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1. 发明申请

US20090148505A1 Novel Antiproliferative Factor and Methods of Use 有权
标题翻译：新型抗增殖因子及其使用方法
公开(公告)号：US20090148505A1
公开(公告)日：2009-06-11
申请号：US11955755
申请日：2007-12-13
申请人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas P. Conrads , Timothy D. Veenstra , Maria Michejda
发明人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas P. Conrads , Timothy D. Veenstra , Maria Michejda
IPC分类号： A61K9/127 , A61K38/08 , A61K35/00 , A61K9/14 , A61K39/395
CPC分类号： C07K9/005 , A61K38/00
摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
摘要翻译：公开了包含糖肽的新型抗增殖因子。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。

2. 发明授权

US06818454B2 Phosphoprotein binding agents and methods of their use 失效
标题翻译：磷蛋白结合剂及其使用方法
公开(公告)号：US06818454B2
公开(公告)日：2004-11-16
申请号：US09788286
申请日：2001-02-16
申请人： Michael B. Goshe , Thomas P. Conrads , Timothy D. Veenstra , Ellen A. Panisko
发明人： Michael B. Goshe , Thomas P. Conrads , Timothy D. Veenstra , Ellen A. Panisko
IPC分类号： C07K122
CPC分类号： G01N33/6842 , G01N33/6803 , Y10S530/811 , Y10T436/13 , Y10T436/24
摘要： The invention provides reagents and methods for characterizing (i.e., identification and/or quantitation) the phosphorylation states of proteins. Proteins may be post-transcriptionally modified such that they contain phosphate groups at either some or all of their serine, threonine, tyrosine, histidine, and/or lysine amino acid residues. In many cases the extent to which a protein is phosphorylated determines it bioactivity, i.e., its ability to effect cell functions such as differentiation, division, and metabolism. Hence, a powerful tool for diagnosing various diseases and for furthering the understanding of protein—protein interactions is provided.
摘要翻译：本发明提供用于表征（即，鉴定和/或定量）蛋白质的磷酸化状态的试剂和方法。蛋白质可以进行后转录修饰，使得它们在丝氨酸，苏氨酸，酪氨酸，组氨酸和/或赖氨酸氨基酸残基的一部分或全部含有磷酸基。在许多情况下，蛋白质被磷酸化的程度决定了其生物活性，即其影响细胞功能如分化，分裂和代谢的能力。因此，提供了用于诊断各种疾病和促进对蛋白质 - 蛋白质相互作用的理解的强大工具。

3. 发明申请

US20120009194A1 ANTIBODIES TO ENDOPLASMIN AND THEIR USE 有权
标题翻译：内分泌抗体及其使用
公开(公告)号：US20120009194A1
公开(公告)日：2012-01-12
申请号：US13161432
申请日：2011-06-15
申请人： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
发明人： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
IPC分类号： A61K39/395 , C07K17/00 , C07H21/04 , C12N15/13 , C12N15/63 , C12N1/19 , A61P35/04 , C12N9/96 , G01N33/577 , C12N5/10 , C12N1/21 , C07K16/18 , A61P35/00
CPC分类号： C07K16/18 , A61K39/00 , A61K47/6843 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3053 , C07K16/3069 , C07K16/3092 , C07K2317/21 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/10 , C12N15/09 , C12N15/62 , C12N15/8258 , C12N15/86 , C12N2800/00 , C12N2810/859 , G01N33/574 , G01N33/577 , G01N2333/47 , G01N2333/4727 , G01N2800/7028
摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.
摘要翻译：本文公开了特异性结合内质网的分离的单克隆抗体。在一些实施方案中，这些抗体是完全人的。编码这些抗体的重组核酸，包括这些核酸的表达载体以及用这些表达载体转化的宿主细胞也在本文中公开。在几个实施方案中，所公开的抗体可用于检测和/或治疗表达内质网例如黑素瘤，乳腺癌，头颈鳞状细胞癌，肾癌，肺癌，神经胶质瘤，膀胱癌，卵巢癌或胰腺癌的肿瘤。在一个实例中，肿瘤是黑素瘤。

4. 发明申请

US20150005183A1 PROTEIN BIOMARKERS OF LATE STAGE BREAST CANCER 审中-公开
标题翻译：蛋白质乳腺癌生物标志物
公开(公告)号：US20150005183A1
公开(公告)日：2015-01-01
申请号：US13932990
申请日：2013-07-01
申请人： David Krizman , Marlene M. Darfler , Thomas P. Conrads , Brian L. Hood
发明人： David Krizman , Marlene M. Darfler , Thomas P. Conrads , Brian L. Hood
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N2800/52 , G01N2800/54 , G01N2800/60
摘要： This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells histologicaly defined as early stage (stage 0) breast cancer and primary breast cancer cells histologicaly defined as late stage (stage 3) breast cancer. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from breast cancer patients to indicate the that a breast cancer patient's cancer is in an early, non-aggressive stage or in a late, aggressive stage. Determination of differential expression of these proteins can also be useful for indicating additional therapies to combat the aggressiveness of late stage breast cancer. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins. These proteins can also be identified as “companion diagnostic” proteins, wherein the differentially expressed proteins that are used as diagnostic and prognostic indicators can also be used as targets for therapeutic intervention of breast cancer. Also disclosed and described herein are isotope labeled versions of peptides from the proteins.
摘要翻译：该专利申请公开并描述了被定义为早期阶段（阶段0）乳腺癌的原发肿瘤乳腺癌细胞组织学和定义为晚期（阶段3）乳腺癌的原发性乳腺癌细胞组织学之间差异表达的蛋白质。这些蛋白质可以在乳腺癌患者的各种生物样品的诊断和预后蛋白测定中单独使用或以特定组合使用，以表明乳腺癌患者的癌症处于早期，非侵袭阶段或晚期侵袭阶段。确定这些蛋白质的差异表达也可用于指示其他治疗方法以抵抗晚期乳腺癌的侵袭性。可以测定全长完整蛋白质，或者可以将这些蛋白质衍生的肽作为这些蛋白质的报告物进行测定。这些蛋白质也可以被鉴定为“伴侣诊断”蛋白质，其中用作诊断和预后指标的差异表达的蛋白质也可以用作乳腺癌的治疗干预的靶标。本文还公开和描述的是来自蛋白质的肽的同位素标记形式。

5. 发明申请

US20150005182A1 PROTEIN BIOMARKERS OF RECURRENT BREAST CANCER 审中-公开
标题翻译：乳腺癌的蛋白质生物标志物
公开(公告)号：US20150005182A1
公开(公告)日：2015-01-01
申请号：US13932843
申请日：2013-07-01
申请人： David Krizman , Marlene M. Darfler , Thomas P. Conrads , Brian L. Hood
发明人： David Krizman , Marlene M. Darfler , Thomas P. Conrads , Brian L. Hood
IPC分类号： G01N33/68
CPC分类号： G01N33/57415 , G01N2800/52 , G01N2800/54 , G01N2800/60
摘要： This patent application discloses and describes proteins found to be differentially expressed between primary tumor breast cancer cells that did not give rise to recurrent breast cancer disease after initial diagnosis and primary breast cancer cells that did give rise to recurrent breast cancer disease after initial diagnosis. These proteins can be used either individually or in specific combinations in diagnostic and prognostic protein assays on various biological samples from breast cancer patients to indicate the likelihood that a breast cancer patient's cancer will recur after initial diagnosis and treatment. Determination of differential expression of these proteins can also be useful for indicating additional therapies to combat the likelihood of recurrent breast cancer. The full length intact proteins can be assayed or peptides derived from these proteins can be assayed as reporters for these proteins. These proteins can also be identified as “companion diagnostic” proteins, wherein the differentially expressed proteins that are used as diagnostic and prognostic indicators can also be used as targets for therapeutic intervention of breast cancer. Also disclosed and described herein are isotope labeled versions of peptides from the proteins.
摘要翻译：该专利申请公开并描述了在初步诊断后不会引起复发性乳腺癌疾病的原发性乳腺癌细胞和初次诊断后引起复发性乳腺癌疾病的原发性乳腺癌细胞之间发现差异表达的蛋白质。这些蛋白质可以在乳腺癌患者的各种生物样品的诊断和预后蛋白质测定中单独使用或以特定组合使用，以指示乳腺癌患者的癌症在初步诊断和治疗后将复发的可能性。确定这些蛋白质的差异表达也可用于指示额外的治疗方法来抵抗复发性乳腺癌的可能性。可以测定全长完整蛋白质，或者可以将这些蛋白质衍生的肽作为这些蛋白质的报告物进行测定。这些蛋白质也可以被鉴定为“伴侣诊断”蛋白质，其中用作诊断和预后指标的差异表达的蛋白质也可以用作乳腺癌的治疗干预的靶标。本文还公开和描述的是来自蛋白质的肽的同位素标记形式。

6. 发明申请

US20140010811A1 ANTIBODIES TO ENDOPLASMIN AND THEIR USE 有权
标题翻译：内分泌抗体及其使用
公开(公告)号：US20140010811A1
公开(公告)日：2014-01-09
申请号：US13929671
申请日：2013-06-27
申请人： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
发明人： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/00 , A61K47/6843 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3053 , C07K16/3069 , C07K16/3092 , C07K2317/21 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/10 , C12N15/09 , C12N15/62 , C12N15/8258 , C12N15/86 , C12N2800/00 , C12N2810/859 , G01N33/574 , G01N33/577 , G01N2333/47 , G01N2333/4727 , G01N2800/7028
摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.
摘要翻译：本文公开了特异性结合内质网的分离的单克隆抗体。在一些实施方案中，这些抗体是完全人的。编码这些抗体的重组核酸，包括这些核酸的表达载体以及用这些表达载体转化的宿主细胞也在本文中公开。在几个实施方案中，所公开的抗体可用于检测和/或治疗表达内质网例如黑素瘤，乳腺癌，头颈鳞状细胞癌，肾癌，肺癌，胶质瘤，膀胱癌，卵巢癌或胰腺癌的肿瘤。在一个实例中，肿瘤是黑素瘤。

7. 发明授权

US08497354B2 Antibodies to endoplasmin and their use 有权
标题翻译：内皮素的抗体及其用途
公开(公告)号：US08497354B2
公开(公告)日：2013-07-30
申请号：US13161432
申请日：2011-06-15
申请人： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
发明人： Soldano Ferrone , Xinhui Wang , Thomas P. Conrads , Elvira Favoino , Brian L. Hood
IPC分类号： C07K16/00 , C12P21/08 , A61K39/395 , A61K39/00 , G01N33/53
CPC分类号： C07K16/18 , A61K39/00 , A61K47/6843 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3053 , C07K16/3069 , C07K16/3092 , C07K2317/21 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/622 , C07K2317/624 , C07K2317/73 , C07K2317/732 , C07K2317/734 , C12N5/10 , C12N15/09 , C12N15/62 , C12N15/8258 , C12N15/86 , C12N2800/00 , C12N2810/859 , G01N33/574 , G01N33/577 , G01N2333/47 , G01N2333/4727 , G01N2800/7028
摘要： Isolated monoclonal antibodies are disclosed herein that specifically bind endoplasmin. In some embodiments these antibodies are fully human. Recombinant nucleic acids encoding these antibodies, expression vectors including these nucleic acids, and host cells transformed with these expression vectors are also disclosed herein. In several embodiments the disclosed antibodies are of use for detecting and/or treating tumors that express endoplasmin, such as melanoma, breast cancer, head and neck squamous cell carcinoma, renal cancer, lung cancer, glioma, bladder cancer, ovarian cancer or pancreatic cancer. In one example, the tumor is a melanoma.
摘要翻译：本文公开了特异性结合内质网的分离的单克隆抗体。在一些实施方案中，这些抗体是完全人的。编码这些抗体的重组核酸，包括这些核酸的表达载体以及用这些表达载体转化的宿主细胞也在本文中公开。在几个实施方案中，所公开的抗体可用于检测和/或治疗表达内质网例如黑素瘤，乳腺癌，头颈鳞状细胞癌，肾癌，肺癌，胶质瘤，膀胱癌，卵巢癌或胰腺癌的肿瘤。在一个实例中，肿瘤是黑素瘤。

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