专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20080039518A1 Maleiimide anti-tumor phosphatase inhibitors 失效
标题翻译：马来酰亚胺抗肿瘤磷酸酶抑制剂
公开(公告)号：US20080039518A1
公开(公告)日：2008-02-14
申请号：US11508605
申请日：2006-08-22
申请人： Christopher Michejda , Wei Yao , Brian Carr , Siddhartha Kar , Maria Michejda
发明人： Christopher Michejda , Wei Yao , Brian Carr , Siddhartha Kar , Maria Michejda
IPC分类号： C07D207/444 , A61K31/4015 , C12N9/99 , A61P35/00
CPC分类号： C07D207/456
摘要： The present invention features maleiimide compounds, pharmaceutical compositions of maleiimide compounds and methods of treating a patient suffering from cancer, the method comprising administering to a patient one or more maleiimide compounds of the invention.
摘要翻译：本发明的特征在于马来酰亚胺化合物，马来酰亚胺化合物的药物组合物和治疗患有癌症的患者的方法，所述方法包括向患者施用本发明的一种或多种马来酰亚胺化合物。

2. 发明申请

US20090148505A1 Novel Antiproliferative Factor and Methods of Use 有权
标题翻译：新型抗增殖因子及其使用方法
公开(公告)号：US20090148505A1
公开(公告)日：2009-06-11
申请号：US11955755
申请日：2007-12-13
申请人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas P. Conrads , Timothy D. Veenstra , Maria Michejda
发明人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas P. Conrads , Timothy D. Veenstra , Maria Michejda
IPC分类号： A61K9/127 , A61K38/08 , A61K35/00 , A61K9/14 , A61K39/395
CPC分类号： C07K9/005 , A61K38/00
摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
摘要翻译：公开了包含糖肽的新型抗增殖因子。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。

3. 发明申请

US20120094933A1 DERIVATIVES OF APF AND METHODS OF USE 有权
标题翻译： APF的衍生物和使用方法
公开(公告)号：US20120094933A1
公开(公告)日：2012-04-19
申请号：US13059292
申请日：2009-08-18
申请人： Christopher Michejda , Maria Michejda , Susan K. Keay , Zoltan Szekely , Piotr Kaczmarek
发明人： Christopher Michejda , Maria Michejda , Susan K. Keay , Zoltan Szekely , Piotr Kaczmarek
IPC分类号： A61K38/14 , A61P29/00 , A61P1/00 , C07K9/00
CPC分类号： A61K38/14
摘要： Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods related to treatment of bladder conditions. In particular embodiments, the glycopeptide comprises D-pipecolic acid or L-pipecolic acid.
摘要翻译：公开了膀胱上皮抗增生因子的衍生物及其使用方法。在具体实施方案中，糖肽组合物可用于治疗和/或预防包括癌症在内的医学病症。在其它实施方案中，存在与治疗膀胱状况相关的组合物和方法。在具体实施方案中，糖肽包含D-哌啶酸或L-哌啶酸。

4. 发明申请

US20100041588A1 DERIVATIVES OF APF AND METHODS OF USE 有权
标题翻译： APF的衍生物和使用方法
公开(公告)号：US20100041588A1
公开(公告)日：2010-02-18
申请号：US12543455
申请日：2009-08-18
申请人： Susan K. Keay , Christopher Michejda , Maria Michejda , Zoltan Szekely
发明人： Susan K. Keay , Christopher Michejda , Maria Michejda , Zoltan Szekely
IPC分类号： A61K38/00 , C07K9/00
CPC分类号： C07K9/005 , A61K38/00
摘要： Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed. In particular embodiments, the glycopeptide comprises D-proline.
摘要翻译：公开了包含糖肽的新型抗增殖因子的衍生物。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。在具体实施方案中，糖肽包含D-脯氨酸。

5. 发明授权

US07883698B2 Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use 有权
标题翻译：从流产引起的非争议性材料和/或组织和治疗用途的方法分离和保存胎儿造血和间歇系统细胞
公开(公告)号：US07883698B2
公开(公告)日：2011-02-08
申请号：US11654737
申请日：2007-01-17
申请人： Maria Michejda
发明人： Maria Michejda
IPC分类号： A01N63/00 , A01N1/02
CPC分类号： A61K35/48 , A01N1/0221
摘要： The present invention is directed to compositions of fetal hematopoietic stem and progenitor cells and stromal (mesencymal) cells derived from second trimester (16-20 weeks gestation) miscarriages, that are isolated, processed and cryopreserved, and the therapeutic uses of such stem and progenitor cells upon application. Such compositions may be useful for hematopoietic reconstitution and/or replacement in patients with various diseases and metabolic disorders. The invention also relates to methods for collecting, isolating, processing and cryopreserving of the fetal stem and progenitor cells of the invention. Importantly, the invention meets an urgent need in regenerative medicine while at the same time ensures utility of the product compositions because it utilizes fetal materials from second trimester (16-20 weeks of gestation) spontaneously lost pregnancies which are free of moral or ethical burdens.
摘要翻译：本发明涉及胎儿造血干细胞和祖细胞和分离，加工和冷冻保存的妊娠中期（16-20周妊娠）流产的基质（mesencymal）细胞的组合物，以及这种干细胞和祖细胞的治疗用途细胞应用后。这些组合物可用于患有各种疾病和代谢紊乱的患者的造血重构和/或置换。本发明还涉及本发明的胎儿干细胞和祖细胞的收集，分离，加工和冷冻保存的方法。重要的是，本发明满足再生医学的迫切需要，同时确保产品组合物的有用性，因为它利用妊娠中期（16-20周）的胎儿材料自发失去了没有道德或道德负担的妊娠。

6. 发明申请

US20100120817A1 AZONAFIDE DERIVED TUMOR AND CANCER TARGETING COMPOUNDS 有权
标题翻译： AZONAFIDE衍生肿瘤和癌症靶向化合物
公开(公告)号：US20100120817A1
公开(公告)日：2010-05-13
申请号：US12441029
申请日：2007-09-12
申请人： Nadya I. Tarasova , Marcin Dyba , Christopher J. Michejda , Maria Michejda
发明人： Nadya I. Tarasova , Marcin Dyba , Christopher J. Michejda , Maria Michejda
IPC分类号： A61K31/473 , C07D221/18 , C07D401/06 , A61P35/00
CPC分类号： C07D221/18 , C07D401/12
摘要： An azonafide-based compound of Formula I, a composition comprising the compound, and a method of using the compound to deliver a cytotoxic azonafide derivative to a cell, as well as related compounds and methods for the use thereof to pre-pare an azonafide-based compound of Formula I.
摘要翻译：式I的基于氮杂酮的化合物，包含该化合物的组合物，以及使用该化合物将细胞毒性偶氮腙衍生物递送至细胞的方法，以及相关化合物及其用途，用于预处理氮杂菲 - 式I化合物。

7. 发明申请

US20100184697A1 PEPTIDE-BASED STAT INHIBITOR 有权
标题翻译：基于肽的STAT抑制剂
公开(公告)号：US20100184697A1
公开(公告)日：2010-07-22
申请号：US12601711
申请日：2008-05-30
申请人： Nadya I. Tarasova , Olga Timofeeva , Vadim Gaponenko , Christopher J. Michejda , Maria Michejda , Alan O. Perantoni , Sergey G. Tarasov
发明人： Nadya I. Tarasova , Olga Timofeeva , Vadim Gaponenko , Christopher J. Michejda , Maria Michejda , Alan O. Perantoni , Sergey G. Tarasov
IPC分类号： A61K38/10 , C07K7/08 , C07K14/00 , C07H21/00 , C07K16/00 , C12N5/00 , A61P35/00
CPC分类号： C07K14/4705 , A61K38/04 , A61K38/1709
摘要： A peptide or peptidomimetic comprising the amino acid sequence of the second helix of a STAT protein, or a variant of such sequence, wherein the peptide or peptidomimetic comprises about 40 or fewer amino acids and binds to a STAT protein, as well as a method of inhibiting a STAT protein in a cell, a method of treating or preventing a disease associated with STAT overexpression in a host, and related compounds, compositions, and methods.
摘要翻译：包含STAT蛋白的第二螺旋的氨基酸序列或这种序列的变体的肽或肽模拟物，其中所述肽或肽模拟物包含约40个或更少的氨基酸并结合STAT蛋白，以及一种抑制细胞中的STAT蛋白，治疗或预防与宿主中STAT过表达相关疾病的方法，以及相关化合物，组合物和方法。

8. 发明申请

US20080171019A1 Isolation and preservation of fetal hematopoietic and mesencymal system cells from non-controversial materials and/or tissues resulting from miscarriages and methods of therapeutic use 有权
标题翻译：从流产引起的非争议性材料和/或组织和治疗用途的方法分离和保存胎儿造血和间歇系统细胞
公开(公告)号：US20080171019A1
公开(公告)日：2008-07-17
申请号：US11654737
申请日：2007-01-17
申请人： Maria Michejda
发明人： Maria Michejda
IPC分类号： A01N63/00 , A01N1/02
CPC分类号： A61K35/48 , A01N1/0221
摘要： The present invention is directed to compositions of fetal hematopoietic stem and progenitor cells and stromal (mesencymal) cells derived from second trimester (16-20 weeks gestation) miscarriages, that are isolated, processed and cryopreserved, and the therapeutic uses of such stem and progenitor cells upon application. Such compositions may be useful for hematopoietic reconstitution and/or replacement in patients with various diseases and metabolic disorders. The invention also relates to methods for collecting, isolating, processing and cryopreserving of the fetal stem and progenitor cells of the invention. Importantly, the invention meets an urgent need in regenerative medicine while at the same time ensures utility of the product compositions because it utilizes fetal materials from second trimester (16-20 weeks of gestation) spontaneously lost pregnancies which are free of moral or ethical burdens.
摘要翻译：本发明涉及胎儿造血干细胞和祖细胞和分离，加工和冷冻保存的妊娠中期（16-20周妊娠）流产的基质（mesencymal）细胞的组合物，以及这种干细胞和祖细胞的治疗用途细胞应用后。这些组合物可用于患有各种疾病和代谢紊乱的患者的造血重构和/或置换。本发明还涉及本发明的胎儿干细胞和祖细胞的收集，分离，加工和冷冻保存的方法。重要的是，本发明满足再生医学的迫切需要，同时确保产品组合物的有用性，因为它利用妊娠中期（16-20周）的胎儿材料自发失去了没有道德或道德负担的妊娠。

9. 发明授权

US4413985A Hydrocephalic antenatal vent for intrauterine treatment (HAVIT) 失效
标题翻译：用于宫内治疗的脑积水产前通气（HAVIT）
公开(公告)号：US4413985A
公开(公告)日：1983-11-08
申请号：US325730
申请日：1981-11-30
申请人： Edward Wellner , Maria Michejda , Gary D. Hodgen
发明人： Edward Wellner , Maria Michejda , Gary D. Hodgen
IPC分类号： A61M1/00 , A61M27/00
CPC分类号： A61M39/0247 , A61M27/006 , A61M2039/025 , A61M2039/0261 , A61M2039/027 , A61M2039/0276 , A61M2210/02 , A61M2210/145
摘要： A hydrocephalic drainage valve consisting of a hollow shank with a pointed conical tip. The shank has an intake port adjacent the conical tip. A ball check valve in the shank is urged by a coiled spring toward closing relationship with the port. A hollow set screw is adjustably mounted in the shank to vary the biasing force on the valve ball. In one form, for manual implantation, a sleeve is slidably mounted on the shank, has a centrally apertured enlarged head and has implantation enlarged threads near the head. The head has aligned opposite radial grooves which are engageable by a manual insertion tool. In other forms, for pneumatic insertion, the shank has an enlarged head, employed as a driving piston in a pneumatic insertion tube. A washer member with implantation barbs is slidably mounted on the shank and is arranged to be locked to the shank subjacent the head responsive to the pneumatic driving action, with its barbs embedded in the fetal skin around the implantation puncture, thus holding the shank in operating position with the intake port exposed in the cranial vault.
摘要翻译：一种脑积水引流阀，由具有尖锐锥形尖端的中空柄组成。柄具有邻近锥形尖端的进气口。螺栓中的球止回阀被螺旋弹簧推向与端口的关系。中空的固定螺钉可调节地安装在柄中以改变阀球上的偏压力。在一种形式中，为了手动植入，套筒可滑动地安装在柄上，具有中心孔径扩大的头部并且在头部附近具有植入放大的线。头部具有可由手动插入工具接合的相对的径向凹槽。在其他形式中，为了气动插入，柄部具有扩大的头部，用作气动插入管中的驱动活塞。具有植入倒钩的垫圈构件可滑动地安装在柄上并且被布置成响应于气动驱动动作而被锁定到位于头部下方的柄部，其倒钩嵌入植入穿刺中的胎儿皮肤中，从而将柄保持在操作中位置与入口端口暴露在颅骨库。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式