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1. 发明授权

US08845583B2 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US08845583B2
公开(公告)日：2014-09-30
申请号：US11651667
申请日：2007-01-10
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
IPC分类号： A61M29/00 , A61F2/01
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

2. 发明授权

US08367063B2 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 有权
公开(公告)号：US08367063B2
公开(公告)日：2013-02-05
申请号：US12782376
申请日：2010-05-18
申请人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John K. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： A61K39/395 , A61K39/00 , C07K16/24 , C07K16/00
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.

3. 发明授权

US07718776B2 Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors 有权
标题翻译：人抗OPGL中和抗体作为选择性OPGL途径抑制剂
公开(公告)号：US07718776B2
公开(公告)日：2010-05-18
申请号：US10408901
申请日：2003-04-07
申请人： William J. Boyle , Eugene Medlock , John J. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
发明人： William J. Boyle , Eugene Medlock , John J. Sullivan , Robin L. Elliott , Frank Martin , Haichun Huang
IPC分类号： C12P21/08 , C07K16/00 , C12P21/04 , A61K39/395
CPC分类号： C07K16/241 , A61K2039/505 , C07K16/2875 , C07K2317/21 , C07K2317/34 , C07K2317/56
摘要： Monoclonal antibodies and hybridomas producing them that interact with osteoprotegerin ligand (OPGL) are provided. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are also provided. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are further provided.
摘要翻译：提供了与骨保护素配体（OPGL）相互作用的单克隆抗体和产生它们的杂交瘤。还提供了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。进一步提供使用OPGL抗体检测样品中OPGL量的方法。

4. 发明授权

US07678128B2 Delivery and recovery sheaths for medical devices 失效
标题翻译：用于医疗器械的输送和恢复护套
公开(公告)号：US07678128B2
公开(公告)日：2010-03-16
申请号：US09897295
申请日：2001-06-29
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C. B. Stalker
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C. B. Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.
摘要翻译：部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。恢复护套可以在内导管上推进以使可膨胀过滤器折叠。内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

5. 发明申请

US20090274688A1 Antibodies to OPGL 有权
标题翻译： OPGL的抗体
公开(公告)号：US20090274688A1
公开(公告)日：2009-11-05
申请号：US11981664
申请日：2007-10-30
申请人： William J. Boyle , Francis H. Martin , Jose R. Corvalan , C. Geoffrey Davis
发明人： William J. Boyle , Francis H. Martin , Jose R. Corvalan , C. Geoffrey Davis
IPC分类号： A61K39/395 , A61K31/711 , C12N15/63 , C12N5/10 , C12P21/02 , A61P19/00 , G01N33/536 , C07K16/24
CPC分类号： C07K16/2875 , A61K39/39541 , A61K39/3955 , A61K45/06 , A61K2039/505 , A61K2039/507 , C07K16/241 , C07K2317/21 , C07K2317/51 , C07K2317/515 , C07K2317/54 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2317/76 , C07K2317/92 , A61K2300/00
摘要： Antibodies that interact with osteoprotegerin ligand (OPGL) are described. Methods of treating osteopenic disorders by administering a pharmaceutically effective amount of antibodies to OPGL are described. Methods of detecting the amount of OPGL in a sample using antibodies to OPGL are described.
摘要翻译：描述了与骨保护素配体（OPGL）相互作用的抗体。描述了通过向OPGL施用药学有效量的抗体来治疗骨质疏松症的方法。描述使用OPGL抗体检测样品中OPGL的量的方法。

6. 发明申请

US20090030445A1 DELIVERY SYSEMS FOR EMBOLIC FILTER DEVICES 审中-公开
标题翻译：用于嵌入式过滤装置的交付符号
公开(公告)号：US20090030445A1
公开(公告)日：2009-01-29
申请号：US12187129
申请日：2008-08-06
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
IPC分类号： A61F2/01 , A61B17/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M25/0668
摘要： A delivery system for an expandable filter device includes a dual lumen delivery sheath which has a lumen for receiving the expandable filter device and a lumen for receiving a primary guide wire. The primary guide wire is utilized to place the delivery sheath and expandable filter into the desired region of the patient's vasculature via an over-the-wire or rapid-exchange arrangement. The delivery sheath can be protracted over the expandable filter device to allow the filter to be deployed within the patient's vasculature at the desired location. The delivery system can be embodied in an alternative design in which the primary guide wire extends through a guide wire lumen located in an obturator which forms part of the expandable filter device. Again, the primary guide wire is utilized to maneuver the filter device into the desired area via an over-the-wire arrangement. A slit extending longitudinally along the length of the sheath facilitates the removal of the guide wire and delivery sheath from the patient's vasculature.
摘要翻译：用于可膨胀过滤器装置的递送系统包括双腔输送护套，其具有用于接收可膨胀过滤器装置的内腔和用于接收主导丝的管腔。主引导线用于通过线上或快速交换布置将输送护套和可扩张过滤器放置在患者血管的期望区域中。输送护套可以延伸在可膨胀的过滤器装置上，以允许过滤器在病人的脉管系统中部署在期望的位置。输送系统可以以替代设计来体现，其中主导丝延伸穿过位于形成可膨胀过滤器装置的一部分的闭孔器中的导丝管腔。再次，主引导线用于通过线上布置来将过滤器装置操纵到期望的区域。沿鞘的长度纵向延伸的狭缝有助于从患者的脉管系统移除导丝和输送鞘。

7. 发明授权

US06679902B1 Reduced profile delivery sheath for use in interventional procedures 有权
标题翻译：减少型材输送护套用于介入手术
公开(公告)号：US06679902B1
公开(公告)日：2004-01-20
申请号：US09619001
申请日：2000-07-19
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter
IPC分类号： A61M2900
CPC分类号： A61M25/0068 , A61F2/95 , A61F2250/0098 , A61M25/0069 , A61M25/0108 , A61M2025/0081
摘要： A delivery sheath is provided for deploying a self-expanding intravascular filter. The sheath includes a stiff proximal portion which provides for good pushability and trackability through tortuous vessels and a soft, flexible, low profile, radiopaque distal tip for holding and delivering a deployable filter. The soft distal tip minimizes the formation of embolic particles that may be produced by contact between the sheath and an arterial lesion. The distal tip may be molded from a polymer containing radiopaque particles held in suspension and thereby provides for good visualization under fluroscopy.
摘要翻译：提供了用于展开自膨胀血管内过滤器的输送鞘。护套包括刚性近端部分，其通过曲折血管提供良好的推进性和可追踪性，以及柔软，柔性，低轮廓，不透射线的远端，用于保持和递送可部署的过滤器。软远侧末端使得可以通过鞘和动脉损伤之间的接触产生的栓塞颗粒的形成最小化。远侧末端可以由含有保持悬浮液的不透射线颗粒的聚合物模制，从而在荧光检查下提供良好的可视化。

8. 发明授权

US06290656B1 Guide wire with damped force vibration mechanism 有权
标题翻译：导丝采用阻尼力振动机构
公开(公告)号：US06290656B1
公开(公告)日：2001-09-18
申请号：US09475381
申请日：1999-12-30
申请人： William J. Boyle , Paul F. Muller
发明人： William J. Boyle , Paul F. Muller
IPC分类号： A61B500
CPC分类号： A61M25/09
摘要： A guide wire having a damped force vibration mechanism which isolates vibrations or shockwaves which otherwise would be transmitted along the length of the guide wire to its distal end. The damped force vibration mechanism helps absorb some of the energy created during the exchange of a delivery catheter or an interventional device on the guide wire or any shock or force generated from an external source. The damped force vibration mechanism absorbs vibrations or shock which would otherwise act on medical devices attached near the distal end of a guide wire. The damped force vibration mechanism may consist of a reduced segment on the guide wire which can be made from a material such as superelastic or plastically deformable, biocompatible materials. The damped force vibration mechanism can have a relatively straight configuration or can have a wave-shaped form, or other shape which helps absorb vibratory motion.
摘要翻译：具有阻尼力振动机构的引导线，其隔离振动或冲击波，否则其将沿着导丝的长度传递到其远端。阻尼力振动机制有助于吸收在导丝或交流导管或介入装置交换导线时产生的一些能量，或从外部源产生的任何冲击或力。阻尼力振动机构吸收振动或冲击，否则这些振动或冲击将作用在附着在导丝末端附近的医疗装置上。阻尼力振动机构可以由导丝上的减少的部分组成，其可由诸如超弹性或塑性变形的生物相容性材料的材料制成。阻尼力振动机构可以具有相对直的构造或者可以具有波形形状或其它有助于吸收振动的形状。

9. 发明授权

US06284740B1 Osteoprotegerin 失效
标题翻译：骨保护素
公开(公告)号：US06284740B1
公开(公告)日：2001-09-04
申请号：US08974186
申请日：1997-11-18
申请人： William J. Boyle , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
发明人： William J. Boyle , David L. Lacey , Frank J. Calzone , Ming-Shi Chang
IPC分类号： A01N4304
CPC分类号： C07K14/70578 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors and host cells for expression, antibodies which bind Osteoprotegerin, and pharmaceutical compositions. The polypeptides are used to treat bone diseases characterized by increased resorption such as osteoporosis.
摘要翻译：本发明公开了一种称为骨保护素的新型分泌多肽，其是肿瘤坏死因子受体超家族的成员，并且参与骨代谢的调节。还公开了编码骨保护素，多肽，重组载体和表达宿主细胞，结合骨保护素的抗体和药物组合物的核酸。多肽用于治疗以增加再吸收为特征的骨疾病，例如骨质疏松症。

10. 发明授权

US6136023A Welded sinusoidal wave stent 有权
标题翻译：焊接正弦波支架
公开(公告)号：US6136023A
公开(公告)日：2000-10-24
申请号：US136394
申请日：1998-08-19
申请人： William J. Boyle
发明人： William J. Boyle
IPC分类号： A61F2/00 , A61F2/90 , A61F2/06
CPC分类号： A61F2/90 , A61F2/88 , B21F45/008 , A61F2240/001 , A61F2250/0014
摘要： A wire stent having a preformed series of peaks alternating with valleys. The wire is formed from a malleable or resilient material and can be wound into a continuous helix. Each pair of peaks and valleys constitutes a wave. The stent has a number of waves per circumferential revolution such that the adjoining waves align off-peak to off-valley with one or more such adjoining waves being affixed to each other at the off-peak to off-valley locations. The waves can be welded at all locations or only at the circumferential revolutions at the proximal and distal ends of the stent, or intermittently, or in barber pole fashion or along one or more longitudinal axes.
摘要翻译：具有与谷交替的预成型系列峰的线支架。导线由可延展的或弹性的材料形成，并且可以缠绕成连续的螺旋。每一对峰谷构成一波。每个圆周旋转支架具有多个波浪，使得邻接的波对准偏离峰值到偏离山谷，其中一个或多个这样的邻接波在非高峰到非谷值位置彼此固定。波可以在所有位置处或仅在支架的近端和远端的周向旋转处或者间歇地或以理发杆方式或沿着一个或多个纵向轴线焊接。

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