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1. 发明申请

US20120094933A1 DERIVATIVES OF APF AND METHODS OF USE 有权
标题翻译： APF的衍生物和使用方法
公开(公告)号：US20120094933A1
公开(公告)日：2012-04-19
申请号：US13059292
申请日：2009-08-18
申请人： Christopher Michejda , Maria Michejda , Susan K. Keay , Zoltan Szekely , Piotr Kaczmarek
发明人： Christopher Michejda , Maria Michejda , Susan K. Keay , Zoltan Szekely , Piotr Kaczmarek
IPC分类号： A61K38/14 , A61P29/00 , A61P1/00 , C07K9/00
CPC分类号： A61K38/14
摘要： Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods related to treatment of bladder conditions. In particular embodiments, the glycopeptide comprises D-pipecolic acid or L-pipecolic acid.
摘要翻译：公开了膀胱上皮抗增生因子的衍生物及其使用方法。在具体实施方案中，糖肽组合物可用于治疗和/或预防包括癌症在内的医学病症。在其它实施方案中，存在与治疗膀胱状况相关的组合物和方法。在具体实施方案中，糖肽包含D-哌啶酸或L-哌啶酸。

2. 发明授权

US08912146B2 Derivatives of APF and methods of use 有权
标题翻译： APF的衍生物和使用方法
公开(公告)号：US08912146B2
公开(公告)日：2014-12-16
申请号：US13059292
申请日：2009-08-18
申请人： Susan K. Keay , Zoltan Szekely , Piotr Kaczmarek , Maria Michejda
发明人： Christopher Michejda , Susan K. Keay , Zoltan Szekely , Piotr Kaczmarek
IPC分类号： A61K38/14
CPC分类号： A61K38/14
摘要： Derivatives of bladder epithelial antiproliferative factor and methods of using them are disclosed. In specific embodiments, the glycopeptide compositions are useful for the treatment and/or prevention of medical conditions, including cancer. In other embodiments, there are compositions and methods related to treatment of bladder conditions. In particular embodiments, the glycopeptide comprises D-pipecolic acid or L-pipecolic acid.
摘要翻译：公开了膀胱上皮抗增生因子的衍生物及其使用方法。在具体实施方案中，糖肽组合物可用于治疗和/或预防包括癌症在内的医学病症。在其它实施方案中，存在与治疗膀胱状况相关的组合物和方法。在具体实施方案中，糖肽包含D-哌啶酸或L-哌啶酸。

3. 发明申请

US20090148505A1 Novel Antiproliferative Factor and Methods of Use 有权
标题翻译：新型抗增殖因子及其使用方法
公开(公告)号：US20090148505A1
公开(公告)日：2009-06-11
申请号：US11955755
申请日：2007-12-13
申请人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas P. Conrads , Timothy D. Veenstra , Maria Michejda
发明人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas P. Conrads , Timothy D. Veenstra , Maria Michejda
IPC分类号： A61K9/127 , A61K38/08 , A61K35/00 , A61K9/14 , A61K39/395
CPC分类号： C07K9/005 , A61K38/00
摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
摘要翻译：公开了包含糖肽的新型抗增殖因子。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。

4. 发明申请

US20100041588A1 DERIVATIVES OF APF AND METHODS OF USE 有权
标题翻译： APF的衍生物和使用方法
公开(公告)号：US20100041588A1
公开(公告)日：2010-02-18
申请号：US12543455
申请日：2009-08-18
申请人： Susan K. Keay , Christopher Michejda , Maria Michejda , Zoltan Szekely
发明人： Susan K. Keay , Christopher Michejda , Maria Michejda , Zoltan Szekely
IPC分类号： A61K38/00 , C07K9/00
CPC分类号： C07K9/005 , A61K38/00
摘要： Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed. In particular embodiments, the glycopeptide comprises D-proline.
摘要翻译：公开了包含糖肽的新型抗增殖因子的衍生物。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。在具体实施方案中，糖肽包含D-脯氨酸。

5. 发明授权

US09085604B2 Antiproliferative factor and methods of use 有权
标题翻译：抗增生因子及使用方法
公开(公告)号：US09085604B2
公开(公告)日：2015-07-21
申请号：US11955755
申请日：2007-12-13
申请人： Susan K. Keay , Zoltan Szekely , Thomas Conrads , Timothy Veenstra , Maria Michejda
发明人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas Conrads , Timothy Veenstra
IPC分类号： C07K9/00 , A61K38/00
CPC分类号： C07K9/005 , A61K38/00
摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
摘要翻译：公开了包含糖肽的新型抗增殖因子。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。

6. 发明授权

US08680056B2 Antiproliferative factor and methods of use 有权
标题翻译：抗增生因子及使用方法
公开(公告)号：US08680056B2
公开(公告)日：2014-03-25
申请号：US11743865
申请日：2007-05-03
申请人： Susan K. Keay , Zoltan Szekely , Thomas Conrads , Timothy Veenstra , Maria Michejda
发明人： Susan K. Keay , Christopher Michejda , Zoltan Szekely , Thomas Conrads , Timothy Veenstra
IPC分类号： A61K38/14 , A61K38/04 , A61K38/08 , C07K7/06 , C07K4/12
CPC分类号： C07K9/005 , A61K38/00
摘要： A novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed.
摘要翻译：公开了包含糖肽的新型抗增殖因子。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。

7. 发明授权

US09079936B2 Derivatives of APF and methods of use 有权
标题翻译： APF的衍生物和使用方法
公开(公告)号：US09079936B2
公开(公告)日：2015-07-14
申请号：US12543455
申请日：2009-08-18
申请人： Susan K. Keay , Zoltan Szekely , Maria Michejda
发明人： Susan K. Keay , Christopher Michejda , Zoltan Szekely
IPC分类号： C07K9/00 , A61K38/00
CPC分类号： C07K9/005 , A61K38/00
摘要： Derivatives of a novel antiproliferative factor comprising a glycopeptide is disclosed. In specific embodiments, the novel antiproliferative factor is associated with the bladder. Compositions, diagnostic kits and reagents, and methods of using the compounds for identifying and/or treating interstitial cystitis and cancer are disclosed. In particular embodiments, the glycopeptide comprises D-proline.
摘要翻译：公开了包含糖肽的新型抗增殖因子的衍生物。在具体实施方案中，新型抗增殖因子与膀胱相关。公开了组合物，诊断试剂盒和试剂以及使用该化合物鉴定和/或治疗间质性膀胱炎和癌症的方法。在具体实施方案中，糖肽包含D-脯氨酸。

8. 发明申请

US20100055113A1 CELLULAR RECEPTOR FOR ANTIPROLIFERATIVE FACTOR 审中-公开
标题翻译：抗细胞因子细胞受体
公开(公告)号：US20100055113A1
公开(公告)日：2010-03-04
申请号：US12374787
申请日：2007-07-27
申请人： Susan K. Keay , Christopher Michejda , Gillian Tocci , Thomas Conrads , Timothy Veenstra , Brian Lewis Hood
发明人： Susan K. Keay , Christopher Michejda , Gillian Tocci , Thomas Conrads , Timothy Veenstra , Brian Lewis Hood
IPC分类号： G01N33/566 , A61K31/7105 , A61K39/395
CPC分类号： G01N33/5011 , C07K16/28 , C07K2317/73 , G01N33/57492
摘要： The present invention concerns the receptor for antiproliferative factor (APF) from bladder epithelial cells. In particular, there are compositions and methods for modulating APF, APF receptor, and/or the binding of APF to APF receptor. Agents that interfere with the binding of APF to its receptor or agents that enhance the binding of APF to its receptor are contemplated. In specific aspects, certain compositions are employed for a therapeutic purpose, such as interstitial cystitis or cancer, for example.
摘要翻译：本发明涉及来自膀胱上皮细胞的抗增殖因子（APF）的受体。特别地，存在用于调节APF，APF受体和/或APF与APF受体的结合的组合物和方法。考虑到干扰APF与其受体或APF与其受体结合增强的药剂结合的药剂。在具体方面，某些组合物用于治疗目的，例如间质性膀胱炎或癌症。

9. 发明授权

US06376197B1 Diagnosis of interstitial cystitis 有权
标题翻译：间质性膀胱炎诊断
公开(公告)号：US06376197B1
公开(公告)日：2002-04-23
申请号：US09576396
申请日：2000-05-22
申请人： Susan K. Keay , John W. Warren , Michael K. Hise
发明人： Susan K. Keay , John W. Warren , Michael K. Hise
IPC分类号： G01N3353
CPC分类号： G01N33/6893 , G01N33/74 , G01N2333/475 , G01N2333/485 , G01N2800/34 , G01N2800/348
摘要： Interstitial cystitis (IC) is a chronic bladder disease for which the exact etiology is unknown and for which there is no reliably effective treatment. However, it is known that the bladder epithelium is often abnormal in IC. We discovered that normal, adult, human bladder epithelial cells are inhibited from proliferating by an anti-proliferative factor (APF) present in IC urine specimens. Inhibited proliferation may cause epithelial abnormalities characteristic of IC such as ulcerations and multiple tears in the bladder epithelium. We further discovered that levels of heparin binding—epidermal growth factor-like growth factor (HB-EGF), a factor known be important for epithelial cell proliferation and wound healing in other tissues, are abnormally low in the urine of patients suffering from IC as compared to asymptomatic controls or patients with acute bacterial cystitis. The invention herein is directed to the use of urine levels of HB-EGF as a diagnostic marker for IC.
摘要翻译：间质性膀胱炎（IC）是一种慢性膀胱疾病，其确切的病因是未知的，并且没有可靠的有效治疗。然而，已知膀胱上皮在IC中通常是异常的。我们发现正常，成人，人膀胱上皮细胞被IC尿液标本中存在的抗增殖因子（APF）抑制增殖。抑制性增殖可能导致IC的特征性上皮异常，如膀胱上皮中的溃疡和多发性泪液。我们进一步发现肝素结合表皮生长因子样生长因子（HB-EGF）的水平是已知对其他组织中的上皮细胞增殖和伤口愈合重要的因素，在IC患者的尿液中异常低与无症状对照或急性细菌性膀胱炎患者相比。本发明涉及使用HB-EGF的尿液水平作为IC的诊断标记物。

10. 发明申请

US20100190684A1 INHIBITION OF PALMITOYL ACYL TRANSFERASE EXPRESSION AND/OR ACTIVITY FOR THE REGULATION OF ANTIPROLIFERATIVE FACTOR ACTIVITY 有权
标题翻译：抑制丙氨酸转移酶表达和/或活性以调节抗增生因子活性
公开(公告)号：US20100190684A1
公开(公告)日：2010-07-29
申请号：US12600571
申请日：2008-05-16
申请人： Susan K. Keay , David Zacharias , Sonia L. Planey
发明人： Susan K. Keay , David Zacharias , Sonia L. Planey
IPC分类号： A61K38/00 , A61K31/7088 , A61P13/10
CPC分类号： C07K14/71 , C12N9/1029 , C12N15/1137 , C12N2310/14
摘要： The invention generally concerns inhibition of a molecule that has a role in post-translational modification of a receptor for antiproliferative factor (APF) of bladder epithelial cells, thereby modulating the APF. In particular, inhibition of DHHC2 activity and/or ZDHHC2 expression results in modulation of APF receptor activity, and in specific aspects such modulation is therapeutic and/or preventative for a bladder condition, such as interstitial cystitis. In addition, inhibition of CKAP4 palmitoylation in certain cases also decreases its activity as a tPA receptor on smooth muscle cells or surfactant A on type II pneumocytes, and/or generally inhibits its function as a cell membrane receptor, cell chaperone molecule, and/or membrane trafficking agent.
摘要翻译：本发明一般涉及在膀胱上皮细胞的抗增殖因子（APF）受体的翻译后修饰中起作用的分子的抑制，从而调节APF。特别地，DHHC2活性和/或ZDHHC2表达的抑制导致APF受体活性的调节，并且在具体方面，这种调节是膀胱状况如间质性膀胱炎的治疗和/或预防性。另外，在某些情况下，CKAP4棕榈酰化的抑制也降低其作用于II型肺细胞上的平滑肌细胞或表面活性剂A上的tPA受体的活性，和/或通常抑制其作为细胞膜受体，细胞分子伴侣分子和/或膜转运剂。

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