma, II
IPC分类号： B01L3/00 , A61J1/14 , B65D51/00
摘要： Example apparatus including septums and related methods are disclosed. An example apparatus includes a septum that includes a first surface and a membrane coupled to at least a portion of the first surface. In addition, the example septum includes a second surface and ribs extending between the membrane and the second surface.

6. 发明授权

US4640776A Plasmapheresis filtration module having pressure balancing and sealing means 失效
标题翻译：具有压力平衡和密封装置的血浆置换过滤模块
公开(公告)号：US4640776A
公开(公告)日：1987-02-03
申请号：US349368
申请日：1982-02-16
申请人： Robert P. Luoma, II , Frank M. Willis
发明人： Robert P. Luoma, II , Frank M. Willis
IPC分类号： A61M1/22 , B01D63/08 , B01D65/08 , B01D13/00
CPC分类号： B01D63/082 , B01D65/08 , B01D2321/2066 , B01D2321/2083
摘要： A plasmapheresis filtration module having stacked grooved plates interleaved with membranes, enclosed in a unitary, flexible, impermeable envelope, sealing being effected by pressing the membranes between blood flow channels and a sealing surface on a plasma side support.
摘要翻译：一种血浆置换术过滤模块，其具有交错隔膜的堆叠的沟槽板，封闭在一体的，柔性的，不可渗透的外壳中，通过在血流通道和等离子体侧支撑件之间的密封表面上按压膜来实现密封。

7. 发明授权

US4501951A Electric heating element for sterilely cutting and welding together thermoplastic tubes 失效
标题翻译：电热元件用于无菌切割和焊接在一起的热塑性管
公开(公告)号：US4501951A
公开(公告)日：1985-02-26
申请号：US408417
申请日：1982-08-16
申请人： Joshua Benin , Robert P. Luoma, II
发明人： Joshua Benin , Robert P. Luoma, II
IPC分类号： B23K3/02 , A61M39/14 , B26F3/08 , B29C53/00 , B29C55/00 , B29C65/00 , B29C65/18 , B29C65/20 , B29C65/30 , B29C65/48 , H05B3/10 , B29C27/06 , B26D7/10
CPC分类号： A61M39/146 , B29C65/2046 , B29C65/30 , B29C66/522 , B29C66/73921 , B29C66/80 , B29C66/81261 , B29C66/81263 , B29C66/5225 , B29C66/8122 , B29L2031/7542 , H05B2203/003 , Y10T156/1054 , Y10T156/1313 , Y10T156/1326 , Y10T83/293
摘要： An electric heating element for sterilely cutting and welding together a pair of thermoplastic tubes transversely of the axis of each tube includes as an outer layer a folded sheet of a metal, such as copper, aluminum, silver or gold, having a thermal conductivity of at least about 173 watts/m.degree.K at a thickness of 0.10 mm and a tensile yield strength of at least 34.times.104 kPa at a 0.10 mm thickness. A resistance heating element, preferably having a positive thermal coefficient of resistance (PTC), in the form of a resistor of stainless steel or the like is disposed inside the fold of the metal sheet and a layer of dielectric adhesive, such as an epoxy or acrylic adhesive, stable to about 260.degree. C., is disposed between the inner surfaces of the metal sheet and the resistor to insulate the resistor from the folded sheet and bond the resulting structure together. The folded edge of the metal sheet forms the melting edge of the heating element. The heating element has a thickness of from about 0.13 mm. to about 0.76 mm.
摘要翻译：用于无菌切割和横向于每个管的轴线的一对热塑性管焊接在一起的电加热元件包括作为外层的折叠的金属片，例如铜，铝，银或金，其导热率为至少约173瓦特/平方米，厚度为0.10毫米，拉伸屈服强度至少为34×104帕，厚度为0.10毫米。优选具有不锈钢等的电阻器形式的具有正的热阻系数（PTC）的电阻加热元件设置在金属片的折叠内部和介电粘合剂层如环氧树脂或稳定到约260℃的丙烯酸粘合剂设置在金属片和电阻器的内表面之间，以使电阻器与折叠片材绝缘，并将所得结构结合在一起。金属板的折叠边缘形成加热元件的熔化边缘。加热元件的厚度为约0.13mm。至约0.76mm。

8. 发明授权

US5419835A Flow restrictor-separation device 失效
标题翻译：流量限制器分离装置
公开(公告)号：US5419835A
公开(公告)日：1995-05-30
申请号：US135246
申请日：1993-10-13
申请人： George A. Adams , Robert P. Luoma, II
发明人： George A. Adams , Robert P. Luoma, II
IPC分类号： G01N33/48 , B01L3/14 , G01N33/49 , B01D21/26
CPC分类号： G01N33/491 , B01L3/50215 , Y10T436/25375
摘要： A method of partitioning a pre-selected phase of a sample of liquid having a plurality of phases of differing densities, a separation device and a tube containing the separation device. The sample of liquid is placed in a first chamber of a linear tube that is separated from a second chamber by a separation device. The separation device slidably engages the interior surface of the tube in an essentially fluid-tight manner and has an axial orifice on the longitudinal axis of the tube that is in fluid flow communication with a flow-restriction channel. The phases are ordered concentrically by rotating the tube around its longitudinal axis e.g. in an axial centrifuge. The volume of the first chamber is reduced by movement of the separation device within the tube, that phase of the liquid located axially within the first chamber flowing into the axial orifice and passing through the flow-restriction channel into the second chamber. The reduction of the volume of the first chamber is controlled using phase-separation information. The method is useful in separation of blood components.
摘要翻译：分离具有不同密度的多个相的液体样品的预选相的方法，分离装置和含有分离装置的管。将液体样品放置在通过分离装置与第二室隔开的直管的第一室中。分离装置以基本上流体密封的方式可滑动地接合管的内表面，并且在管的纵向轴线上具有与流动限制通道流体流动连通的轴向孔口。通过围绕其纵向轴旋转管，相位相同地排列，例如在轴向离心机中。通过分离装置在管内的移动来减小第一室的体积，液体的轴向位于第一室内的液相流入轴向孔口并通过流动限制通道进入第二室。使用相分离信息来控制第一室的体积的减小。该方法可用于分离血液成分。

9. 发明授权

US4461951A Method of monitoring the temperature of a sterile docking cutting means 失效
标题翻译：监测无菌对接切割装置的温度的方法
公开(公告)号：US4461951A
公开(公告)日：1984-07-24
申请号：US408416
申请日：1982-08-16
申请人： Robert P. Luoma, II , Helen E. Roxlo
发明人： Robert P. Luoma, II , Helen E. Roxlo
IPC分类号： A61B17/11 , A61L2/04 , G05D23/24 , H05B3/00 , H05B1/02
CPC分类号： G05D23/2401
摘要： There is disclosed a method of monitoring the temperature of a cutting element in a sterile docking apparatus for splicing two sterile thermoplastic tubes together by using a resistor-heated cutting means, the method comprises (1) supplying a constant current to the resistor; (2) measuring the initial voltage of the resistor; (3) calculating, according to predetermined empirical relationship(s), the voltage, time or both required to achieve a desired cutting means temperature if the initial voltage is within a suitable range, (4) measuring repeatedly the voltage of the resistor and the time to determine whether (a) the voltage reaches the calculated voltage within a specified time frame or (b) the calculated time has been reached within a specified voltage range and (5) splicing the tubes with the cutting means if the time frame or voltage range is met. The method is also applicable to other resistor-heated elements in other devices having a constant heat load environment.
摘要翻译：公开了一种在无菌对接设备中监测切割元件的温度的方法，用于通过使用电阻加热的切割装置将两个无菌热塑性管接合在一起，该方法包括（1）向电阻器提供恒定电流; （2）测量电阻器的初始电压; （3）根据预定的经验关系，如果初始电压在合适的范围内，则计算实现所需切割装置温度所需的电压，时间或两者，（4）重复地测量电阻器的电压和时间来确定（a）电压是否在规定的时间范围内达到计算电压，或者（b）在规定的电压范围内达到了计算的时间，（5）如果时间框架或电压范围得到满足。该方法也适用于具有恒定热负荷环境的其他装置中的其它电阻加热元件。

10. 发明授权

US5389265A Phase-separation tube 失效
标题翻译：相分离管
公开(公告)号：US5389265A
公开(公告)日：1995-02-14
申请号：US71137
申请日：1993-06-02
申请人： Robert P. Luoma, II
发明人： Robert P. Luoma, II
IPC分类号： G01N33/48 , B01D17/038 , B01D17/12 , B01L3/14 , B04B5/02 , G01N1/10 , G01N1/28 , G01N1/36 , G01N33/49
CPC分类号： B01L3/5021 , G01N33/491 , B01L2300/0851 , Y10T436/111666
摘要： A tube and method of partitioning a pre-selected phase of a sample of liquid having a plurality of phases of differing densities. The tube has a smaller diameter at one end. In use, a sample of liquid is passed through a first end of a linear tube and into a first chamber of said tube. The first chamber is located at the first end of the tube and is separated from a second chamber located at a second opposed end of the tube by a separation device. The separation device slidably engages the interior surface of the tube in an essentially fluid-tight manner and has a flow-restriction orifice therein to permit fluid flow communication between the first and second chambers under the influence of force. The phases are then ordered within the tube using e.g. axial centrifugation. The volume of the first chamber is reduced by movement of the separation device within the tube, such that one phase of the liquid in the first chamber flows through the flow-restriction orifice and into the second chamber. The method is monitored using the section of the tube that has the smaller diameter.
摘要翻译：分配具有不同密度的多个相的液体样品的预选相的管和方法。管在一端具有较小的直径。在使用中，液体样品通过线性管的第一端并进入所述管的第一腔。第一室位于管的第一端，并通过分离装置与位于管的第二相对端的第二室分离。分离装置以基本上流体密封的方式可滑动地接合管的内表面，并且在其中具有限流孔，以允许在力的影响下第一和第二室之间的流体流动连通。然后使用例如在管中排列相。轴向离心。通过分离装置在管内的移动来减小第一室的体积，使得第一室中的液体的一相流经流量限制孔并进入第二室。使用具有较小直径的管的截面来监测该方法。

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