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1. 发明授权

US08503844B2 Imaging catheter with integrated reference reflector 有权
公开(公告)号：US08503844B2
公开(公告)日：2013-08-06
申请号：US13298836
申请日：2011-11-17
申请人： Christopher L. Petersen , Stephen M. McCartin , Joseph M. Schmitt , Joel M. Friedman
发明人： Christopher L. Petersen , Stephen M. McCartin , Joseph M. Schmitt , Joel M. Friedman
IPC分类号： G02B6/06 , A61B5/05
CPC分类号： G02B23/2423 , A61B5/0066 , A61B5/6852 , G02B5/08
摘要： In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.

2. 发明授权

US06891984B2 Scanning miniature optical probes with optical distortion correction and rotational control 有权
公开(公告)号：US06891984B2
公开(公告)日：2005-05-10
申请号：US10205374
申请日：2002-07-25
申请人： Christopher L. Petersen , Edward I. McNamara , Ronald B. Lamport , Michael Atlas , Joseph M. Schmitt , Paul Magnin , Eric A. Swanson
发明人： Christopher L. Petersen , Edward I. McNamara , Ronald B. Lamport , Michael Atlas , Joseph M. Schmitt , Paul Magnin , Eric A. Swanson
IPC分类号： G02B23/26 , A61B1/00 , A61B5/00 , G02B23/24 , G02B6/00
CPC分类号： G02B23/2407 , A61B5/0066 , A61B5/0084 , A61B5/6852 , G01B9/0205 , G01B9/02091
摘要： Optical probes having a diameter less than substantially 500 μm for use in scanning light from a long, highly flexible fiber to a sample. In one embodiment the probe includes a viscous damping fluid suitable to prevent non-uniform rotational distortion (NURD).

3. 发明授权

US08449468B2 Opto-acoustic imaging devices and methods 有权
标题翻译：光声成像装置及方法
公开(公告)号：US08449468B2
公开(公告)日：2013-05-28
申请号：US13051567
申请日：2011-03-18
申请人： Christopher L. Petersen , Joseph M. Schmitt
发明人： Christopher L. Petersen , Joseph M. Schmitt
IPC分类号： A61B8/14 , A61B6/00
CPC分类号： A61B5/0066 , A61B5/0095 , A61B5/6852 , A61B8/12 , A61B8/445 , A61B8/4461
摘要： In one aspect, the invention relates to a probe. The probe includes a sheath, a flexible, bi-directionally rotatable, optical subsystem positioned within the sheath, the optical subsystem comprising a transmission fiber, the optical subsystem capable of transmitting and collecting light of a predetermined range of wavelengths along a first beam having a predetermined beam size. The probe also includes an ultrasound subsystem, the ultrasound subsystem positioned within the sheath and adapted to propagate energy of a predetermined range of frequencies along a second beam having a second predetermined beam size, wherein a portion of the first and second beams overlap a region during a scan.
摘要翻译：一方面，本发明涉及一种探针。探针包括位于护套内的护套，柔性双向可旋转的光学子系统，光学子系统包括传输光纤，该光学子系统能够沿着具有第一光束的第一光束发射和收集预定波长范围的光预定的光束尺寸。所述探针还包括超声子系统，所述超声子系统位于护套内并且适于沿具有第二预定光束尺寸的第二光束传播预定频率范围的能量，其中第一和第二光束的一部分在扫描。

4. 发明授权

US08116605B2 Imaging catheter with integrated reference reflector 有权
标题翻译：成像导管与集成参考反射器
公开(公告)号：US08116605B2
公开(公告)日：2012-02-14
申请号：US12886265
申请日：2010-09-20
申请人： Christopher L. Petersen , Stephen M. McCartin , Joseph M. Schmitt , Joel M. Friedman
发明人： Christopher L. Petersen , Stephen M. McCartin , Joseph M. Schmitt , Joel M. Friedman
IPC分类号： G02B6/06
CPC分类号： G02B23/2423 , A61B5/0066 , A61B5/6852 , G02B5/08
摘要： In part, the invention relates to a lens assembly. The lens assembly includes a micro-lens; a beam director in optical communication with the micro-lens; and a substantially transparent film. The substantially transparent film is capable of bi-directionally transmitting light, and generating a controlled amount of backscatter. In addition, the film surrounds a portion of the beam director.
摘要翻译：部分地，本发明涉及一种透镜组件。透镜组件包括微透镜; 与微透镜进行光通信的光束导向器; 和基本透明的薄膜。基本透明的薄膜能够双向透射光，并产生受控量的反向散射。另外，胶片围绕光束导向器的一部分。

5. 发明授权

US06879851B2 Fiber optic endoscopic gastrointestinal probe 有权
标题翻译：光纤内窥镜胃肠道探针
公开(公告)号：US06879851B2
公开(公告)日：2005-04-12
申请号：US09876834
申请日：2001-06-07
申请人： Edward I. McNamara , Ron B. Lamport , Christopher L. Petersen , Joseph M. Schmitt
发明人： Edward I. McNamara , Ron B. Lamport , Christopher L. Petersen , Joseph M. Schmitt
IPC分类号： A61B1/07 , A61B1/12 , A61B1/273 , A61B5/00
CPC分类号： A61B5/6852 , A61B1/00082 , A61B1/00172 , A61B1/00183 , A61B1/043 , A61B1/07 , A61B1/2736 , A61B1/307 , A61B5/0062 , A61B5/0066 , A61B5/0073 , A61B5/0084 , A61B5/4233 , A61M25/10
摘要： A fiber optic probe and a balloon catheter used in conjunction with optical imaging systems, in particular with systems which deliver and collect a single spatial mode beam, such as a single photon, a multiphoton, confocal imaging and ranging systems, such as fluorescence imaging systems.
摘要翻译：与光学成像系统结合使用的光纤探针和气囊导管，特别是用于传送和收集单个空间模式光束的系统，例如单个光子，多光子，共聚焦成像和测距系统，例如荧光成像系统。

6. 发明授权

US08412312B2 Apparatus, systems, and methods of in-vivo blood clearing in a lumen 有权
标题翻译：体内血液清除的装置，系统和方法
公开(公告)号：US08412312B2
公开(公告)日：2013-04-02
申请号：US12888355
申请日：2010-09-22
申请人： Neil Judell , Robert Steinbrecher , Joel Friedman , Christopher L. Petersen
发明人： Neil Judell , Robert Steinbrecher , Joel Friedman , Christopher L. Petersen
IPC分类号： A61B5/00
CPC分类号： A61B5/0073 , A61B5/0066 , A61B5/02007 , A61B5/6852 , A61B5/7285
摘要： In one aspect, the invention relates to a computer-implemented method of triggering optical coherence tomography data collection. The method includes collecting optical coherence tomography data with respect to a vessel using an optical coherence tomography probe disposed in the vessel; determining a clearing radius and a quality value for each frame of optical coherence tomography data collected for the vessel using a computer; determining if a blood clearing state has occurred using at least one clearing radius and at least one quality value; and generating a trigger signal in response to the blood clearing state.
摘要翻译：一方面，本发明涉及触发光学相干层析成像数据采集的计算机实现的方法。该方法包括使用设置在容器中的光学相干断层摄影探针来收集关于血管的光学相干断层摄影数据; 使用计算机为所述船舶收集的光学相干断层摄影数据的每帧确定清除半径和质量值; 使用至少一个清除半径和至少一个质量值来确定是否已经发生血液清除状态; 以及响应于血液清除状态产生触发信号。

7. 发明授权

US5501226A Short coherence length, doppler velocimetry system 失效
标题翻译：短相干长度，多普勒测速系统
公开(公告)号：US5501226A
公开(公告)日：1996-03-26
申请号：US325675
申请日：1994-10-19
申请人： Christopher L. Petersen , Thomas Hellmuth
发明人： Christopher L. Petersen , Thomas Hellmuth
IPC分类号： A61B5/0285 , A61B3/12 , A61B5/02
CPC分类号： A61B3/1233
摘要： Apparatus for measuring the speed of blood in blood vessels in biological samples, for example, in retinal blood vessels, which apparatus includes: (a) a source of a beam of radiation having a principal wavelength, which radiation is substantially spatially coherent and has a temporal coherence length which is less than 1 picosecond; (b) a beam splitter for splitting the beam into a sample beam and reference beam; (c) optical apparatus for directing the sample beam to an area within the biological sample; (d) a reflector for reflecting the reference beam; (e) a detector for detecting an interference between the sample beam reflected from the area and the reflected reference beam and for generating an interference signal; (f) apparatus for altering an optical path length of the reference beam from the beam splitter to the detector at an alteration velocity; and (g) an analyzer for analyzing the interference signal to determine the speed of the blood in the area from a shift of a central frequency of a frequency spectrum of the interference signal from a frequency determined from the alteration velocity and the principal wavelength.
摘要翻译：用于测量生物样品中例如视网膜血管中血管速度的装置，该装置包括：（a）具有主波长的辐射束源，该辐射基本上在空间上相干并具有时间相干长度小于1皮秒; （b）用于将光束分成样品光束和参考光束的分束器; （c）用于将样品束引导到生物样品内的区域的光学装置; （d）反射参考光束的反射器; （e）检测器，用于检测从该区域反射的采样光束与反射参考光束之间的干涉并产生干涉信号; （f）用于以改变速度改变参考光束从分束器到检测器的光路长度的装置; 以及（g）分析器，用于分析干扰信号，以根据干扰信号的频谱的中心频率从由改变速度和主波长确定的频率的移动来确定该区域中的血液的速度。

8. 发明授权

US06552796B2 Apparatus and method for selective data collection and signal to noise ratio enhancement using optical coherence tomography 失效
标题翻译：使用光学相干断层扫描的选择性数据采集和信噪比增强的装置和方法
公开(公告)号：US06552796B2
公开(公告)日：2003-04-22
申请号：US09826897
申请日：2001-04-06
申请人： Paul Magnin , John W. Goodnow , Christopher L. Petersen , Joseph Schmitt
发明人： Paul Magnin , John W. Goodnow , Christopher L. Petersen , Joseph Schmitt
IPC分类号： G01B902
CPC分类号： A61B5/6852 , A61B5/0066 , G01B9/02067 , G01B9/02083 , G01B9/02091
摘要： Methods and apparatuses are provided for performing optical imaging on a sample. The method and apparatuses continually adjust the path-length of a reference arm or data acquisition in a manner such that imaging information is obtained only from a longitudinal range that contains a selective portion of a sample from which imaging information is to be obtained. The apparatuses include a starting point adjustment device that determines a point with respect to a sample at which imaging information collection is to be started. A controller then controls a second scanning mechanism, in addition to a first scanning mechanism, such that imaging information is obtained only from a longitudinal range that contains a selective portion of a sample from which imaging information is to be obtained. In this way, the amount of data collected can be reduced to that within the area of interest.
摘要翻译：提供了用于对样品执行光学成像的方法和装置。该方法和设备以这样的方式连续地调整参考臂或数据采集的路径长度，使得仅从包含要从其获得成像信息的样本的选择性部分的纵向范围获得成像信息。这些装置包括起点调整装置，其确定相对于要开始成像信息收集的样本的点。然后，控制器除了第一扫描机构之外还控制第二扫描机构，使得仅从包含要从其获得成像信息的样本的选择性部分的纵向范围获得成像信息。以这种方式，收集的数据量可以减少到感兴趣区域内的数据量。

9. 发明授权

US06445939B1 Ultra-small optical probes, imaging optics, and methods for using same 有权
标题翻译：超小型光学探针，成像光学元件及其使用方法
公开(公告)号：US06445939B1
公开(公告)日：2002-09-03
申请号：US09370756
申请日：1999-08-09
申请人： Eric Swanson , Christopher L. Petersen , Edward McNamara , Ronald B. Lamport , David L. Kelly
发明人： Eric Swanson , Christopher L. Petersen , Edward McNamara , Ronald B. Lamport , David L. Kelly
IPC分类号： A61B500
CPC分类号： A61B5/6852 , A61B5/0066 , G02B6/2552 , G02B6/4203
摘要： Ultra-small optical probes comprising a single-mode optical fiber and a lens which has substantially the same diameter as the optical fiber. The optical fiber and lens are positioned in a probe housing which is in the form of an insertional medical device such as a guidewire. Connector elements are provided to facilitate the attachment of the probe to an optical system and the quick disconnection of the probe from the optical system. The probe is used to obtain optical measurements in situ in the body of an organism and can be used to guide interventional procedures by a surgeon.
摘要翻译：包括单模光纤和具有与光纤基本相同直径的透镜的超小型光学探针。光纤和透镜被定位在探针壳体中，探针壳体是诸如导丝的插入医疗装置的形式。提供连接器元件以便于将探针附接到光学系统以及探针与光学系统的快速断开。该探针用于在生物体内原位获得光学测量，并可用于指导外科医生的介入手术。

10. 发明授权

US6053613A Optical coherence tomography with new interferometer 失效
标题翻译：新型干涉仪的光学相干断层扫描
公开(公告)号：US6053613A
公开(公告)日：2000-04-25
申请号：US79908
申请日：1998-05-15
申请人： Jay Wei , David Huang , Christopher L. Petersen
发明人： Jay Wei , David Huang , Christopher L. Petersen
IPC分类号： A61B3/11 , A61B3/10 , A61B5/00 , G01B9/02 , G01B11/24
CPC分类号： A61B5/0066 , A61B3/1005 , A61B3/102 , A61B5/0073 , G01B9/02002 , G01B9/02028 , G01B9/02091 , G01B2290/15 , G01B2290/35
摘要： Embodiments of the present invention are method and apparatus for simply and economically providing efficient scanning in an optical coherence tomography ("OCT") apparatus. In particular, an embodiment of the present invention is an OCT apparatus which examines an object, which OCT apparatus comprises: (a) a source of short coherence radiation; (b) a coupler which (i) couples a first portion of the radiation to a reference arm; (ii) couples a second portion of the radiation to a sample arm; (iii) combines radiation transmitted thereto from the reference path and the sample path; and (iv) couples the combined radiation to an analyzer; wherein (c) the reference arm transmits the first portion of the radiation to a measurement range variation apparatus and transmits radiation output from the measurement range variation apparatus back to the coupler; (d) the sample path transmits the second portion of the radiation to the object and transmits radiation scattered by the object back to the coupler; and (e) the measurement range variation apparatus comprises: (i) a transmitter which transmits a portion of the radiation incident thereupon; (ii) a reflector which reflects radiation transmitted by the transmitter; and (iii) a scanner coupled to scan the reflector.
摘要翻译：本发明的实施例是用于在光学相干断层摄影（“OCT”）装置中简单且经济地提供有效扫描的方法和装置。特别地，本发明的一个实施例是一种检查对象的OCT设备，该OCT设备包括：（a）短相干辐射源; （b）耦合器，其（i）将所述辐射的第一部分耦合到参考臂; （ii）将第二部分辐射耦合到样品臂; （iii）组合从参考路径传送到其上的辐射和样本路径; 和（iv）将组合的辐射耦合到分析仪; 其中（c）参考臂将辐射的第一部分传送到测量范围变化装置，并将从测量范围变化装置输出的辐射传送回耦合器; （d）采样路径将辐射的第二部分传送到物体，并将由物体散射的辐射传回给耦合器; 和（e）测量范围变化装置包括：（i）发射在其上发生的辐射的一部分的发射器; （ii）反射由发射器发射的辐射的反射器; 和（iii）扫描器，其连接以扫描反射器。

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