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1. 发明申请

US20050205241A1 Closed-loop microchannel cooling system 失效
标题翻译：闭环微通道冷却系统
公开(公告)号：US20050205241A1
公开(公告)日：2005-09-22
申请号：US11136793
申请日：2005-05-25
申请人： Kenneth Goodson , Chuan-Hua Chen , David Huber , Linan Jiang , Thomas Kenny , Jae-Mo Koo , Daniel Laser , James Mikkelsen , Juan Santiago , Evelyn Wang , Shulin Zeng , Lian Zhang
发明人： Kenneth Goodson , Chuan-Hua Chen , David Huber , Linan Jiang , Thomas Kenny , Jae-Mo Koo , Daniel Laser , James Mikkelsen , Juan Santiago , Evelyn Wang , Shulin Zeng , Lian Zhang
IPC分类号： B81B1/00 , F04B19/00 , F04F99/00 , F25D1/02 , F25D9/00 , F28D15/00 , H01L23/473 , H05K7/20 , F25B21/02 , F28F7/00
CPC分类号： H01L23/473 , F04B19/006 , F28D15/00 , F28F2260/02 , H01L2224/16225 , H01L2224/32145 , H01L2224/32225 , H01L2224/45169 , H01L2224/48227 , H01L2224/73265 , H01L2225/06562 , H01L2924/01078 , H01L2924/01322 , H01L2924/09701 , H01L2924/10158 , H01L2924/10253 , H01L2924/1461 , H01L2924/3011 , H01L2924/00
摘要： Apparatus and methods according to the present invention utilize micropumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These micropumps are fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These micropumps also can allow for recapture of evolved gases and deposited materials, which may provide for long-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the spatial and temporal characteristics of the device temperature profiles. Novel enclosed microchannel structures are also described.
摘要翻译：根据本发明的装置和方法利用能够在不移动机械部件的情况下产生高压和流动以及相关的不可接受的电和噪声噪声的产生以及相关的可靠性降低的微型泵。这些微型泵用与目前可用的微型泵相比提高性能，效率以及降低重量和制造成本的材料和结构制造。这些微型泵还可以重新捕获可能提供长期闭环操作的演化气体和沉积材料。根据本发明的装置和方法还允许通过电流控制通过泵的流动来主动调节装置的温度，并且可以利用多个冷却回路来允许独立调节装置温度曲线的空间和时间特性。还描述了新的封闭微通道结构。

2. 发明申请

US20050098299A1 Electroosmotic microchannel cooling system 失效
标题翻译： Electroosmotic微通道冷却系统
公开(公告)号：US20050098299A1
公开(公告)日：2005-05-12
申请号：US10933068
申请日：2004-09-02
申请人： Kenneth Goodson , Chuan-Hua Chen , David Huber , Linan Jiang , Thomas Kenny , Jae-Mo Koo , Daniel Laser , James Mikkelsen , Juan Santiago , Evelyn Wang , Shulin Zeng , Lian Zhang
发明人： Kenneth Goodson , Chuan-Hua Chen , David Huber , Linan Jiang , Thomas Kenny , Jae-Mo Koo , Daniel Laser , James Mikkelsen , Juan Santiago , Evelyn Wang , Shulin Zeng , Lian Zhang
IPC分类号： B81B1/00 , F04B19/00 , F04F99/00 , F25D1/02 , F25D9/00 , F28D15/00 , H01L23/473 , H05K7/20 , F28F7/00
CPC分类号： H01L23/473 , F04B19/006 , F28D15/00 , F28F2260/02 , H01L2224/16225 , H01L2224/32145 , H01L2224/32225 , H01L2224/45169 , H01L2224/48227 , H01L2224/73265 , H01L2225/06562 , H01L2924/01078 , H01L2924/01322 , H01L2924/09701 , H01L2924/10158 , H01L2924/10253 , H01L2924/1461 , H01L2924/3011 , H01L2924/00
摘要： Apparatus and methods according to the present invention preferably utilize electroosmotic pumps that are capable of generating high pressure and flow without moving mechanical parts and the associated generation of unacceptable electrical and acoustic noise, as well as the associated reduction in reliability. These electroosmotic pumps are preferably fabricated with materials and structures that improve performance, efficiency, and reduce weight and manufacturing cost relative to presently available micropumps. These electroosmotic pumps also preferably allow for recapture of evolved gases and deposited materials, which may provide for long,-term closed-loop operation. Apparatus and methods according to the present invention also allow active regulation of the temperature of the device through electrical control of the flow through the pump and can utilize multiple cooling loops to allow independent regulation of the special and temporal characteristics of the device temperature profiles. Novel microchannel structures are also described.
摘要翻译：根据本发明的装置和方法优选地利用电渗泵，其能够在不移动机械部件的情况下产生高压和流动，并且相关联地产生不可接受的电和噪声噪声以及相关联的可靠性降低。这些电渗泵优选地由相对于目前可用的微量泵提高性能，效率以及降低重量和制造成本的材料和结构来制造。这些电渗泵还优选地允许重新产生放出的气体和沉积的材料，这可以提供长时间的闭环操作。根据本发明的装置和方法还允许通过电流控制通过泵的流动来主动调节装置的温度，并且可以利用多个冷却回路来允许独立调节装置温度曲线的特殊和时间特性。还描述了新颖的微通道结构。

3. 发明授权

US06362915B1 Bichromal beads having crystalline materials therein 失效
标题翻译：双色珠在其中具有结晶性材料
公开(公告)号：US06362915B1
公开(公告)日：2002-03-26
申请号：US09427656
申请日：1999-10-26
申请人： Nicholas K. Sheridon , Edward A. Richley , James Mikkelsen
发明人： Nicholas K. Sheridon , Edward A. Richley , James Mikkelsen
IPC分类号： G02B2600
CPC分类号： G09F9/372 , G02B26/026
摘要： A display media with an encapsulant medium, and bichromal beads having a crystalline material, wherein the bichromal beads are dispersed or contained in the encapsulant medium is set forth.
摘要翻译：具有密封剂介质的显示介质和具有结晶材料的双色珠，其中分色或包含在所述密封剂介质中的双重色珠。

4. 发明申请

US20060165559A1 Automated system for handling microfluidic devices 有权
公开(公告)号：US20060165559A1
公开(公告)日：2006-07-27
申请号：US11133943
申请日：2005-05-20
申请人： Michael Greenstein , Colin Kennedy , James Mikkelsen
发明人： Michael Greenstein , Colin Kennedy , James Mikkelsen
IPC分类号： G01N35/00
CPC分类号： G01N35/00584 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2300/0819 , G01N21/05 , G01N21/11 , G01N21/13 , G01N35/04 , G01N35/1095 , G01N2021/0346 , G01N2021/058
摘要： The present invention is an automated microfluidic chip processing apparatus that includes a deck for holding at least one microfluidic chip and capable of being accessed by a liquid handling system, a fluid control system, and a detection system, wherein a chip handling device transports the chip from the deck to the fluid control system and the detection system. The present invention also includes a chip for use with an automated microfluidic chip processing apparatus, and a method for processing a microfluidic chip using such an apparatus.

5. 发明授权

US5001995A Sweep tillage tool 失效
标题翻译：扫耕工具
公开(公告)号：US5001995A
公开(公告)日：1991-03-26
申请号：US320079
申请日：1989-03-06
申请人： James Mikkelsen
发明人： James Mikkelsen
IPC分类号： A01B35/26 , A01C5/06
CPC分类号： A01C5/062 , A01B35/26
摘要： Sweep tillage tools (10, 10') according to the preferred teachings of the present invention are disclosed including generally flat, horizontal sweep blades (18) generally located behind the implement shank (12) and above the point (28) of the spike (16, 16'). Specifically, the front corners of the sweep blades (18) between their front cutting edges (36) and inside edges (40) are integrally connected to the side edges (34) of a central portion (32, 32'). Gussets (20) are provided having a first side (48) integrally connected generally perpendicular to the inside edges (40) of the sweep blades (18) and having a second side (50) integrally connected to the side edges (34) of the central portion (32, 32') to provide catilever mounting of the sweep blades (18) and to provide support for soil passing over the spike (16, 16') and the sweep blades (18) at their intersection. Furrow fillers (22) are provided having top edges (52) integrally connected to the bottom faces (46) of the sweep blades (18) for moving the soil behind the implement shank (12) and the gussets (20). Applicators (64) may be provided generally behind point (28) of spike (16, 16') and generally in front of sweep blades (18) for applying fertilizer. Thus, tools (10, 10') according to the teachings of the present invention till, fertilize, and incorporate granular fertilizer and/or herbicides into the soil in a one-pass tillage operation.
摘要翻译：公开了根据本发明的优选教导的扫掠耕作机具（10,10'），其包括大致平坦的横向扫掠叶片（18），其通常位于所述工具柄（12）的后面并且在所述钉的点（28）上方 16，16'）。具体地说，其前切削刃（36）和内刃（40）之间的刮刀（18）的前角与中心部分（32,32'）的侧边缘（34）整体连接。角撑板（20）设置有具有大致垂直于所述刮刀（18）的内边缘（40）整体连接的第一侧面（48），并且具有与所述刮板（18）的侧边缘（34）整体连接的第二侧面中心部分（32,32'），以提供扫掠叶片（18）的牵引器安装，并为在其交叉点处通过钉（16,16'）和扫掠叶片（18）提供的土壤提供支撑。沟槽填料（22）具有一体地连接到扫掠刀片（18）的底面（46）的顶部边缘（52），用于移动在工具柄（12）和角撑板（20）后面的土壤。施用器（64）通常可以设置在钉（16,16'）的点（28）后面，并且通常在扫掠刀片（18）的前面用于施加肥料。因此，根据本发明的教导，在单次耕作操作中，将肥料和/或除草剂纳入土壤中的工具（10,10'）。

6. 发明申请

US20050027111A1 Methods, devices and systems for characterizing proteins 审中-公开
标题翻译：表征蛋白质的方法，装置和系统
公开(公告)号：US20050027111A1
公开(公告)日：2005-02-03
申请号：US10769296
申请日：2004-01-30
申请人： Andrea Chow , Bahram Fathollahi , James Mikkelsen , Michael Spaid , Adrian Winoto
发明人： Andrea Chow , Bahram Fathollahi , James Mikkelsen , Michael Spaid , Adrian Winoto
IPC分类号： C07K1/24 , G01N27/447 , C07K1/10
CPC分类号： G01N27/44747 , C07K1/24 , G01N27/44791
摘要： A method of characterizing a polypeptide, comprising providing a first capillary channel having a separation buffer disposed within, wherein the separation buffer comprises a non-crosslinked polymer solution, a buffering agent, a detergent, and a lipophilic dye. The separation buffer is provided such that, at the time of detection, the detergent concentration in the buffer is not above the critical micelle concentration. The polypeptide is introduced into one end of the capillary channel. An electric field is applied across a length of the capillary channel, which transports polypeptides of different sizes through the polymer solution at different rates. The polypeptide is then detected as it passes a point along the length of the capillary channel.
摘要翻译：一种表征多肽的方法，包括提供其中设置有分离缓冲液的第一毛细通道，其中所述分离缓冲液包含非交联聚合物溶液，缓冲剂，洗涤剂和亲脂性染料。提供分离缓冲液，使得在检测时，缓冲液中的洗涤剂浓度不高于临界胶束浓度。将多肽引入毛细管通道的一端。在毛细通道的一段长度上施加电场，毛细通道以不同的速率输送不同尺寸的多肽通过聚合物溶液。然后当毛细通道沿着毛细通道的长度通过点时，检测该多肽。

7. 发明申请

US20050054905A1 Apparatus for ascertaining blood characteristics and probe for use therewith 失效
标题翻译：用于确定血液特性的装置和与其一起使用的探针
公开(公告)号：US20050054905A1
公开(公告)日：2005-03-10
申请号：US10658926
申请日：2003-09-09
申请人： Paul Corl , James Mikkelsen , Harry Nguyen , Amos Gottlieb , Margaret Webber
发明人： Paul Corl , James Mikkelsen , Harry Nguyen , Amos Gottlieb , Margaret Webber
IPC分类号： A61B5/00
CPC分类号： A61B5/14542 , A61B5/01 , A61B5/14539 , A61B5/14546 , A61B5/1473 , A61B5/6852 , A61B2562/227
摘要： An apparatus for use with a patient having a vessel carrying blood to ascertain characteristics of the blood. The apparatus includes a display module and a probe having a distal extremity adapted to be inserted into the vessel of the patient and having a proximal extremity coupled to the display module. The probe includes a sensor in the distal extremity for providing an electrical signal to the display module when the probe is disposed in the blood. The probe can have an antithrombogenic surface treatment for inhibiting the adhesion of blood components to the probe when disposed in the blood.
摘要翻译：一种用于患有携带血液的血管以确定血液特征的患者的装置。该装置包括显示模块和探针，其具有适于插入病人容器中的远端，并具有耦合到显示模块的近端。探头包括远端末端的传感器，用于当探针设置在血液中时向显示模块提供电信号。探针可以具有抗血栓形成表面处理，用于当设置在血液中时抑制血液成分对探针的粘附。

8. 发明授权

US5717283A Display sheet with a plurality of hourglass shaped capsules containing marking means responsive to external fields 失效
标题翻译：具有多个具有响应于外部场的标记装置的沙漏形胶囊的显示片
公开(公告)号：US5717283A
公开(公告)日：1998-02-10
申请号：US582311
申请日：1996-01-03
申请人： David K. Biegelsen , Warren B. Jackson , Guerino G. Sacripante , James Mikkelsen , Thomas W. Smith , Nicholas K. Sheridon
发明人： David K. Biegelsen , Warren B. Jackson , Guerino G. Sacripante , James Mikkelsen , Thomas W. Smith , Nicholas K. Sheridon
IPC分类号： G09F9/30 , G09F9/37 , H01J63/04
CPC分类号： G02B26/004 , G09F9/372
摘要： An external field activated display sheet is disclosed which comprises a plurality of hourglass shaped capsules for each pixel of an image. Each hourglass shaped capsule contains ink in one of its chambers. The ink in each hourglass shaped capsule is responsive to an external field being applied across the capsule for the movement from one chamber to the other. An opaque medial sheet blocks the visibility of the ink in the chambers under the medial sheet. Applying an external field across an hourglass shaped capsule causes the ink to be moved into the chamber above the medial sheet where it is visible. By applying an external field across selective hourglass shaped cavities, an image can be displayed.
摘要翻译：公开了一种外场活化显示片，其包括用于图像的每个像素的多个沙漏形胶囊。每个沙漏形胶囊在其一个腔室中含有墨水。每个沙漏形胶囊中的墨水响应于跨过胶囊施加的外部场，用于从一个腔室移动到另一个腔室。不透明的内侧片阻挡了在中间片下的腔室中的墨水的可视性。将外场施加在沙漏形胶囊上，使得墨水可以移动到中间片上方的可见的内部。通过在选择性沙漏形腔上应用外部场，可以显示图像。

9. 发明授权

US4825782A Sweep-spike combination tillage tool 失效
标题翻译：扫穗组合耕作工具
公开(公告)号：US4825782A
公开(公告)日：1989-05-02
申请号：US170922
申请日：1988-03-21
申请人： James Mikkelsen
发明人： James Mikkelsen
IPC分类号： A01B35/26 , A01C5/06 , A01C23/02
CPC分类号： A01B35/26 , A01C5/062
摘要： A sweep-spike combination tillage tool (10) according to the preferred teachings of the present invention is disclosed including generally flat, horizontal sweep blades (18) located behind a spike (16) and above the point (28) of the spike (16). Specifically, the front corners of the sweep blades (18) between their front cutting edges (36) and inside edges (40) are integrally connected to the side edges (34) of the spike (16). Gussets (20) are provided having a first side (48) integrally connected generally perpendicular to the inside edges (40) of the sweep blades (18) and having a second side (50) integrally connected generally tangentially to the side edges (34) of the spike (16) to provide cantilever mounting of the sweep blades (18) and to provide support for soil passing over the spike (16) and the sweep blades (18) at their interconnection. Furrow fillers (22) are provided having top edges (52) integrally connected to the bottom faces ( 46) of the sweep blades (18) for moving the soil behind the implement shank (12) and the gussets (20). Applicators (64) may be provided behind point (28) of spike (16) and in front of sweep blades (18) for applying fertilizer. Thus, tool (10) according to the teachings of the present invention tills, fertilizes, and incorporates granular fertilizer and/or herbicides into the soil in a one-pass tillage operation.
摘要翻译：公开了根据本发明的优选教导的扫穗组合耕作工具（10），其包括位于钉（16）后面并且在钉（16）的点（28）之上的大致平坦的水平扫掠刀片（18））。具体地说，它们的前切削刃（36）和内边缘（40）之间的扫掠刀片（18）的前角与尖钉（16）的侧边缘（34）整体连接。角撑板（20）设置有具有大致垂直于扫掠叶片（18）的内边缘（40）整体连接的第一侧面（48），并且具有通常与侧边缘（34）切线地整体连接的第二侧面（50）的尖端（16）以提供悬臂安装扫掠叶片（18）并且为在其互连处通过尖钉（16）和扫掠叶片（18）的土壤提供支撑。沟槽填料（22）具有一体地连接到扫掠刀片（18）的底面（46）的顶部边缘（52），用于移动在工具柄（12）和角撑板（20）后面的土壤。施加器（64）可以设置在钉（16）的点（28）之后并且在用于施加肥料的扫掠刀片（18）的前面。因此，根据本发明的教导的工具（10）在一次性耕作操作中，将颗粒肥料和/或除草剂掺入土壤中。

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