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1. 发明授权

US5837228A Bioerodible implants 失效
标题翻译：生物蚀刻植入物
公开(公告)号：US5837228A
公开(公告)日：1998-11-17
申请号：US939539
申请日：1992-09-02
申请人： Chung Shih , Gaylen M. Zentner , Randall V. Sparer , R. Lee Seward
发明人： Chung Shih , Gaylen M. Zentner , Randall V. Sparer , R. Lee Seward
IPC分类号： A61K9/00 , A61K9/20 , A61K9/58 , A61K31/35 , A61K31/365 , A61K31/74 , A61K47/48 , A61P33/00 , A61P33/10 , A61K9/14 , A61F2/02
CPC分类号： A61K9/0024 , A61K47/48192 , A61K47/482 , A61K9/204 , Y10S514/953
摘要： A bioerodible controlled release dosage form is disclosed comprising a polymer formed by condensing beneficial agents having a hydroxyl functionality of two or more with diketene acetals or divinyl ethers which delivers beneficial agents to a biological environment of use. A statistically significant portion of the beneficial agent is covalently bonded within the polymer matrix.
摘要翻译：公开了一种生物腐蚀性控制释放剂型，其包含通过将具有两个或更多个羟基官能团的有益剂与双烯酮缩醛或二乙烯基醚缩合形成的聚合物，其将有益剂递送到生物生物学环境。有益试剂的统计学显着部分共价键合在聚合物基质内。

2. 发明申请

US20090264537A1 BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY 有权
标题翻译：用于药物递送的可生物降解的嵌段共聚物组合物
公开(公告)号：US20090264537A1
公开(公告)日：2009-10-22
申请号：US12490968
申请日：2009-06-24
申请人： Chung Shih , Gaylen M. Zentner
发明人： Chung Shih , Gaylen M. Zentner
IPC分类号： A61K47/34
CPC分类号： A61K47/34 , A61K9/0024 , A61K31/765 , A61K31/77 , A61K47/10 , C08G2261/126 , C08L71/02 , C08L2666/18 , C08L2666/02
摘要： An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.
摘要翻译：公开了改进的药物递送组合物和使用方法。组合物包含一种或多种可生物降解的嵌段共聚物药物载体; 和包含聚乙二醇（PEG），PEG衍生物或PEG和PEG衍生物的混合物的重构增强和使能剂。组合物可以按照或在被溶解或快速重构在水性载体中以提供均匀的溶液或均匀的胶体体系来施用。

3. 发明授权

US07649023B2 Biodegradable block copolymeric compositions for drug delivery 有权
标题翻译：用于药物递送的可生物降解的嵌段共聚物组合物
公开(公告)号：US07649023B2
公开(公告)日：2010-01-19
申请号：US10186462
申请日：2002-06-28
申请人： Chung Shih , Gaylen M. Zentner
发明人： Chung Shih , Gaylen M. Zentner
IPC分类号： A61K47/00 , A61K31/335 , C07D305/00 , A61F2/00 , A01N25/00 , A01N43/02
CPC分类号： A61K47/34 , A61K9/0024 , A61K31/765 , A61K31/77 , A61K47/10 , C08G2261/126 , C08L71/02 , C08L2666/18 , C08L2666/02
摘要： An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.
摘要翻译：公开了改进的药物递送组合物和使用方法。组合物包含一种或多种可生物降解的嵌段共聚物药物载体; 和包含聚乙二醇（PEG），PEG衍生物或PEG和PEG衍生物的混合物的重构增强和使能剂。组合物可以按照或在被溶解或快速重构在水性载体中以提供均匀的溶液或均匀的胶体体系来施用。

4. 发明申请

US20090048346A1 THERAPEUTIC FORMULATIONS 审中-公开
标题翻译：治疗配方
公开(公告)号：US20090048346A1
公开(公告)日：2009-02-19
申请号：US11721662
申请日：2005-11-30
申请人： Gaylen M. Zentner , Chung Shih
发明人： Gaylen M. Zentner , Chung Shih
IPC分类号： A61K31/166 , A61P35/00
CPC分类号： A61K31/165
摘要： The present invention features pharmaceutical compositions that improve the bioavailability of hydrophobic pharmaceutical agents that induce apoptosis in mammalian cells. Also featured are injectable formulations for the parenteral delivery of such hydrophobic pharmaceutical agents into patients in need of such treatment, as well as methods of making and using both the compositions and formulations, including methods for the treatment of cell proliferation or hyperproliferative diseases and disorders.
摘要翻译：本发明的特征在于提高诱导哺乳动物细胞凋亡的疏水性药剂的生物利用度的药物组合物。还特征在于用于将这种疏水性药剂肠胃外输送到需要这种治疗的患者中的可注射制剂，以及制备和使用组合物和制剂的方法，包括治疗细胞增殖或过度增殖性疾病和病症的方法。

5. 发明授权

US06592899B2 PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water 有权
标题翻译： PLA / PLGA低聚物与嵌段共聚物结合，以增加药物在水中的溶解度
公开(公告)号：US06592899B2
公开(公告)日：2003-07-15
申请号：US09971082
申请日：2001-10-03
申请人： Kirk Dee Fowers , Gaylen M. Zentner , Chung Shih , Ai-Zhi Piao
发明人： Kirk Dee Fowers , Gaylen M. Zentner , Chung Shih , Ai-Zhi Piao
IPC分类号： A61K914
CPC分类号： A61K47/34 , C08L67/04 , C08L2666/18
摘要： Polymeric compositions having improved capability of solubilizing a drug in a hydrophilic environment to form a solution, comprising: a biodegradable polyester oligomer; and biodegradable AB-type, ABA-type, or BAB-type block copolymers are disclosed. The copolymers are comprised of about 50.1 to 65% by weight of a biodegradable, hydrophobic A polymer block comprising a biodegradable polyester, and about 35 to 49.9% by weight of a hydrophilic B polymer block comprising a polyethylene glycol (PEG), and wherein the block copolymer has a weight averaged molecular weight of between 2400 to 4999. The biodegradable polyester oligomer of said composition is within a range of 0.01% to 30% by weight of the total polymer mixture, and the content of the biodegradable AB-type, ABA-type, or BAB-type block copolymer is within a range of 70% to 99.99% by weight of the total polymer mixture.
摘要翻译：具有改善在亲水环境中溶解药物以形成溶液的能力的聚合物组合物，包括：可生物降解的聚酯低聚物; 并且公开了可生物降解的AB型，ABA型或BAB型嵌段共聚物。共聚物由约50.1至65重量％的包含可生物降解聚酯的可生物降解的疏水性A聚合物嵌段和约35至49.9重量％的包含聚乙二醇（PEG）的亲水性B聚合物嵌段组成，并且其中嵌段共聚物的重均分子量在2400至4999之间。所述组合物的可生物降解的聚酯低聚物在总聚合物混合物的重量的0.01％至30％的范围内，并且可生物降解的AB型，ABA的含量型或BAB型嵌段共聚物在总聚合物混合物的70重量％至99.99重量％的范围内。

6. 发明授权

US08642666B2 Biodegradable block copolymeric compositions for drug delivery 有权
标题翻译：用于药物递送的可生物降解的嵌段共聚物组合物
公开(公告)号：US08642666B2
公开(公告)日：2014-02-04
申请号：US12490968
申请日：2009-06-24
申请人： Chung Shih , Gaylen M. Zentner
发明人： Chung Shih , Gaylen M. Zentner
IPC分类号： A61K47/14 , A61K31/335 , C07D305/00 , A61F2/00 , A01N25/00 , A01N43/02
CPC分类号： A61K47/34 , A61K9/0024 , A61K31/765 , A61K31/77 , A61K47/10 , C08G2261/126 , C08L71/02 , C08L2666/18 , C08L2666/02
摘要： An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.
摘要翻译：公开了改进的药物递送组合物和使用方法。组合物包含一种或多种可生物降解的嵌段共聚物药物载体; 和包含聚乙二醇（PEG），PEG衍生物或PEG和PEG衍生物的混合物的重构增强和使能剂。组合物可以按照或在被溶解或快速重构在水性载体中以提供均匀的溶液或均匀的胶体体系来施用。

7. 发明申请

US20100076067A1 BIODEGRADABLE BLOCK COPOLYMERIC COMPOSITIONS FOR DRUG DELIVERY 审中-公开
标题翻译：用于药物递送的可生物降解的嵌段共聚物组合物
公开(公告)号：US20100076067A1
公开(公告)日：2010-03-25
申请号：US12627175
申请日：2009-11-30
申请人： Chung Shih , Gaylen M. Zentner
发明人： Chung Shih , Gaylen M. Zentner
IPC分类号： A61K47/30 , A61K31/337 , A61P35/00
CPC分类号： A61K47/34 , A61K9/0024 , A61K31/765 , A61K31/77 , A61K47/10 , C08G2261/126 , C08L71/02 , C08L2666/18 , C08L2666/02
摘要： An improved drug delivery composition and method of use is disclosed. The composition comprises one or more biodegradable block copolymer drug carriers; and a reconstitution enhancing and enabling agent comprising polyethylene glycol (PEG), a PEG derivative or a mixture of PEG and a PEG derivative. The composition can be administered as is or after being be dissolved or rapidly reconstituted in an aqueous vehicle to afford a homogeneous solution or uniform colloidal systems.
摘要翻译：公开了改进的药物递送组合物和使用方法。组合物包含一种或多种可生物降解的嵌段共聚物药物载体; 和包含聚乙二醇（PEG），PEG衍生物或PEG和PEG衍生物的混合物的重构增强和使能剂。组合物可以按照或在被溶解或快速重构在水性载体中以提供均匀的溶液或均匀的胶体体系来施用。

8. 发明申请

US20090069350A1 PHARMACEUTICAL COMPOSITIONS AND USE THEREOF 审中-公开
标题翻译：药物组合物及其用途
公开(公告)号：US20090069350A1
公开(公告)日：2009-03-12
申请号：US12272378
申请日：2008-11-17
申请人： Gaylen M. Zentner , Chung Shih , James C. McRea
发明人： Gaylen M. Zentner , Chung Shih , James C. McRea
IPC分类号： A61K31/517 , A61P35/00
CPC分类号： A61K31/517 , A61K9/0019 , A61K47/10 , A61K47/44
摘要： The present invention relates to pharmaceutical compositions and dosage compositions of compounds, including injectable formulations for the parenteral delivery of such compounds into patients in need of such treatment. Also featured are methods of making and using the compositions, including methods for the treatment of neoplastic diseases.
摘要翻译：本发明涉及化合物的药物组合物和剂量组合物，包括用于将这些化合物胃肠外递送给需要这种治疗的患者的可注射制剂。还特征在于制备和使用组合物的方法，包括治疗肿瘤疾病的方法。

9. 发明授权

US06287588B1 Agent delivering system comprised of microparticle and biodegradable gel with an improved releasing profile and methods of use thereof 有权
标题翻译：由微粒和可生物降解的凝胶组成的具有改进的释放特征的药剂递送系统及其使用方法
公开(公告)号：US06287588B1
公开(公告)日：2001-09-11
申请号：US09559507
申请日：2000-04-27
申请人： Chung Shih , Gaylen M. Zentner
发明人： Chung Shih , Gaylen M. Zentner
IPC分类号： A61F200
CPC分类号： A61K47/34 , A61K9/06
摘要： A composition and method for releasing a bio-active agent or a drug within a biological environment in a controlled manner is disclosed. The composition is a dual phase polymeric agent-delivery composition comprising a continuous biocompatible gel phase, a discontinuous particulate phase comprising defined microparticles and an agent to be delivered. A microparticle containing a bio-active agent is releasably entrained within a biocompatible polymeric gel matrix. The bio-active agent release may be contained in the microparticle phase alone or in both the microparticles and the gel matrix. The release of the agent is prolonged over a period of time, and the delivery may be modulated and/or controlled. In addition, a second agent may be loaded in some of the microparticles and/or the gel matrix.
摘要翻译：公开了以可控制的方式在生物环境中释放生物活性剂或药物的组合物和方法。组合物是双相聚合物递送组合物，其包含连续的生物相容性凝胶相，包含限定的微粒的不连续颗粒相和待递送的试剂。含有生物活性剂的微粒可释放地夹带在生物相容性聚合物凝胶基质内。生物活性剂释放可以单独包含在微粒相中，也可以包含在微粒和凝胶基质中。试剂的释放在一段时间内延长，并且递送可以被调节和/或控制。另外，第二种试剂可以装载在一些微粒和/或凝胶基质中。

10. 发明申请

US20100087538A1 DRUG SUBSTANCE PREPARATIONS, PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS 有权
标题翻译：药物物质制剂，药物组合物和剂型
公开(公告)号：US20100087538A1
公开(公告)日：2010-04-08
申请号：US12533323
申请日：2009-07-31
申请人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Stephen J. Martin , Norman T. Smith , Catriona A. Oare
发明人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Stephen J. Martin , Norman T. Smith , Catriona A. Oare
IPC分类号： A61K31/19
CPC分类号： A61K9/2018 , A61K9/2054 , A61K31/19
摘要： The invention relates to drug substance preparations, pharmaceutical compositions and dosage forms containing (R)-(−)-2-(2-fluoro-4-biphenylyl) propionic acid as the active pharmaceutical ingredient, and limited amounts of specific product-related and process-related impurities.
摘要翻译：本发明涉及含有（R） - （ - ） - 2-（2-氟-4-联苯基）丙酸作为活性药物成分的药物制剂，药物组合物和剂型，并且具体产品相关和与工艺有关的杂质。

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