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1. 发明申请

US20060133968A1 Parallel reactor with internal sensing and method of using same 审中-公开
公开(公告)号：US20060133968A1
公开(公告)日：2006-06-22
申请号：US11272249
申请日：2005-11-10
申请人： G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
发明人： G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
IPC分类号： B01J19/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

2. 发明授权

US06732574B2 Method of using a high throughput viscometer 失效
标题翻译：使用高通量粘度计的方法
公开(公告)号：US06732574B2
公开(公告)日：2004-05-11
申请号：US10104203
申请日：2002-03-22
申请人： Damian Hajduk , Paul Mansky
发明人： Damian Hajduk , Paul Mansky
IPC分类号： G01N1106
CPC分类号： G01N11/06
摘要： An apparatus and method for measuring viscosity or related properties of fluid samples in parallel is disclosed. The apparatus includes a plurality of tubes and reservoirs in fluid communication with the tubes. The tubes provide flow paths for the fluid samples, which are initially contained within the reservoirs. The apparatus also includes a mechanism for filling the reservoirs with the fluid samples, and a device for determining volumetric flow rates of fluid samples flowing from the reservoirs through the plurality of tubes simultaneously. The disclosed apparatus is capable of measuring viscosity or related properties of at least five fluid samples simultaneously. Useful reservoirs and tubes include syringes.
摘要翻译：公开了一种并行测量流体样品的粘度或相关性质的装置和方法。该装置包括与管流体连通的多个管和储存器。管提供流体样品的流动路径，其最初包含在储存器内。该装置还包括用于用流体样本填充储存器的机构，以及用于确定从贮存器同时流过多个管的流体样品的体积流量的装置。所公开的装置能够同时测量至少五个流体样品的粘度或相关性质。有用的储存器和管子包括注射器。

3. 发明申请

US20050179156A1 High throughput preparation and analysis of materials 审中-公开
公开(公告)号：US20050179156A1
公开(公告)日：2005-08-18
申请号：US11103692
申请日：2005-04-12
申请人： Eric Carlson , Damian Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky
发明人： Eric Carlson , Damian Hajduk , Leonid Matsiev , Adam Safir , Paul Mansky
IPC分类号： B01F5/10 , B01F7/00 , B01F7/08 , B01F13/10 , B01J19/00 , B01L3/00 , G01N1/28 , G01N35/00 , G01N35/02 , G01B1/00 , B29B15/00
CPC分类号： B01L3/5085 , B01F5/104 , B01F7/00341 , B01F7/00416 , B01F7/082 , B01F13/1013 , B01F13/1022 , B01J19/0046 , B01J2219/00274 , B01J2219/00756 , B01L2200/12 , B01L2300/0812 , B01L2300/0829 , G01N1/286 , G01N35/00 , G01N35/00009 , G01N35/021 , G01N2001/2866 , G01N2035/00495 , G01N2035/00534
摘要： A rapid throughput method for the preparation, analysis or both of libraries of material samples is provided. According to the method, a plurality of samples is provided. Providing the plurality of samples can include a variety of sample formation techniques including, but not limited to, extruding, milling, compression preparation, rotary mixing, microcentrifugation, molding and casting. Preferably, the samples are solidified into a near net shape configuration appropriate for testing of properties or characteristics of the samples.

4. 发明授权

US06393898B1 High throughput viscometer and method of using same 失效
标题翻译：高通量粘度计及其使用方法
公开(公告)号：US06393898B1
公开(公告)日：2002-05-28
申请号：US09578997
申请日：2000-05-25
申请人： Damian Hajduk , Paul Mansky
发明人： Damian Hajduk , Paul Mansky
IPC分类号： G01N1106
CPC分类号： G01N11/06
摘要： An apparatus and method for measuring viscosity or related properties of fluid samples in parallel is disclosed. The apparatus includes a plurality of tubes and reservoirs in fluid communication with the tubes. The tubes provide flow paths for the fluid samples, which are initially contained within the reservoirs. The apparatus also includes a mechanism for filling the reservoirs with the fluid samples, and a device for determining volumetric flow rates of fluid samples flowing from the reservoirs through the plurality of tubes simultaneously. The disclosed apparatus is capable of measuring viscosity or related properties of at least five fluid samples simultaneously. Useful reservoirs and tubes include syringes.
摘要翻译：公开了一种并行测量流体样品的粘度或相关性质的装置和方法。该装置包括与管流体连通的多个管和储存器。管提供流体样品的流动路径，其最初包含在储存器内。该装置还包括用于用流体样本填充储存器的机构，以及用于确定从储存器同时流过多个管的流体样品的体积流量的装置。所公开的装置能够同时测量至少五个流体样品的粘度或相关性质。有用的储存器和管子包括注射器。

5. 发明申请

US20130022570A1 CROSSLINKED POLYVINYLAMINE, POLYALLYLAMINE, AND POLYETHYLENEIMINE FOR USE AS BILE ACID SEQUESTRANTS 有权
标题翻译：交联的聚乙烯胺，聚甲基丙烯酸和聚乙烯亚胺作为双酸序列使用
公开(公告)号：US20130022570A1
公开(公告)日：2013-01-24
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Quaker , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

6. 发明授权

US06833276B2 Polymer brushes for immobilizing molecules to a surface and having water-soluble or water-dispersible segments therein and probes bonded thereto 失效
标题翻译：用于将分子固定在表面上并具有水溶性或水分散性区段的聚合物刷和与其结合的探针
公开(公告)号：US06833276B2
公开(公告)日：2004-12-21
申请号：US09911683
申请日：2001-07-24
申请人： Gerrit Klaerner , Ralph B. Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura T. Mazzola
发明人： Gerrit Klaerner , Ralph B. Nielsen , Paul Mansky , Didier Benoit , Dominique Charmot , Bernd Jandeleit , Laura T. Mazzola
IPC分类号： G01N33545
CPC分类号： G01N33/54353 , C08F4/00 , C08F220/54 , C08F220/58 , G01N27/44747 , Y10T428/8305 , Y10T436/10
摘要： Sensors for determining the presence and concentration of bio-molecules in a biological sample are provided in the form of polymer brushes, which comprise a substrate having a surface that is modified with a water-dispersible or water-soluble polymer segment having functional groups that bind probes. The method of synthesis of such sensors preferably includes use of controlled free radical polymerization techniques, and in particular the use of an iniferter initiator, which allows for controlled architecture polymers to modify the surface of the substrate. In this manner functional groups in the polymer chain are removed from the surface, which allows for solution chemistry to be more realistically reproduced with the benefits of a solid bound probe.
摘要翻译：用于确定生物样品中生物分子的存在和浓度的传感器以聚合物刷的形式提供，所述聚合物刷包含具有表面的基底，所述基底具有用水分散性或水溶性聚合物链段修饰，所述水分散性或水溶性聚合物链段具有结合探针。合成这种传感器的方法优选包括使用受控的自由基聚合技术，特别是使用引发剂，其允许可控结构聚合物改性基材的表面。以这种方式，从表面去除聚合物链中的官能团，这允许溶液化学更具体地再现，具有固体结合探针的优点。

7. 发明授权

US06668230B2 Computer readable medium for performing sensor array based materials characterization 失效
标题翻译：用于执行基于传感器阵列的材料表征的计算机可读介质
公开(公告)号：US06668230B2
公开(公告)日：2003-12-23
申请号：US10315519
申请日：2002-12-10
申请人： Paul Mansky , James Bennett
发明人： Paul Mansky , James Bennett
IPC分类号： G01N3100
CPC分类号： G01N25/005 , B01J19/0046 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , G01N25/18 , G01N27/72
摘要： A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for sending electrical signals to and receiving electrical signals from the sensor array; an apparatus for making electrical contact to the sensors in the standardized array format; an apparatus for routing signals between one or more selected sensors and the electronic test and measurement apparatus and a computer including a computer readable having a computer program recorded therein for controlling the operator of the apparatus. The sensor array is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array. The interconnection apparatus and sensor array and contact pad allow measurement of many different material properties by using substrates carrying different sensor types, with only minor modifications if any to the electronic test and measurement apparatus and test procedures. By using a sensor array that is separate from the electronic apparatus, and by including standardized contacting and signal routing apparatuses, the apparatus creates a modular “plug-and-play” system that eliminates the need for multiple materials characterization machines, and eliminates the need for application-specific active circuitry within the sensor arrays themselves. Further, the modular sensor array system can characterize large numbers of material samples rapidly, on the order of at least 50 samples per hour, reducing the time needed for screening of materials libraries.
摘要翻译：模块化材料表征装置包括设置在基板上的传感器阵列，具有标准化的阵列和接触垫格式; 电子测试和测量装置，用于向传感器阵列发送电信号并接收电信号; 用于以标准阵列格式与传感器电接触的装置; 用于在一个或多个选择的传感器和电子测试和测量装置之间路由信号的装置和包括计算机可读的计算机，其中记录有计算机程序以控制装置的操作者。传感器阵列优选地以用于组合化学应用中的标准化格式布置，用于将样品材料快速沉积在传感器阵列上。互连装置和传感器阵列和接触垫允许通过使用携带不同传感器类型的基板来测量许多不同的材料性质，只要对电子测试和测量装置和测试程序进行微小的修改即可。通过使用与电子设备分离的传感器阵列，并且通过包括标准化的接触和信号路由设备，该设备创建了模块化的“即插即用”系统，其消除了对多种材料表征机器的需要，并且消除了需要用于传感器阵列本身内的特定于应用的有源电路。此外，模块化传感器阵列系统可以快速表征大量材料样品，每小时至少50个样品量级，减少了材料库筛选所需的时间。

8. 发明授权

US06535824B1 Sensor array-based system and method for rapid materials characterization 失效
公开(公告)号：US06535824B1
公开(公告)日：2003-03-18
申请号：US09458398
申请日：1999-12-10
申请人： Paul Mansky , James Bennett
发明人： Paul Mansky , James Bennett
IPC分类号： G01N3100
CPC分类号： G01N25/005 , B01J19/0046 , B01J2219/00605 , B01J2219/00612 , B01J2219/00621 , B01J2219/00637 , B01J2219/00653 , B01J2219/00659 , B01J2219/00707 , B01J2219/00745 , B01J2219/00747 , C40B30/08 , C40B40/18 , G01N25/18 , G01N27/72
摘要： A modular materials characterization apparatus includes a sensor array disposed on a substrate, with a standardized array and contact pad format; electronic test and measurement apparatus for sending electrical signals to and receiving electrical signals from the sensor array; an apparatus for making electrical contact to the sensors in the standardized array format; an apparatus for routing signals between one or more selected sensors and the electronic test and measurement apparatus and a computer including a computer readable having a computer program recorded therein for controlling the operator of the apparatus. The sensor array is preferably arranged in a standardized format used in combinatorial chemistry applications for rapid deposition of sample materials on the sensor array. The interconnection apparatus and sensor array and contact pad allow measurement of many different material properties by using substrates carrying different sensor types, with only minor modifications if any to the electronic test and measurement apparatus and test procedures. By using a sensor array that is separate from the electronic apparatus, and by including standardized contacting and signal routing apparatuses, the apparatus creates a modular “plug-and-play” system that eliminates the need for multiple materials characterization machines, and eliminates the need for application-specific active circuitry within the sensor arrays themselves. Further, the modular sensor array system can characterize large numbers of material samples rapidly, on the order of at least 50 samples per hour, reducing the time needed for screening of materials libraries.

9. 发明授权

US09181364B2 Crosslinked polyvinylamine, polyallylamine, and polyethyleneimine for use as bile acid sequestrants 有权
标题翻译：交联聚乙烯胺，聚烯丙胺和聚乙烯亚胺，用作胆汁酸螯合剂
公开(公告)号：US09181364B2
公开(公告)日：2015-11-10
申请号：US13581049
申请日：2011-02-24
申请人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
发明人： Jordan Kopping , Kalpesh Biyani , Eric Connor , Scott Hecker , Inez Lees , Grace Huynh , Faleh Salaymeh , Hongmin Zhang , David Bergbreiter , Paul Mansky , YongQi Mu , Michael James Cope , Elizabeth Goka , Angela Lee , Deidre Madsen , Jun Shao
IPC分类号： C08F226/02 , A61P3/06 , A61K31/785 , C08F20/52 , C08F22/38 , C08F232/08
CPC分类号： A61K31/785 , A61K45/06 , C08F20/52 , C08F22/385 , C08F222/385 , C08F226/02 , C08F232/08
摘要： The present invention provides a crosslinked amine and amide polymers effective for binding and removing bile salts from the gastrointestinal tract. These bile acid binding polymers or pharmaceutical compositions thereof can be administered to subjects to treat various conditions, including hypercholesteremia, diabetes, pruritis, irritable bowel syndrome-diarrhea (IBS-D), bile acid malabsorption, and the like.
摘要翻译：本发明提供了一种有效地从胃肠道结合和除去胆汁盐的交联的胺和酰胺聚合物。这些胆汁酸结合聚合物或其药物组合物可以施用于受试者以治疗各种病症，包括高胆固醇血症，糖尿病，瘙痒症，肠易激综合征 - 腹泻（IBS-D），胆汁酸吸收不良等。

10. 发明授权

US08586097B2 Methods for preparing core-shell composites having cross-linked shells and core-shell composites resulting therefrom 有权
标题翻译：制备具有交联壳和由其产生的核 - 壳复合材料的核 - 壳复合材料的方法
公开(公告)号：US08586097B2
公开(公告)日：2013-11-19
申请号：US12088611
申请日：2006-10-02
申请人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
发明人： Futian Liu , Han-Ting Chang , Dominique Charmot , Eric Connor , Paul Mansky , Mingjun Liu
IPC分类号： A61K9/14 , A61K9/58
CPC分类号： A61K31/795 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5042
摘要： The present invention provides methods and compositions for the treatment of ion imbalances using core-shell composites and compositions comprising such core-shell composites. In particular, the invention provides core-shell particles and compositions comprising potassium binding polymers, and core-shell particles and compositions comprising sodium binding polymers, and in each case, pharmaceutical compositions thereof. Methods of use of the polymeric and pharmaceutical compositions for therapeutic and/or prophylactic benefits are also disclosed. The compositions and methods of the invention offer improved approaches for treatment of hyperkalemia and other indications related to potassium ion homeostasis, and for treatment of hypertension and other indicates related to sodium ion homeostasis.
摘要翻译：本发明提供了使用核 - 壳复合材料和包含这种核 - 壳复合材料的组合物来处理离子不平衡的方法和组合物。特别地，本发明提供了核 - 壳颗粒和包含钾结合聚合物的组合物，以及包含钠结合聚合物的核 - 壳颗粒和组合物，并且在每种情况下都是其药物组合物。还公开了用于治疗和/或预防益处的聚合物和药物组合物的使用方法。本发明的组合物和方法提供治疗高钾血症和与钾离子稳态相关的其它适应症的改进方法，以及用于治疗与钠离子稳态有关的高血压和其它指征。

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