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1. 发明申请

US20150102257A1 SUB-STOICHIOMETRIC, CHALCOGEN-CONTAINING-GERMANIUM, TIN, OR LEAD ANODES FOR LITHIUM OR SODIUM ION BATTERIES 有权
标题翻译：用于锂离子电池或钠离子电池的低分子量，含氯化钠，锡或铅阳极
公开(公告)号：US20150102257A1
公开(公告)日：2015-04-16
申请号：US14513951
申请日：2014-10-14
申请人： Charles Buddie Mullins , Paul Abel , Adam Heller , Kyle C. Klavetter
发明人： Charles Buddie Mullins , Paul Abel , Adam Heller , Kyle C. Klavetter
IPC分类号： H01M4/58
CPC分类号： H01M4/581 , H01B1/02 , H01G11/30 , H01G11/50 , H01M4/134 , H01M4/136 , H01M4/405 , H01M4/5815 , H01M10/05 , H01M10/0525 , H01M10/054 , H01M2004/021 , Y02E60/13 , Y02T10/7022
摘要： The disclosure relates to an anode or an electrolytic capacitor electrode including an active anode material containing a chalcogen-containing-germanium composition in which the germanium:chalcogen atom ratio is between 80:20 and 98:2. The disclosure also relates to an anode including an active anode material containing a lithium and germanium-containing alloy wherein the lithium:germanium atom ratio is 22:5 or less. The anode also includes a non-cycling lithium chalcogenide. The disclosure further relates to lithium ion batteries including such anodes. The disclosure additionally relates to capacitor electrodes containing similar materials and capacitors containing such electrodes.
摘要翻译：本公开涉及一种阳极或电解电容器电极，其包括含有含硫族元素的锗组合物的活性阳极材料，其中锗：硫属原子比为80:20至98:2。本公开还涉及包含含有锂和锗的合金的活性阳极材料的阳极，其中锂：锗原子比为22:5或更小。阳极还包括非循环锂硫属化物。本公开还涉及包括这种阳极的锂离子电池。本公开另外涉及包含类似材料的电容器电极和包含这种电极的电容器。

2. 发明授权

US09680151B2 Sub-stoichiometric, chalcogen-containing-germanium, tin, or lead anodes for lithium or sodium ion batteries 有权
公开(公告)号：US09680151B2
公开(公告)日：2017-06-13
申请号：US14513951
申请日：2014-10-14
申请人： Charles Buddie Mullins , Paul Abel , Adam Heller , Kyle C. Klavetter
发明人： Charles Buddie Mullins , Paul Abel , Adam Heller , Kyle C. Klavetter
IPC分类号： H01B1/02 , H01M4/58 , H01M4/40 , H01M10/05 , H01G11/50 , H01G11/30 , H01M4/134 , H01M4/136 , H01M10/0525 , H01M10/054 , H01M4/02
CPC分类号： H01M4/581 , H01B1/02 , H01G11/30 , H01G11/50 , H01M4/134 , H01M4/136 , H01M4/405 , H01M4/5815 , H01M10/05 , H01M10/0525 , H01M10/054 , H01M2004/021 , Y02E60/13 , Y02T10/7022
摘要： The disclosure relates to an anode or an electrolytic capacitor electrode including an active anode material containing a chalcogen-containing-germanium composition in which the germanium:chalcogen atom ratio is between 80:20 and 98:2. The disclosure also relates to an anode including an active anode material containing a lithium and germanium-containing alloy wherein the lithium:germanium atom ratio is 22:5 or less. The anode also includes a non-cycling lithium chalcogenide. The disclosure further relates to lithium ion batteries including such anodes. The disclosure additionally relates to capacitor electrodes containing similar materials and capacitors containing such electrodes.

3. 发明授权

US09066697B2 Analyte monitoring device and methods of use 有权
标题翻译：分析物监测装置及使用方法
公开(公告)号：US09066697B2
公开(公告)日：2015-06-30
申请号：US13283562
申请日：2011-10-27
申请人： Thomas Peyser , Adam Heller
发明人： Thomas Peyser , Adam Heller
IPC分类号： A61B5/1486 , A61B5/1473 , A61B5/00 , A61B5/145
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/0031 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/4839 , A61B5/742 , A61B5/7445 , G06F19/00
摘要： An analyte monitor including a sensor, a sensor control unit, and a display unit is disclosed. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.
摘要翻译：公开了一种包括传感器，传感器控制单元和显示单元的分析物监视器。分析物监测器还可以是药物递送系统的一部分，以基于使用传感器获得的数据来改变分析物的水平。

4. 发明授权

US08880137B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08880137B2
公开(公告)日：2014-11-04
申请号：US10420057
申请日：2003-04-18
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00 , A61B5/1473 , A61B5/1468 , A61B5/145 , G06F19/00 , A61B5/1486 , H01L23/495 , H01L23/31
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

5. 发明授权

US08741590B2 Subcutaneous glucose electrode 有权
标题翻译：皮下葡萄糖电极
公开(公告)号：US08741590B2
公开(公告)日：2014-06-03
申请号：US11695612
申请日：2007-04-03
申请人： Adam Heller , Michael V. Pishko
发明人： Adam Heller , Michael V. Pishko
IPC分类号： C12Q1/54
CPC分类号： C12Q1/54 , C12Q1/006 , Y10S435/817 , Y10S435/917 , Y10S435/962
摘要： A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow “one-point” in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.
摘要翻译：描述了设计用于皮下体内电导率监测葡萄糖的小直径柔性电极。电极被设计成允许“一点”体内校准，即即使在血清或血液的其它电反应物质的存在下也能在零葡萄糖浓度下具有零输出电流。电极优选为三层或四层，其中层叠在聚酰胺绝缘金线的尖端上的凹槽内。第一葡萄糖浓度 - 电流转导层用电绝缘和葡萄糖通量限制层（第二层）涂覆，其上任选地沉积固定的干扰消除辣根过氧化物酶基膜（第三层）。外（第四）层是生物相容的。

6. 发明授权

US08650751B2 Methods of making small volume in vitro analyte sensors 有权
标题翻译：制作体积小体积分析物传感器的方法
公开(公告)号：US08650751B2
公开(公告)日：2014-02-18
申请号：US12569350
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R43/20
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

7. 发明授权

US08641619B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08641619B2
公开(公告)日：2014-02-04
申请号：US12643977
申请日：2009-12-21
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/00 , A61B5/05 , C12Q1/54
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

8. 发明授权

US08480580B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08480580B2
公开(公告)日：2013-07-09
申请号：US11737671
申请日：2007-04-19
申请人： Howard Wolpert , Adam Heller
发明人： Howard Wolpert , Adam Heller
IPC分类号： A61B5/00
CPC分类号： A61B5/1486 , A61B5/0002 , A61B5/1118 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/14865 , A61B5/4839 , A61B5/7275 , A61B5/7445 , A61B2560/0252 , A61B2560/063 , A61M5/14244 , A61M5/1723 , A61M2205/3569 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

9. 发明授权

US08473021B2 Analyte monitoring device and methods of use 有权
公开(公告)号：US08473021B2
公开(公告)日：2013-06-25
申请号：US12533680
申请日：2009-07-31
申请人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
发明人： James Say , Michael F. Tomasco , Adam Heller , Yoram Gal , Behrad Aria , Ephraim Heller , Phillip John Plante , Mark S. Vreeke , Keith A. Friedman , Fredric C. Colman
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/14865 , A61B5/0002 , A61B5/002 , A61B5/01 , A61B5/14503 , A61B5/1451 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/1486 , A61B5/1495 , A61B5/4839 , A61B5/72 , A61B5/7278 , A61B5/7282 , A61B5/7405 , A61B5/743 , A61B5/7445 , A61B5/7455 , A61B2560/0252 , A61M5/1723 , C12Q1/54 , G06F19/00 , G06F19/34 , H01L23/3107 , H01L23/49548 , H01L2924/0002 , H01L2924/19041 , H01L2924/3011 , Y10S128/903 , Y10T29/49 , Y10T29/49124 , H01L2924/00
摘要： An analyte monitor includes a sensor, a sensor control unit, and a display unit. The sensor has, for example, a substrate, a recessed channel formed in the substrate, and conductive material disposed in the recessed channel to form a working electrode. The sensor control unit typically has a housing adapted for placement on skin and is adapted to receive a portion of an electrochemical sensor. The sensor control unit also includes two or more conductive contacts disposed on the housing and configured for coupling to two or more contact pads on the sensor. A transmitter is disposed in the housing and coupled to the plurality of conductive contacts for transmitting data obtained using the sensor. The display unit has a receiver for receiving data transmitted by the transmitter of the sensor control unit and a display coupled to the receiver for displaying an indication of a level of an analyte. The analyte monitor may also be part of a drug delivery system to alter the level of the analyte based on the data obtained using the sensor.

10. 发明授权

US08444834B2 Redox polymers for use in analyte monitoring 有权
标题翻译：用于分析物监测的氧化还原聚合物
公开(公告)号：US08444834B2
公开(公告)日：2013-05-21
申请号：US12051835
申请日：2008-03-19
申请人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： G01N27/327 , C07F15/00
CPC分类号： C07F15/0026 , C12Q1/002 , C12Q1/004
摘要： Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.
摘要翻译：描述了用作电化学生物传感器中的氧化还原介体的聚合物。连接到聚合物主链上的过渡金属络合物可用作酶基电化学传感器中的氧化还原介体。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。

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