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1. 发明授权

US6053613A Optical coherence tomography with new interferometer 失效
标题翻译：新型干涉仪的光学相干断层扫描
公开(公告)号：US6053613A
公开(公告)日：2000-04-25
申请号：US79908
申请日：1998-05-15
申请人： Jay Wei , David Huang , Christopher L. Petersen
发明人： Jay Wei , David Huang , Christopher L. Petersen
IPC分类号： A61B3/11 , A61B3/10 , A61B5/00 , G01B9/02 , G01B11/24
CPC分类号： A61B5/0066 , A61B3/1005 , A61B3/102 , A61B5/0073 , G01B9/02002 , G01B9/02028 , G01B9/02091 , G01B2290/15 , G01B2290/35
摘要： Embodiments of the present invention are method and apparatus for simply and economically providing efficient scanning in an optical coherence tomography ("OCT") apparatus. In particular, an embodiment of the present invention is an OCT apparatus which examines an object, which OCT apparatus comprises: (a) a source of short coherence radiation; (b) a coupler which (i) couples a first portion of the radiation to a reference arm; (ii) couples a second portion of the radiation to a sample arm; (iii) combines radiation transmitted thereto from the reference path and the sample path; and (iv) couples the combined radiation to an analyzer; wherein (c) the reference arm transmits the first portion of the radiation to a measurement range variation apparatus and transmits radiation output from the measurement range variation apparatus back to the coupler; (d) the sample path transmits the second portion of the radiation to the object and transmits radiation scattered by the object back to the coupler; and (e) the measurement range variation apparatus comprises: (i) a transmitter which transmits a portion of the radiation incident thereupon; (ii) a reflector which reflects radiation transmitted by the transmitter; and (iii) a scanner coupled to scan the reflector.
摘要翻译：本发明的实施例是用于在光学相干断层摄影（“OCT”）装置中简单且经济地提供有效扫描的方法和装置。特别地，本发明的一个实施例是一种检查对象的OCT设备，该OCT设备包括：（a）短相干辐射源; （b）耦合器，其（i）将所述辐射的第一部分耦合到参考臂; （ii）将第二部分辐射耦合到样品臂; （iii）组合从参考路径传送到其上的辐射和样本路径; 和（iv）将组合的辐射耦合到分析仪; 其中（c）参考臂将辐射的第一部分传送到测量范围变化装置，并将从测量范围变化装置输出的辐射传送回耦合器; （d）采样路径将辐射的第二部分传送到物体，并将由物体散射的辐射传回给耦合器; 和（e）测量范围变化装置包括：（i）发射在其上发生的辐射的一部分的发射器; （ii）反射由发射器发射的辐射的反射器; 和（iii）扫描器，其连接以扫描反射器。

2. 发明授权

US06293674B1 Method and apparatus for diagnosing and monitoring eye disease 有权
标题翻译：诊断和监测眼睛疾病的方法和装置
公开(公告)号：US06293674B1
公开(公告)日：2001-09-25
申请号：US09614537
申请日：2000-07-11
申请人： David Huang , Alan R. Kirschbaum , Jay Wei
发明人： David Huang , Alan R. Kirschbaum , Jay Wei
IPC分类号： A61B310
CPC分类号： A61B3/102 , G06T7/60 , G06T2207/10101 , G06T2207/30041
摘要： Embodiments of the present invention provide method and apparatus for diagnosing and monitoring eye disease such as, for example, glaucoma. In particular, embodiments of the present invention analyze OCT scans of a retina to determine one or more of the following measures for diagnosing and monitoring glaucomatous retinal nerve fiber layer (“NFL”) change: an NFL thickness; a ratio of NFL thickness in a vertical quadrant (superior and inferior quadrants in an OCT scan are combined in a vertical average) and a horizontal quadrant (nasal and temporal quadrants in the OCT scan are combined in a horizontal average); and an NFL signal ratio (“NSR”) of a sum of signal strengths in a predetermined portion of the NFL and a sum of signal strengths in a predetermined region below a retina-pigment epithelium (“RPE”) interface.
摘要翻译：本发明的实施例提供了用于诊断和监测眼疾病例如青光眼的方法和装置。特别地，本发明的实施例分析视网膜的OCT扫描以确定用于诊断和监测青光眼性视网膜神经纤维层（“NFL”）变化的一种或多种以下措施：NFL厚度; 垂直象限中的NFL厚度（OCT扫描中的上下象限以垂直平均值组合）和水平象限（OCT扫描中的鼻和时间象限以水平平均值组合）的比率; 以及NFL的预定部分中的信号强度之和的NFL信号比（“NSR”），以及在视网膜色素上皮（“RPE”）界面下方的预定区域中的信号强度之和。

3. 发明授权

US08770753B2 Scanning and processing using optical coherence tomography 有权
标题翻译：使用光学相干断层扫描进行扫描和处理
公开(公告)号：US08770753B2
公开(公告)日：2014-07-08
申请号：US13310626
申请日：2011-12-02
申请人： Michael Hee , Jay Wei , David Huang , Qienyuan Zhou , Yonghua Zhao , Ben Jang , Tony Ko
发明人： Michael Hee , Jay Wei , David Huang , Qienyuan Zhou , Yonghua Zhao , Ben Jang , Tony Ko
IPC分类号： A61B3/14 , A61B3/10 , A61B3/12
CPC分类号： A61B3/102 , A61B3/0025 , A61B3/107 , A61B3/1225 , A61B3/14
摘要： In accordance with some embodiments, a method of eye examination includes acquiring OCT data with a scan pattern centered on an eye cornea that includes n radial scans repeated r times, c circular scans repeated r times, and n* raster scans where the scan pattern is repeated m times, where each scan includes a A-scans, and where n is an integer that is 0 or greater, r is an integer that is 1 or greater, c is an integer that is 0 or greater, n* is an integer that is 0 or greater, m is an integer that is 1 or greater, and a is an integer greater than 1, the values of n, r, c, n*, and m being chosen to provide OCT data for a target measurement, and processing the OCT data to obtain the target measurement.
摘要翻译：根据一些实施例，眼睛检查的方法包括以包括眼睛角膜为中心的扫描图案来获取OCT数据，该扫描图案包括重复r次的n个径向扫描，c次循环扫描重复r次，以及扫描模式为重复m次，其中每个扫描包括A扫描，并且其中n是0或更大的整数，r是1或更大的整数，c是0或更大的整数，n *是整数 0或更大，m是1或更大的整数，a是大于1的整数，n，r，c，n *和m的值被选择为提供用于目标测量的OCT数据，并处理OCT数据以获得目标测量。

4. 发明授权

US07744221B2 Method of eye examination by optical coherence tomography 有权
标题翻译：光学相干断层扫描眼科检查方法
公开(公告)号：US07744221B2
公开(公告)日：2010-06-29
申请号：US11656075
申请日：2007-01-19
申请人： Jay Wei , Ben Jang , David Huang , Yonghua Zhao
发明人： Jay Wei , Ben Jang , David Huang , Yonghua Zhao
IPC分类号： A61B3/00
CPC分类号： A61B3/102 , A61B3/113 , G06T7/11 , G06T2207/10101 , G06T2207/20128 , G06T2207/30041
摘要： A method of performing an OCT image scan is presented. Other images are taken and a template is formed to correct the OCT images, for example, for eye motion, blood vessel placement, and center offset. In some embodiments, video images are taken simultaneously with the OCT images and utilized to correct the OCT images. In some embodiments, a template OCT image is formed prior to acquisition of the OCT images and the template OCT image is utilized as a template from which to correct all of the OCT images.
摘要翻译：提出了执行OCT图像扫描的方法。拍摄其他图像，并且形成模板以校正OCT图像，例如用于眼动，血管放置和中心偏移。在一些实施例中，与OCT图像同时拍摄视频图像并用于校正OCT图像。在一些实施例中，在获取OCT图像之前形成模板OCT图像，并且将模板OCT图像用作校正所有OCT图像的模板。

5. 发明申请

US20070195269A1 Method of eye examination by optical coherence tomography 有权
标题翻译：光学相干断层扫描眼科检查方法
公开(公告)号：US20070195269A1
公开(公告)日：2007-08-23
申请号：US11656075
申请日：2007-01-19
申请人： Jay Wei , Ben Jang , David Huang , Yonghua Zhao
发明人： Jay Wei , Ben Jang , David Huang , Yonghua Zhao
IPC分类号： A61B3/10
CPC分类号： A61B3/102 , A61B3/113 , G06T7/11 , G06T2207/10101 , G06T2207/20128 , G06T2207/30041
摘要： A method of performing an OCT image scan is presented. Other images are taken and a template is formed to correct the OCT images, for example, for eye motion, blood vessel placement, and center offset. In some embodiments, video images are taken simultaneously with the OCT images and utilized to correct the OCT images. In some embodiments, a template OCT image is formed prior to acquisition of the OCT images and the template OCT image is utilized as a template from which to correct all of the OCT images.
摘要翻译：提出了执行OCT图像扫描的方法。拍摄其他图像，并且形成模板以校正OCT图像，例如用于眼动，血管放置和中心偏移。在一些实施例中，与OCT图像同时拍摄视频图像并用于校正OCT图像。在一些实施例中，在获取OCT图像之前形成模板OCT图像，并且将模板OCT图像用作校正所有OCT图像的模板。

6. 发明申请

US20180344147A1 OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY METHODS 审中-公开
公开(公告)号：US20180344147A1
公开(公告)日：2018-12-06
申请号：US16000824
申请日：2018-06-05
申请人： David Huang , Yali Jia
发明人： David Huang , Yali Jia
IPC分类号： A61B3/00 , A61B3/12 , A61B3/14 , A61B3/10
CPC分类号： A61B3/0025 , A61B3/0041 , A61B3/102 , A61B3/1233 , A61B3/1241 , A61B3/14
摘要： Methods of applying OCT angiography are disclosed. In particular, methods of detecting, visualizing and measuring the extent of retinal neovascularization are disclosed. Further disclosed are methods measuring retinal nonperfusion area and choriocapillaris defect area.

7. 发明授权

US09918630B2 Systems and methods of glaucoma diagnosis based on frequency analysis of inner retinal surface profile measured by optical coherence tomography 有权
公开(公告)号：US09918630B2
公开(公告)日：2018-03-20
申请号：US15253597
申请日：2016-08-31
申请人： Ou Tan , David Huang
发明人： Ou Tan , David Huang
IPC分类号： A61B3/12 , A61B3/00 , A61B3/10
CPC分类号： A61B3/1225 , A61B3/0025 , A61B3/102 , G06T7/136 , G06T2207/30041
摘要： A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.

8. 发明授权

US09621334B2 Data transmission method and system 有权
公开(公告)号：US09621334B2
公开(公告)日：2017-04-11
申请号：US12212418
申请日：2008-09-17
申请人： David Huang , Wei-Chih Chang , Tsung-Pao Kuan
发明人： David Huang , Wei-Chih Chang , Tsung-Pao Kuan
IPC分类号： H03D1/00 , H04J11/00 , H04L7/02 , H04B7/04 , H04L7/033
CPC分类号： H04L7/02 , H04B7/04 , H04L7/033
摘要： A data transmission method for a data transmission system including a first device and a second device is disclosed. The method comprises the steps of transmitting a clock signal to synchronize the first device and the second device; transmitting a mode signal from the first device to the second device, wherein the mode signal indicates a transmission mode between the first device and the second device; and transmitting a serial data between the first device and the second device based on the clock signal, wherein the length of the serial data is determined based on the transmission mode.

9. 发明申请

US20170055829A1 SYSTEMS AND METHODS OF GLUACOMA DIAGNOSIS BASED ON FREQUENCY ANALYSIS OF INNER RETINAL SURFACE PROFILE MEASURED BY OPTICAL COHERENCE TOMOGRAPHY 有权
标题翻译：基于通过光学相干测量法测量的内膜表面轮廓的频率分析的GLUACOMA诊断系统和方法
公开(公告)号：US20170055829A1
公开(公告)日：2017-03-02
申请号：US15253597
申请日：2016-08-31
申请人： Ou Tan , David Huang
发明人： Ou Tan , David Huang
IPC分类号： A61B3/12 , A61B3/10 , A61B3/00
CPC分类号： A61B3/1225 , A61B3/0025 , A61B3/102 , G06T7/136 , G06T2207/30041
摘要： A method for detecting glaucoma in a subject based on spatial frequency analysis of the inner limiting membrane (ILM) as obtained from optical coherence tomography (OCT) image data is disclosed. Based on the spatial frequency content of the analyzed ILM profile, a quantity called the Retinal surface contour variability (RSCV) is calculated and the presence or absence of a glaucoma condition is determined based on the RSCV magnitude.
摘要翻译：公开了一种基于从光学相干断层摄影（OCT）图像数据获得的内部限制膜（ILM）的空间频率分析来检测受试者中的青光眼的方法。基于所分析的ILM谱的空间频率含量，计算称为视网膜表面轮廓变异性（RSCV）的量，并且基于RSCV幅度确定青光眼状况的存在或不存在。

10. 发明申请

US20160287071A1 METHODS OF MEASURING TOTAL RETINAL BLOOD FLOW USING EN FACE DOPPLER OCT 审中-公开
标题翻译：使用表面多普勒OCT测量总体血液流量的方法
公开(公告)号：US20160287071A1
公开(公告)日：2016-10-06
申请号：US15089803
申请日：2016-04-04
申请人： Ou Tan , David Huang
发明人： Ou Tan , David Huang
IPC分类号： A61B3/12 , G06T5/00 , G06T7/00 , A61B3/10 , A61B3/00
CPC分类号： A61B3/1233 , A61B3/0025 , A61B3/102 , A61B3/1241 , A61B5/7203 , A61B6/5258 , G06K9/0061 , G06K9/52 , G06K2209/05 , G06T7/0012 , G06T2207/10101 , G06T2207/30041 , G06T2207/30104
摘要： Methods of performing en face Doppler total retinal blood flow measurement are disclosed. The methods involve obtaining a set of structural OCT scans; calculating a noise-reduced set of Doppler phase shift images by dividing the full spectrum OCT fringe data into a set of narrower filtered frequency bands for phase shift calculation; removing bulk motion along a depth direction; detecting retinal vessels in the set of images; applying a phase unwrapping algorithm to the images; classifying the vessels as veins and arteries; and calculating total retinal blood flow based on that classification.
摘要翻译：公开了执行面部多普勒总视网膜血流量测量的方法。该方法涉及获得一组结构OCT扫描; 通过将全谱OCT边缘数据划分成一组较窄的滤波频带以进行相移计算，来计算多普勒相移图像的噪声降低集合; 沿深度方向去除大量运动; 检测该组图像中的视网膜血管; 对图像应用相位解包算法; 将血管分类为静脉和动脉; 并根据该分类计算总视网膜血流量。

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