专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06592899B2 PLA/PLGA oligomers combined with block copolymers for enhancing solubility of a drug in water 有权
标题翻译： PLA / PLGA低聚物与嵌段共聚物结合，以增加药物在水中的溶解度
公开(公告)号：US06592899B2
公开(公告)日：2003-07-15
申请号：US09971082
申请日：2001-10-03
申请人： Kirk Dee Fowers , Gaylen M. Zentner , Chung Shih , Ai-Zhi Piao
发明人： Kirk Dee Fowers , Gaylen M. Zentner , Chung Shih , Ai-Zhi Piao
IPC分类号： A61K914
CPC分类号： A61K47/34 , C08L67/04 , C08L2666/18
摘要： Polymeric compositions having improved capability of solubilizing a drug in a hydrophilic environment to form a solution, comprising: a biodegradable polyester oligomer; and biodegradable AB-type, ABA-type, or BAB-type block copolymers are disclosed. The copolymers are comprised of about 50.1 to 65% by weight of a biodegradable, hydrophobic A polymer block comprising a biodegradable polyester, and about 35 to 49.9% by weight of a hydrophilic B polymer block comprising a polyethylene glycol (PEG), and wherein the block copolymer has a weight averaged molecular weight of between 2400 to 4999. The biodegradable polyester oligomer of said composition is within a range of 0.01% to 30% by weight of the total polymer mixture, and the content of the biodegradable AB-type, ABA-type, or BAB-type block copolymer is within a range of 70% to 99.99% by weight of the total polymer mixture.
摘要翻译：具有改善在亲水环境中溶解药物以形成溶液的能力的聚合物组合物，包括：可生物降解的聚酯低聚物; 并且公开了可生物降解的AB型，ABA型或BAB型嵌段共聚物。共聚物由约50.1至65重量％的包含可生物降解聚酯的可生物降解的疏水性A聚合物嵌段和约35至49.9重量％的包含聚乙二醇（PEG）的亲水性B聚合物嵌段组成，并且其中嵌段共聚物的重均分子量在2400至4999之间。所述组合物的可生物降解的聚酯低聚物在总聚合物混合物的重量的0.01％至30％的范围内，并且可生物降解的AB型，ABA的含量型或BAB型嵌段共聚物在总聚合物混合物的70重量％至99.99重量％的范围内。

IPRDB

热门服务

关于我们

友情链接

联系方式