专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US06759409B2 Inhibitors of papilloma virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US06759409B2
公开(公告)日：2004-07-06
申请号：US10023975
申请日：2001-12-17
申请人： Christiane Yoakim , Bruno Haché , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , Bruno Haché , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K315355
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映体或非对映异构体：其中：A， X，W，R 1，Y; R 3; 和R 4如本文所定义。本发明的化合物可以用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

2. 发明授权

US07119099B2 Inhibitors of papilloma virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US07119099B2
公开(公告)日：2006-10-10
申请号：US10772721
申请日：2004-02-04
申请人： Christiane Yoakim , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K31/41 , C07D285/06
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映体或非对映异构体：其中：A， X，W，R 1，Y; 3＆lt; 3＆gt; R 4和R 4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

3. 发明授权

US07807670B2 Inhibitors of papilloma virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US07807670B2
公开(公告)日：2010-10-05
申请号：US12270207
申请日：2008-11-13
申请人： Christiane Yoakim , Bruno Hache , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , Bruno Hache , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K31/343 , A61K31/5377 , A61P31/12 , C07D307/94 , C07D265/30
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映体或非对映异构体：其中：A， X，W，R1，Y; R3; 和R4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

4. 发明申请

US20100041649A1 INHIBITORS OF PAPILLOMA VIRUS 有权
标题翻译： PAPILLOMA病毒的抑制剂
公开(公告)号：US20100041649A1
公开(公告)日：2010-02-18
申请号：US12270207
申请日：2008-11-13
申请人： Christiane Yoakim , Bruno Hache , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , Bruno Hache , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K31/343 , C07D307/94 , C07D265/30 , A61K31/5377 , A61P31/12
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein.The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映异构体或非对映异构体：其中：A，X，W，R 1，Y; R3; 和R4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

5. 发明授权

US07528167B2 Inhibitors of papilloma virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US07528167B2
公开(公告)日：2009-05-05
申请号：US11382969
申请日：2006-05-12
申请人： Christiane Yoakim , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , William W. Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K31/34 , C07D317/72
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映异构体或非对映异构体：其中：A，X，W，R 1，Y; R3; 和R4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

6. 发明申请

US20060235010A1 Inhibitors of Papilloma Virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US20060235010A1
公开(公告)日：2006-10-19
申请号：US11382969
申请日：2006-05-12
申请人： Christiane Yoakim , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K31/5377 , A61K31/4747 , A61K31/4245 , A61K31/41
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映异构体或非对映异构体：其中：A，X，W，R 1，Y; 3＆lt; 3＆gt; R 4和R 4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

7. 发明申请

US20050009855A1 Inhibitors of papilloma virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US20050009855A1
公开(公告)日：2005-01-13
申请号：US10772721
申请日：2004-02-04
申请人： Christiane Yoakim , Bruno Hache , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , Bruno Hache , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： C07D307/94 , C07D405/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D493/04 , C07D493/10 , C07D495/12 , A61K31/4747 , A61K31/4025 , C07
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映体或非对映异构体：其中：A， X，W，R 1，Y; R 3; 和R 4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

8. 发明授权

US06825176B2 E2 displacement assay for identifying inhibitors of HPV 有权
标题翻译：用于鉴定HPV抑制剂的E2位移测定
公开(公告)号：US06825176B2
公开(公告)日：2004-11-30
申请号：US10358790
申请日：2003-02-05
申请人： Peter White , Christiane Yoakim
发明人： Peter White , Christiane Yoakim
IPC分类号： A01N4304
CPC分类号： C07D407/12 , C07D491/10 , G01N33/532 , G01N33/533 , G01N33/534 , G01N33/535 , G01N33/542 , G01N33/56983 , G01N33/581 , G01N33/582 , G01N33/583 , G01N33/60 , G01N2333/025 , G01N2500/10
摘要： The present invention generally relates to an assay for identifying inhibitors of Human Papillomavirus (HPV), comprising: a) contacting a HPV E2 transactivation domain with a probe to form a E2:probe complex and measuring a signal from said probe to establish a base line level; b) incubating the E2:probe complex with a test compound and measuring the signal from said probe; c) comparing the signal from step b) with the signal from step a); wherein said probe is a compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein R1, A, X, W, Y, R3 and R4 are as defined herein; or a derivative thereof, wherein said derivative is a probe of formula (I) labeled with a detectable label or an affinity tag, wherein wavy lines represent bonds of unspecified stereochemistry; and wherein said signal is selected from: fluorescence, resonance energy transfer, time resolved fluorescence, radioactivity, fluorescence polarization, change in the intrinsic spectral properties, luminescence and plasma-resonance; whereby a modulation in said signal is an indication that said test compound binds to said transactivation domain.
摘要翻译：本发明一般涉及用于鉴定人乳头瘤病毒（HPV）抑制剂的测定法，其包括：a）使HPV E2反式激活结构域与探针接触以形成E2：探针复合物并测量来自所述探针的信号以建立基线 b）将E2：探针复合物与测试化合物孵育并测量来自所述探针的信号; c）将来自步骤b）的信号与来自步骤a）的信号进行比较;其中所述探针是式（I）的化合物，或其对映体或非对映异构体：其中R 1，A，X，W，Y，R 3和R 4如本文所定义; 或其衍生物，其中所述衍生物是用可检测标记或亲和标签标记的式（I）的探针，其中波浪线表示未指定的立体化学键; 并且其中所述信号选自：荧光，共振能量转移，时间分辨荧光，放射性，荧光偏振，固有光谱性质的变化，发光和等离子体共振; 由此所述信号中的调节是所述测试化合物结合所述反式激活结构域的指示。

9. 发明授权

US07167801B2 Method of identifying potential inhibitors of human papillomavirus protein E2 using x-ray atomic coordinates 有权
标题翻译：使用x射线原子坐标识别人乳头瘤病毒蛋白E2的潜在抑制剂的方法
公开(公告)号：US07167801B2
公开(公告)日：2007-01-23
申请号：US10193460
申请日：2002-07-11
申请人： Dale R. Cameron , Jacques Archambault , Christiane Yoakim , Peter White , Yong Wang
发明人： Dale R. Cameron , Jacques Archambault , Christiane Yoakim , Peter White , Yong Wang
IPC分类号： G06F7/58
CPC分类号： C07D405/12 , C07D417/12 , C07K14/005 , C07K2299/00 , C12N2710/20022
摘要： A crystallizable composition, comprising an human papillomavirus (HPV-11) E2 transactivation domain (TAD)-like polypeptide of SEQ ID NO. 2 complexed with an inhibitor L (sodium (2R,3R,4S,5R)-5-(3,4-dichlorophenyl)-5′-methyl-1′,3′-dioxo-4-({[4-(1,2,3-thiadiazol-4-yl)phenyl]amino}carbonyl)-1′,3′,4,5-tetrahydro-3H-spiro[furan-2,2′-indene]-3-carboxylate). The invention also provides a method for producing the crystallized HPV E2 TAD-inhibitor complex (HPV E2 TAD-L) comprising: a) mixing purified HPV E2 TAD, contained in a purification buffer, with solublized inhibitor L to generate a complex solution containing the HPV E2 TAD-L complex; and b) crystallizing the complex from a) in a crystallization buffer. The invention also provides a method for producing crystallized apo HPV E2 TAD, comprising: a) mixing apo HPV E2 TAD, contained in a purification buffer, with a crystallization buffer.X-ray crystal structure coordinates the HPV E2 TAD-L complex, are also provided, which define an inhibitor binding pocket. The inhibitor binding pocket is useful for screening potential small molecule inhibitors that bind to the pocket that may be inhibitors of papillomavirus infection.
摘要翻译：一种可结晶组合物，其包含SEQ ID NO.1的人乳头状瘤病毒（HPV-11）E2反式激活结构域（TAD）样多肽。 2与抑制剂L（（2R，3R，4S，5R）-5-（3,4-二氯苯基）-5'-甲基-1'，3'-二氧代-4 - （{[4-（1 ，2,3-噻二唑-4-基）苯基]氨基}羰基）-1'，3'，4,5-四氢-3H-螺[呋喃-2,2'-茚] -3-羧酸乙酯）。本发明还提供了一种生产结晶的HPV E2 TAD抑制剂复合物（HPV E2 TAD-L）的方法，包括：a）将纯化缓冲液中纯化的HPV E2 TAD与溶出的抑制剂L混合以产生含有 HPV E2 TAD-L复合物; 和b）从结晶缓冲液中的a）结晶复合物。本发明还提供了一种用于生产结晶apo HPV E2 TAD的方法，其包括：a）将包含在纯化缓冲液中的apo HPV E2 TAD与结晶缓冲液混合。还提供X射线晶体结构协调HPV E2 TAD-L复合物，其定义了抑制剂结合口袋。抑制剂结合口袋可用于筛选结合口袋的可能是乳头瘤病毒感染抑制剂的潜在小分子抑制剂。

10. 发明授权

US08669523B2 Contour-based defect detection using an inspection apparatus 有权
标题翻译：使用检查装置进行基于轮廓的缺陷检测
公开(公告)号：US08669523B2
公开(公告)日：2014-03-11
申请号：US13410506
申请日：2012-03-02
申请人： Chien-Huei Chen , Peter White , Michael J. Van Riet , Sankar Venkataraman , Hai Jiang , Hedong Yang , Ajay Gupta
发明人： Chien-Huei Chen , Peter White , Michael J. Van Riet , Sankar Venkataraman , Hai Jiang , Hedong Yang , Ajay Gupta
IPC分类号： H01J37/28 , G01N23/04 , G06T5/50
CPC分类号： H01J37/28 , G01N23/04 , G06T5/50 , G06T7/001 , G06T2207/30148 , H01J37/05 , H01J37/222 , H01J37/244
摘要： One embodiment relates to a method of inspecting a site location on a target substrate. Contours are obtained, the contours having been generated from a reference image using a design clip. A target image of the site location is acquired. The contours are aligned to the target image, and contrast values are computed for pixels on the contours. A threshold is applied to the contrast values to determine contour-based defect blobs. Another embodiment relates to a method of generating contours for use in inspecting a site location for defects. Other embodiments, aspects and features are also disclosed.
摘要翻译：一个实施例涉及一种检查目标基板上的位置位置的方法。获得轮廓，使用设计剪辑从参考图像生成轮廓。获取站点位置的目标图像。轮廓与目标图像对齐，并且对轮廓线上的像素计算对比度值。将阈值应用于对比度值以确定基于轮廓的缺陷斑点。另一个实施例涉及一种产生用于检查位置缺陷的轮廓的方法。还公开了其它实施例，方面和特征。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式