专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4367235A 2-Benzimidazolinone compounds and therapeutic compositions 失效
标题翻译： 2-苯并咪唑啉酮化合物和治疗组合物
公开(公告)号：US4367235A
公开(公告)日：1983-01-04
申请号：US171940
申请日：1980-07-18
申请人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
发明人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
IPC分类号： A61K31/415 , A61K31/4184 , A61P9/00 , A61P25/02 , C07D235/02 , C07D235/26
CPC分类号： A61K31/415 , C07D235/02 , C07D235/26
摘要： 2-benzimidazolinone compounds of the formula ##STR1## wherein R is lower alkyl,R.sub.1 and R.sub.2, which can be the same or different, are lower straight-chained or branched alkyl and one of R.sub.1 and R.sub.2 can also be hydrogen orR.sub.1 and R.sub.2 together represent an alkylene radical and R.sub.3 is hydrogen or acyl, i.e., alkanoyl or aromatic carboxylic acid moieties;and the pharmacologically acceptable salts thereof; have marked .beta.-receptor blocking action and are outstandingly useful in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：其中R是低级烷基，可以相同或不同的R 1和R 2的低级直链或支链烷基，R 1和R 2之一也可以是氢或R 1和R 2 一起代表亚烷基，R3是氢或酰基，即烷酰基或芳族羧酸部分; 及其药理学上可接受的盐; 具有明显的β-受体阻断作用，并且在治疗或预防心脏和循环系统疾病方面非常有用。

2. 发明授权

US4215134A 4-Hydroxy-2-benzimidazoline-thione compounds and pharmaceutical compositions containing them 失效
标题翻译： 4-羟基-2-苯并咪唑啉 - 硫酮化合物和含有它们的药物组合物
公开(公告)号：US4215134A
公开(公告)日：1980-07-29
申请号：US2129
申请日：1979-01-09
申请人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
发明人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
IPC分类号： A61K31/415 , A61K31/4184 , A61P9/00 , C07D235/02 , C07D235/28 , C07D303/22
CPC分类号： C07D235/02 , C07D235/28 , C07D303/22
摘要： Novel 4-hydroxy-2-benzimidazoline-thione compound of the formula: ##STR1## wherein R is lower alkyl;R.sub.1 and R.sub.2, which can be the same or different, are hydrogen or lower straight-chained or branched alkyl orR.sub.1 and R.sub.2 together represent alkylene; andR.sub.3 is a hydrogen atom or an acyl radical;and the pharmacologically acceptable salts thereof; have marked .beta.-receptor blocking action and are outstandingly useful in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：下式的新型4-羟基-2-苯并咪唑啉 - 硫酮化合物：其中R是低级烷基; R 1和R 2可以相同或不同，为氢或低级直链或支链烷基或R 1和R 2一起表示亚烷基; 并且R 3是氢原子或酰基; 及其药理学上可接受的盐; 具有明显的β-受体阻断作用，并且在治疗或预防心脏和循环系统疾病方面非常有用。

3. 发明授权

US4428955A Benzopyran compounds, pharmaceutical compositions containing them and methods of use 失效
标题翻译：苯并吡喃化合物，含有它们的药物组合物和使用方法
公开(公告)号：US4428955A
公开(公告)日：1984-01-31
申请号：US372415
申请日：1982-04-27
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Egon Roesch , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Egon Roesch , Otto-Henning Wilhelms
IPC分类号： C07D409/14 , A61K31/35 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P37/08 , A61P43/00 , C07D311/22 , C07D405/06 , C07D405/12 , C07D405/14
CPC分类号： C07D405/12 , Y10S514/87
摘要： The present invention provides benzopyranyl ethers of the general formula: ##STR1## wherein A is an alkylene radical containing 2 to 4 carbon atoms and R is a hydrogen atom or an acyl radical; as well as the salts thereof with pharmacologically acceptable acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them. Furthermore, the present invention is concerned with the use of these compounds for treating allergic diseases.
摘要翻译：本发明提供以下通式的苯并吡喃基醚：其中A是含有2至4个碳原子的烷基，R是氢原子或酰基; 以及其与药理学上可接受的酸的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。此外，本发明涉及这些化合物用于治疗过敏性疾病的用途。

4. 发明授权

US4378363A Certain heterocyclic-carboxamido-phenoxy-aminopropanols, compositions containing same and methods of using same 失效
标题翻译：某些杂环 - 甲酰胺基 - 苯氧基 - 氨基丙醇，含有它们的组合物及其使用方法
公开(公告)号：US4378363A
公开(公告)日：1983-03-29
申请号：US207527
申请日：1980-11-17
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Gisbert Sponer , Karl Dietmann
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Gisbert Sponer , Karl Dietmann
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4406 , A61K31/4418 , A61K31/455 , A61P9/00 , A61P25/02 , C07D207/26 , C07D207/27 , C07D207/34 , C07D209/18 , C07D209/42 , C07D209/43 , C07D213/81 , C07D213/82 , C07D215/48 , C07D235/24 , C07D307/85
CPC分类号： C07D207/27 , C07D207/34 , C07D209/18 , C07D209/42 , C07D213/81 , C07D213/82 , C07D215/48 , C07D235/24 , C07D307/85 , Y10S514/821
摘要： This invention relates to new aminopropanol compounds having beta-adrenergic activity. In addition, the invention is directed to pharmaceutical compositions containing such compounds for the treatment of cardiac and circulatory infirmities and to methods for treating such infirmities.More particularly, the invention relates to new aminopropanol compound of the formula ##STR1## wherein R.sub.1 is a low alkyl moiety, which can be substituted, if desired, by a group Z-R.sub.5 ;R.sub.2 is hydrogen or a low alkanoyl group;R.sub.3 is a mono- or bicyclic heterocyclic compound having 1 to 2 hetero atoms, which can be mono- or polysubstituted, if desired, by halogen, amino, hydroxyl, low alkoxyl, low alkyl;R.sub.4 is hydrogen, a low alkanoyl group or an aroyl group;R.sub.5 is hydrogen or a carbocyclic or heterocyclic aryl moiety, which can be mono- or polysubstituted, if desired, by hydroxyl, low alkyl, low alkenyl, low alkoxyl or low alkenyloxyl;X is a valence bond or a methylene group; andZ is a valence bond, an oxygen atom, or a sulfur atom, and their pharmacologically compatible salts.
摘要翻译：本发明涉及具有β-肾上腺素能活性的新的氨基丙醇化合物。此外，本发明涉及含有用于治疗心脏和循环系统疾病的化合物的药物组合物以及用于治疗这些病症的方法。更具体地，本发明涉及式（I）的新的氨基丙醇化合物，其中R 1是低级烷基部分，如果需要，可以被Z-R5基团取代; R2是氢或低烷酰基; R3是具有1至2个杂原子的单环或双环杂环化合物，如果需要，可以被卤素，氨基，羟基，低烷氧基，低级烷基单取代或多取代; R4是氢，低级烷酰基或芳酰基; R5是氢或碳环或杂环芳基部分，如果需要，可以被羟基，低级烷基，低级链烯基，低烷氧基或低链烯氧基单取代或多取代; X是价键或亚甲基; Z是价键，氧原子或硫原子，以及它们的药理学上相容的盐。

5. 发明授权

US4146630A Blood pressure lowering and adrenergic .beta.-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers 失效
标题翻译：血压降低和ADRENERGIC“ - 抑制3-（4-苯甲酰氨基哌啶）丙基苯基醚
公开(公告)号：US4146630A
公开(公告)日：1979-03-27
申请号：US846057
申请日：1977-10-27
申请人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
发明人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D401/12 , A61K31/403 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/445 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D209/90 , C07D211/22 , C07D231/56
CPC分类号： C07D211/22 , C07D231/56
摘要： A 3-(4-phenoxymethylpiperidino)-propyl-phenyl-ether of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, lower alkyl, hydroxyalkyl, lower alkanoyloxyalkyl or --CO--Z,Z is hydroxy, lower alkyloxy or ##STR2## R.sub.6 and R.sub.7 each independently is hydrogen, lower alkyl or hydroxyalkyl,R.sub.3 is hydrogen or --O--R.sub.8,R.sub.8 is hydrogen, lower alkanoyl or aroyl optionally substituted by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, hydroxyl, alkylthio, nitrile, nitro or trifluoromethyl,R.sub.4 and R.sub.5 each independently is hydrogen, halogen, hydroxy, benzyloxy, lower alkyl, lower alkoxy, lower alkylthio, carboxy, benzyloxycarbonyl or lower alkoxycarbonyl,X and Y each independently is nitrogen or ##STR3## R.sub.9 is hydrogen, lower allkyl optionally substituted by --O--R.sub.8, or --CO--Z,or a pharmacologically acceptable salt thereof. The compounds lower blood pressure and inhibit adrenergic .beta.-receptors.

6. 发明授权

US4346093A Heterocyclic oxypropanolamine compounds and pharmaceutical compositions 失效
公开(公告)号：US4346093A
公开(公告)日：1982-08-24
申请号：US117190
申请日：1980-01-31
申请人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Wolfgang Bartsch , Karl Dietmann
发明人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D251/72 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/00 , A61P9/08 , A61P9/12 , A61P25/02 , C07D209/04 , C07D209/08 , C07D209/42 , C07D209/43 , C07D231/56 , C07D233/00 , C07D235/02 , C07D235/06 , C07D235/26 , C07D235/28 , C07D249/08 , C07D249/18 , C07D401/12 , C07D405/12 , A61K31/41
CPC分类号： C07D209/08 , C07D209/42 , C07D235/26 , C07D249/18 , Y10S514/929
摘要： The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl, hydroxyalkyl, alkoxycarbonyl or alkanoyloxyalkyl radicals or together represent an alkylene radical, R.sub.4 is a hydrogen atom or a lower alkanoyl radical or an aroyl radical, R.sub.5 is a hydrogen atom or a lower alkyl radical or an aralkyl radical, R.sub.6 is a hydrogen atom or a lower alkyl radical, R.sub.7 is a hydrogen atom, a hydroxyl group or a lower alkyl radical, Z is a valency bond, a methylene radical or an oxygen or sulphur atom, Ar is a carbocyclic aryl radical or a pyridyl radical, R.sub.8, R.sub.9 and R.sub.10, which can be the same or different, are hydrogen or halogen atoms, hydroxyl groups, lower alkanoyl radicals, lower alkyl radicals, lower alkenyl radicals, lower alkoxy radicals, aralkoxy radicals, allyloxy radicals, lower alkylthio radicals, aminocarbonyl radicals, aminosulphonyl radicals or lower alkanoylamino radicals or R.sub.8 and R.sub.9 together represent a lower alkylenedioxy radical or R.sub.7 and R.sub.8 together represent a --CH.sub.2 --O-- radical and A is --X.sub.1 --Y.sub.1, in which X.sub.1 is a methylene or --NR.sub.11 -- radical, R.sub.11 being a hydrogen atom or a lower alkyl radical, and Y.sub.1 is a methylene radical or .dbd.C.dbd.Q, Q being an oxygen or sulphur atom; or A is --X.sub.2 .dbd.Y.sub.2 --, in which X.sub.2 and Y.sub.2, which can be the same or different and signify nitrogen atoms or .dbd.C(R.sub.12)-- groups, R.sub.12 being a hydrogen atom or a lower alkyl or an alkoxycarbonyl radical, and when --X.sub.2 .dbd.Y.sub.2 -- represents a --CH.dbd.N-- group and R.sub.1 is an alkyl or aralkyl radical, because of the ability of indazole to tautomerise, this can also be localized on the nitrogen atom represented by Y.sub.2, with the proviso that Y.sub.1 or Y.sub.2 is joined to .dbd.N--R.sub.1 in general formula (I), and, when Q is an oxygen atom or --X.sub.2 .dbd.Y.sub.2 -- represents --CR.sub.12 .dbd.CR.sub.12 -- and Z is a valency bond or when --X.sub.1 --Y.sub.1 -- represents ##STR2## and Z is an oxygen atom or a valency bond, either the two symbols R.sub.2 and R.sub.3 do not simultaneously represent hydrogen atoms or R.sub.7 and R.sub.8 together must form a --CH.sub.2 --O-- radical; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.Furthermore, the present invention is concerned with the use of these compounds for the treatment of cardiac and circulatory diseases.

7. 发明授权

US4486442A Anti-allergy bicyclic phenol ethers 失效
标题翻译：抗过敏双酚酚醚
公开(公告)号：US4486442A
公开(公告)日：1984-12-04
申请号：US469856
申请日：1983-02-25
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch nee Apostolides , Wolfgang Schaumann
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch nee Apostolides , Wolfgang Schaumann
IPC分类号： A61K31/443 , A61K31/445 , A61P37/08 , C07D307/83 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , C07D307/83 , C07D405/12
摘要： The present invention provides bicyclic phenol ethers of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom or an acyl radical,X is an oxygen or sulphur atom or an --NH-- group;Y is a --CO--CHR.sub.3 -- group or a ##STR2## group; R.sub.3 is a hydrogen atom, a lower alkyl radical which can be optionally substituted by an aryl radical, or a cycloalkyl radical containing 3 to 7 carbon atoms; andR.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms, lower alkyl radicals, lower alkyl radicals, alkenyl radicals containing 2 to 16 carbon atoms, which can be optionally substituted by an aryl radical, or an aryl radical; orR.sub.4 and R.sub.5, together with the carbon atom to which they are attached, form a cycloalkyl ring containing 3 to 7 carbon atoms; and thesalts thereof with pharmacologically acceptable acids.The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.
摘要翻译：本发明提供以下通式的双环酚醚：其中R 1为氢原子或低级烷基，R 2为氢原子或酰基，X为氧或硫原子或 - NH-基团; Y是-CO-CHR3-基团或基团; R3是氢原子，可任意被芳基取代的低级烷基或含有3至7个碳原子的环烷基; 和可以相同或不同的R 4和R 5是氢原子，低级烷基，低级烷基，含有2至16个碳原子的烯基，其可任选被芳基或芳基取代; 或R 4和R 5与它们所连接的碳原子一起形成含有3至7个碳原子的环烷基环; 其盐与药理学上可接受的酸。本发明还提供了制备这些化合物的方法，以及含有它们的药物组合物。

8. 发明授权

US4348401A N-Phenoxyalkylpiperidine derivatives 失效
标题翻译： N-苯氧基烷基哌啶衍生物
公开(公告)号：US4348401A
公开(公告)日：1982-09-07
申请号：US185839
申请日：1980-09-10
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Max Thiel , Wolfgang Schaumann , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Max Thiel , Wolfgang Schaumann , Otto-Henning Wilhelms
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61P11/14 , A61P37/00 , C07D211/22 , C07D211/58 , C07D401/12 , C07D409/12 , C07D409/14 , A61K31/455 , C07D403/12 , C07D407/12
CPC分类号： C07D211/58 , C07D211/22 , Y10S514/87
摘要： An N-phenoxyalkylpiperidine derivative of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R.sub.2 is a hydroxymethyl radical, a cyano group, an amidino group, an amidino group substituted by hydroxyl, a 1H tetrazol-5-yl radical or a --CO--R.sub.3 radical, R.sub.3 is a hydroxyl group, a lower alkoxy radical, an amino group, or an amino group substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms, and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; or a pharmacologically acceptable salt thereof. The compounds exhibit anti-histaminic, anti-oedematous and anti-phlogistic activity.
摘要翻译：其中R 1是氢原子，酰基或任意取代的芳基，R 2是羟甲基，氰基，脒基，被羟基取代的脒基， 1H-四唑-5-基或-CO-R 3基团，R 3是羟基，低级烷氧基，氨基或被1H-四唑-5-基取代的氨基，X是亚氨基基团或氧甲基，A是含有2至4个碳原子的亚烷基，B是价键或4-羟基嘧啶-2,5-二基; 或其药理学上可接受的盐。该化合物表现出抗组胺，抗氧化和抗病毒活性。

9. 发明授权

US4234585A 1,2-Dihydroquinoline-2-one derivatives 失效
标题翻译： 1,2-二氢喹啉-2-酮衍生物
公开(公告)号：US4234585A
公开(公告)日：1980-11-18
申请号：US45472
申请日：1979-06-04
申请人： Werner Winter , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
发明人： Werner Winter , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
IPC分类号： C07D215/22 , A61K31/4704 , A61K31/495 , A61P37/08 , C07D215/227 , C07D215/26 , C07D401/12
CPC分类号： C07D215/227 , C07D215/26
摘要： A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 each independently is hydrogen or a lower alkyl radical,R.sub.4 is hydrogen, halogen, or a lower alkyl or lower alkoxy radical,n is 2, 3, 4 or 5 andA is a valency bond or a methylene radical optionally substituted by a phenyl radical,or a salt thereof, which exhibits anti-allergic and anti-hypertensive activity.
摘要翻译：下式的（4-取代 - 哌嗪-1-基） - 烷氧基-2-氧代-1,2-二氢喹啉：其中R 1，R 2和R 3各自独立地是氢或低级烷基，R 4是氢，卤素或低级烷基或低级烷氧基，n为2,3,4或5，A为任选被苯基或其盐取代的价键或亚甲基，其表现出抗过敏和抗高血压活动。

10. 发明授权

US4904666A Pyrazolo(3,4-d)pyrimidine compounds, compositions and method of use 失效
标题翻译：吡唑并（3,4-d）嘧啶化合物，组合物和使用方法
公开(公告)号：US4904666A
公开(公告)日：1990-02-27
申请号：US181729
申请日：1988-04-14
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Otto-Henning Wilhelms
IPC分类号： A61K31/505 , A61K31/519 , A61P11/08 , A61P11/16 , A61P29/00 , A61P37/08 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides pyrazolo[3,4-d]-pyrimidines of the general formula: ##STR1## wherein R.sub.1 is a C.sub.1 to C.sub.6 -alkyl radical, a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aryl radical, R.sub.2 is a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aralkyl or hetaralkyl radical with 1 to 6 carbon atoms in the alkyl moiety and substituted, if desired, one or more times by halogen, C.sub.1 to C.sub.6 -alkyl, hydroxyl, C.sub.1 to C.sub.6 -alkoxy, C.sub.1 to C.sub.3 -haloalkyl, C.sub.3 to C.sub.7 -alkoxy carbonyl, aminocarbonyl, C.sub.2 to C.sub.7 -alkylaminocarbonyl, C.sub.3 to C.sub.13 -dialkylaminocarbonyl, cyano or C.sub.1 to C.sub.6 -alkylthio and R.sub.3 is a hydrogen atom or a C.sub.2 to C.sub.6 -alkyl radical substituted, if desired, one or more times by hydroxyl or is a tetrahydrofuranyl or tetrahydropyranyl radical, with the proviso that R.sub.2 cannot be an unsubstituted benzyl radical when R.sub.1 is a methyl radical, and the physiologically acceptable salts thereof with inorganic and organic acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
摘要翻译：本发明提供通式如下的吡唑并[3,4-d] - 嘧啶：其中R 1为C 1至C 6 - 烷基，C 2至C 6链烯基，C 3至C 7环烷基基团或芳基，R 2是C 2至C 6 - 烯基，C 3至C 7 - 环烷基或在烷基部分具有1至6个碳原子的芳烷基或杂烷基，如果需要，卤素，C1至C6烷基，羟基，C1至C6烷氧基，C1至C3-卤代烷基，C3至C7-烷氧基羰基，氨基羰基，C2至C7-烷基氨基羰基，C3至C13-二烷基氨基羰基，氰基或C1至C6-烷硫基并且R 3是氢原子或C 2至C 6烷基如果需要，被羟基取代一次或多次，或者是四氢呋喃基或四氢吡喃基，条件是当R 1是甲基时，R 2不能是未被取代的苄基，以及其与无机和有机酸的生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式