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1. 发明申请

US20050009855A1 Inhibitors of papilloma virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US20050009855A1
公开(公告)日：2005-01-13
申请号：US10772721
申请日：2004-02-04
申请人： Christiane Yoakim , Bruno Hache , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , Bruno Hache , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： C07D307/94 , C07D405/12 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D493/04 , C07D493/10 , C07D495/12 , A61K31/4747 , A61K31/4025 , C07
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A,; X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映体或非对映异构体：其中：A， X，W，R 1，Y; R 3; 和R 4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

2. 发明申请

US20060235010A1 Inhibitors of Papilloma Virus 有权
标题翻译：乳头状瘤病毒抑制剂
公开(公告)号：US20060235010A1
公开(公告)日：2006-10-19
申请号：US11382969
申请日：2006-05-12
申请人： Christiane Yoakim , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
发明人： Christiane Yoakim , William Ogilvie , Jeffrey O'Meara , Peter White , Nathalie Goudreau
IPC分类号： A61K31/5377 , A61K31/4747 , A61K31/4245 , A61K31/41
CPC分类号： C07D405/12 , C07D307/94 , C07D407/12 , C07D407/14 , C07D413/12 , C07D417/12 , C07D491/04 , C07D491/048 , C07D493/04 , C07D493/10 , C07D495/12 , C07D495/20
摘要： A compound of formula (I) or its enantiomers or diastereoisomers thereof: wherein: A, X, W, R1, Y; R3; and R4 are as defined herein. The compounds of the invention may be used as inhibitors of the papilloma virus E1-E2-DNA complex. The invention further provides a method of treating or preventing human papilloma virus infection.
摘要翻译：式（I）化合物或其对映异构体或非对映异构体：其中：A，X，W，R 1，Y; 3＆lt; 3＆gt; R 4和R 4如本文所定义。本发明的化合物可用作乳头瘤病毒E1-E2-DNA复合物的抑制剂。本发明还提供了治疗或预防人乳头状瘤病毒感染的方法。

3. 发明授权

US07273861B2 Non-nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US07273861B2
公开(公告)日：2007-09-25
申请号：US10662606
申请日：2003-09-15
申请人： Christiane Yoakim , Jeffrey O'Meara , Bruno Simoneau , William Ogilvie , Robert Déziel
发明人： Christiane Yoakim , Jeffrey O'Meara , Bruno Simoneau , William Ogilvie , Robert Déziel
IPC分类号： A61P31/18 , A61K31/551 , C07D471/22
CPC分类号： C07D471/22
摘要： Compounds represented by formula 1: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or methyl; R3 is H or (C1-4)alkyl; R4 is H or (C1-4)alkyl; R5 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cyclo-alkyl or (C3-7)cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1′-biphenyl, 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C1-4)alkyl, which in turn can be optionally substituted with a carboxy or (C1-4)alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.
摘要翻译：由式1表示的化合物：其中R 1是H，卤素，（C 1-4烷基）烷基，O（C 1-4）烷基和卤代烷基; R 2是H或甲基; R 3是H或（C 1-4 - ）烷基; R 4是H或（C 1-4烷基）烷基; R 5是（C 1-4烷基）烷基，（C 1-4 - ）烷基（C 1-3 - 亚烷基））环烷基或（C 3-7）环烷基; W是具有一个或两个选自N或S的杂原子的稠合苯基-5或6元杂环; 或W是苯基，1,1'-联苯基，2,3-二氢-1H-茚，1,2,3,4-四氢萘基或萘基; 所述W任选被（C 1-4烷基）烷基取代，其又可以任选地被羧基或（C 1-4 - ）烷氧基羰基取代，或其盐或其酯。该化合物对野生型，单突变和双突变株具有抑制活性。

4. 发明授权

US07105510B2 Non-nucleoside reverse transcriptase inhibitors 有权
标题翻译：非核苷逆转录酶抑制剂
公开(公告)号：US07105510B2
公开(公告)日：2006-09-12
申请号：US10662856
申请日：2003-09-15
申请人： Christiane Yoakim , Eric Malenfant , Bounkham Thavonekham , William Ogilvie , Robert Déziel
发明人： Christiane Yoakim , Eric Malenfant , Bounkham Thavonekham , William Ogilvie , Robert Déziel
IPC分类号： C07D471/14 , A61K31/55 , A61P31/18
CPC分类号： C07D471/14
摘要： Compounds represented by formula I: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or (C1-4)alkyl; R3 is H or (C1-4)alkyl; R4 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cycloalkyl, or (C3-7)cycloalkyl; and Q is a fused phenyl-5 or 6-membered saturated heterocycle having one to two heteroatoms selected from O and N, said Q being optionally substituted with hydroxy, or (C1-4)alkyl which in turn maybe optionally substituted with pyridinyl-N-oxide or C(O)OR wherein R is H or (C1-4)alkyl; or a salt thereof. The compounds have inhibitory activity against Wild Type, and single and double mutants strains, of HIV.
摘要翻译：由式I表示的化合物：其中R 1是H，卤素，（C 1-4烷基）烷基，O（C 1-4 - ） - 烷基和卤代烷基; R 2是H或（C 1-4 - ）烷基; R 3是H或（C 1-4 - ）烷基; R 4是（C 1-4烷基）烷基，（C 1-4 - ）烷基（C 1-3 - >）环烷基，或（C 3-7）环烷基; 并且Q是具有一个到两个选自O和N的杂原子的稠合苯基-5或6元饱和杂环，所述Q任选被羟基或（C 1-4烷基）烷基取代，可以任选地被吡啶基-N-氧化物或C（O）OR取代，其中R是H或（C 1-4）烷基; 或其盐。该化合物对野生型具有抑制活性，并具有HIV和HIV的单和双突变株。

5. 发明申请

US20080077243A1 INTERVERTEBRAL PROSTHESIS ENDPLATE HAVING DOUBLE DOME AND SURGICAL TOOLS FOR IMPLANTING SAME 有权
标题翻译：具有两面植入物的双层球囊和手术工具的椎间孔内窥镜
公开(公告)号：US20080077243A1
公开(公告)日：2008-03-27
申请号：US11862012
申请日：2007-09-26
申请人： Casey Lee , George Makris , Alastair Clemow , William Ogilvie
发明人： Casey Lee , George Makris , Alastair Clemow , William Ogilvie
IPC分类号： A61F2/44
CPC分类号： A61B17/1671 , A61B17/1659 , A61F2/30771 , A61F2/442 , A61F2/4611 , A61F2002/30069 , A61F2002/30125 , A61F2002/30563 , A61F2002/30884 , A61F2002/3092 , A61F2230/0008 , A61F2230/008
摘要： An endplate for an intervertebral prosthesis prosthesis endplate of the invention includes: a generally planar base plate, a first elevated region, or dome, within the base plate periphery, and a second elevated region, or dome, within the boundary of the first elevated region. The antero-posterior and side-to-side (medial-lateral) dimensions of the first elevated region are made to be unequal in order to provide resistance to torsional stresses, and the laterally opposite sidewalls of the first elevated region are defined by arcs that terminate in sagittal planes of the endplate, and are symmetrical with respect to a coronal plane of the endplate. A bone rasp for preparing a surgical site for implantation of the prosthesis has a rasp head having a pivot point and rasp teeth arranged to produce a recess or seat of predetermined shape. A groove-cutter for preparing a medial antero-posterior groove in a vertebral body without damaging the anterior rim of the vertebral body has a guide head that is seated in a prepared recess in the vertebral body and a reciprocable tooth that can be stowed in a recess while the cutter is initially positioned within the intervertebral space.
摘要翻译：用于本发明的椎间假体假体终板的终板包括：在基板周边内的大致平坦的基板，第一升高区域或圆顶，以及在第一升高区域的边界内的第二升高区域或圆顶。使第一升高区域的前后和侧向（侧向）（内侧）的尺寸不相等以提供抵抗扭转应力的阻力，并且第一升高区域的横向相对的侧壁由弧定义终止于终板的矢状平面，并且相对于端板的冠状面对称。用于准备用于植入假体的手术部位的骨锉具有具有枢轴点和锉齿的锉刀头，所述锉刀头被设置成产生预定形状的凹部或座。用于在椎体中制备内侧前后槽而不损伤椎体的前边缘的槽切割器具有位于椎体中的预备凹槽中的引导头和可收纳在椎体中的可往复运动的牙齿凹槽，同时切割器最初位于椎间空间内。

6. 发明申请

US20050033426A1 Carpometacarpal joint prosthesis 失效
标题翻译：腕掌关节假体
公开(公告)号：US20050033426A1
公开(公告)日：2005-02-10
申请号：US10753108
申请日：2004-01-06
申请人： William Ogilvie , Charles Mumme , Ian Trail
发明人： William Ogilvie , Charles Mumme , Ian Trail
IPC分类号： A61F2/00 , A61F2/30 , A61F2/42 , A61F2/28
CPC分类号： A61F2/4241 , A61F2/30767 , A61F2002/30014 , A61F2002/30021 , A61F2002/30026 , A61F2002/3008 , A61F2002/30112 , A61F2002/30158 , A61F2002/3026 , A61F2002/30301 , A61F2002/30574 , A61F2002/30616 , A61F2002/30685 , A61F2002/30878 , A61F2002/4258 , A61F2230/0004 , A61F2230/0026 , A61F2230/008 , A61F2230/0095 , A61F2250/0018 , A61F2250/0098 , A61F2310/00173 , A61F2310/00574
摘要： Hemi joint replacements for the base of the first metacarpal of the CMC joint are provided which can effectively restore and reestablish functional joint mechanics while preserving the soft tissues that contribute to joint stability and function. The implants have a unique head shape with a saddle-like articular surface that is shaped somewhat similar to a conventional bicycle seat. A set of four proportionately larger and smaller implants allows a surgeon to choose the appropriately sized prosthesis for implantation in respect of the metacarpal osteotomy.
摘要翻译：提供了用于CMC关节第一掌骨基部的半关节置换术，可有效恢复和重新建立功能关节力学，同时保留有助于关节稳定性和功能的软组织。植入物具有独特的头部形状，其具有鞍状的关节表面，其形状有点类似于传统的自行车座椅。一组四个成比例地较大和较小的植入物允许外科医生选择适当尺寸的假体以进行针骨截骨术的植入。

7. 发明申请

US20080026593A1 Method and Apparatus for the Manufacture of Electric Circuits 审中-公开
标题翻译：电路制造方法与装置
公开(公告)号：US20080026593A1
公开(公告)日：2008-01-31
申请号：US10587912
申请日：2004-10-01
申请人： William Ogilvie
发明人： William Ogilvie
IPC分类号： H01L21/31
CPC分类号： H05K3/388 , H05K1/0284 , H05K3/102 , H05K3/14 , H05K3/467
摘要： A method of manufacturing a patterned electric circuit. The method comprises the steps of providing a cold gas-dynamic spraying (CGDS) device, providing a substrate, and depositing a pattern of electrically conductive material with the CGDS device on the substrate by relative movement between the CGDS device to the substrate.
摘要翻译：一种图案化电路的制造方法。该方法包括以下步骤：通过CGDS器件与衬底之间的相对运动，提供冷气体动态喷涂（CGDS）器件，提供衬底，以及通过CGDS器件在衬底上沉积导电材料图案。

8. 发明申请

US20060241778A1 Interpositional biarticular disk implant 有权
标题翻译：间隙性双关节椎间盘植入物
公开(公告)号：US20060241778A1
公开(公告)日：2006-10-26
申请号：US10552951
申请日：2004-04-16
申请人： William Ogilvie
发明人： William Ogilvie
IPC分类号： A61F2/42
CPC分类号： A61F2/4225 , A61F2/4241 , A61F2002/302 , A61F2002/30311 , A61F2002/30685 , A61F2002/30754 , A61F2002/4238 , A61F2002/4256 , A61F2002/4258 , A61F2230/0065 , A61F2310/00574
摘要： An interpositional biarticular disk implant (11) having a circular peripheral rim, a generally toroidal axial center opening (13) and convex upper and lower surfaces (15, 17) is implanted between resected concave surfaces of the metacarpal base and the trapezium or other carpal bone in a CMC joint replacement. The disk (11) is anchored in operative position through the use of a flexable cond, such as a harvested tendon that passes through the center opening (13) and through osseous passageways created in the two facing bones.
摘要翻译：具有圆形周边边缘的大体环形轴向中心开口（13）和凸形上下表面（15,17）的插入式多关节盘植入物（11）被植入到掌骨基部和梯形或其他腕管的切除的凹表面之间骨在CMC关节置换。盘（11）通过使用可弯曲的圆柱（例如通过中心开口13）的收获的腱和通过在两个面骨中产生的骨通道而被锚定在操作位置。

9. 发明申请

US20090102594A1 FUSE 审中-公开
标题翻译：保险丝
公开(公告)号：US20090102594A1
公开(公告)日：2009-04-23
申请号：US12066987
申请日：2006-06-12
申请人： William Ogilvie
发明人： William Ogilvie
IPC分类号： B05D5/12 , H01H85/04
CPC分类号： H01H85/11 , H01H69/02
摘要： A method of creating a fuse. The method comprises the steps of creating a fusible link electrically connecting a first terminal portion to a second terminal portion, the fusible link, the first terminal portion and the second terminal portion being made of a first electrically conductive material; and spraying a coating of a second electrically conductive material onto the fusible link. The second electrically conductive material has a lower melting point than the first electrically conductive material and is absorbable in the first electrically conductive material.
摘要翻译：一种创建保险丝的方法。该方法包括以下步骤：产生将第一端子部分与第二端子部分电连接的熔丝，第一端子部分和第二端子部分由第一导电材料制成; 以及将第二导电材料的涂层喷涂到所述可熔连接件上。第二导电材料具有比第一导电材料更低的熔点，并且可吸收在第一导电材料中。

10. 发明授权

US06291640B1 Peptidomimetic inhibitors of the human cytomegalovirus protease 失效
标题翻译：人巨细胞病毒蛋白酶的拟肽抑制剂
公开(公告)号：US06291640B1
公开(公告)日：2001-09-18
申请号：US09171554
申请日：1998-10-19
申请人： Murray D. Bailey , Gulrez Fazal , Pierre Lavallee , William Ogilvie , Marc-Andre Poupart
发明人： Murray D. Bailey , Gulrez Fazal , Pierre Lavallee , William Ogilvie , Marc-Andre Poupart
IPC分类号： C07K510
CPC分类号： C07K5/1027 , A61K38/00 , C07K5/0202 , C07K5/06191 , C07K5/0827
摘要： A compound of formula (I) is disclosed: wherein X, z, W, Y, R1 through R5, m and n are as define herein. These compounds are peptidomimetic inhibitors of human cytomegalovirus (HCMV) protease and are useful for the treatment of human cytomegalovirus infection.
摘要翻译：公开了式（I）化合物：其中X，z，W，Y，R 1至R 5，m和n如本文所定义。这些化合物是人巨细胞病毒（HCMV）蛋白酶的拟肽抑制剂，可用于治疗人巨细胞病毒感染。

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