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1. 发明授权

US08444834B2 Redox polymers for use in analyte monitoring 有权
标题翻译：用于分析物监测的氧化还原聚合物
公开(公告)号：US08444834B2
公开(公告)日：2013-05-21
申请号：US12051835
申请日：2008-03-19
申请人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： G01N27/327 , C07F15/00
CPC分类号： C07F15/0026 , C12Q1/002 , C12Q1/004
摘要： Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.
摘要翻译：描述了用作电化学生物传感器中的氧化还原介体的聚合物。连接到聚合物主链上的过渡金属络合物可用作酶基电化学传感器中的氧化还原介体。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。

2. 发明授权

US08268143B2 Oxygen-effect free analyte sensor 有权
标题翻译：无氧效应的分析物传感器
公开(公告)号：US08268143B2
公开(公告)日：2012-09-18
申请号：US12172589
申请日：2008-07-14
申请人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： C12Q1/32
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61B2560/0252 , A61B2560/0276 , A61M5/1723 , A61M2205/3576 , A61M2205/3584 , A61M2205/505 , A61M2230/201 , C12Q1/004 , C12Q1/32
摘要： The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.
摘要翻译：本发明提供一种电化学传感器，其具有基本上没有任何“氧效应”的感测化学物质。电化学传感器可用于确定来自受试者的生物样品中分析物的水平。本发明还提供了包括电化学传感器的传感器组件及其使用方法。

3. 发明申请

US20120132525A1 REDOX POLYMERS FOR USE IN ANALYTE MONITORING 有权
标题翻译：用于分析监测的REDOX聚合物
公开(公告)号：US20120132525A1
公开(公告)日：2012-05-31
申请号：US12051835
申请日：2008-03-19
申请人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： G01N33/50 , C08F126/06
CPC分类号： C07F15/0026 , C12Q1/002 , C12Q1/004
摘要： Polymers for use as redox mediators in electrochemical biosensors are described. The transition metal complexes attached to polymeric backbones can be used as redox mediators in enzyme based electrochemical sensors. In such instances, transition metal complexes accept electrons from, or transfer electrons to, enzymes at a high rate and also exchange electrons rapidly with the sensor. The transition metal complexes include at least one substituted or unsubstituted biimidazole ligand and may further include a second substituted or unsubstituted biimidazole ligand or a substituted or unsubstituted bipyridine or pyridylimidazole ligand.
摘要翻译：描述了用作电化学生物传感器中的氧化还原介体的聚合物。连接到聚合物主链上的过渡金属络合物可用作酶基电化学传感器中的氧化还原介体。在这种情况下，过渡金属配合物以高速率接受电子或将电子转移到酶，并且还与传感器快速交换电子。过渡金属络合物包括至少一个取代或未取代的双咪唑配体，并且还可以包括第二取代或未取代的双咪唑配体或取代或未取代的联吡啶或吡啶基咪唑配体。

4. 发明申请

US20090099434A1 OXYGEN-EFFECT FREE ANALYTE SENSOR 有权
标题翻译：氧气效应免费分析仪传感器
公开(公告)号：US20090099434A1
公开(公告)日：2009-04-16
申请号：US12172589
申请日：2008-07-14
申请人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
发明人： Zenghe Liu , Tianmei Ouyang , Hyun Cho , Yohannes Goti , Benjamin J. Feldman , Fei Mao , Adam Heller
IPC分类号： A61B5/1473 , G01N27/26 , A61M37/00 , A61K38/28
CPC分类号： A61B5/14532 , A61B5/002 , A61B5/14865 , A61B5/4839 , A61B2560/0223 , A61B2560/0252 , A61B2560/0276 , A61M5/1723 , A61M2205/3576 , A61M2205/3584 , A61M2205/505 , A61M2230/201 , C12Q1/004 , C12Q1/32
摘要： The present invention provides an electrochemical sensor having a sensing chemistry that operates substantially free of any “oxygen effect”. The electrochemical sensors are useful in determining the level of an analyte in a biological sample from a subject. The present invention also provides sensor assemblies including the electrochemical sensors as well as methods of using the same.
摘要翻译：本发明提供一种电化学传感器，其具有基本上没有任何“氧效应”的感测化学物质。电化学传感器可用于确定来自受试者的生物样品中分析物的水平。本发明还提供了包括电化学传感器的传感器组件及其使用方法。

5. 发明授权

US08761857B2 Analyte sensor, and associated system and method employing a catalytic agent 有权
标题翻译：分析物传感器，以及使用催化剂的相关系统和方法
公开(公告)号：US08761857B2
公开(公告)日：2014-06-24
申请号：US13437692
申请日：2012-04-02
申请人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
发明人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/686 , A61B5/14514 , A61B5/14528 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/004 , C12Q1/005 , C12Q1/006
摘要： An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
摘要翻译：描述了与生物流体结合使用的分析物传感器。分析物传感器可以包括生物流体和生物流体的衍生物之间的任何合适的界面以及关于分析物的任何合适的信息传感器。在界面的区域或附近提供至少一种催化剂。催化剂，例如蛋白质剂或非蛋白质的有机金属剂，足以催化可能存在于界面附近的活性氧和/或氮物质的降解。还描述了分析物感测套件和感测分析物的方法。

6. 发明授权

US08165651B2 Analyte sensor, and associated system and method employing a catalytic agent 有权
标题翻译：分析物传感器，以及使用催化剂的相关系统和方法
公开(公告)号：US08165651B2
公开(公告)日：2012-04-24
申请号：US11007617
申请日：2004-12-07
申请人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
发明人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
IPC分类号： A61B5/05 , A61B5/00
CPC分类号： A61B5/686 , A61B5/14514 , A61B5/14528 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/004 , C12Q1/005 , C12Q1/006
摘要： An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
摘要翻译：描述了与生物流体结合使用的分析物传感器。分析物传感器可以包括生物流体和生物流体的衍生物之间的任何合适的界面以及关于分析物的任何合适的信息传感器。在界面的区域或附近提供至少一种催化剂。催化剂，例如蛋白质剂或非蛋白质的有机金属剂，足以催化可能存在于界面附近的活性氧和/或氮物质的降解。还描述了分析物感测套件和感测分析物的方法。

7. 发明申请

US20130006079A1 Analyte Sensor, and Associated System and Method Employing a Catalytic Agent 有权
标题翻译：分析物传感器，以及使用催化剂的相关系统和方法
公开(公告)号：US20130006079A1
公开(公告)日：2013-01-03
申请号：US13437692
申请日：2012-04-02
申请人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
发明人： Benjamin J. Feldman , Zenghe Liu , David C. Cohen , Adam Heller
IPC分类号： A61B5/1486 , A61B5/145
CPC分类号： A61B5/686 , A61B5/14514 , A61B5/14528 , A61B5/14532 , A61B5/14865 , C12Q1/002 , C12Q1/004 , C12Q1/005 , C12Q1/006
摘要： An analyte sensor for use in connection with a biofluid is described. The analyte sensor may comprise any suitable interface between the biofluid and a derivative of the biofluid and any suitable transducer of information concerning an analyte. At least one catalytic agent is provided in a locale or vicinity of the interface. The catalytic agent, such as a proteinaceous agent or a non-proteinaceous, organic-metal agent, is sufficient to catalyze the degradation of reactive oxygen and/or nitrogen species that may be present in the vicinity of the interface. An analyte-sensing kit and a method of sensing an analyte are also described.
摘要翻译：描述了与生物流体结合使用的分析物传感器。分析物传感器可以包括生物流体和生物流体的衍生物之间的任何合适的界面以及关于分析物的任何合适的信息传感器。在界面的区域或附近提供至少一种催化剂。催化剂，例如蛋白质剂或非蛋白质的有机金属剂，足以催化可能存在于界面附近的活性氧和/或氮物质的降解。还描述了分析物感测套件和感测分析物的方法。

8. 发明授权

US07699964B2 Membrane suitable for use in an analyte sensor, analyte sensor, and associated method 有权
标题翻译：适用于分析物传感器，分析物传感器和相关方法的膜
公开(公告)号：US07699964B2
公开(公告)日：2010-04-20
申请号：US10819498
申请日：2004-04-06
申请人： Benjamin Feldman , Zenghe Liu , Fei Mao , Adam Heller
发明人： Benjamin Feldman , Zenghe Liu , Fei Mao , Adam Heller
IPC分类号： G01N27/40 , G01N27/327
CPC分类号： C12Q1/005
摘要： A multifunctional membrane is provided. The multifunctional membrane is suitable for use in an analyte sensor. In a particular application, the multifunctional membrane may be used in connection with an amperometric biosensor, such as a transcutaneous amperometric biosensor. Some functions of the membrane are associated with properties of membrane itself, which is comprised of crosslinked polymers containing heterocyclic nitrogen groups. For example, the membrane, by virtue of its polymeric composition, may regulate the flux of an analyte to a sensor. Such regulation generally improves the kinetic performance of the sensor over a broad range of analyte concentration. Other functions of the membrane are associated with functional components, such as a superoxide-dismutating/catalase catalyst, either in the form of an enzyme or an enzyme mimic, that can be bound to the scaffold provided by the membrane. The effect of any such enzyme or enzyme mimic is to lower the concentration of a metabolite, such as superoxide and/or hydrogen peroxide, in the immediate vicinity of the sensing layer of the biosensor. Lowering the concentrations of such metabolites, which are generally deleterious to the function of the sensor, generally protects or enhances biosensor integrity and performance. The membrane is thus an important tool for use in connection with analyte sensors, amperometric sensors, biosensors, and particularly, transcutaneous biosensors. A membrane-covered sensor and a method for making same are also provided.
摘要翻译：提供多功能膜。多功能膜适用于分析物传感器。在特定应用中，多功能膜可以与电流计生物传感器（例如经皮电流生物传感器）结合使用。膜的一些功能与膜本身的性质相关，膜本身由包含杂环氮基团的交联聚合物组成。例如，膜由于其聚合物组合物可以将分析物的通量调节到传感器。这种调节通常改善传感器在宽范围的分析物浓度下的动力学性能。膜的其它功能与可以结合到由膜提供的支架结合的酶或酶模拟物的形式的功能组分如超氧化物歧化/过氧化氢酶催化剂相关联。任何此类酶或酶模拟物的作用是降低生物传感器感应层附近代谢物如超氧化物和/或过氧化氢的浓度。降低通常对传感器功能有害的代谢物的浓度通常保护或增强生物传感器的完整性和性能。因此，膜是分析物传感器，电流传感器，生物传感器，特别是经皮生物传感器的重要工具。还提供了膜覆盖传感器及其制造方法。

9. 发明授权

US08650751B2 Methods of making small volume in vitro analyte sensors 有权
标题翻译：制作体积小体积分析物传感器的方法
公开(公告)号：US08650751B2
公开(公告)日：2014-02-18
申请号：US12569350
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R43/20
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry; and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.
摘要翻译：描述了利用不可浸出或可扩散的氧化还原介体的传感器。传感器包括用于保持样品与工作电极电解接触的样品室，并且在至少一些情况下，传感器还含有不可浸出或可扩散的第二电子转移剂。传感器和/或所使用的方法响应于能够与介体引起的背景信号区分的分析物产生传感器信号。本发明可用于测定生物流体如血液或血清中生物分子如葡萄糖或乳酸的浓度，使用诸如库仑法，电流分析法; 和电位法。通常可以提供能够催化生物分子的电氧化或电还原的酶作为第二电子转移剂。

10. 发明授权

US08272125B2 Method of manufacturing in vitro analyte sensors 有权
标题翻译：制造体外分析物传感器的方法
公开(公告)号：US08272125B2
公开(公告)日：2012-09-25
申请号：US12569179
申请日：2009-09-29
申请人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
发明人： Benjamin J. Feldman , Adam Heller , Ephraim Heller , Fei Mao , Joseph A. Vivolo , Jeffery V. Funderburk , Fredric C. Colman , Rajesh Krishnan
IPC分类号： H01R9/00 , H05K3/02
CPC分类号： G01N27/3272 , C12Q1/001 , C12Q1/006 , C12Q1/32 , G01N27/3271 , G01N27/3274 , Y10T29/49002 , Y10T29/49004 , Y10T29/49007 , Y10T29/49126 , Y10T29/49128 , Y10T29/4913 , Y10T29/49147 , Y10T29/49155 , Y10T29/49204 , Y10T29/49208 , Y10T29/4921 , Y10T29/49794 , Y10T156/1052
摘要： Provided are methods of manufacturing a plurality of electrochemical sensors. The methods include forming a plurality of working electrodes on a first electrode region of a substrate, forming a plurality of counter electrodes on a second electrode region of the substrate, disposing a spacer layer on one of the first and second electrode regions, folding the substrate with the spacer layer between the first electrode region and the second electrode region to form a layered structure, and separating or cutting the layered structure to form individual electrochemical sensors.
摘要翻译：提供制造多个电化学传感器的方法。所述方法包括在基板的第一电极区域上形成多个工作电极，在基板的第二电极区域上形成多个对置电极，在第一和第二电极区域之一上设置间隔层，折叠基板其中间隔层在第一电极区域和第二电极区域之间以形成层状结构，并且分离或切割层状结构以形成单独的电化学传感器。

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