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1. 发明授权

US12071674B2 Nucleic acid probe set and nucleic acid lateral flow immunoassay having the same 有权
公开(公告)号：US12071674B2
公开(公告)日：2024-08-27
申请号：US17355623
申请日：2021-06-23
申请人： National Defense Medical Center
发明人： Cheng-Che Liu , Po-Da Hong , Yi-Huei Huang , Kuan-Yi Yu , Shou-Ping Huang , Shou-Hung Tang , Juin-Hong Cherng
IPC分类号： C12Q1/6804 , C12Q1/6813 , C12Q1/70 , G01N33/53 , B01L3/00
CPC分类号： C12Q1/701 , C12Q1/6804 , C12Q1/6813 , C12Q1/70 , G01N33/5308 , B01L3/5027 , B01L3/502715 , G01N2333/025
摘要： A nucleic acid probe set is disclosed. The nucleic acid probe set comprises a detection probe and a capture probe, and the detection probe and the capture probe both include a nucleotide sequence that is extracted from a conserved region of a genome sequence belong to a BK virus. A nucleic acid lateral flow immunoassay for using in detection of BK virus is also disclosed. The nucleic acid lateral flow immunoassay comprises: the forgoing nucleic acid probe set, a test strip, and a streptavidin (SA) solution. Experimental data have proved that, the nucleic acid lateral flow immunoassay can be adopted for conducting a BK virus detection on a sample that is collected from environmental water, sewage water, drinking water, urine, or serum.

2. 发明申请

US20190137511A1 METHOD OF ASSESSING RISK OF PML 审中-公开
公开(公告)号：US20190137511A1
公开(公告)日：2019-05-09
申请号：US16115350
申请日：2018-08-28
申请人： BIOGEN MA INC.
发明人： Gary Lewis BLOOMGREN , Carmen BOZIC , Sophia LEE , Amy PACE , Tatiana PLAVINA , Meena SUBRAMANYAM
IPC分类号： G01N33/68 , C07K16/28 , G01N33/569 , C12N7/00
CPC分类号： G01N33/6854 , C07K16/2842 , C07K2317/24 , C12N7/00 , C12N2710/22011 , C12Q1/70 , G01N33/56983 , G01N2333/025 , G01N2469/20 , G01N2800/24 , G01N2800/28 , G01N2800/50
摘要： The invention relates to methods of assessing a patient's risk of developing Progressive multifocal leukoencephalopathy (PML).

3. 发明申请

US20180259523A1 IMMUNOLOGICAL TEST FOR THE DETECTION OF E7 ONCOPROTEINS IN BIOLOGICAL SAMPLES 审中-公开
公开(公告)号：US20180259523A1
公开(公告)日：2018-09-13
申请号：US15517150
申请日：2015-10-30
申请人： Mikrogen GmbH , Österreichische Akademie der Wissenschaften
发明人： Pidder JANSEN-DÜRR , Oliver BÖCHER , Isabel KOCH , Erwin SOUTSCHEK
IPC分类号： G01N33/569 , G01N33/574 , C07K16/08 , G01N33/541 , G01N33/531
CPC分类号： G01N33/56983 , C07K16/084 , G01N33/531 , G01N33/541 , G01N33/57411 , G01N2333/025 , G01N2800/50 , G01N2800/52 , G01N2800/56 , G01N2800/7028
摘要： The present invention relates to a diagnostic test for the detection of an E7 protein of a human papilloma virus in a biological sample wherein a sandwich ELISA as capture antibody at least two different rabbit monoclonal antibodies which bind to at least two different epitopes are used and as detection antibody at least two different polyclonal anti E7 antibodies are used.

4. 发明申请

US20180223360A1 METHODS FOR ASSESSING RISK OF DEVELOPING A VIRAL DISEASE USING A GENETIC TEST 审中-公开
公开(公告)号：US20180223360A1
公开(公告)日：2018-08-09
申请号：US15639591
申请日：2017-06-30
申请人： Eli HATCHWELL , Peggy S. EIS , Edward B. SMITH, III , Yassine TAOUFIK
发明人： Eli HATCHWELL , Peggy S. EIS , Edward B. SMITH, III , Yassine TAOUFIK
IPC分类号： C12Q1/68 , C07K16/28 , G01N33/569
CPC分类号： C12Q1/6883 , A61K2039/505 , A61K2039/54 , A61K2039/545 , C07K16/2839 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , G01N33/56983 , G01N2333/025 , G01N2800/065 , G01N2800/285 , G01N2800/52
摘要： This document provides methods and materials related to treating a disease. For example, this document provides methods for treating a subject's disease based on identifying the risk of progressive multifocal leukoencephalopathy PML using a genetic test.

5. 发明授权

US10018629B2 Correlation of disease activity with clonal expansions of human papillomavirus 16-specific CD8+ T-cells in patients with severe erosive oral lichen planus 有权
公开(公告)号：US10018629B2
公开(公告)日：2018-07-10
申请号：US14910612
申请日：2014-08-08
申请人： INSTITUT PASTEUR , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , UNIVERSITE PARIS DIDEROT PARIS 7 , ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
发明人： Marie-Lise Gougeon , Manuelle Viguier , Hervé Bachelez , Nicolas Fazilleau
IPC分类号： C07K14/025 , G01N33/569 , A61K39/12 , C07K14/005 , C07K14/235 , C12N7/00 , C12Q1/04 , C12Q1/6869 , A61K31/675 , A61K39/02 , A61K45/06 , A61N5/06 , C12Q1/70 , G01N33/50 , A61K39/00
CPC分类号： G01N33/56983 , A61K31/675 , A61K39/099 , A61K39/12 , A61K45/06 , A61K2039/545 , A61K2039/572 , A61K2039/575 , A61N5/0613 , C07K14/005 , C07K14/235 , C07K2319/55 , C12N7/00 , C12N2710/20034 , C12Q1/04 , C12Q1/6869 , C12Q1/708 , C12Q2600/158 , G01N33/5008 , G01N33/502 , G01N33/505 , G01N33/5091 , G01N33/56972 , G01N2333/025 , G01N2333/7051 , G01N2800/18 , G01N2800/52
摘要： A massive clonal expansion of activated CD8+ T-cells with increased frequency of HPV 16-specific CD8+ T-cells was discovered to be a characteristic of oral lichen planus (OLP), indicating a causal link between HPV infection and the dysimmune process. The invention relates to compositions and methods for the diagnosis and treatment of OLP patients.

6. 发明申请

US20170037132A1 METHOD OF TREATING CANCER USING IMMUNE CHECKPOINT INHIBITOR 审中-公开
标题翻译：使用免疫检查点抑制剂治疗癌症的方法
公开(公告)号：US20170037132A1
公开(公告)日：2017-02-09
申请号：US15210612
申请日：2016-07-14
申请人： BRISTOL-MYERS SQUIBB COMPANY
发明人： Demetrios MANEKAS , Joseph Grosso , Jeffrey Anderson
IPC分类号： C07K16/28 , C12Q1/70 , G01N33/574
CPC分类号： C07K16/2827 , A61K2039/507 , A61K2039/545 , C07K16/2818 , C07K2317/21 , C07K2317/24 , C07K2317/51 , C07K2317/76 , C07K2317/92 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/158 , G01N33/57407 , G01N33/5743 , G01N2333/025 , G01N2800/52
摘要： This disclosure provides a method for treating HPV-positive squamous cell carcinoma of the head and neck comprising administering to the subject an immune checkpoint inhibitor, e.g., an anti-PD-1 antibody or an anti-PD-L1 antibody. The disclosure also provides a method for treating HPV-negative squamous cell carcinoma of the head and neck administering to the subject an immune checkpoint inhibitor, e.g., an anti-PD-1 antibody or an anti-PD-L1 antibody. The subject can be additionally administered another anti-cancer agent.
摘要翻译：本公开提供了一种治疗头颈部HPV阳性鳞状细胞癌的方法，其包括对受试者施用免疫检查点抑制剂，例如抗PD-1抗体或抗PD-L1抗体。本公开还提供了一种治疗头颈部HPV阴性鳞状细胞癌的方法，其向受试者施用免疫检查点抑制剂，例如抗PD-1抗体或抗-PD-L1抗体。受试者可另外施用另一种抗癌剂。

7. 发明申请

US20160194687A1 METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS 审中-公开
标题翻译：直接化学分析的方法和组合
公开(公告)号：US20160194687A1
公开(公告)日：2016-07-07
申请号：US15067428
申请日：2016-03-11
申请人： Becton, Dickinson and Company
发明人： Feng Yang , Sha-Sha Wang , Laurence Michael Vaughan , Michael Porter , Elaine Rose
IPC分类号： C12Q1/68 , G01N33/569 , C12Q1/70 , C12N1/06
CPC分类号： C12Q1/6806 , C12N1/06 , C12Q1/708 , G01N33/56983 , G01N2333/025 , C12Q2527/137 , C12Q2527/125
摘要： A direct chemical lysis composition includes an assay compatible buffer composition and an assay compatible surfactant. When combined with a specimen storage composition, such compositions prevent undesired modifications to nucleic acid and proteins lysed from cells in the biological sample. Assays of samples from such compositions do not require expensive and time-consuming steps such as centrifugation and prolonged high temperature processing. The direct chemical lysis composition of the present invention permits direct nucleic acid extraction from the cells in the biological sample without the need to decant off the transport media or otherwise exchange the transport media with assay compatible buffers. There is no need to combine the sample with proteinase K or another enzyme to extract nucleic acids from the cells. A method for lysing cells to obtain target nucleic acid for assay and a kit for combining the direct chemical lysis composition with a sample are also contemplated.
摘要翻译：直接化学裂解组合物包括测定相容缓冲液组合物和测定相容性表面活性剂。当与样品储存组合物组合时，这种组合物防止对生物样品中细胞裂解的核酸和蛋白质的不期望的修饰。来自这些组合物的样品的测定不需要昂贵且耗时的步骤，例如离心和长时间的高温处理。本发明的直接化学溶解组合物允许从生物样品中的细胞中直接进行核酸提取，而不需要从运输介质中滗出或以其它方式与测定相容的缓冲液交换传输介质。不需要将样品与蛋白酶K或其他酶组合从细胞中提取核酸。还考虑了用于裂解细胞以获得用于测定的靶核酸的方法和用于将直接化学裂解组合物与样品组合的试剂盒。

8. 发明申请

US20160187337A1 ASSAY FOR JC VIRUS ANTIBODIES 审中-公开
标题翻译：测试JC病毒抗体
公开(公告)号：US20160187337A1
公开(公告)日：2016-06-30
申请号：US15063777
申请日：2016-03-08
申请人： Biogen MA Inc.
发明人： Leonid Gorelik , Kenneth J. Simon , Meena Subramanyam , Mia Marie Rushe
IPC分类号： G01N33/569
CPC分类号： G01N33/56983 , G01N2333/025 , G01N2469/20 , G01N2800/50
摘要： The disclosure relates to methods and reagents for analyzing samples for the presence of JC virus antibodies. Disclosed is a method that includes obtaining a biological sample from a subject (e.g., plasma, serum, blood, urine, or cerebrospinal fluid), contacting the sample with highly purified viral-like particles HPVLPs) under conditions suitable for binding of a JCV antibody in the sample to an HPVLP, and detecting the level of JCV antibody binding in the sample to HPVLP In one embodiment, determining the level of anti-JCV antibodies in the subject sample provides a method of identifying PML risk in a subject.
摘要翻译：本公开涉及用于分析样品存在JC病毒抗体的方法和试剂。公开了一种方法，其包括从适合于JCV抗体结合的条件下获得来自受试者（例如血浆，血清，血液，尿液或脑脊液）的生物样品，使样品与高度纯化的病毒样颗粒HPVLP接触）在样品中检测HPVLP，并检测样品中JCV抗体与HPVLP结合的水平。在一个实施方案中，确定受试样品中抗JCV抗体的水平提供了在受试者中鉴定PML风险的方法。

9. 发明授权

US09249212B2 Anti-HPV E7 antibodies 有权
标题翻译：抗HPV E7抗体
公开(公告)号：US09249212B2
公开(公告)日：2016-02-02
申请号：US13578985
申请日：2011-02-16
申请人： Pidder Jansen-Dürr , Werner Zwerschke , Haymo Pircher , Daniela Ehehalt , Barbara Lener , Kerstin Dreier
发明人： Pidder Jansen-Dürr , Werner Zwerschke , Haymo Pircher , Daniela Ehehalt , Barbara Lener , Kerstin Dreier
IPC分类号： C07K16/08 , G01N33/569
CPC分类号： C07K16/084 , C07K2317/33 , C07K2317/34 , G01N33/56983 , G01N2333/025 , G01N2469/10
摘要： Monoclonal anti-HPV (human papillomavirus) E7 antibodies are capable of specifically recognizing an epitope of the C-terminal or the N-terminal region of a HPV E7 protein.
摘要翻译：单克隆抗HPV（人乳头瘤病毒）E7抗体能够特异性识别HPV E7蛋白的C-末端或N-末端区域的表位。

10. 发明申请

US20160025729A1 Systems And Methods For Early Detection Of Cervical Cancer By Multiplex Protein Biomarkers 审中-公开
标题翻译：通过多重蛋白质生物标志物早期检测宫颈癌的系统和方法
公开(公告)号：US20160025729A1
公开(公告)日：2016-01-28
申请号：US14810333
申请日：2015-07-27
申请人： OncoGenesis Inc.
发明人： Nam Woo Kim , Peter Paul Gombrich
IPC分类号： G01N33/574
CPC分类号： G01N33/57411 , G01N2333/025 , G01N2333/46 , G01N2333/4704 , G01N2333/4742 , G01N2333/705 , G01N2333/8139 , G01N2333/912 , G01N2333/9128
摘要： Method for diagnosis and prognosis of premalignant and malignant cervical disease by using multiple neoplastic protein biomarkers are provided. In particular, methods and systems for screening cervical cells for the expression of proteins, which occur as a result of premalignant cervical disease and progression to invasive cervical cancer.
摘要翻译：提供了通过使用多种肿瘤蛋白生物标记物诊断和预后恶化和恶性宫颈疾病的方法。特别地，用于筛选宫颈细胞用于表达蛋白质的方法和系统，其作为癌前期宫颈疾病和进展为侵入性宫颈癌的结果而发生。

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