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1. 发明申请

US20060133968A1 Parallel reactor with internal sensing and method of using same 审中-公开
公开(公告)号：US20060133968A1
公开(公告)日：2006-06-22
申请号：US11272249
申请日：2005-11-10
申请人： G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
发明人： G. Dales , Johannes van Beek , Damian Hajduk , Ralph Nielsen , Paul Mansky , Leonid Matsiev , Eric McFarland
IPC分类号： B01J19/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

2. 发明授权

US06864092B1 Parallel reactor with internal sensing and method of using same 有权
公开(公告)号：US06864092B1
公开(公告)日：2005-03-08
申请号：US09723926
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , G01N31/10
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.

3. 发明授权

US06818183B2 Multi-temperature modular reactor and method of using same 有权
标题翻译：多温度模块式反应器及其使用方法
公开(公告)号：US06818183B2
公开(公告)日：2004-11-16
申请号：US10134556
申请日：2002-04-29
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3348
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.
摘要翻译：公开了一种用于实施和监测多重反应的进展和性质的装置和方法。该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。此外，该装置可以包括用于独立地控制每个容器中的压力的装置。单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。

4. 发明授权

US06528026B2 Multi-temperature modular reactor and method of using same 失效
公开(公告)号：US06528026B2
公开(公告)日：2003-03-04
申请号：US09417125
申请日：1998-11-19
申请人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
发明人： Damian A. Hajduk , Ralph B. Nielsen , Adam Safir , Leonid Matsiev , Eric McFarland , Paul Mansky
IPC分类号： G01N3300
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28D15/00 , F28D2021/0077 , F28F27/00 , G01K13/00 , G01N21/253 , Y10T436/10 , Y10T436/11 , Y10T436/25
摘要： An apparatus and method for carrying out and monitoring the progress and properties of multiple reactions is disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight.

5. 发明授权

US06455316B1 Parallel reactor with internal sensing and method of using same 有权
标题翻译：具有内部感测的并联电抗器及其使用方法
公开(公告)号：US06455316B1
公开(公告)日：2002-09-24
申请号：US09548848
申请日：2000-04-13
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. VanBeek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： G01N3110
CPC分类号： B01F15/00207 , B01F13/065 , B01F13/08 , B01F15/00357 , B01F15/00396 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00745 , B01L3/50851 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , F28F27/00 , G01K13/00 , G01N21/253 , G01N35/1079 , Y10T436/11
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译：公开了用于控制和监测多个反应的进展和性质的装置和方法。该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。

6. 发明授权

US06890492B1 Parallel reactor with internal sensing and method of using same 有权
标题翻译：具有内部感测的并联电抗器及其使用方法
公开(公告)号：US06890492B1
公开(公告)日：2005-05-10
申请号：US09724276
申请日：2000-11-28
申请人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
发明人： Howard Turner , G. Cameron Dales , Lynn VanErden , Johannes A. M. Van Beek , Damian A. Hajduk , Ralph B. Nielsen , Paul Mansky , Leonid Matsiev , Pei Wang , Eric McFarland
IPC分类号： B01F15/00 , B01J19/00 , B01L3/00 , B01L7/00 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/10 , B01F7/00
CPC分类号： B01L3/50851 , B01F13/0818 , B01F13/0827 , B01F15/00201 , B01F15/00207 , B01F15/00246 , B01J19/0006 , B01J19/0013 , B01J19/004 , B01J19/0046 , B01J2219/00029 , B01J2219/00162 , B01J2219/002 , B01J2219/00283 , B01J2219/00308 , B01J2219/0031 , B01J2219/00333 , B01J2219/00335 , B01J2219/00351 , B01J2219/00367 , B01J2219/00373 , B01J2219/00389 , B01J2219/00418 , B01J2219/00477 , B01J2219/00481 , B01J2219/00495 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00601 , B01J2219/00686 , B01J2219/00689 , B01J2219/00691 , B01J2219/00695 , B01J2219/00698 , B01J2219/00702 , B01J2219/00704 , B01J2219/0072 , B01J2219/00722 , B01J2219/00736 , B01J2219/00738 , B01J2219/00745 , B01L3/50853 , B01L7/54 , B01L2200/026 , B01L2300/049 , B01L2300/06 , B01L2300/0627 , B01L2300/14 , B01L2300/1805 , C40B40/14 , C40B40/18 , G01K13/00 , G01N11/16 , G01N35/1079 , Y10T436/11 , Y10T436/115831 , Y10T436/119163 , Y10T436/12 , Y10T436/25 , Y10T436/25875
摘要： Devices and methods for controlling and monitoring the progress and properties of multiple reactions are disclosed. The method and apparatus are especially useful for synthesizing, screening, and characterizing combinatorial libraries, but also offer significant advantages over conventional experimental reactors as well. The apparatus generally includes multiple vessels for containing reaction mixtures, and systems for controlling the stirring rate and temperature of individual reaction mixtures or groups of reaction mixtures. In addition, the apparatus may include provisions for independently controlling pressure in each vessel, and a system for injecting liquids into the vessels at a pressure different than ambient pressure. In situ monitoring of individual reaction mixtures provides feedback for process controllers, and also provides data for determining reaction rates, product yields, and various properties of the reaction products, including viscosity and molecular weight. Computer-based methods are disclosed for process monitoring and control, and for data display and analysis.
摘要翻译：公开了用于控制和监测多个反应的进展和性质的装置和方法。该方法和装置对于组合文库的合成，筛选和表征特别有用，但是与常规实验反应器相比也具有显着的优点。该装置通常包括用于容纳反应混合物的多个容器和用于控制各个反应混合物或反应混合物组的搅拌速率和温度的系统。此外，该装置可以包括用于独立地控制每个容器中的压力的装置，以及用于以不同于环境压力的压力将液体注入容器的系统。单独反应混合物的原位监测为过程控制器提供反馈，并提供了确定反应速率，产物产率和反应产物各种性质（包括粘度和分子量）的数据。公开了基于计算机的方法，用于过程监控和控制，以及数据显示和分析。

7. 发明授权

US06336353B2 Method and apparatus for characterizing materials by using a mechanical resonator 有权
标题翻译：通过使用机械谐振器表征材料的方法和装置
公开(公告)号：US06336353B2
公开(公告)日：2002-01-08
申请号：US09801165
申请日：2001-03-07
申请人： Leonid Matsiev , James Bennett , Eric McFarland
发明人： Leonid Matsiev , James Bennett , Eric McFarland
IPC分类号： G01N2902
CPC分类号： G01N29/4418 , B01J2219/00704 , G01H13/00 , G01N5/04 , G01N9/002 , G01N11/16 , G01N29/022 , G01N29/036 , G01N29/348 , G01N29/42 , G01N2009/006 , G01N2291/014 , G01N2291/0224 , G01N2291/0255 , G01N2291/02818 , G01N2291/02863 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： A method and apparatus for measuring properties of a fluid composition includes a mechanical resonator connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the mechanical resonator, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the fluid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range. The mechanical resonator's response over the frequency range depends on various characteristics of the fluid being tested, such as the temperature, viscosity, and other physical properties. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.
摘要翻译：用于测量流体组合物的性质的方法和装置包括连接到测量电路的机械谐振器。测量电路向机械谐振器提供可变频率输入信号，使机械谐振器振荡。为了测试液体组合物的性质，将机械谐振器放置在含有少量流体的样品孔内。然后将输入信号发送到机械谐振器并扫过选定的频率范围。机械谐振器在频率范围内的响应取决于被测流体的各种特性，例如温度，粘度和其他物理性质。本发明特别适用于组合化学应用，需要快速分析筛选的化学性质。

8. 发明授权

US06957565B2 Method and apparatus for characterizing materials by using a mechanical resonator 有权
标题翻译：通过使用机械谐振器表征材料的方法和装置
公开(公告)号：US06957565B2
公开(公告)日：2005-10-25
申请号：US10685962
申请日：2003-10-15
申请人： Leonid Matsiev , James Bennett , Eric McFarland
发明人： Leonid Matsiev , James Bennett , Eric McFarland
IPC分类号： G01H13/00 , G01N9/00 , G01N9/34 , G01N11/16 , G01N29/02 , G01N29/036 , G01N29/30 , G01N29/34 , G01N29/42 , G01N29/44 , G10K11/02 , H03H9/19
CPC分类号： G01H13/00 , B01J2219/00704 , G01N9/002 , G01N9/34 , G01N11/16 , G01N29/022 , G01N29/036 , G01N29/30 , G01N29/348 , G01N29/42 , G01N29/4418 , G01N29/4427 , G01N29/4436 , G01N2009/006 , G01N2291/014 , G01N2291/0224 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0422 , G01N2291/0423 , G01N2291/0427 , G10K11/02
摘要： A method for measuring properties of a fluid that includes oscillating a tuning fork resonator in a fluid. The invention is particularly suitable for in-line monitoring of various physical and electrical properties of fluids flowing in a conduit.
摘要翻译：一种用于测量流体性质的方法，该方法包括在液体中振荡音叉谐振器。本发明特别适用于在管道中流动的流体的各种物理和电学特性的在线监测。

9. 发明授权

US06393895B1 Method and apparatus for characterizing materials by using a mechanical resonator 失效
标题翻译：通过使用机械谐振器表征材料的方法和装置
公开(公告)号：US06393895B1
公开(公告)日：2002-05-28
申请号：US09133171
申请日：1998-08-12
申请人： Leonid Matsiev , James Bennett , Eric McFarland
发明人： Leonid Matsiev , James Bennett , Eric McFarland
IPC分类号： G01N2902
CPC分类号： G01N29/4418 , B01J2219/00704 , G01H13/00 , G01N5/04 , G01N9/002 , G01N11/16 , G01N29/022 , G01N29/036 , G01N29/348 , G01N29/42 , G01N2009/006 , G01N2291/014 , G01N2291/0224 , G01N2291/0255 , G01N2291/02818 , G01N2291/02863 , G01N2291/0422 , G01N2291/0423 , G01N2291/0426 , G01N2291/0427
摘要： A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a thickness shear mode resonator or a tuning fork resonator, connected to a measurement circuit. The measurement circuit provides a variable frequency input signal to the tuning fork, causing the mechanical resonator to oscillate. To test the properties of a liquid composition, the mechanical resonator is placed inside a sample well containing a small amount of the liquid. The input signal is then sent to the mechanical resonator and swept over a selected frequency range, preferably less than 1 MHz to prevent the liquid being tested from exhibiting gel-like characteristics and causing false readings. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. Particular mechanical resonators, such as tuning fork resonators, can also be used to measure a liquid composition's electrical properties, such as the dielectric constant and conductivity, because the tuning fork's structure allows a high degree of electrical coupling between the tuning fork and the surrounding liquid. The mechanical resonator can be covered with a coating to impart additional special detection properties to the resonator, and multiple resonators can be attached together as a single sensor to obtain multiple frequency responses. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.
摘要翻译：用于测量液体组合物性质的方法和装置包括连接到测量电路的机械谐振器，例如厚度剪切模式谐振器或音叉谐振器。测量电路向音叉提供可变频率输入信号，使机械谐振器振荡。为了测试液体组合物的性质，将机械谐振器放置在含有少量液体的样品孔内。然后将输入信号发送到机械谐振器并扫过选定的频率范围，优选小于1MHz，以防止被测试的液体表现出凝胶状特征并导致错误的读数。机械谐振器在频率范围内的响应取决于待测液体的各种特性，例如温度，粘度和其他物理性质。由于音叉的结构允许音叉和周围液体之间的高度电耦合，所以诸如音叉谐振器的特殊的机械谐振器也可用于测量液体组合物的电性能，例如介电常数和导电性。可以用涂层覆盖机械谐振器以赋予谐振器附加的特殊检测特性，并且多个谐振器可以作为单个传感器附接在一起以获得多个频率响应。本发明特别适用于组合化学应用，需要快速分析筛选的化学性质。

10. 发明授权

US06904786B2 Method and apparatus for characterizing materials by using a mechanical resonator 失效
标题翻译：通过使用机械谐振器表征材料的方法和装置
公开(公告)号：US06904786B2
公开(公告)日：2005-06-14
申请号：US10266047
申请日：2002-10-07
申请人： Leonid Matsiev , James Bennett , Eric McFarland
发明人： Leonid Matsiev , James Bennett , Eric McFarland
IPC分类号： G01H13/00 , G01N9/00 , G01N9/34 , G01N11/16 , G01N29/02 , G01N29/036 , G01N29/30 , G01N29/34 , G01N29/42 , G01N29/44 , G10K11/02 , H03H9/19
CPC分类号： G01H13/00 , B01J2219/00704 , G01N9/002 , G01N9/34 , G01N11/16 , G01N29/022 , G01N29/036 , G01N29/30 , G01N29/348 , G01N29/42 , G01N29/4418 , G01N29/4427 , G01N29/4436 , G01N2009/006 , G01N2291/014 , G01N2291/0224 , G01N2291/0255 , G01N2291/0256 , G01N2291/02818 , G01N2291/0422 , G01N2291/0423 , G01N2291/0427 , G10K11/02
摘要： A method and apparatus for measuring properties of a liquid composition includes a mechanical resonator, such as a cantilever, connected to a measurement circuit. The mechanical resonator's response over the frequency range depends on various characteristics of the liquid being tested, such as the temperature, viscosity, and other physical properties. The invention is particularly suitable for combinatorial chemistry applications, which require rapid analysis of chemical properties for screening.
摘要翻译：用于测量液体组合物性质的方法和装置包括连接到测量电路的诸如悬臂的机械谐振器。机械谐振器在频率范围内的响应取决于待测液体的各种特性，例如温度，粘度和其他物理性质。本发明特别适用于组合化学应用，需要快速分析筛选的化学性质。

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