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1. 发明申请

US20100087538A1 DRUG SUBSTANCE PREPARATIONS, PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS 有权
标题翻译：药物物质制剂，药物组合物和剂型
公开(公告)号：US20100087538A1
公开(公告)日：2010-04-08
申请号：US12533323
申请日：2009-07-31
申请人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Stephen J. Martin , Norman T. Smith , Catriona A. Oare
发明人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Stephen J. Martin , Norman T. Smith , Catriona A. Oare
IPC分类号： A61K31/19
CPC分类号： A61K9/2018 , A61K9/2054 , A61K31/19
摘要： The invention relates to drug substance preparations, pharmaceutical compositions and dosage forms containing (R)-(−)-2-(2-fluoro-4-biphenylyl) propionic acid as the active pharmaceutical ingredient, and limited amounts of specific product-related and process-related impurities.
摘要翻译：本发明涉及含有（R） - （ - ） - 2-（2-氟-4-联苯基）丙酸作为活性药物成分的药物制剂，药物组合物和剂型，并且具体产品相关和与工艺有关的杂质。

2. 发明授权

US08653139B2 Drug substance preparations, pharmaceutical compositions and dosage forms 有权
标题翻译：药物制剂，药物组合物和剂型
公开(公告)号：US08653139B2
公开(公告)日：2014-02-18
申请号：US12533323
申请日：2009-07-31
申请人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Stephen J. Martin , Norman T. Smith , Catriona A. Oare
发明人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Stephen J. Martin , Norman T. Smith , Catriona A. Oare
IPC分类号： A61K31/19
CPC分类号： A61K9/2018 , A61K9/2054 , A61K31/19
摘要： The invention relates to drug substance preparations, pharmaceutical compositions and dosage forms containing (R)-(−)-2-(2-fluoro-4-biphenylyl) propionic acid as the active pharmaceutical ingredient, and limited amounts of specific product-related and process-related impurities.
摘要翻译：本发明涉及含有（R） - （ - ） - 2-（2-氟-4-联苯基）丙酸作为活性药物成分的药物制剂，药物组合物和剂型，并且具体产品相关和与工艺有关的杂质。

3. 发明申请

US20110111025A1 High Drug Load Formulations and Dosage Forms 审中-公开
标题翻译：高药物制剂和剂型
公开(公告)号：US20110111025A1
公开(公告)日：2011-05-12
申请号：US12771621
申请日：2010-04-30
申请人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Gregory T. Oerhtman , Tracy Annette Powers
发明人： Gaylen M. Zentner , James C. McRea , Mark S. Williams , Gregory T. Oerhtman , Tracy Annette Powers
IPC分类号： A61K31/192 , A61K9/28 , A61P25/28
CPC分类号： A61K9/2077 , A61K9/2018 , A61K9/2054 , A61K9/2095 , A61K31/192
摘要： The invention relates to high drug load formulations containing (R)-2-(2-fluoro-4-biphenylyl)propionic acid as an active pharmaceutical ingredient.
摘要翻译：本发明涉及含有（R）-2-（2-氟-4-联苯基）丙酸作为活性药物成分的高药物负荷制剂。

4. 发明申请

US20130087665A1 DISPLAY MOUNTING TECHNIQUES 有权
标题翻译：显示安装技术
公开(公告)号：US20130087665A1
公开(公告)日：2013-04-11
申请号：US13270359
申请日：2011-10-11
申请人： Douglas A. Lostoski , Geoff M. Sieron , Andrew P. Kaufman , William M. Ruddy , Daniel L. Stefaniak , Douglas R. Bodmann , Gary Dan Dotson , Mark S. Williams , Senthil P. Kumar
发明人： Douglas A. Lostoski , Geoff M. Sieron , Andrew P. Kaufman , William M. Ruddy , Daniel L. Stefaniak , Douglas R. Bodmann , Gary Dan Dotson , Mark S. Williams , Senthil P. Kumar
IPC分类号： H05K7/00 , F16B2/20 , B23P11/00 , F16L3/08
CPC分类号： H05K5/02 , H05K5/0017 , H05K5/0204 , H05K7/1481 , Y10T29/49826
摘要： The disclosed subject matter comprises a display retention bracket (DRB) that can be attached to, and can retain and horizontally mount, a display using display retention components, without using fasteners, for insertion of the display in a bezel that does not support horizontal mounting; and includes: a cable retention component that enables the cable to withstand a specified pull-out force to maintain connection of the cable to the display; a cable guide to maintain cable wires in a desired position in relation to other components; alignment pins to align the DRB and display with a bezel housing; non-symmetrical tabs to ensure the display is oriented correctly; offset columns that desirably offset loads on the display when an adapter plate is applied onto the DRB and display, and fastened to the bezel to secure the display; and a ground clip to extend the ground path from the bezel to the display.
摘要翻译：所公开的主题包括可以使用显示保持部件连接到并且可以保持和水平地安装显示器的显示器保持支架（DRB），而不使用紧固件，用于将显示器插入到不支持水平安装的边框中 ; 并且包括：电缆保持部件，其使得电缆能够承受指定的拉出力以保持电缆与显示器的连接; 电缆引导件，用于将电缆线相对于其他部件保持在期望的位置; 对齐针脚以使DRB对准并用挡板外壳显示; 非对称标签，以确保显示方向正确; 偏移列，当适配器板被施加到DRB并显示时，期望地偏移显示器上的负载，并且紧固到边框以固定显示器; 和一个接地夹，用于将接地路径从挡板延伸到显示器。

5. 发明授权

US08171658B2 Snowshoe with flexible tail 有权
标题翻译：雪鞋与柔性尾巴
公开(公告)号：US08171658B2
公开(公告)日：2012-05-08
申请号：US12313913
申请日：2008-11-24
申请人： Rudy Lucas Samuels , Chris Barchet , Dodd Grande , Mark S. Williams , Scott Youmans , Rachel Lin
发明人： Rudy Lucas Samuels , Chris Barchet , Dodd Grande , Mark S. Williams , Scott Youmans , Rachel Lin
IPC分类号： A43B5/04 , A43B5/00
CPC分类号： A63C13/003 , A63C13/001 , A63C13/005 , A63C13/006
摘要： A snowshoe of molded plastic material has a tail section with greater flexibility than the main body section, thereby allowing the tail to give and deform as the snowshoe tail is engaged against the terrain during the gait of the user. At the same time, the tail is stiff enough to provide flotation needed when the full weight of the user is on one snowshoe fully engaged against terrain, such as soft snow.
摘要翻译：模制塑料材料的雪橇具有比主体部分更大的柔性的尾部部分，从而当用户的步态期间雪鞋尾巴与地形接合时允许尾巴产生和变形。同时，当用户的全部重量在雪地上完全接合地形（如软雪）时，尾部足够坚固，可提供所需的浮选。

6. 外观设计

USD516281S1 Toe cap for athletic footwear equipment 有权
公开(公告)号：USD516281S1
公开(公告)日：2006-03-07
申请号：US29229277
申请日：2005-05-05
申请人： Mark S. Williams
设计人： Mark S. Williams

7. 发明申请

US20120276019A1 TISSUE KALLIKREIN FOR THE TREATMENT OF PARKINSON'S DISEASE 审中-公开
标题翻译：组织KALLIKREIN治疗帕金森病
公开(公告)号：US20120276019A1
公开(公告)日：2012-11-01
申请号：US13494788
申请日：2012-06-12
申请人： Matthew L. Charles , Mark S. Williams
发明人： Matthew L. Charles , Mark S. Williams
IPC分类号： A61K38/48 , A61P25/16 , A61N1/05 , A61P25/00 , A61P25/24 , A61K9/12 , A61P25/28
CPC分类号： A61K9/0043 , A61K38/4853 , A61K45/06 , A61N1/36067 , A61K2300/00
摘要： Provided herein are methods of treating Parkinson's disease, dementia with Lewy bodies, and conditions associated with Parkinson's disease and dementia with Lewy bodies. These methods include administering to a subject in need thereof a therapeutically effective amount of a tissue kallikrein (KLK1) polypeptide, including active variants and fragments thereof.
摘要翻译：本文提供了治疗帕金森病，路易体痴呆和与帕金森病和路易体痴呆相关的病症的方法。这些方法包括向有需要的受试者施用治疗有效量的组织激肽释放酶（KLK1）多肽，包括其活性变体和片段。

8. 发明申请

US20100126046A1 Snowshoe with flexible tail 有权
标题翻译：雪鞋与柔性尾巴
公开(公告)号：US20100126046A1
公开(公告)日：2010-05-27
申请号：US12313913
申请日：2008-11-24
申请人： Rudy Lucas Samuels , Chris Barchet , Dodd Grande , Mark S. Williams , Scott Youmans , Rachel Lin
发明人： Rudy Lucas Samuels , Chris Barchet , Dodd Grande , Mark S. Williams , Scott Youmans , Rachel Lin
IPC分类号： A43B5/04
CPC分类号： A63C13/003 , A63C13/001 , A63C13/005 , A63C13/006
摘要： A snowshoe of molded plastic material has a tail section with greater flexibility than the main body section, thereby allowing the tail to give and deform as the snowshoe tail is engaged against the terrain during the gait of the user. At the same time, the tail is stiff enough to provide flotation needed when the full weight of the user is on one snowshoe fully engaged against terrain, such as soft snow.
摘要翻译：模制塑料材料的雪橇具有比主体部分更大的柔性的尾部部分，从而当用户的步态期间雪鞋尾巴与地形接合时允许尾巴产生和变形。同时，当用户的全部重量在雪地上完全接合地形（如软雪）时，尾部足够坚固，可提供所需的浮选。

9. 外观设计

USD518946S1 Toe cap for athletic footwear equipment 失效
标题翻译：运动鞋类设备的鞋帽
公开(公告)号：USD518946S1
公开(公告)日：2006-04-18
申请号：US29204070
申请日：2004-04-23
申请人： Mark S. Williams
设计人： Mark S. Williams

10. 发明授权

US06775928B2 Lacing system for skates 有权
标题翻译：溜冰鞋系统
公开(公告)号：US06775928B2
公开(公告)日：2004-08-17
申请号：US10165602
申请日：2002-06-07
申请人： Dodd H. Grande , Darrin J. Haugen , Mark S. Williams , John E. Svensson
发明人： Dodd H. Grande , Darrin J. Haugen , Mark S. Williams , John E. Svensson
IPC分类号： A43B1100
CPC分类号： A43C7/00 , A43C11/20 , Y10T24/3713 , Y10T24/3984
摘要： A skate upper (120) of the type having an elongate vamp (122) with lace keepers (123) and a tongue (130) disposed generally in the vamp is provided with an attached lace locker. The lace locker (150) fixedly attached near the top of the upper, preferably to an upper portion of the tongue. A lace (124) is retained by the lace keepers and releasably engaged by the lace locker. A strap assembly (126) is provided below the lace locker. A lace guide (140) is attached to the tongue, below the lace locker and below the strap assembly. The invention positions the lace locker more conveniently above the strap assembly, and permits the user to tighten and loosen the lace with one hand.
摘要翻译：具有带有花边保持器（123）的长形鞋面（122）和通常设置在鞋面中的舌部（130）的类型的滑冰鞋面（120）设置有附接的花边储物柜。该鞋带储物柜（150）固定地附接在上部的顶部附近，优选地固定到舌头的上部。鞋带（124）由花边保持器保持并且可松开地由花边储物柜接合。带子组件（126）设置在花边储物柜的下方。鞋带引导件（140）附接到舌头，在花边储物柜下方并在带组件下方。本发明更方便地将花边储物柜放置在带组件的上方，并且允许使用者用一只手紧固并松开蕾丝。

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