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1. 发明授权

US08048441B2 Nanobead releasing medical devices 有权
标题翻译： Nanobead发布医疗器械
公开(公告)号：US08048441B2
公开(公告)日：2011-11-01
申请号：US11823007
申请日：2007-06-25
申请人： Charles H. Craig , John E. Papp , Dudley Jayasinghe , Lionel G. Hines , Dennis Orosa
发明人： Charles H. Craig , John E. Papp , Dudley Jayasinghe , Lionel G. Hines , Dennis Orosa
IPC分类号： A61F2/04 , A61K31/337 , A61K31/4353 , A61K31/445 , A61K31/496 , A61K31/56 , A61P9/00 , A61P9/10
CPC分类号： A61L31/18 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2300/624 , A61L2420/08
摘要： Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.
摘要翻译：提供了包含一种或多种生物活性剂的纳米胶囊的医疗装置及其使用方法。

2. 发明申请

US20080317813A1 Nanobead releasing medical devices 有权
标题翻译： Nanobead发布医疗器械
公开(公告)号：US20080317813A1
公开(公告)日：2008-12-25
申请号：US11823007
申请日：2007-06-25
申请人： Charles H. Craig , John E. Papp , Dudley Jayasinghe , Lionel G. Hines , Dennis Orosa
发明人： Charles H. Craig , John E. Papp , Dudley Jayasinghe , Lionel G. Hines , Dennis Orosa
IPC分类号： A61F2/04 , A61K31/337 , A61K31/4353 , A61K31/445 , A61K31/496 , A61K31/56 , A61P9/00 , A61P9/10
CPC分类号： A61L31/18 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2300/624 , A61L2420/08
摘要： Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.
摘要翻译：提供了包含一种或多种生物活性剂的纳米胶囊的医疗装置及其使用方法。

3. 发明申请

US20120003291A1 NANOBEAD RELEASING MEDICAL DEVICES 审中-公开
标题翻译： NANOBEAD释放医疗器械
公开(公告)号：US20120003291A1
公开(公告)日：2012-01-05
申请号：US13231515
申请日：2011-09-13
申请人： Charles H. Craig , John E. Papp , Dudley Jayasinghe , Lionel G. Hines , Dennis Orosa
发明人： Charles H. Craig , John E. Papp , Dudley Jayasinghe , Lionel G. Hines , Dennis Orosa
IPC分类号： A61P7/04 , A61K31/565 , A61K33/00 , A61K38/44 , A61K31/445 , A61P9/10 , A61K31/573 , A61K31/506 , A61K31/553 , A61K9/00 , A61P9/00 , A61K31/337 , A61K31/436
CPC分类号： A61L31/18 , A61L31/10 , A61L31/16 , A61L2300/606 , A61L2300/624 , A61L2420/08
摘要： Medical devices comprising nanobeads encapsulating one or more bioactive agents and methods of use thereof are provided.
摘要翻译：提供了包含一种或多种生物活性剂的纳米胶囊的医疗装置及其使用方法。

4. 发明申请

US20120073733A1 PROCESSES FOR MAKING CRUSH RECOVERABLE POLYMER SCAFFOLDS 有权
标题翻译：制造可重复使用聚合物的方法
公开(公告)号：US20120073733A1
公开(公告)日：2012-03-29
申请号：US13090164
申请日：2011-04-19
申请人： Michael H. Ngo , Mikael Trollsas , John E. Papp , Hung T. Nguyen , Dudley Jayasinghe , Ron Farnbach , Gregory C. Orr , Joshua Smith , Yongjin Xie , Yu-Chun Ku
发明人： Michael H. Ngo , Mikael Trollsas , John E. Papp , Hung T. Nguyen , Dudley Jayasinghe , Ron Farnbach , Gregory C. Orr , Joshua Smith , Yongjin Xie , Yu-Chun Ku
IPC分类号： B29C65/02
CPC分类号： A61F2/844 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2002/9522 , A61F2002/9583 , A61F2210/0071 , A61F2230/0054 , A61F2230/0056 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2103/42 , B23K2103/50 , B29C49/0073 , B29C49/08 , B29C55/26 , B29C2049/0089 , B29C2793/0009 , B29K2067/046 , B29L2031/753 , B29L2031/7534 , Y10T156/1002
摘要： Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.
摘要翻译：描述了通过球囊导管进行支架制备的方法。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架结构具有包括不对称或对称闭孔的图案，以及连接这种闭孔的连接。

5. 发明授权

US09345602B2 Processes for making crush recoverable polymer scaffolds 有权
标题翻译：制备压碎可回收聚合物支架的方法
公开(公告)号：US09345602B2
公开(公告)日：2016-05-24
申请号：US13090164
申请日：2011-04-19
申请人： Michael H. Ngo , Mikael Trollsas , John E. Papp , Hung T. Nguyen , Dudley Jayasinghe , Ron Farnbach , Gregory C. Orr , Joshua Takeshi Smith , Yongjin Xie , Yu-Chun Ku
发明人： Michael H. Ngo , Mikael Trollsas , John E. Papp , Hung T. Nguyen , Dudley Jayasinghe , Ron Farnbach , Gregory C. Orr , Joshua Takeshi Smith , Yongjin Xie , Yu-Chun Ku
IPC分类号： B29C65/02 , A61F2/915 , A61F2/958 , B29C55/26 , A61F2/95 , B29L31/00
CPC分类号： A61F2/844 , A61F2/89 , A61F2/915 , A61F2/958 , A61F2002/91566 , A61F2002/91575 , A61F2002/91583 , A61F2002/9522 , A61F2002/9583 , A61F2210/0071 , A61F2230/0054 , A61F2230/0056 , B23K26/361 , B23K26/362 , B23K26/402 , B23K2103/42 , B23K2103/50 , B29C49/0073 , B29C49/08 , B29C55/26 , B29C2049/0089 , B29C2793/0009 , B29K2067/046 , B29L2031/753 , B29L2031/7534 , Y10T156/1002
摘要： Methods for making scaffolds for delivery via a balloon catheter are described. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold structure has patterns that include an asymmetric or symmetric closed cell, and links connecting such closed cells.
摘要翻译：描述了通过球囊导管进行支架制备的方法。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架结构具有包括不对称或对称闭孔的图案，以及连接这种闭孔的连接。

6. 发明授权

US08568471B2 Crush recoverable polymer scaffolds 有权
标题翻译：粉碎可回收的聚合物支架
公开(公告)号：US08568471B2
公开(公告)日：2013-10-29
申请号：US13015488
申请日：2011-01-27
申请人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
发明人： Mikael Trollsas , Michael H. Ngo , Boris Anukhin , Alexander Nikanorov , Syed Hossainy , John E. Papp , Dudley Jayasinghe , Zella Solter
IPC分类号： A61F2/82
CPC分类号： A61F2/958 , A61F2/82 , A61F2/844 , A61F2/86 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/825 , A61F2002/91558 , A61F2002/91566 , A61F2002/91575 , A61F2002/9522 , A61F2210/0004 , A61F2210/0014 , A61F2210/0019 , A61F2210/0076 , A61F2230/0006 , A61F2230/0008 , A61F2250/0067 , A61F2250/0096 , A61F2250/0098 , A61L27/00 , A61L31/06 , A61L31/14 , B21D39/046 , B29C35/08 , B29C2035/0838 , B29K2067/046 , B29L2023/00 , B29L2031/7543 , Y10T29/49826 , Y10T29/4987 , Y10T29/49908 , Y10T29/49925 , Y10T29/49927 , C08L67/04 , C08L71/02
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold has a pattern including an asymmetric closed cell connecting links connecting the closed cells.
摘要翻译：医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架具有图案，其包括连接连接封闭单元的链接的非对称封闭单元。

7. 发明授权

US08808353B2 Crush recoverable polymer scaffolds having a low crossing profile 有权
标题翻译：粉碎具有低交叉分布的可回收聚合物支架
公开(公告)号：US08808353B2
公开(公告)日：2014-08-19
申请号：US13015474
申请日：2011-01-27
申请人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John E. Papp
发明人： Boris Anukhin , Michael H. Ngo , Mikael Trollsas , Syed Hossainy , John E. Papp
IPC分类号： A61F2/82
CPC分类号： A61F2/89 , A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91575 , A61F2240/002 , A61M25/1034 , B23P11/005 , B29C55/24 , B29C69/00 , Y10T29/49908
摘要： A medical device includes a polymer scaffold crimped to a catheter having an expansion balloon. The scaffold, after being deployed by the balloon, provides a crush recovery of about 90% after the diameter of the scaffold has been pinched or crushed by 50%. The scaffold also has a reduced crimped profile and a modification of the scaffold's ring structure at the crowns that contributes to the reduced crimped profile.
摘要翻译：医疗装置包括压接到具有膨胀气囊的导管的聚合物构架。支架在被气囊部署之后，在支架的直径被挤压或压碎50％后，提供约90％的压碎回收率。支架还具有减小的卷曲轮廓和在冠部处的支架环结构的改进，其有助于减小卷曲轮廓。

8. 发明授权

US08591540B2 Embolic filtering devices 有权
标题翻译：栓塞过滤装置
公开(公告)号：US08591540B2
公开(公告)日：2013-11-26
申请号：US10675611
申请日：2003-09-29
申请人： William J. Boyle , John E. Papp , Charles R. Peterson , Paul F. Muller , Donald Schwarten , Kathern J. Lind
发明人： William J. Boyle , John E. Papp , Charles R. Peterson , Paul F. Muller , Donald Schwarten , Kathern J. Lind
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/97 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An embolic filtering system includes a guide wire, a filter device disposed on the guide wire, a sheath adapted to maintain the filter device in an unexpanded position and a torque device having a lumen for receiving the guide wire and a locking mechanism for locking the torque device to the guide wire. The torque device may include a side port adapted to receive the proximal end of the sheath to allow a portion of the guide wire to shear the sheath from the guide wire through retraction of the sheath through the side port. The torque device may include an extension arm having a distal opening adapted to receive both the guide wire and the sheath. A second lumen may be used to allow a portion of the guide wire to shear the sheath away from the guide wire through retraction of the sheath through the second lumen.
摘要翻译：栓塞过滤系统包括引导线，设置在引导线上的过滤器装置，适于将过滤装置保持在未膨胀位置的护套和具有用于容纳引导线的内腔的扭矩装置和用于锁定扭矩的锁定机构设备到导丝。扭矩装置可以包括适于容纳护套的近端的侧端口，以允许导线的一部分通过护套通过侧端部缩回而从引导线剪切护套。扭矩装置可以包括延伸臂，其具有适于接纳导丝和护套的远端开口。可以使用第二内腔来允许引导线的一部分通过使护套通过第二内腔缩回而将护套从引导线上剪切。

9. 发明申请

US20110039013A1 System and Method for Coating a Medical Device 有权
标题翻译：医疗器械涂敷系统及方法
公开(公告)号：US20110039013A1
公开(公告)日：2011-02-17
申请号：US12540302
申请日：2009-08-12
申请人： John E. Papp , Matthew J. Gillick , Kent C. B. Stalker
发明人： John E. Papp , Matthew J. Gillick , Kent C. B. Stalker
IPC分类号： B05D3/04 , B05C5/00 , B05C13/02 , B05C11/00
CPC分类号： F26B9/06 , A61F2/82 , A61F2310/00389 , A61L2420/02 , B05B13/0221 , B05B13/0228 , B05B13/041 , B05B16/20 , B05B16/60 , B05B16/90 , B05D1/002 , B05D1/02 , B05D3/0413 , B05D3/0493 , B05D7/584
摘要： A system and method allows for processing of two groups of medical devices, both groups being alternatingly spray coated within the same enclosure. The two groups repeatedly move back and forth between a spray area and a drying area which is isolated from the spray area. One group moves into the spray area as the other group moves out and into the drying area. Thereafter, the group in the spray area moves out and into the drying area and the other group moves back into the spraying area for a second coating. The alternating process may be repeated any number of times. The spray area may be located inside a sealed spray isolator enclosure and surrounded by gas discharge nozzles.
摘要翻译：一种系统和方法允许处理两组医疗装置，两组在相同外壳内交替喷涂。两组反复在喷雾区域和与喷雾区域隔离的干燥区域之间来回移动。随着另一组移出并进入干燥区域，一组移入喷雾区域。此后，喷雾区域中的组移出并进入干燥区域，而另一组移回喷涂区域进行第二次涂覆。交替过程可以重复任意次数。喷射区域可以位于密封的喷雾隔离器外壳内并被气体排放喷嘴包围。

10. 发明申请

US20110029008A1 GUIDE WIRE WITH EMBOLIC FILTERING ATTACHMENT 有权
标题翻译：导线与导线连接
公开(公告)号：US20110029008A1
公开(公告)日：2011-02-03
申请号：US12904001
申请日：2010-10-13
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

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