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1. 发明授权

US4486442A Anti-allergy bicyclic phenol ethers 失效
标题翻译：抗过敏双酚酚醚
公开(公告)号：US4486442A
公开(公告)日：1984-12-04
申请号：US469856
申请日：1983-02-25
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch nee Apostolides , Wolfgang Schaumann
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch nee Apostolides , Wolfgang Schaumann
IPC分类号： A61K31/443 , A61K31/445 , A61P37/08 , C07D307/83 , C07D401/12 , C07D405/12 , C07D409/12
CPC分类号： C07D401/12 , C07D307/83 , C07D405/12
摘要： The present invention provides bicyclic phenol ethers of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom or an acyl radical,X is an oxygen or sulphur atom or an --NH-- group;Y is a --CO--CHR.sub.3 -- group or a ##STR2## group; R.sub.3 is a hydrogen atom, a lower alkyl radical which can be optionally substituted by an aryl radical, or a cycloalkyl radical containing 3 to 7 carbon atoms; andR.sub.4 and R.sub.5, which can be the same or different, are hydrogen atoms, lower alkyl radicals, lower alkyl radicals, alkenyl radicals containing 2 to 16 carbon atoms, which can be optionally substituted by an aryl radical, or an aryl radical; orR.sub.4 and R.sub.5, together with the carbon atom to which they are attached, form a cycloalkyl ring containing 3 to 7 carbon atoms; and thesalts thereof with pharmacologically acceptable acids.The present invention also provides processes for the preparation of these compounds, as well as pharmaceutical compositions containing them.
摘要翻译：本发明提供以下通式的双环酚醚：其中R 1为氢原子或低级烷基，R 2为氢原子或酰基，X为氧或硫原子或 - NH-基团; Y是-CO-CHR3-基团或基团; R3是氢原子，可任意被芳基取代的低级烷基或含有3至7个碳原子的环烷基; 和可以相同或不同的R 4和R 5是氢原子，低级烷基，低级烷基，含有2至16个碳原子的烯基，其可任选被芳基或芳基取代; 或R 4和R 5与它们所连接的碳原子一起形成含有3至7个碳原子的环烷基环; 其盐与药理学上可接受的酸。本发明还提供了制备这些化合物的方法，以及含有它们的药物组合物。

2. 发明授权

US4348401A N-Phenoxyalkylpiperidine derivatives 失效
标题翻译： N-苯氧基烷基哌啶衍生物
公开(公告)号：US4348401A
公开(公告)日：1982-09-07
申请号：US185839
申请日：1980-09-10
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Max Thiel , Wolfgang Schaumann , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Max Thiel , Wolfgang Schaumann , Otto-Henning Wilhelms
IPC分类号： A61K31/4427 , A61K31/4433 , A61K31/445 , A61K31/4468 , A61P11/14 , A61P37/00 , C07D211/22 , C07D211/58 , C07D401/12 , C07D409/12 , C07D409/14 , A61K31/455 , C07D403/12 , C07D407/12
CPC分类号： C07D211/58 , C07D211/22 , Y10S514/87
摘要： An N-phenoxyalkylpiperidine derivative of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, an acyl radical or an optionally substituted aryl radical, R.sub.2 is a hydroxymethyl radical, a cyano group, an amidino group, an amidino group substituted by hydroxyl, a 1H tetrazol-5-yl radical or a --CO--R.sub.3 radical, R.sub.3 is a hydroxyl group, a lower alkoxy radical, an amino group, or an amino group substituted by a 1H-tetrazol-5-yl radical, X is an imino group or an oxymethyl radical, A is an alkylene radical containing 2 to 4 carbon atoms, and B is a valency bond or a 4-hydroxypyrimidin-2,5-diyl radical; or a pharmacologically acceptable salt thereof. The compounds exhibit anti-histaminic, anti-oedematous and anti-phlogistic activity.
摘要翻译：其中R 1是氢原子，酰基或任意取代的芳基，R 2是羟甲基，氰基，脒基，被羟基取代的脒基， 1H-四唑-5-基或-CO-R 3基团，R 3是羟基，低级烷氧基，氨基或被1H-四唑-5-基取代的氨基，X是亚氨基基团或氧甲基，A是含有2至4个碳原子的亚烷基，B是价键或4-羟基嘧啶-2,5-二基; 或其药理学上可接受的盐。该化合物表现出抗组胺，抗氧化和抗病毒活性。

3. 发明授权

US3996361A N.sup.6 -Substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenines 失效
标题翻译： N {HU 6 {B-取代-9- {8- 3-（4-苯基 - 哌嗪基） - 丙基{9-腺嘌呤
公开(公告)号：US3996361A
公开(公告)日：1976-12-07
申请号：US531420
申请日：1974-12-10
申请人： Walter-Gunar Friebe , Max Thiel , Werner Winter , Androniki Roesch , Wolfgang Schaumann
发明人： Walter-Gunar Friebe , Max Thiel , Werner Winter , Androniki Roesch , Wolfgang Schaumann
IPC分类号： C07D473/34 , A61K31/395 , A61K31/50 , A61K31/52 , C07D20060101 , C07D241/04 , C07D295/04 , C07D295/12 , C07D295/13 , C07D403/06 , C07D403/14 , C07D405/06 , C07D473/00 , C07D475/06
CPC分类号： Y10S514/826
摘要： A N.sup.6 -substituted-9-[3-(4-phenyl-piperazino)-propyl]-adenine of the formula ##STR1## wherein R.sub.1 is hydrogen or a lower alkyl radical, andR.sub.2 is a lower alkyl radical, a lower alkyl radical substituted by at least one of phenyl and hydroxyl, a lower alkenyl radical, a cycloalkyl radical or an aryl radical, orR.sub.1 and R.sub.2 together with the nitrogen atom to which they are attached form a piperidine, pyrrolidine or morpholine ring, andR.sub.3 is hydrogen, halogen, a lower alkyl radical or a lower alkoxy radical,Or a salt thereof with a pharmacologically compatible acid, which compounds are characterized by marked anti-edematous activity as well as by activity in reducing capillary permeability.
摘要翻译：式（I）的N6-取代-9- [3-（4-苯基 - 哌嗪子基） - 丙基] - 腺嘌呤，其中R 1是氢或低级烷基，R 2是低级烷基，被苯基和羟基中的至少一个取代的低级烷基，低级烯基，环烷基或芳基，或者R 1和R 2与它们所连接的氮原子一起形成哌啶，吡咯烷或吗啉环，以及 R3是氢，卤素，低级烷基或低级烷氧基，或其盐与药理学上相容的酸，其化合物由标记的抗病毒活性表征，以及活性降低毛细管渗透性。

4. 发明授权

US4288442A Inhibiting adrenergic .beta.-receptors with piperidinopropyl derivatives 失效
标题翻译：用哌啶丙基衍生物抑制肾上腺素β受体
公开(公告)号：US4288442A
公开(公告)日：1981-09-08
申请号：US117172
申请日：1980-01-31
申请人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Gisbert Sponer , Wolfgang Schaumann
发明人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Gisbert Sponer , Wolfgang Schaumann
IPC分类号： C07D401/12 , A61K31/44 , A61K31/4427 , A61K31/4523 , A61K31/505 , A61P9/08 , A61P9/12 , A61P25/02 , C07C205/56 , C07D209/04 , C07D209/08 , C07D209/82 , C07D211/14 , C07D211/22 , C07D235/04 , C07D401/14 , A61K31/445
CPC分类号： C07D211/22 , C07C205/56
摘要： A piperidinopropyl derivative of the formula ##STR1## in which R.sub.1 and R.sub.2 each independently is hydrogen or a lower alkyl radical, or together are an alkylene radical,R.sub.3 is hydrogen, hydroxy, or acyloxy,R.sub.4 is hydrogen or formyl,A together with the adjacent benzene ring and N-R.sub.4 forms a benzimidazolin-2-one, benzimidazoline-2-thione, oxindole, indazole carbazole, benztriazole, benzimidazole, indoline or indole moiety, andB is a heterocyclic radical or, under certain circumstances, a phenyl radical, either of which is optionally substituted by halogen, hydroxy, lower alkyl, hydroxy-lower alkyl, carboxamido-lower alkyl, lower alkoxy, amino, carboxamido, lower alkyl-carbonylamino, acyl or lower alkylsulphonylamino,or a pharmacologically acceptable salt thereof. The compounds inhibit adrenergic .beta.-receptors and lower blood pressure.
摘要翻译：其中R 1和R 2各自独立地是氢或低级烷基，或者一起是亚烷基，R 3是氢，羟基或酰氧基，R 4是氢或甲酰基，A和相邻的苯环和N-R4形成苯并咪唑啉-2-酮，苯并咪唑啉-2-硫酮，羟吲哚，吲唑咔唑，苯并三唑，苯并咪唑，二氢吲哚或吲哚部分，B为杂环基团，或在某些情况下为苯基羟基，低级烷基，羟基 - 低级烷基，甲酰胺基 - 低级烷基，低级烷氧基，氨基，甲酰氨基，低级烷基 - 羰基氨基，酰基或低级烷基磺酰基氨基，或其药理学上可接受的盐。这些化合物抑制肾上腺素能β受体和降低血压。

5. 发明授权

US4212866A Pharmaceutically active derivatives of 9-[3-(4-amino-piperidino)-propyl]-adenines 失效
标题翻译： 9- [3-（4-氨基 - 哌啶子基） - 丙基] - 腺苷的药物活性衍生物
公开(公告)号：US4212866A
公开(公告)日：1980-07-15
申请号：US006050
申请日：1979-01-24
申请人： Walter-Gunar Friebe , Max Thiel , Androniki Roesch , Otto-Henning Wilhelms , Wolfgang Schaumann
发明人： Walter-Gunar Friebe , Max Thiel , Androniki Roesch , Otto-Henning Wilhelms , Wolfgang Schaumann
IPC分类号： A61K31/52 , A61P29/00 , A61P37/08 , C07D211/58 , C07D473/34 , C07D473/00
CPC分类号： C07D473/34 , C07D211/58 , Y10S514/826
摘要： Novel 9-[3-(4-amino-piperidino)-propyl]-adenine derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl radical,R.sub.2 is a hydrogen atom, an aryl radical, a lower alkyl radical, a hydroxy lower alkyl radical, or together with R.sub.1 and the nitrogen atom to which they are attached form a heterocyclic ring, andR.sub.3 is a hydrogen atom or an acyl radical,or salts thereof with pharmacologically acceptable acids, characterized by anti-allergic, anti-inflammatory and anti-oedematous activity.
摘要翻译：新颖的式[IMAGE]的9- [3-（4-氨基 - 哌啶子基） - 丙基] - 腺嘌呤衍生物，其中R1是氢原子或低级烷基，R2是氢原子，芳基，低级烷基基团，羟基低级烷基或与R 1和它们所连接的氮原子一起形成杂环，并且R 3是氢原子或酰基，或其与药理学上可接受的酸的盐，其特征在于抗过敏，抗炎和抗水肿活性。

6. 发明授权

US4234585A 1,2-Dihydroquinoline-2-one derivatives 失效
标题翻译： 1,2-二氢喹啉-2-酮衍生物
公开(公告)号：US4234585A
公开(公告)日：1980-11-18
申请号：US45472
申请日：1979-06-04
申请人： Werner Winter , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
发明人： Werner Winter , Walter-Gunar Friebe , Wolfgang Kampe , Androniki Roesch , Otto-Henning Wilhelms
IPC分类号： C07D215/22 , A61K31/4704 , A61K31/495 , A61P37/08 , C07D215/227 , C07D215/26 , C07D401/12
CPC分类号： C07D215/227 , C07D215/26
摘要： A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 each independently is hydrogen or a lower alkyl radical,R.sub.4 is hydrogen, halogen, or a lower alkyl or lower alkoxy radical,n is 2, 3, 4 or 5 andA is a valency bond or a methylene radical optionally substituted by a phenyl radical,or a salt thereof, which exhibits anti-allergic and anti-hypertensive activity.
摘要翻译：下式的（4-取代 - 哌嗪-1-基） - 烷氧基-2-氧代-1,2-二氢喹啉：其中R 1，R 2和R 3各自独立地是氢或低级烷基，R 4是氢，卤素或低级烷基或低级烷氧基，n为2,3,4或5，A为任选被苯基或其盐取代的价键或亚甲基，其表现出抗过敏和抗高血压活动。

7. 发明授权

US4904666A Pyrazolo(3,4-d)pyrimidine compounds, compositions and method of use 失效
标题翻译：吡唑并（3,4-d）嘧啶化合物，组合物和使用方法
公开(公告)号：US4904666A
公开(公告)日：1990-02-27
申请号：US181729
申请日：1988-04-14
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Otto-Henning Wilhelms
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Otto-Henning Wilhelms
IPC分类号： A61K31/505 , A61K31/519 , A61P11/08 , A61P11/16 , A61P29/00 , A61P37/08 , C07D487/04
CPC分类号： C07D487/04
摘要： The present invention provides pyrazolo[3,4-d]-pyrimidines of the general formula: ##STR1## wherein R.sub.1 is a C.sub.1 to C.sub.6 -alkyl radical, a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aryl radical, R.sub.2 is a C.sub.2 to C.sub.6 -alkenyl radical, a C.sub.3 to C.sub.7 -cycloalkyl radical or an aralkyl or hetaralkyl radical with 1 to 6 carbon atoms in the alkyl moiety and substituted, if desired, one or more times by halogen, C.sub.1 to C.sub.6 -alkyl, hydroxyl, C.sub.1 to C.sub.6 -alkoxy, C.sub.1 to C.sub.3 -haloalkyl, C.sub.3 to C.sub.7 -alkoxy carbonyl, aminocarbonyl, C.sub.2 to C.sub.7 -alkylaminocarbonyl, C.sub.3 to C.sub.13 -dialkylaminocarbonyl, cyano or C.sub.1 to C.sub.6 -alkylthio and R.sub.3 is a hydrogen atom or a C.sub.2 to C.sub.6 -alkyl radical substituted, if desired, one or more times by hydroxyl or is a tetrahydrofuranyl or tetrahydropyranyl radical, with the proviso that R.sub.2 cannot be an unsubstituted benzyl radical when R.sub.1 is a methyl radical, and the physiologically acceptable salts thereof with inorganic and organic acids.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.
摘要翻译：本发明提供通式如下的吡唑并[3,4-d] - 嘧啶：其中R 1为C 1至C 6 - 烷基，C 2至C 6链烯基，C 3至C 7环烷基基团或芳基，R 2是C 2至C 6 - 烯基，C 3至C 7 - 环烷基或在烷基部分具有1至6个碳原子的芳烷基或杂烷基，如果需要，卤素，C1至C6烷基，羟基，C1至C6烷氧基，C1至C3-卤代烷基，C3至C7-烷氧基羰基，氨基羰基，C2至C7-烷基氨基羰基，C3至C13-二烷基氨基羰基，氰基或C1至C6-烷硫基并且R 3是氢原子或C 2至C 6烷基如果需要，被羟基取代一次或多次，或者是四氢呋喃基或四氢吡喃基，条件是当R 1是甲基时，R 2不能是未被取代的苄基，以及其与无机和有机酸的生理上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的药物组合物。

8. 发明授权

US4721717A .alpha.-(aminoalkylaminomethyl)phenylmethanols, composition containing them, and use thereof to treat certain heart and circulatory diseases 失效
标题翻译： α-（氨基烷基氨基甲基）苯基甲醇，含有它们的组合物及其用于治疗某些心脏和循环系统疾病的用途
公开(公告)号：US4721717A
公开(公告)日：1988-01-26
申请号：US760128
申请日：1985-07-29
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Erwin Bohm , Klaus Strein
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Erwin Bohm , Klaus Strein
IPC分类号： A61K31/135 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/496 , A61K31/505 , A61P9/00 , C07C67/00 , C07C213/00 , C07C213/04 , C07C215/30 , C07C215/60 , C07C301/00 , C07C303/40 , C07C311/08 , C07C313/00 , C07C315/04 , C07C317/32 , C07C317/36 , C07C317/48 , C07D209/30 , C07D231/38 , C07D231/56 , C07D235/04 , C07D239/54 , C07D235/30 , C07D239/10
CPC分类号： C07D231/38 , C07D231/56
摘要： The present invention provides aminoalcohols of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which can be same or different, are hydrogen atoms, hydroxyl groups, C.sub.1 -C.sub.4 -alkoxy, benzyloxy, C.sub.1 -C.sub.4 -alkoxycarbonyl, C.sub.1 -C.sub.4 -alkanesulphonylamino, C.sub.1 -C.sub.4 -alkanesulphinyl or C.sub.1 -C.sub.4 -alkanesulphonyl radicals, m is 2, 3 or 4, X and Y, which can be the same or different, are hydrogen atoms or benzyl radicals and R.sub.3 is a phenyl radical substituted twice by C.sub.1 -C.sub.6 -alkyl radicals, a nitrophenyl radical, an aminophenyl radical, a 1,3,5-tri-C.sub.1 -C.sub.6 -alkyl-2,4-dioxo-1H,3H-pyrimidin-6-yl radical, an indolyl radical, an indazolyl radical, a benzimidazolyl radical, a 1,4-di-C.sub.1 -C.sub.6 -alkylpyrazol-5-yl radical or a radical of the general formula: ##STR2## wherein R.sub.4 and R.sub.5, which can be the same or different, are C.sub.1 -C.sub.4 -alkyl radicals and R.sub.6 is a C.sub.1 -C.sub.6 -alkyl, C.sub.2 -C.sub.6 -alkenyl, phenyl or benzyl radical; and the pharmacologically acceptable salts there, as well as methods for making and using these compounds and compositions containing them. There are useful as cardiovascular medicaments.
摘要翻译：本发明提供以下通式的氨基醇：其中R 1和R 2可以相同或不同，为氢原子，羟基，C 1 -C 4 - 烷氧基，苄氧基，C 1 -C 4 - 烷氧基羰基，C 1 C 1-4烷基磺酰基氨基，C 1 -C 4烷基亚磺酰基或C 1 -C 4烷基磺酰基，m为2,3或4，X和Y可相同或不同，为氢原子或苄基，R 3为苯基由C 1 -C 6烷基取代两次，硝基苯基，氨基苯基，1,3,5-三-C1- C6-烷基-2,4-二氧代-1H，3H-嘧啶-6-基，吲哚基，吲唑基，苯并咪唑基，1,4-二-C1- C6烷基吡唑-5-基或通式如下的基团：其中R4和R5可以是 C 1 -C 4 - 烷基，R 6是C 1 -C 6 - 烷基，C 2 -C 6 - 烯基，苯基或苄基; 和其中的药理学上可接受的盐，以及制备和使用这些化合物和含有它们的组合物的方法。有用的心血管药物。

9. 发明授权

US4906666A Hydroxamic acids and pharmaceutical compositions containing them, and anti-allergic use thereof 失效
标题翻译：羟肟酸和含有它们的药物组合物及其抗过敏应用
公开(公告)号：US4906666A
公开(公告)日：1990-03-06
申请号：US11096
申请日：1987-02-05
申请人： Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
发明人： Erhard Reinholz , Walter-Gunar Friebe , Wolfgang Kampe , Jurgen Mertin , Otto-Henning Wilhelms
IPC分类号： A61K31/10 , A61K31/135 , A61K31/165 , A61K31/19 , A61K31/235 , A61K31/26 , A61K31/275 , A61K31/41 , A61P11/00 , A61P29/00 , A61P37/08 , C07C67/00 , C07C313/00 , C07C315/02 , C07C317/18 , C07C317/44 , C07C323/12 , C07C323/14 , C07C323/20 , C07C323/52 , C07C323/54 , C07C323/60 , C07C325/00 , C07C331/04 , C07D257/04 , C07D257/06
CPC分类号： C07D257/04 , A61K31/10 , A61K31/26 , A61K31/275 , C07C323/12 , C07C323/52 , C07C323/60 , C07C331/04 , C07D257/06
摘要： The present invention provides compounds of the general formula: ##STR1## wherein Ar is a phenyl radical optionally substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen, A is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 aliphatic hydrocarbon radical which is optionally substituted by a hydroxyl group, n is 0, 1 or 2, B is a straight-chained or branched, saturated or unsaturated C.sub.1 -C.sub.8 -aliphatic hydrocarbon radical and R is 5-(1H)-tetrazolyl, --CO--NH-tetrazolyl, ##STR2## CN, SCN, OH, halogen, 5-(1H)-tetrazolylthio, ##STR3## or CO--O--NH--R.sub.1, wherein R.sub.1 is a hydrogen atom, an alkyl radical optionally substituted by cycloalkyl or an alkenyl, cycloalkyl, aralkyl or aryl radical, wherein the aromatic moiety can be substituted by alkyl, alkenyl, alkoxy, alkylthio, alkanoyl, hydroxyl, hydroxyalkyl, carboxyl, alkoxycarbonyl, carbamoyl, nitro, amino or halogen; and the pharmacologically acceptable salts thereof. The present invention also provides processes for preparing these compounds and pharmaceutical compositions containing them for combating allergic diseases.
摘要翻译：本发明提供以下通式的化合物：其中Ar是任选被烷基，烯基，烷氧基，烷硫基，烷酰基，羟基，羟基烷基，羧基，烷氧基羰基，氨基甲酰基，硝基，氨基或卤素取代的苯基 A是直链或支链，饱和或不饱和的C1-C8脂族烃基，其任选被羟基取代，n是0,1或2，B是直链或支链的饱和或不饱和的C1- C8-脂族烃基，R是5-（1H） - 四唑基，-CO-NH-四唑基，CN，SCN，OH，卤素，5-（1H） - 四唑基硫代， NH-R1，其中R1是氢原子，任选被环烷基或烯基，环烷基，芳烷基或芳基取代的烷基，其中芳族部分可以被烷基，烯基，烷氧基，烷硫基，烷酰基，羟基，羟烷基，羧基，烷氧基羰基，氨基甲酰基，硝基，氨基或卤素; 及其药理学上可接受的盐。本发明还提供了制备这些化合物的方法和含有它们的用于防治过敏性疾病的药物组合物。

10. 发明授权

US4146630A Blood pressure lowering and adrenergic .beta.-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers 失效
标题翻译：血压降低和ADRENERGIC“ - 抑制3-（4-苯甲酰氨基哌啶）丙基苯基醚
公开(公告)号：US4146630A
公开(公告)日：1979-03-27
申请号：US846057
申请日：1977-10-27
申请人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
发明人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D401/12 , A61K31/403 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/445 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D209/90 , C07D211/22 , C07D231/56
CPC分类号： C07D211/22 , C07D231/56
摘要： A 3-(4-phenoxymethylpiperidino)-propyl-phenyl-ether of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, lower alkyl, hydroxyalkyl, lower alkanoyloxyalkyl or --CO--Z,Z is hydroxy, lower alkyloxy or ##STR2## R.sub.6 and R.sub.7 each independently is hydrogen, lower alkyl or hydroxyalkyl,R.sub.3 is hydrogen or --O--R.sub.8,R.sub.8 is hydrogen, lower alkanoyl or aroyl optionally substituted by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, hydroxyl, alkylthio, nitrile, nitro or trifluoromethyl,R.sub.4 and R.sub.5 each independently is hydrogen, halogen, hydroxy, benzyloxy, lower alkyl, lower alkoxy, lower alkylthio, carboxy, benzyloxycarbonyl or lower alkoxycarbonyl,X and Y each independently is nitrogen or ##STR3## R.sub.9 is hydrogen, lower allkyl optionally substituted by --O--R.sub.8, or --CO--Z,or a pharmacologically acceptable salt thereof. The compounds lower blood pressure and inhibit adrenergic .beta.-receptors.

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