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1. 发明授权

US5378638A Analysis element and process for its manufacture 失效
标题翻译：分析元件及其制造工艺
公开(公告)号：US5378638A
公开(公告)日：1995-01-03
申请号：US63069
申请日：1993-05-20
申请人： Rolf Deeg , Eberhard Maurer , Sigmar Klose , Bernhard Kopfer , Reiner Babiel
发明人： Rolf Deeg , Eberhard Maurer , Sigmar Klose , Bernhard Kopfer , Reiner Babiel
IPC分类号： G01N31/22 , C40B60/14 , G01N33/52 , G01N33/543 , G01N33/558
CPC分类号： G01N33/521 , G01N33/54386 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00614 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00657 , B01J2219/00659 , C40B60/14 , Y10S435/805 , Y10S435/81 , Y10S435/969 , Y10S435/97 , Y10S436/805 , Y10S436/807 , Y10S436/809 , Y10S436/81
摘要： An analysis element for the determination of an analyte in a liquid sample, especially for medicinal uses. A carrier layer (2) contains, in a reagent domain (4), a reagent applied in a defined pattern by an ink-jet process. The pattern comprises several sets (A, B, C) of compartments (11-20), the compartments (e.g. 11, 13, 15, 17, 19) of the same set (e.g. A) having the same chemical composition, the compartments (11, 13, 15, 17, 19 or 12, 16, 20) of different sets (A or B) containing different reagents and the compartments of different sets being arranged in alteration so that the compartments containing different reagents are close together but nevertheless spatially separated.
摘要翻译：用于测定液体样品中的分析物的分析元件，特别是用于药用。载体层（2）在试剂区域（4）中包含通过喷墨方法以限定图案施加的试剂。该模式包括几组（A，B，C）隔室（11-20），具有相同化学组成的相同组（例如A）的隔室（例如11,13,15,17,19），隔室（11,13,15,17,19或12,16,20）含有不同试剂的不同组（A或B），并且不同组的隔室排列变化，使得含有不同试剂的隔室紧密结合，但是空间分离。

2. 发明授权

US5338688A Method for the metered application of a biochemical analytical liquid to a target 失效
标题翻译：将生化分析液计量应用于目标的方法
公开(公告)号：US5338688A
公开(公告)日：1994-08-16
申请号：US19828
申请日：1993-02-19
申请人： Rolf Deeg , Eberhard Maurer , Reiner Babiel , Sigmar Klose , Bernhard Kopfer
发明人： Rolf Deeg , Eberhard Maurer , Reiner Babiel , Sigmar Klose , Bernhard Kopfer
IPC分类号： C12M1/34 , B01L3/02 , C12Q1/26 , C12Q1/28 , C40B60/14 , G01N1/00 , G01N33/543 , G01N35/00 , G01N35/10 , G01N1/10
CPC分类号： B01L3/0268 , B82Y30/00 , G01N35/1002 , B01J2219/00378 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/0063 , B01J2219/00637 , B01J2219/00641 , B01J2219/00659 , B01J2219/00677 , C40B60/14 , G01N2035/1041 , G01N35/00009 , G01N35/0099 , Y10T436/110833 , Y10T436/112499 , Y10T436/2575
摘要： A method for the metered application of a biochemical analytical liquid to a target, wherein the liquid is ejected in small quantities on to the target through a jet from a jet chamber by a procedure in which a partial volume of the liquid in the jet chamber is evaporated and expanded for a short time whenever a quantity of the liquid is to be ejected. The invention further relates to a device with a disposable jet element which contains prepackaged analytical liquid.
摘要翻译：一种用于向目标物质计量施用生物化学分析液体的方法，其中通过喷射室中的液体的部分体积是通过喷射室的射流将液体少量喷射到靶上的方法每当要排出一定量的液体时，蒸发并膨胀短时间。本发明还涉及一种具有一次性喷射元件的装置，其包含预包装的分析液体。

3. 发明授权

US07920971B2 Quantification schemes for quantifying nucleic acids 有权
标题翻译：定量核酸定量方案
公开(公告)号：US07920971B2
公开(公告)日：2011-04-05
申请号：US10571958
申请日：2004-09-24
申请人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
发明人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
IPC分类号： G01N33/48
CPC分类号： C12Q1/6851 , C12Q2537/165
摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic value of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.
摘要翻译：方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物量相关的测量结果确定控制进度参数的特征值; 以及使用至少目标的特征值，根据预定义或选择的量化方案量化目标的原始量。

4. 发明申请

US20060292571A1 Quantification schemes for quantifying nucleic acids 失效
标题翻译：定量核酸定量方案
公开(公告)号：US20060292571A1
公开(公告)日：2006-12-28
申请号：US10571958
申请日：2004-09-14
申请人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
发明人： Reiner Babiel , Norbert Franken , Hermann Leying , Judith Pinsl-Ober , Thomas Vess , Guenter Ziegler
IPC分类号： C12Q1/68 , G06F19/00 , C12P19/34
CPC分类号： C12Q1/6851 , C12Q2537/165
摘要： Method and apparatus, including computer program products, implement techniques for quantifying a target nucleic acid (target) in a test sample. The techniques include providing a target and a defined initial amount of an internal control nucleic acid (control) different from the target; amplifying the target and control in a common amplification process; measuring a quantity indicating the amount of amplification product for the target and for the control in relation to a parameter representing the progress of the amplification; determining a characteristic value of the progress parameter for the target based on measurement results related to the amount of target amplification product; possibly determining a characteristic value of the progress parameter for the control based on measurement results related to the amount of control amplification product; and quantifying the original amount of target according to a predefined or selected quantification scheme using at least the characteristic value for the target.
摘要翻译：方法和装置，包括计算机程序产品，实现了在测试样品中定量目标核酸（靶标）的技术。所述技术包括提供目标和定义的初始量的不同于目标的内部对照核酸（对照）; 在常见的扩增过程中放大靶和控制; 相对于表示放大进度的参数，测量指示靶的扩增产物量和对于控制的量的量; 基于与目标扩增产物量相关的测量结果，确定目标进度参数的特征值; 可能基于与控制扩增产物量相关的测量结果确定控制进度参数的特征值; 以及使用至少所述目标的特征值，根据预定义或选择的量化方案量化原始目标量。

5. 发明申请

US20120196283A1 Qualitative and Quantitative Detection of Microbial Nucleic Acids 有权
标题翻译：微生物核酸的定性和定量检测
公开(公告)号：US20120196283A1
公开(公告)日：2012-08-02
申请号：US13191700
申请日：2011-07-27
申请人： Reiner Babiel , Frank Bergmann , Dorothea Johanna Sizmann
发明人： Reiner Babiel , Frank Bergmann , Dorothea Johanna Sizmann
IPC分类号： G01N21/64 , C12M1/40
CPC分类号： C12Q1/686 , C12P19/34 , C12Q1/68 , C12Q1/6851 , G01N21/6428 , G01N2021/6432 , G01N2021/6441
摘要： The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example the polymerase chain reaction. Further provided are kits comprising components for performing said methods and uses.
摘要翻译：本发明涉及使用至少第一对照核酸或不同浓度的第一和第二对照核酸定性和定量检测微生物核酸的新方法和用途。该方法基于核酸的扩增，例如聚合酶链反应。还提供了包括用于执行所述方法和用途的组件的套件。

6. 发明授权

US08877464B2 Qualitative and quantitative detection of microbial nucleic acids 有权
标题翻译：定性和定量检测微生物核酸
公开(公告)号：US08877464B2
公开(公告)日：2014-11-04
申请号：US13191700
申请日：2011-07-27
申请人： Reiner Babiel , Frank Bergmann , Dorothea Johanna Sizmann
发明人： Reiner Babiel , Frank Bergmann , Dorothea Johanna Sizmann
IPC分类号： C12P19/34 , C12Q1/68 , G01N21/64
CPC分类号： C12Q1/686 , C12P19/34 , C12Q1/68 , C12Q1/6851 , G01N21/6428 , G01N2021/6432 , G01N2021/6441
摘要： The present invention relates to new methods and uses for the qualitative and quantitative detection of microbial nucleic acids using at least a first control nucleic acid, or a first and a second control nucleic acid in different concentrations. The method is based on amplification of nucleic acids, for example the polymerase chain reaction. Further provided are kits comprising components for performing said methods and uses.
摘要翻译：本发明涉及使用至少第一对照核酸或不同浓度的第一和第二对照核酸定性和定量检测微生物核酸的新方法和用途。该方法基于核酸的扩增，例如聚合酶链反应。还提供了包括用于执行所述方法和用途的组件的套件。

7. 发明申请

US20100041040A1 Internally Controlled Multiplex Detection and Quantification of Microbial Nucleic Acids 审中-公开
标题翻译：微生物核酸的内部控制多重检测和定量
公开(公告)号：US20100041040A1
公开(公告)日：2010-02-18
申请号：US12479643
申请日：2009-06-05
申请人： Reiner Babiel , Joachim Glaubitz , Lutz Guertler , Dorothea Sizmann , Karen K.Y. Young
发明人： Reiner Babiel , Joachim Glaubitz , Lutz Guertler , Dorothea Sizmann , Karen K.Y. Young
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： C12Q1/6888 , C12Q2600/16 , C12Q2600/166
摘要： The present invention relates to new methods and uses for the detection and quantification of microbial nucleic acids employing an internal quantitative reference. Preferred methods are based on the amplification of nucleic acids, preferably the polymerase chain reaction. Further provided are kits comprising components for performing said methods and uses. Moreover, an analytical system for advantageously performing the method according to the invention is disclosed.
摘要翻译：本发明涉及使用内部定量参考来检测和定量微生物核酸的新方法和用途。优选的方法是基于核酸的扩增，优选聚合酶链反应。还提供了包括用于执行所述方法和用途的组件的套件。此外，公开了一种有利地执行根据本发明的方法的分析系统。

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