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1. 发明授权

US06630350B1 Monoclonal antibodies against a human act and serine protease complex 失效
标题翻译：针对人类行为和丝氨酸蛋白酶复合物的单克隆抗体
公开(公告)号：US06630350B1
公开(公告)日：2003-10-07
申请号：US09284128
申请日：1999-09-03
申请人： Christa Hubner-Parajsz , Hartmut Schetters , Rosemarie Kientsch-Engel , Thomas Meier , Martin Kaufmann , Andreas Gallusser , Rolf Deeg
发明人： Christa Hubner-Parajsz , Hartmut Schetters , Rosemarie Kientsch-Engel , Thomas Meier , Martin Kaufmann , Andreas Gallusser , Rolf Deeg
IPC分类号： C12H1585
CPC分类号： C07K14/705 , C07K16/38 , C07K16/40 , G01N33/57434
摘要： The invention concerns monoclonal antibodies against a complex of human ACT and a serine protease, preferably against a ACT-PSA, which have essentially no cross-reactivity with free, non-complexed human ACT and with free, non-complexed PSA, as well as diagnostic test methods for detecting serine protease-ACT complexes, in particular PSA-ACT, using these monoclonal antibodies.
摘要翻译：本发明涉及针对人ACT和丝氨酸蛋白酶的复合物的抗体，优选地针对ACT-PSA，其与游离的，非络合的人ACT和游离的，非络合的PSA基本上不具有交叉反应性，以及使用这些单克隆抗体检测丝氨酸蛋白酶-ACT复合物，特别是PSA-ACT的诊断测试方法。

2. 发明授权

US4868139A Aqueous cholesterol standard solution and process for its preparation 失效
标题翻译：水性胆固醇标准溶液及其制备方法
公开(公告)号：US4868139A
公开(公告)日：1989-09-19
申请号：US122019
申请日：1987-11-17
申请人： Rolf Deeg , Gisela Dengler , Joachim Ziegenhorn
发明人： Rolf Deeg , Gisela Dengler , Joachim Ziegenhorn
IPC分类号： G01N33/50 , C12Q1/60 , G01N33/92
CPC分类号： C12Q1/60 , Y10T436/104165 , Y10T436/108331
摘要： The present invention provides an aqueous cholesterol standard solution with a definite content of cholesterol, wherein it contains a detergent mixture of 10 to 90% of cholic acid and 90 to 10% of desoxycholic acid or of appropriate salts or derivatives of these acids.The present invention also provides a process for the preparation of this aqueous cholesterol standard solution, wherein a detergent mixture of cholic acid and desoxycholic acid or of appropriate salts and derivatives of these acids is dissolved in distilled water or in 0.9% aqueous sodium chloride solution, an appropriate preservation agent and/or a buffer effective in the pH range of from 7 to 9 optionally added thereto, and a definite, precisely defined amount of cholesterol is dissolved in the solution thus obtained, while stirring and warming to 40.degree. to 60.degree. C.
摘要翻译：本发明提供具有一定胆固醇含量的胆固醇水溶液，其中含有10-90％胆酸和90-10％脱氧胆酸或这些酸的适当盐或衍生物的洗涤剂混合物。本发明还提供了制备这种胆固醇水溶液标准溶液的方法，其中将胆酸和脱氧胆酸的洗涤剂混合物或这些酸的适当盐和衍生物溶解在蒸馏水中或在0.9％氯化钠水溶液中，适当的保存剂和/或在任意添加的pH范围为7〜9的有效缓冲液中，将一定精确定量的胆固醇溶于所得溶液中，同时搅拌并升温至40〜60℃ C。

3. 发明授权

US5362624A Process for the determination of an immunologically detectable substance and a suitable reaction vessel therefor 失效
标题翻译：用于测定免疫学可检测物质及其合适的反应容器的方法
公开(公告)号：US5362624A
公开(公告)日：1994-11-08
申请号：US925300
申请日：1992-08-05
申请人： Urban Schmitt , Eberhard Maurer , Wolfgang Rudinger , Rolf Deeg , Thomas Geiger , Wolf D. Engel
发明人： Urban Schmitt , Eberhard Maurer , Wolfgang Rudinger , Rolf Deeg , Thomas Geiger , Wolf D. Engel
IPC分类号： G01N33/531 , G01N33/543 , G01N33/569 , G01N33/574 , G01N33/58 , C01N33/576 , C01N33/547
CPC分类号： G01N33/57473 , G01N33/531 , G01N33/54366 , G01N33/56988 , G01N33/58 , Y10S435/82 , Y10S436/811
摘要： For the determination of an immunologically detectable substance based on a heterogeneous immunoassay by use of a solid phase on which one of the immunologically active reaction components is bound, a reaction vessel is used as the solid phase on the inner surface of which streptavidin or avidin is bound in such an amount that 0.1 to 2.5 .mu.g are present per ml reaction volume.A suitable reaction vessel for this has optically transparent wall areas which face one another and has avidin or streptavidin coated walls which are at least partially within the inner wall region intended as a receptacle for liquid, wherein the inner space of the container intended as a receptacle for liquid and the respective streptavidin or avidin content of the coating are so matched that 0.1 to 2.5 .mu.g streptavidin or avidin are present per ml reaction volume.
摘要翻译：为了通过使用其上结合有免疫活性的反应组分的固相来测定基于非均相免疫测定的免疫学可检测物质，使用反应容器作为其内表面上的固相，其中链霉亲和素或抗生物素蛋白为结合量为每ml反应体积存在0.1至2.5μg。合适的反应容器具有相互面对的光学透明壁区域，并且具有至少部分位于旨在作为液体容器的内壁区域内的抗生物素蛋白或链霉抗生物素蛋白包被的壁，其中容器的内部空间用作容器对于液体，并且涂层的各自的链霉抗生物素蛋白或抗生物素蛋白含量如此匹配，每ml反应体积存在0.1至2.5μg链霉亲和素或抗生物素蛋白。

4. 发明授权

US4816393A Nucleoside triphosphate-dependent 1-methylhydantoinase, a process for obtaining it and the use thereof 失效
标题翻译：核苷三磷酸依赖性1-甲基乙内酰脲酶，其获得方法及其用途
公开(公告)号：US4816393A
公开(公告)日：1989-03-28
申请号：US704712
申请日：1985-02-25
申请人： Joachim Siedel , Rolf Deeg , Albert Roder , Joachim Ziegenhorn , Hans Mollering , Helmgard Gauhl
发明人： Joachim Siedel , Rolf Deeg , Albert Roder , Joachim Ziegenhorn , Hans Mollering , Helmgard Gauhl
IPC分类号： C12N9/14 , C12N9/86 , C12Q1/34 , C12R1/01 , C12R1/06 , C12R1/13 , C12R1/265 , G01N33/70 , C12Q1/26 , C12Q1/32
CPC分类号： C12N9/86 , C12Q1/34 , G01N33/70 , G01N2333/986 , Y10S435/81
摘要： The present invention provides 1-methylhydantoinase, which hydrolyses 1-methylhydantoin in the presence of a nucleoside triphosphate and of polyvalent metal ions.The present invention also provides a process for obtaining 1-methylhydantoinase and a reagent containing it.Furthermore, the present invention provides a process for the determination of creatinine by the conversion of the creatinine with creatinine deiminase (E.C. 3.5.4.21) into 1-methylhydantoin, hydrolysis of the latter with the 1-methylhydantoinase in the presence of nucleoside triphosphate and of polyvalent metal ions and determination(a) of the hydrolysis product formed from 1-methylhydantoin with N-carbamoylsarcosinamidohydrolase with formation of sarcosine and detection of the sarcosine with sarcosine oxidase or sarcosine dehydrogenase or(b) of the simultaneously formed nucleoside diphosphate.
摘要翻译：本发明提供1-甲基乙内酰脲酶，其在核苷三磷酸和多价金属离子的存在下水解1-甲基乙内酰脲。本发明还提供了获得1-甲基乙内酰脲酶和含有它的试剂的方法。此外，本发明提供了通过将肌酐与肌酐去酰亚胺酶（EC 3.5.4.21）转化为1-甲基乙内酰脲来测定肌酸酐的方法，后者在核苷三磷酸存在下用1-甲基乙内酰脲酶水解，测定（a）由N-甲基乙内酰脲与N-氨基甲酰基肌氨酰氨基水解酶形成的水解产物（肌氨酸形成），并用肌氨酸氧化酶或肌氨酸脱氢酶检测肌氨酸，或（b）同时形成的二磷酸核苷。

5. 发明授权

US4438204A Determination of glycosilated hemoglobin 失效
标题翻译：测定糖化血红蛋白
公开(公告)号：US4438204A
公开(公告)日：1984-03-20
申请号：US426510
申请日：1982-09-29
申请人： Rolf Deeg , Urban Schmitt , Joachim Ziegenhorn
发明人： Rolf Deeg , Urban Schmitt , Joachim Ziegenhorn
IPC分类号： G01N33/52 , G01N21/78 , G01N30/88 , G01N33/53 , G01N33/66 , G01N33/72
CPC分类号： G01N33/723 , Y10T436/107497
摘要： A process for the determination of glycosilated hemoglobin in a blood sample comprises liberating glycosilated and non-glycosilated hemoglobin from the erythrocytes by chemical or physical treatment; converting, if desired, the hemoglobin into methemoglobin, and thereafter differentiating the glycosilated and non-glycosilated hemoglobin portion using its reaction with haptoglobin, and determining the glycosilated and/or the non-glycosilated hemoglobin portion.The present invention also provides a reagent for the determination of glycosilated hemoglobin in a blood sample, as well as a reagent for the differentiation of glycosilated and non-glycosilated hemoglobin, comprising haptoglobin.
摘要翻译：用于测定血液样品中糖基化血红蛋白的方法包括通过化学或物理处理从红细胞释放糖基化和非糖基化血红蛋白; 如果需要，将血红蛋白转化成高铁血红蛋白，然后使用其与触珠蛋白的反应来分化糖基化和非糖基化血红蛋白部分，并测定糖基化和/或非糖基化血红蛋白部分。本发明还提供了用于测定血液样品中的糖基化血红蛋白的试剂，以及包含触珠蛋白的糖基化和非糖化血红蛋白的分化试剂。

6. 发明授权

US5378638A Analysis element and process for its manufacture 失效
标题翻译：分析元件及其制造工艺
公开(公告)号：US5378638A
公开(公告)日：1995-01-03
申请号：US63069
申请日：1993-05-20
申请人： Rolf Deeg , Eberhard Maurer , Sigmar Klose , Bernhard Kopfer , Reiner Babiel
发明人： Rolf Deeg , Eberhard Maurer , Sigmar Klose , Bernhard Kopfer , Reiner Babiel
IPC分类号： G01N31/22 , C40B60/14 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/521 , G01N33/54386 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00614 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , C40B60/14 , Y10S435/805 , Y10S435/81 , Y10S435/969 , Y10S435/97 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10S436/81
摘要： An analysis element for the determination of an analyte in a liquid sample, especially for medicinal uses. A carrier layer (2) contains, in a reagent domain (4), a reagent applied in a defined pattern by an ink-jet process. The pattern comprises several sets (A, B, C) of compartments (11-20), the compartments (e.g. 11, 13, 15, 17, 19) of the same set (e.g. A) having the same chemical composition, the compartments (11, 13, 15, 17, 19 or 12, 16, 20) of different sets (A or B) containing different reagents and the compartments of different sets being arranged in alteration so that the compartments containing different reagents are close together but nevertheless spatially separated.
摘要翻译：用于测定液体样品中的分析物的分析元件，特别是用于药用。载体层（2）在试剂区域（4）中包含通过喷墨方法以限定图案施加的试剂。该模式包括几组（A，B，C）隔室（11-20），具有相同化学组成的相同组（例如A）的隔室（例如11,13,15,17,19），隔室（11,13,15,17,19或12,16,20）含有不同试剂的不同组（A或B），并且不同组的隔室排列变化，使得含有不同试剂的隔室紧密结合，但是空间分离。

7. 发明授权

US5316784A Process for the production of a solid phase matrix coated with an immunologically active substance 失效
标题翻译：制备涂有免疫活性物质的固相基质的方法
公开(公告)号：US5316784A
公开(公告)日：1994-05-31
申请号：US994487
申请日：1992-12-21
申请人： Eberhard Maurer , Rolf Deeg
发明人： Eberhard Maurer , Rolf Deeg
IPC分类号： G01N33/543 , B05D3/06 , G01N33/53
CPC分类号： G01N33/54353
摘要： To produce a solid phase coated with an immunologically active substance, a carrier material is absorptively coated with a mixture of an immunologically active substance and a compound which contains at least two functional groups which can be photoactivated and at least one moiety which interacts with the carrier material and the immunologically active substance and it is subsequently irradiated for the cross-linkage.
摘要翻译：为了产生涂覆有免疫活性物质的固相，用免疫活性物质和含有至少两个可被光活化的官能团和至少一个与载体相互作用的官能团的化合物的混合物吸收载体材料材料和免疫活性物质，随后将其照射用于交联。

8. 发明授权

US4695552A Process and reagent for the determination of the hemoglobin-haptoglobin complex in the presence of free hemoglobin 失效
标题翻译：在游离血红蛋白存在下测定血红蛋白 - 触珠蛋白复合物的方法和试剂
公开(公告)号：US4695552A
公开(公告)日：1987-09-22
申请号：US601801
申请日：1984-04-19
申请人： Urban Schmitt , Rolf Deeg , Joachim Ziegenhorn
发明人： Urban Schmitt , Rolf Deeg , Joachim Ziegenhorn
IPC分类号： C12Q1/28 , G01N33/72
CPC分类号： C12Q1/28 , G01N33/725 , C12Q2326/30 , Y10T436/25125
摘要： The present invention provides a process for the determination of the hemoglobin-haptoglobin complex in the presence of free hemoglobin by utilization of the different peroxidate properties of free and of bound hemoglobin, wherein, for the selective inhibition of the peroxidase activity of the free hemoglobin, a detergent is added and the residual peroxidate activity of the reaction mixture is measured.The present invention also provides a reagent for carrying out this process wherein, besides the substances required for the determination of the peroxidase activity, it contains a detergent for the inhibition of the peroxidase activity of free hemoglobin.Furthermore, the present invention provides a process for determining the haptoglobin content of a sample, as well as a process for determining glycosilated hemoglobin in a sample.
摘要翻译：本发明提供了一种通过利用游离血红蛋白和结合血红蛋白的不同过氧化物特性在游离血红蛋白存在下测定血红蛋白 - 触珠蛋白复合物的方法，其中，对于选择性抑制游离血红蛋白的过氧化物酶活性，添加洗涤剂，并测量反应混合物的过氧化物的残留活性。本发明还提供了一种用于进行该方法的试剂，其中除了确定过氧化物酶活性所需的物质外，还含有用于抑制游离血红蛋白的过氧化物酶活性的洗涤剂。此外，本发明提供了测定样品的触珠蛋白含量的方法，以及测定样品中糖基化血红蛋白的方法。

9. 发明授权

US5338688A Method for the metered application of a biochemical analytical liquid to a target 失效
标题翻译：将生化分析液计量应用于目标的方法
公开(公告)号：US5338688A
公开(公告)日：1994-08-16
申请号：US19828
申请日：1993-02-19
申请人： Rolf Deeg , Eberhard Maurer , Reiner Babiel , Sigmar Klose , Bernhard Kopfer
发明人： Rolf Deeg , Eberhard Maurer , Reiner Babiel , Sigmar Klose , Bernhard Kopfer
IPC分类号： C12M1/34 , B01L3/02 , C12Q1/26 , C12Q1/28 , C40B60/14 , G01N1/00 , G01N33/543 , G01N35/00 , G01N35/10 , G01N1/10
CPC分类号： B01L3/0268 , B82Y30/00 , G01N35/1002 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , C40B60/14 , G01N2035/1041 , G01N35/00009 , G01N35/0099 , Y10T436/110833 , Y10T436/112499 , Y10T436/2575
摘要： A method for the metered application of a biochemical analytical liquid to a target, wherein the liquid is ejected in small quantities on to the target through a jet from a jet chamber by a procedure in which a partial volume of the liquid in the jet chamber is evaporated and expanded for a short time whenever a quantity of the liquid is to be ejected. The invention further relates to a device with a disposable jet element which contains prepackaged analytical liquid.
摘要翻译：一种用于向目标物质计量施用生物化学分析液体的方法，其中通过喷射室中的液体的部分体积是通过喷射室的射流将液体少量喷射到靶上的方法每当要排出一定量的液体时，蒸发并膨胀短时间。本发明还涉及一种具有一次性喷射元件的装置，其包含预包装的分析液体。

10. 发明授权

US5061640A Process for preparing a carrier useful in immunoassays by deposition of a complex of a specifically binding substance with hydrophobic protein, and the resulting carrier 失效
标题翻译：通过沉积特异性结合物质与疏水性蛋白质和结果载体的复合物制备携带者在免疫中的应用方法
公开(公告)号：US5061640A
公开(公告)日：1991-10-29
申请号：US124871
申请日：1987-11-24
申请人： Wilhelm Tischer , Josef Maier , Rolf Deeg
发明人： Wilhelm Tischer , Josef Maier , Rolf Deeg
IPC分类号： G01N33/531 , G01N33/543 , G01N33/544 , G01N33/547 , G01N33/552 , G01N33/78
CPC分类号： G01N33/552 , G01N33/531 , G01N33/544 , G01N33/78
摘要： The present invention provides a process for the preparation of a specifically bindable protein substance bound to an insoluble carrier material, especially for use in a heterogeneous analysis process, wherein a soluable protein with a molecular weight above about 500,000, which is more hydrophobic than the specifically bindable substance, is coupled to the specifically bindable substance and then the conjugate of reaction component and protein is adsorbed on a hydrophobic solid phase.The present invention also provides a carrier material for use in solid phase immunoassays including a hydrophobic solid phase which is adsorbed on a conjugate of a hydrophobic protein with a molecular weight above about 500,000 and of a specifically bindable protein or protein containing substance.
摘要翻译：本发明提供了制备与不溶性载体材料结合的特异性结合蛋白质物质的方法，特别是用于异构分析方法中，其中分子量高于约500,000的可溶性蛋白质，其比特异性更疏水可结合物质与特异性结合物质偶联，然后将反应成分和蛋白质的缀合物吸附在疏水性固相上。本发明还提供了用于固相免疫测定的载体材料，其包括吸附在分子量高于约500,000的疏水性蛋白质的结合物和特异性可结合蛋白质或蛋白质的物质的疏水性固相。

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