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1. 发明授权

US07390785B2 τ-conotoxin peptides 有权
标题翻译： tau-芋螺毒素肽
公开(公告)号：US07390785B2
公开(公告)日：2008-06-24
申请号：US11267257
申请日：2005-11-07
申请人： Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人： Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
IPC分类号： C07K7/02 , A61K38/00
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译：本发明涉及相对较短的肽（本文中称为tau-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个二硫键。

2. 发明授权

US06630573B1 Tau-conotoxin peptides 有权
标题翻译：芋螺毒素肽
公开(公告)号：US06630573B1
公开(公告)日：2003-10-07
申请号：US09497491
申请日：2000-02-04
申请人： Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steele , Robert Jones
发明人： Craig Walker , Reshma Shetty , Baldomero M. Olivera , David Hooper , Richard Jacobsen , Doug Steele , Robert Jones
IPC分类号： A61K3808
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed &tgr;-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译：本发明涉及相对较短的肽（本文中称为tau-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个二硫键。

3. 发明申请

US20070173457A1 Tau-conotoxin peptides 有权
标题翻译：芋螺毒素肽
公开(公告)号：US20070173457A1
公开(公告)日：2007-07-26
申请号：US11267257
申请日：2005-11-07
申请人： Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人： Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
IPC分类号： A61K38/10 , C07K7/08
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译：本发明涉及相对较短的肽（本文中称为tau-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个二硫键。

4. 发明申请

US20050124547A1 Tau-conotoxin peptides 审中-公开
标题翻译：芋螺毒素肽
公开(公告)号：US20050124547A1
公开(公告)日：2005-06-09
申请号：US10619473
申请日：2003-07-16
申请人： Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
发明人： Craig Walker , Reshma Shetty , Baldomero Olivera , David Hooper , Richard Jacobsen , Doug Steel , Robert Jones
IPC分类号： C12N15/09 , A61K38/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P29/00 , A61P43/00 , C07K7/06 , C07K7/08 , C07K14/435 , C12N15/12 , A61K38/08 , A61K38/14
CPC分类号： C07K14/43504 , A61K38/00
摘要： The invention relates to relatively short peptides (termed τ-conotoxins herein), about 10-25 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include two disulfide bonds.
摘要翻译：本发明涉及相对较短的肽（本文中称为tau-芋螺毒素），长度约10-25个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括两个二硫键。

5. 发明授权

US06624288B1 Gamma-conopeptides 有权
标题翻译：伽玛肽
公开(公告)号：US06624288B1
公开(公告)日：2003-09-23
申请号：US09210952
申请日：1998-12-15
申请人： Michael Fainzilber , Karel S. Kits , Alma L. Burlingame , Baldomero M. Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes J. Cruz , Julita Imperial , Clark Colledge
发明人： Michael Fainzilber , Karel S. Kits , Alma L. Burlingame , Baldomero M. Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes J. Cruz , Julita Imperial , Clark Colledge
IPC分类号： C07K500
CPC分类号： C07K14/43504 , A61K38/00
摘要： This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more &ggr;-carboxyglutamate residues. More specifically, the present invention is directed to &ggr;-conopeptides having the general formula I: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7 (SEQ ID NO:1), as described herein; or having the general formula II: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8 (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7 (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:4), as described herein; or having the general formula V: Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa8-Leu-Xaa9 (SEQ ID NO:5), as described herein. The invention further relates to specific &ggr;-conopeptides, specific pro-&ggr;-conopeptides and nucleic acids encoding the pro-&ggr;-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.
摘要翻译：本发明涉及长度约25-40个残基的相对较短的肽，其在锥形蜗牛的毒液中或天然存在的肽的类似物中天然可用量少，并且其包括三个环化二硫键和一个或多个γ- 羧基谷氨酸残基。更具体地，本发明涉及具有通式I的X射线衍生肽：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7（SEQ ID NO：1），如本文所述; 或具有如本文所定义的通式II：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8（SEQ ID NO：2）或具有通式III：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa2-Cys-Xaa7（SEQ ID NO：3）在这里或具有通式IV：Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7（SEQ ID NO：4）在这里或具有通式V：Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr -Cys-Xaa8-Leu-Xaa9（SEQ ID NO：5），如本文所述。本发明进一步涉及具体的γ-配体肽，特异性前-γ-肽和编码前γ-多肽的核酸。本发明还包括肽的药学上可接受的盐。这些肽可用作神经元起搏器钙通道的激动剂。

6. 发明授权

US06767895B2 I-superfamily conotoxins 失效
标题翻译： I超家族芋螺毒素
公开(公告)号：US06767895B2
公开(公告)日：2004-07-27
申请号：US09894882
申请日：2001-06-29
申请人： Craig S. Walker , Reshma Shetty , Elsie C. Jimenez , J. Michael McIntosh , Baldomero M. Olivera , Maren Watkins , Robert M. Jones , Gregory S. Shen
发明人： Craig S. Walker , Reshma Shetty , Elsie C. Jimenez , J. Michael McIntosh , Baldomero M. Olivera , Maren Watkins , Robert M. Jones , Gregory S. Shen
IPC分类号： A61K3816
CPC分类号： C07K14/43504
摘要： The invention relates to relatively short peptides (termed I-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.
摘要翻译：本发明涉及相对短的肽（本文中称为I-芋螺毒素），长度约30-50个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括四个二硫键。

7. 发明申请

US20050214213A1 Cone snail peptides 审中-公开
标题翻译：锥蜗牛肽
公开(公告)号：US20050214213A1
公开(公告)日：2005-09-29
申请号：US11097315
申请日：2005-04-04
申请人： Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
发明人： Baldomero Olivera , J. McIntosh , Maren Watkins , James Garrett , Lourdes Cruz , Michelle Grilley , Robert Schoenfeld , Craig Walker , Reshma Shetty , Robert Jones
IPC分类号： A61K38/00 , C07K14/435 , C12N5/02 , A61K51/00 , A61K38/16
CPC分类号： C07K14/43504 , A61K38/00
摘要： The present invention is directed to conotoxin peptides, derivatives or pharmaceutically acceptable salts thereof. The present invention is further directed to the use of this peptide, derivatives thereof and pharmaceutically acceptable salts thereof for the treatment of disorders associated with voltage-gated ion channels, voltage-gated ligand channels and/or receptors. The invention is further directed to nucleic acid sequences encoding the conotoxin peptides and encoding propeptides, as well as the propeptides.
摘要翻译：本发明涉及芋螺毒素肽，其衍生物或药学上可接受的盐。本发明进一步涉及该肽，其衍生物和其药学上可接受的盐在治疗与电压门控离子通道，电压门控配体通道和/或受体相关的病症中的用途。本发明还涉及编码芋螺毒素肽和编码前肽以及前肽的核酸序列。

8. 发明申请

US20050096270A1 I-superfamily conotoxins 审中-公开
标题翻译： I超家族芋螺毒素
公开(公告)号：US20050096270A1
公开(公告)日：2005-05-05
申请号：US10894314
申请日：2004-07-20
申请人： Craig Walker , Reshma Shetty , Elsie Jimenez , J. McIntosh , Baldomero Olivera , Maren Watkins , Robert Jones , Gregory Shen
发明人： Craig Walker , Reshma Shetty , Elsie Jimenez , J. McIntosh , Baldomero Olivera , Maren Watkins , Robert Jones , Gregory Shen
IPC分类号： C07K14/435 , A61K38/16
CPC分类号： C07K14/43504
摘要： The invention relates to relatively short peptides (termed 1-conotoxins herein), about 30-50 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogous to the naturally available peptides, and which preferably include four disulfide bonds.
摘要翻译：本发明涉及相对短的肽（本文中称为1-芋螺毒素），长度约30-50个残基，其在锥形蜗牛的毒液中天然可以微量天然存在或类似于天然可得的肽，并且优选包括四个二硫键。

9. 发明申请

US20060223984A1 Gamma-conopeptides 审中-公开
公开(公告)号：US20060223984A1
公开(公告)日：2006-10-05
申请号：US10647519
申请日：2003-08-26
申请人： Michael Fainzilber , Karel Kits , Alma Burlingame , Baldomero Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes Cruz , Julita Imperial , Clark Colledge
发明人： Michael Fainzilber , Karel Kits , Alma Burlingame , Baldomero Olivera , Craig Walker , Maren Watkins , Reshma Shetty , Lourdes Cruz , Julita Imperial , Clark Colledge
IPC分类号： C07K7/08 , C07K14/435
CPC分类号： C07K14/43504 , A61K38/00
摘要： This invention relates to relatively short peptides about 25-40 residues in length, which are naturally available in minute amounts in the venom of the cone snails or analogs to the naturally available peptides, and which include three cyclizing disulfide linkages and one or more γcarboxyglutamate residues. More specifically, the present invention is directed to γ-conopeptides having the general formula I: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Cys-Xaa6-Cys-Xaa7 (SEQ ID NO:1), as described herein; or having the general formula II: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Cys-Cys-Xaa5-Xaa6-Cys-Xaa7-Cys-Xaa8 (SEQ ID NO:2), as defined herein; or having the general formula III: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:3), as described herein; or having the general formula IV: Xaa1-Cys-Xaa2-Cys-Xaa3-Xaa4-Xaa5-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Xaa6-Cys-Xaa7 (SEQ ID NO:4), as described herein; or having the general formula V: Xaa1-Xaa2-Cys-Xaa3-Xaa4-Phe-Xaa5-Cys-Thr-Xaa6-Ser-Xaa7-Cys-Cys-Ser-Asn-Ser-Cys-Asp-Gln-Thr-Tyr-Cys-Xaa8-Leu-Xaa9 (SEQ ID NO:5), as described herein. The invention further relates to specific γ-conopeptides, specific pro-γ-conopeptides and nucleic acids encoding the pro-γ-conopeptides. The invention also includes pharmaceutically acceptable salts of the conopeptides. These conopeptides are useful as agonists of neuronal pacemaker calcium channels.

10. 发明申请

US20120040870A1 Method For Assembly Of Polynucleic Acid Sequences 有权
公开(公告)号：US20120040870A1
公开(公告)日：2012-02-16
申请号：US13140473
申请日：2009-12-18
申请人： Austin Che , Tom Knight , Barry Canton , Jason Kelly , Reshma Shetty
发明人： Austin Che , Tom Knight , Barry Canton , Jason Kelly , Reshma Shetty
IPC分类号： C12P19/34 , C40B50/06
CPC分类号： C12N15/66 , C12N15/1093 , C12N15/64
摘要： The present invention provides a method for the assembly of a polynucleic acid sequence from a plurality of nucleic acid sequences in which the polynucleic acid sequence is of a formula Nn+1, in which N represents a nucleic acid sequence and where n is 1 or greater than 1 and each N may be the same or a different nucleic acid sequence, in which the method comprises: (i) providing a first nucleic acid sequence N1 which has an oligonucleotide linker sequence L13 at the 3′-end of the nucleic acid sequence; (ii) providing a second nucleic acid sequence N2 which optionally has an oligonucleotide linker sequence L23′ at the 3′-end of the nucleic acid sequence and which has an oligonucleotide linker sequence L25′ at the 5′-end of the nucleic acid sequence, wherein the 5′-end linker sequence L25′ of nucleic acid sequence N2 is complementary to the 3′-end linker sequence L13′ of nucleic acid sequence N1; (iii) optionally providing one or more additional nucleic acid sequences N, wherein nucleic acid sequence N2 has an oligonucleotide linker sequence L23′ at the 3′-end of the nucleic acid sequence, and wherein said one or more additional nucleic acid sequences N comprises a terminal additional nucleic acid sequence NZ, and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 3′-end, wherein said terminal additional nucleic acid sequence NZ optionally lacks an oligonucleotide linker sequence at its 3′-end and wherein each additional nucleic acid sequence N has an oligonucleotide linker sequence at its 5′-end, wherein for the first additional nucleic acid sequence N3 the 5′-end linker sequence L35′ is complementary to the 3′-end linker sequence L23′ of nucleic acid sequence N2 and for each second and subsequent additional nucleic acid sequence N the 5′-end linker sequence is complementary to the 3′-end linker sequence of the respective preceding additional nucleic acid sequence; and (iv) ligating said nucleic acid sequences to form said polynucleic acid sequence.

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