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1. 发明授权

US06562298B1 Structure for determination of item of interest in a sample 有权
标题翻译：用于确定样品中感兴趣项目的结构
公开(公告)号：US06562298B1
公开(公告)日：2003-05-13
申请号：US09298711
申请日：1999-04-23
申请人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
发明人： David C. Arnquist , Grady Barnes, III , Richard D. Button , Chadwick M. Dunn , Richard C. East, Jr. , Patrick P. Fritchie , Charles M. Galitz , Gregory E. Gardner , Cass J. Grandone , Robert C. Gray , James T. Holen , Robert P. Luoma, II , Jimmy D. McCoy , James E. Mitchell , Adrian John Murray , David W. Murray , Jack F. Ramsey , Neal T. Sleszynski , Julius J. Toth
IPC分类号： G01N3504
CPC分类号： G01N35/0092 , G01N35/025 , G01N35/04 , G01N2035/00534 , G01N2035/00752 , G01N2035/0465 , G01N2035/0467 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： The embodiments disclosed relate to determination of an item of interest in a sample. One embodiment relates to a structure which comprises a process path. The process path comprises a process lane including a process step performance lane where a process step is performed, and a process step avoidance lane where the process step is avoided. A first prime mover is operatively connected with the process path for moving a container holding the sample along the process path. A first pipetting system is operatively associated with the process path for introducing the sample to the container. A second pipetting system is operatively associated with the process path for introducing a reagent to the container. A device is operatively connected with the process path and is selectively engagable with the container for mixing the sample and the reagent in the container. A second prime mover is operatively connected with the process path for selectively positioning the container in a selected one of the process step performance lane and the process step avoidance lane. A reader is operatively connected with the process path for determining the item of interest in the sample based upon a reaction between the sample and the reagent.
摘要翻译：所公开的实施例涉及确定样品中的感兴趣物品。一个实施例涉及包括处理路径的结构。处理路径包括包括执行处理步骤的处理步骤执行通道的处理通道，以及避免处理步骤的处理步骤回避通道。第一原动机与工艺路径可操作地连接，用于沿着处理路径移动容纳样品的容器。第一移液系统与用于将样品引入容器的过程路径可操作地相关联。第二移液系统与用于将试剂引入容器的过程路径可操作地相关联。一种装置与工艺路径可操作地连接，并且与该容器选择性地接合，用于将样品和试剂混合在容器中。第二原动机与工艺路径可操作地连接，用于将容器选择性地定位在所选择的一个工艺步骤性能车道和工艺步骤回避车道中。读取器可操作地与处理路径连接，用于基于样品和试剂之间的反应来确定样品中的感兴趣物品。

2. 发明授权

US06599749B1 Method of conveying sample rack and automated analyzer in which sample rack is conveyed 有权
标题翻译：输送样品架和自动分析仪的方法
公开(公告)号：US06599749B1
公开(公告)日：2003-07-29
申请号：US09389583
申请日：1999-09-03
申请人： Ryuichiro Kodama , Hiroshi Mitsumaki , Tomonori Mimura , Takayuki Noda
发明人： Ryuichiro Kodama , Hiroshi Mitsumaki , Tomonori Mimura , Takayuki Noda
IPC分类号： G01N3504
CPC分类号： G01N35/00584 , G01N35/0095 , G01N35/026 , G01N35/04 , G01N2035/00643 , Y10T436/113332 , Y10T436/114165
摘要： An automated analyzer device has a main conveyance line capable of conveying a sample rack holding a sample, a plurality of analysis units arranged along the main conveyance line, a rack supplying device for supplying the sample rack to the main conveyance line and a rack housing device for housing the sample rack conveyed by the main conveyance line. The automated analyzer includes a controller for confirming that there is no sample rack on the main conveyance line before the main conveyance line receives the sample rack from the rack supplying device. The controller controls operation of the main conveyance line so as to convey the sample rack received from the rack supplying device by the main conveyance line to a position corresponding to a specific one of the plurality of analysis units by which the sample rack is to be received without stopping.
摘要翻译：一种自动分析装置，具有能够输送保持试样的检体架的主输送线，沿主输送线排列的多个分析部，将检体架供给到主输送线的支架供给装置，用于容纳由主输送线输送的样品架。所述自动分析装置包括控制器，用于在所述主输送线从所述架子供给装置接收所述样架之前，确认所述主输送线上没有样架。控制器控制主输送线的操作，以将从主输送线将从架架供应装置接收的样架传送到与待接收样品架的多个分析单元中的特定一个分析单元相对应的位置不停止。

3. 发明授权

US06426228B1 Method for feeding containers into and out of an analytical instrument 有权
标题翻译：容器进出分析仪器的方法
公开(公告)号：US06426228B1
公开(公告)日：2002-07-30
申请号：US09504272
申请日：2000-02-15
申请人： Beri Cohen , Thomas W. DeYoung , Krunoslav Esteban Draganovic , Paul E. Purpura
发明人： Beri Cohen , Thomas W. DeYoung , Krunoslav Esteban Draganovic , Paul E. Purpura
IPC分类号： G01N3504
CPC分类号： G01N35/04 , G01N35/026 , G01N2035/00752 , G01N2035/0465 , G01N2035/0493 , G01N2035/1025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/2575
摘要： A method whereby a sample handler moves and positions racks, containing sample tubes, in an analytical instrument. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. The racks are seated within the in-feed and are transported onto a cross-feed. The racks and tubes contained thereon are moved past detection devices that identify the samples and measure various properties thereof. Thereafter, the cross-feed moves the racks to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.
摘要翻译：样品处理器在分析仪器中移动并定位包含样品管的机架的方法。样品处理器具有进料和出料，使用步进梁机构推进样品管架。机架位于进料内，并被运送到交叉进给。包含在其上的机架和管被移动通过识别样品并测量其各种性质的检测装置。此后，交叉进给将机架移动到出料口后面的位置，在步行梁机构将管架移出分析仪器。

4. 发明授权

US06183694B2 Spectrophotometric apparatus for reducing fluid carryover 有权
标题翻译：用于减少流体携带的分光光度仪
公开(公告)号：US06183694B2
公开(公告)日：2001-02-06
申请号：US09182313
申请日：1998-10-30
申请人： Marilyn Radtke , Gary E. Rehm
发明人： Marilyn Radtke , Gary E. Rehm
IPC分类号： G01N3504
CPC分类号： G01N21/8483
摘要： An apparatus adapted to inspect reagent strips having fluid samples, such as urine samples, disposed thereon and to reduce the likelihood of contamination of one of the fluid samples with another of the fluid samples is provided with a reagent strip support (22) adapted to support a reagent strip (14) having a plurality of reagent pads (26) disposed in a longitudinal direction along the reagent strip (26), including reagent pad which has a reagent sensitive to contamination. The apparatus also includes a reagent strip mover (18 and/or 80) adapted to cause the reagent strip (14) to be moved in a direction generally transverse to the longitudinal direction from an initial reagent strip location to an inspection location (120 or 122), a light emitter (64 or 68) adapted to illuminate the reagent strip (14) when the reagent strip (14) is supported by the reagent strip support (18 and/or 80) at the inspection location (120 or 122), and a detector (66 or 70) adapted to receive light from the reagent strip (14) when the reagent strip (14) is being illuminated by the light emitter (64 or 68).
摘要翻译：适于检查具有设置在其上的流体样品（例如尿液样品）并且降低其中一个流体样品与另一个流体样品的污染的可能性的试剂条设置有适于支撑的试剂条支撑件（22）具有沿着试剂条（26）沿长度方向设置的多个试剂垫（26）的试剂条（14），包括具有对污染敏感的试剂的试剂垫。所述装置还包括试剂条移动器（18和/或80），其适于使试剂条（14）沿着从纵向方向大致横向的方向从初始试剂条位置移动到检查位置（120或122 ），当所述试剂条（14）在所述检查位置（120或122）由所述试剂条支撑件（18和/或80）支撑时，适于照亮所述试剂条（14）的光发射器（64或68）以及当所述试剂条（14）被所述光发射器（64或68）照射时适于接收来自所述试剂条（14）的光的检测器（66或70）。

5. 发明授权

US06541261B1 Method using a slide stainer with independent slide heating regulation 有权
标题翻译：使用独立的载玻片加热调节的滑动染色机的方法
公开(公告)号：US06541261B1
公开(公告)日：2003-04-01
申请号：US09688619
申请日：2000-10-16
申请人： Steven A. Bogen , Herbert H. Loeffler , John A. Purbrick
发明人： Steven A. Bogen , Herbert H. Loeffler , John A. Purbrick
IPC分类号： G01N3504
CPC分类号： B01L7/52 , B01L3/0293 , B01L9/52 , B01L2200/147 , B01L2300/0822 , B01L2300/1827 , B01L2400/049 , G01N1/312 , G01N35/0092 , G01N35/025 , G01N2001/317 , G01N2035/00039 , G01N2035/00049 , G01N2035/00138 , G01N2035/00366 , G01N2035/0093 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated slide stainer with slides mounted in a horizontal position on a rotary carousel. Reagents and rinse liquids are automatically dispensed onto tissue sections or cells mounted on slides for the purpose of performing chemical or immunohistochemical stains. The rinse liquids are removed by an aspiration head connected to a source of vacuum. Individual slides or groups of slides are supported on flat heating stations for heating to individual temperatures. Temperature control electronics on the carousel are controlled by a user interface off of the carousel.
摘要翻译：一种具有安装在旋转圆盘传送带上的水平位置的滑块的自动滑动染色机。试剂和冲洗液体自动分配到安装在载玻片上的组织切片或细胞上，以进行化学或免疫组织化学染色。通过连接到真空源的抽吸头去除冲洗液体。在平面加热站支持单个滑轨或滑块组，以加热到单独的温度。旋转木马上的温度控制电子设备由离开传送带的用户界面控制。

6. 发明授权

US06429016B1 System and method for sample positioning in a robotic system 有权
标题翻译：机器人系统中样品定位的系统和方法
公开(公告)号：US06429016B1
公开(公告)日：2002-08-06
申请号：US09411748
申请日：1999-10-01
申请人： John McNeil
发明人： John McNeil
IPC分类号： G01N3504
CPC分类号： G01N35/0099 , G01N2035/00782 , G01N2035/0489 , G01N2035/0491 , G01N2035/0494 , G05D1/0291 , G05D2201/0216 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/115831
摘要： A system and method for positioning a sample, or cargo, with respect to a device in a robotic system is provided. The system includes a macro positioning system for “gross” movement of the sample between stations and a micro positioning system for precisely locating the sample in a predetermined location at a station with respect to a device that will interact with the sample. The macro positioning system provides a positioning mechanism for the general movement of a sample along a pathway between various destinations or stations wherein the sample is “grossly” positioned with respect to the station. Once at the station, the micro positioning subsystem disposed between a sample carrier and the station provides a positioning mechanism for “precisely” positioning the sample in a predetermined location at the station with respect to a device that will interact with, or perform some function on, the sample. The system and method provide for multiple sample carrying robots having autonomous navigation thereby providing flexibility and stacker-like queuing for near 100% device utilization.
摘要翻译：提供了一种用于将样品或货物相对于机器人系统中的装置定位的系统和方法。该系统包括用于站间样品“大”移动的宏定位系统和用于相对于将与样品相互作用的装置将样品精确地定位在工位的预定位置的微定位系统。宏定位系统提供了一种定位机构，用于沿着各个目的地或站之间的路径的样本的一般移动，其中样本相对于站“被”大大地定位“。一旦在车站，设置在采样载体和车站之间的微型定位子系统提供了一种定位机构，用于“精确地”将样本相对于将与车辆相互作用或执行某些功能的设备在车站的预定位置，例子。该系统和方法提供了具有自主导航的多个携带携带机器人，从而为近100％的设备利用率提供灵活性和堆垛机状排队。

7. 发明授权

US06355488B1 Method for continuous or discontinuous automatic analyzing of samples placed in containers 有权
标题翻译：连续或不连续自动分析置于容器中的样品的方法
公开(公告)号：US06355488B1
公开(公告)日：2002-03-12
申请号：US09242307
申请日：1999-08-12
申请人： Alain Rousseau , Jean-Francois Gelin
发明人： Alain Rousseau , Jean-Francois Gelin
IPC分类号： G01N3504
CPC分类号： G01N35/026 , G01N2035/0415 , Y10T436/113332 , Y10T436/114165
摘要： A method provides for the placing of samples containers inside holders, a first displacement bringing the holders to an zone with access to the blood analyser pipetting area, identifying the containers during this displacement, a second rectilinear displacement through the pipetting zone along a path perpendicular to the first, a third rectilinear displacement bringing the holders to a second zone acceding to the pipetting area a fourth displacement through the pipetting area and bringing the holders to second outlet zone located on the first path and a path bringing the holder, to the first access zone or an evacuating zone. The method is particularly useful for carrying out hemostasis test on centrifuged blood samples.
摘要翻译：一种方法提供将样品容器放置在保持器内，第一位移使支架移动到具有进入血液分析器移液区域的区域，在该位移期间识别容器，沿着垂直于第一，第三直线位移，使保持器到达移液区域的第二区域通过移液区域的第四位移，并将保持器带到位于第一路径上的第二出口区域和带有保持器的路径到第一通道区域或撤离区域。该方法对离心血样进行止血试验尤其有用。

8. 发明授权

US06325114B1 Pipetting station apparatus 失效
标题翻译：移液站装置
公开(公告)号：US06325114B1
公开(公告)日：2001-12-04
申请号：US09495106
申请日：2000-02-01
申请人： JoeBen Bevirt , Gabriel Noah Brinton , Eric Rollins
发明人： JoeBen Bevirt , Gabriel Noah Brinton , Eric Rollins
IPC分类号： G01N3504
CPC分类号： G01N35/1074 , G01N35/028 , G01N2035/042
摘要： A pipette station is described for use in the field of sample analysis. The pipette station increases the rate and ease with which a liquid may be manipulated into and out of sample carriers such as microwell plates. The pipette station includes shafts in the X, Y, and Z direction which possess ball screws which are integrated with motor shafts thus improving accuracy and eliminating the need for a coupling apparatus thereby reducing the space required for the pipette station. The pipette station may be interfaced with an automated laboratory system.
摘要翻译：描述了用于样品分析领域的移液器站。移液器站增加了液体可以被操纵进入和离开样品载体如微孔板的速率和容易程度。吸液站包括X，Y和Z方向上的轴，其具有与电动机轴结合的滚珠丝杠，从而提高了精度，并且消除了对耦合装置的需要，从而减少了移液管站所需的空间。吸液站可以与自动化实验室系统连接。

9. 发明授权

US06599477B1 Chemical analysis apparatus 失效
标题翻译：化学分析仪
公开(公告)号：US06599477B1
公开(公告)日：2003-07-29
申请号：US09136070
申请日：1998-08-19
申请人： Ryo Miyake , Akira Koide , Takeo Takagi , Takao Terayama , Yasushi Nomura , Hiroshi Mitsumaki
发明人： Ryo Miyake , Akira Koide , Takeo Takagi , Takao Terayama , Yasushi Nomura , Hiroshi Mitsumaki
IPC分类号： G01N3504
CPC分类号： G01N35/1002 , F04B43/043 , G01N35/025 , G01N35/1016 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/119163 , Y10T436/2575
摘要： A chemically analyzing apparatus includes a plurality of reaction containers, a reaction container holder for holding the plurality of reaction containers and for supplying a sample and reagent at predetermined positions, a plurality of reagent containers for holding reagent adapted to be supplied into the reaction containers, a reagent container holder provided above the reaction container holder, for holding the plurality of reagent containers, a measuring part for measuring physical properties of the sample, a liquid feed mechanism provided in a lower part of each of the plurality of reagent containers, for supplying a predetermined quantity of reagent from each of the reagent container into the associated reaction containers by means of the liquid feed mechanism. With this arrangement, it is possible to provide a chemically analyzing apparatus incorporating a reagent supply mechanism which can prevent reagent from being uselessly consumed, which does not substantially require washing liquid, which does not require periodical disassembly and washing, and which can easily change the feed quantity of reagent.
摘要翻译：化学分析装置包括多个反应容器，用于保持多个反应容器并用于在预定位置供应样品和试剂的反应容器保持器，用于保持适于供应到反应容器中的试剂的多个试剂容器，设置在反应容器保持器上方的用于保持多个试剂容器的试剂容器保持器，用于测量样品的物理性质的测量部件，设置在多个试剂容器的每个的下部的液体供给机构，用于供给通过液体供给机构将来自每个试剂容器的预定量的试剂输送到相关联的反应容器中。通过这种布置，可以提供一种化学分析装置，其包括试剂供给机构，该试剂供给机构能够防止不需要定期拆卸和洗涤的基本上不需要洗涤液的试剂被无用地消耗，并且可以容易地改变试剂的供料量。

10. 发明授权

US06426044B1 Automatic handler for feeding containers into and out of an analytical instrument 有权
公开(公告)号：US06426044B1
公开(公告)日：2002-07-30
申请号：US09504366
申请日：2000-02-15
申请人： Beri Cohen , Thomas W. DeYoung , Krunoslav Esteban Draganovic , Paul E. Purpura
发明人： Beri Cohen , Thomas W. DeYoung , Krunoslav Esteban Draganovic , Paul E. Purpura
IPC分类号： G01N3504
CPC分类号： G01N35/04 , G01N35/026 , G01N2035/00752 , G01N2035/0465 , G01N2035/0493 , G01N2035/1025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/2575
摘要： Racks having sample containers mounted therein are transported within an analytical system so that a robotic arm can remove the sample containers and deliver them to a desired location within the system. The sample handler has an in-feed and out-feed that advance sample tube racks using a walking beam mechanism. Sample tube racks are seated within the in-feed and are transported onto a cross-feed. The cross-feed comprises a movable track having a platform mounted thereto. The cross-feed moves the sample tube racks from a position behind the in-feed to a position behind the out-feed where the walking beam mechanism moves the tube racks out of the analytical instrument.

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