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1. 发明授权

US4346093A Heterocyclic oxypropanolamine compounds and pharmaceutical compositions 失效
公开(公告)号：US4346093A
公开(公告)日：1982-08-24
申请号：US117190
申请日：1980-01-31
申请人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Wolfgang Bartsch , Karl Dietmann
发明人： Walter-Gunar Friebe , Helmut Michel , Carl H. Ross , Fritz Wiedemann , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D251/72 , A61K31/40 , A61K31/403 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/443 , A61P9/00 , A61P9/08 , A61P9/12 , A61P25/02 , C07D209/04 , C07D209/08 , C07D209/42 , C07D209/43 , C07D231/56 , C07D233/00 , C07D235/02 , C07D235/06 , C07D235/26 , C07D235/28 , C07D249/08 , C07D249/18 , C07D401/12 , C07D405/12 , A61K31/41
CPC分类号： C07D209/08 , C07D209/42 , C07D235/26 , C07D249/18 , Y10S514/929
摘要： The present invention provides heterocyclic oxypropanol derivatives of the general formula: ##STR1## wherein R.sub.1 is a hydrogen atom or a lower alkyl, aralkyl or lower alkanoyl radical, R.sub.2 and R.sub.3, which can be the same or different, are hydrogen atoms or lower alkyl, hydroxyalkyl, alkoxycarbonyl or alkanoyloxyalkyl radicals or together represent an alkylene radical, R.sub.4 is a hydrogen atom or a lower alkanoyl radical or an aroyl radical, R.sub.5 is a hydrogen atom or a lower alkyl radical or an aralkyl radical, R.sub.6 is a hydrogen atom or a lower alkyl radical, R.sub.7 is a hydrogen atom, a hydroxyl group or a lower alkyl radical, Z is a valency bond, a methylene radical or an oxygen or sulphur atom, Ar is a carbocyclic aryl radical or a pyridyl radical, R.sub.8, R.sub.9 and R.sub.10, which can be the same or different, are hydrogen or halogen atoms, hydroxyl groups, lower alkanoyl radicals, lower alkyl radicals, lower alkenyl radicals, lower alkoxy radicals, aralkoxy radicals, allyloxy radicals, lower alkylthio radicals, aminocarbonyl radicals, aminosulphonyl radicals or lower alkanoylamino radicals or R.sub.8 and R.sub.9 together represent a lower alkylenedioxy radical or R.sub.7 and R.sub.8 together represent a --CH.sub.2 --O-- radical and A is --X.sub.1 --Y.sub.1, in which X.sub.1 is a methylene or --NR.sub.11 -- radical, R.sub.11 being a hydrogen atom or a lower alkyl radical, and Y.sub.1 is a methylene radical or .dbd.C.dbd.Q, Q being an oxygen or sulphur atom; or A is --X.sub.2 .dbd.Y.sub.2 --, in which X.sub.2 and Y.sub.2, which can be the same or different and signify nitrogen atoms or .dbd.C(R.sub.12)-- groups, R.sub.12 being a hydrogen atom or a lower alkyl or an alkoxycarbonyl radical, and when --X.sub.2 .dbd.Y.sub.2 -- represents a --CH.dbd.N-- group and R.sub.1 is an alkyl or aralkyl radical, because of the ability of indazole to tautomerise, this can also be localized on the nitrogen atom represented by Y.sub.2, with the proviso that Y.sub.1 or Y.sub.2 is joined to .dbd.N--R.sub.1 in general formula (I), and, when Q is an oxygen atom or --X.sub.2 .dbd.Y.sub.2 -- represents --CR.sub.12 .dbd.CR.sub.12 -- and Z is a valency bond or when --X.sub.1 --Y.sub.1 -- represents ##STR2## and Z is an oxygen atom or a valency bond, either the two symbols R.sub.2 and R.sub.3 do not simultaneously represent hydrogen atoms or R.sub.7 and R.sub.8 together must form a --CH.sub.2 --O-- radical; and the pharmacologically acceptable salts thereof.The present invention also provides processes for the preparation of these compounds and pharmaceutical compositions containing them.Furthermore, the present invention is concerned with the use of these compounds for the treatment of cardiac and circulatory diseases.

2. 发明授权

US4146630A Blood pressure lowering and adrenergic .beta.-receptor inhibiting 3-(4-phenoxymethylpiperidino)-propyl-phenyl ethers 失效
标题翻译：血压降低和ADRENERGIC“ - 抑制3-（4-苯甲酰氨基哌啶）丙基苯基醚
公开(公告)号：US4146630A
公开(公告)日：1979-03-27
申请号：US846057
申请日：1977-10-27
申请人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
发明人： Wolfgang Kampe , Walter-Gunar Friebe , Fritz Wiedemann , Gisbert Sponer , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D401/12 , A61K31/403 , A61K31/4184 , A61K31/44 , A61K31/4427 , A61K31/445 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07D209/90 , C07D211/22 , C07D231/56
CPC分类号： C07D211/22 , C07D231/56
摘要： A 3-(4-phenoxymethylpiperidino)-propyl-phenyl-ether of the formula ##STR1## wherein R.sub.1 and R.sub.2 each independently is hydrogen, lower alkyl, hydroxyalkyl, lower alkanoyloxyalkyl or --CO--Z,Z is hydroxy, lower alkyloxy or ##STR2## R.sub.6 and R.sub.7 each independently is hydrogen, lower alkyl or hydroxyalkyl,R.sub.3 is hydrogen or --O--R.sub.8,R.sub.8 is hydrogen, lower alkanoyl or aroyl optionally substituted by halogen, lower alkyl, lower alkoxy, alkoxycarbonyl, hydroxyl, alkylthio, nitrile, nitro or trifluoromethyl,R.sub.4 and R.sub.5 each independently is hydrogen, halogen, hydroxy, benzyloxy, lower alkyl, lower alkoxy, lower alkylthio, carboxy, benzyloxycarbonyl or lower alkoxycarbonyl,X and Y each independently is nitrogen or ##STR3## R.sub.9 is hydrogen, lower allkyl optionally substituted by --O--R.sub.8, or --CO--Z,or a pharmacologically acceptable salt thereof. The compounds lower blood pressure and inhibit adrenergic .beta.-receptors.

3. 发明授权

US4378363A Certain heterocyclic-carboxamido-phenoxy-aminopropanols, compositions containing same and methods of using same 失效
标题翻译：某些杂环 - 甲酰胺基 - 苯氧基 - 氨基丙醇，含有它们的组合物及其使用方法
公开(公告)号：US4378363A
公开(公告)日：1983-03-29
申请号：US207527
申请日：1980-11-17
申请人： Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Gisbert Sponer , Karl Dietmann
发明人： Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Gisbert Sponer , Karl Dietmann
IPC分类号： A61K31/40 , A61K31/403 , A61K31/404 , A61K31/4406 , A61K31/4418 , A61K31/455 , A61P9/00 , A61P25/02 , C07D207/26 , C07D207/27 , C07D207/34 , C07D209/18 , C07D209/42 , C07D209/43 , C07D213/81 , C07D213/82 , C07D215/48 , C07D235/24 , C07D307/85
CPC分类号： C07D207/27 , C07D207/34 , C07D209/18 , C07D209/42 , C07D213/81 , C07D213/82 , C07D215/48 , C07D235/24 , C07D307/85 , Y10S514/821
摘要： This invention relates to new aminopropanol compounds having beta-adrenergic activity. In addition, the invention is directed to pharmaceutical compositions containing such compounds for the treatment of cardiac and circulatory infirmities and to methods for treating such infirmities.More particularly, the invention relates to new aminopropanol compound of the formula ##STR1## wherein R.sub.1 is a low alkyl moiety, which can be substituted, if desired, by a group Z-R.sub.5 ;R.sub.2 is hydrogen or a low alkanoyl group;R.sub.3 is a mono- or bicyclic heterocyclic compound having 1 to 2 hetero atoms, which can be mono- or polysubstituted, if desired, by halogen, amino, hydroxyl, low alkoxyl, low alkyl;R.sub.4 is hydrogen, a low alkanoyl group or an aroyl group;R.sub.5 is hydrogen or a carbocyclic or heterocyclic aryl moiety, which can be mono- or polysubstituted, if desired, by hydroxyl, low alkyl, low alkenyl, low alkoxyl or low alkenyloxyl;X is a valence bond or a methylene group; andZ is a valence bond, an oxygen atom, or a sulfur atom, and their pharmacologically compatible salts.
摘要翻译：本发明涉及具有β-肾上腺素能活性的新的氨基丙醇化合物。此外，本发明涉及含有用于治疗心脏和循环系统疾病的化合物的药物组合物以及用于治疗这些病症的方法。更具体地，本发明涉及式（I）的新的氨基丙醇化合物，其中R 1是低级烷基部分，如果需要，可以被Z-R5基团取代; R2是氢或低烷酰基; R3是具有1至2个杂原子的单环或双环杂环化合物，如果需要，可以被卤素，氨基，羟基，低烷氧基，低级烷基单取代或多取代; R4是氢，低级烷酰基或芳酰基; R5是氢或碳环或杂环芳基部分，如果需要，可以被羟基，低级烷基，低级链烯基，低烷氧基或低链烯氧基单取代或多取代; X是价键或亚甲基; Z是价键，氧原子或硫原子，以及它们的药理学上相容的盐。

4. 发明授权

US4367235A 2-Benzimidazolinone compounds and therapeutic compositions 失效
标题翻译： 2-苯并咪唑啉酮化合物和治疗组合物
公开(公告)号：US4367235A
公开(公告)日：1983-01-04
申请号：US171940
申请日：1980-07-18
申请人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
发明人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
IPC分类号： A61K31/415 , A61K31/4184 , A61P9/00 , A61P25/02 , C07D235/02 , C07D235/26
CPC分类号： A61K31/415 , C07D235/02 , C07D235/26
摘要： 2-benzimidazolinone compounds of the formula ##STR1## wherein R is lower alkyl,R.sub.1 and R.sub.2, which can be the same or different, are lower straight-chained or branched alkyl and one of R.sub.1 and R.sub.2 can also be hydrogen orR.sub.1 and R.sub.2 together represent an alkylene radical and R.sub.3 is hydrogen or acyl, i.e., alkanoyl or aromatic carboxylic acid moieties;and the pharmacologically acceptable salts thereof; have marked .beta.-receptor blocking action and are outstandingly useful in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：其中R是低级烷基，可以相同或不同的R 1和R 2的低级直链或支链烷基，R 1和R 2之一也可以是氢或R 1和R 2 一起代表亚烷基，R3是氢或酰基，即烷酰基或芳族羧酸部分; 及其药理学上可接受的盐; 具有明显的β-受体阻断作用，并且在治疗或预防心脏和循环系统疾病方面非常有用。

5. 发明授权

US4215134A 4-Hydroxy-2-benzimidazoline-thione compounds and pharmaceutical compositions containing them 失效
标题翻译： 4-羟基-2-苯并咪唑啉 - 硫酮化合物和含有它们的药物组合物
公开(公告)号：US4215134A
公开(公告)日：1980-07-29
申请号：US2129
申请日：1979-01-09
申请人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
发明人： Carl H. Ross , Walter-Gunar Friebe , Wolfgang Kampe , Wolfgang Bartsch , Egon Roesch
IPC分类号： A61K31/415 , A61K31/4184 , A61P9/00 , C07D235/02 , C07D235/28 , C07D303/22
CPC分类号： C07D235/02 , C07D235/28 , C07D303/22
摘要： Novel 4-hydroxy-2-benzimidazoline-thione compound of the formula: ##STR1## wherein R is lower alkyl;R.sub.1 and R.sub.2, which can be the same or different, are hydrogen or lower straight-chained or branched alkyl orR.sub.1 and R.sub.2 together represent alkylene; andR.sub.3 is a hydrogen atom or an acyl radical;and the pharmacologically acceptable salts thereof; have marked .beta.-receptor blocking action and are outstandingly useful in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：下式的新型4-羟基-2-苯并咪唑啉 - 硫酮化合物：其中R是低级烷基; R 1和R 2可以相同或不同，为氢或低级直链或支链烷基或R 1和R 2一起表示亚烷基; 并且R 3是氢原子或酰基; 及其药理学上可接受的盐; 具有明显的β-受体阻断作用，并且在治疗或预防心脏和循环系统疾病方面非常有用。

6. 发明授权

US4801596A Nitroxy amino propanols for treating heart and circulatory diseases 失效
标题翻译：用于治疗心脏和循环系统疾病的硝基氨基丙醇
公开(公告)号：US4801596A
公开(公告)日：1989-01-31
申请号：US803497
申请日：1985-12-02
申请人： Herbert Simon , Helmut Michel , Walter-Gunar Friebe , Wolfgang Bartsch
发明人： Herbert Simon , Helmut Michel , Walter-Gunar Friebe , Wolfgang Bartsch
IPC分类号： A61K31/135 , A61K31/165 , A61K31/21 , A61K31/275 , A61K31/443 , A61K31/445 , A61P9/08 , A61P9/10 , A61P9/12 , A61P25/02 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/12 , C07C233/16 , C07C235/08 , C07C235/34 , C07C239/00 , C07C253/00 , C07C255/54 , C07C255/59 , C07C269/00 , C07C275/50 , C07C301/00 , C07C311/30 , C07C311/37 , C07C313/00 , C07C317/18 , C07C317/46 , C07D211/22 , C07D211/46 , C07D295/04 , C07D303/22 , C07D405/12
CPC分类号： C07D303/22 , C07C255/00 , C07D211/22 , C07D211/46 , C07D405/12
摘要： The present invention provides new aminopropanol derivatives of the general formula: ##STR1## wherein A is a direct bond, a straight-chained or branched alkylene chain containing up to 3 carbon atoms or a --CO--CH.sub.2 -- group; X is a direct bond or a carbonyl group; B is a straight-chained or branched, saturated or unsaturated alkylene chain containing up to 12 carbon atoms, in which one or two --CH.sub.2 -- groups can also be replaced by a saturated or unsaturated alkylene ring containing 3 to 7 carbon atoms and/or by an oxygen or sulphur atom or an --S(.dbd.O)-- or --S(.dbd.O).sub.2 -- group, n is 1, 2 or 3; R.sub.1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated alkyl radical containing up to 6 carbon atoms or a --B--(ONO.sub.2).sub.n group, in which B and n have the same meanings as above, or when A is a --CO--CH.sub.2 -- group and X is a direct bond, R.sub.1 together with the nitrogen atom and a carbon atom of chain B can represent a heteroaliphatic ring containing 2 to 7 carbon atoms; R.sub.2 is a hydrogen or halogen atom or a cyano, hydroxyl, amino, nitro, carboxyl, carbamoyl, ureido or sulphamoyl group or an alkyl, alkoxy, alkylamino, alkylthio, hydroxyalkyl, aminoalkyl, alkoxycarbonyl, alkylcarbonyl, alkylaminocarbonyl, alkylcarbonylamino, alkoxycarbonylamino or alkylaminocarbonylamino radical; and R.sub.3 is an alkyl or nitroxyalkyl radical containing 3 to 8 carbon atoms; and the physiologically acceptable salts thereof.The present invention also provides processes for the preparation of these aminopropanol derivatives and pharmaceutical compositions containing them, as well as intermediates for the preparation of the new aminopropanol derivatives.
摘要翻译：本发明提供了以下通式的新的氨基丙醇衍生物：其中A是直接键，含有至多3个碳原子的直链或支链亚烷基链或-CO-CH 2 - 基团; X是直接键或羰基; B是含有至多12个碳原子的直链或支链，饱和或不饱和的亚烷基链，其中一个或两个-CH 2 - 基团也可以被含有3至7个碳原子的饱和或不饱和亚烷基环和/或通过氧或硫原子或-S（= O） - 或-S（= O）2 - 基团，n是1,2或3; R1是氢原子或含有至多6个碳原子的直链或支链，饱和或不饱和的烷基或-B-（ONO 2）n基团，其中B和n具有与上述相同的含义，或当A 是-CO-CH 2 - 基团，X是直接键，R 1与氮原子一起形成，链B的碳原子可以表示含有2至7个碳原子的杂脂肪族环; R2是氢或卤原子或氰基，羟基，氨基，硝基，羧基，氨基甲酰基，脲基或氨磺酰基或烷基，烷氧基，烷基氨基，烷硫基，羟基烷基，氨基烷基，烷氧基羰基，烷基羰基，烷基氨基羰基，烷基羰基氨基，烷氧基羰基氨基或烷基氨基羰基氨基激进; R3为含有3-8个碳原子的烷基或硝基烷基; 及其生理上可接受的盐。本发明还提供制备这些氨基丙醇衍生物和含有它们的药物组合物的方法，以及制备新的氨基丙醇衍生物的中间体。

7. 发明授权

US4229464A Aminopropanol substituted indole compounds and compositions for the treatment of cardiac and circulatory diseases 失效
标题翻译：氨基丙醇取代的吲哚化合物和用于治疗心脏和循环系统疾病的组合物
公开(公告)号：US4229464A
公开(公告)日：1980-10-21
申请号：US943512
申请日：1978-09-18
申请人： Wolfgang Kampe , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
发明人： Wolfgang Kampe , Kurt Stach, deceased , by Werner Plattner, administrator , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
IPC分类号： C07D209/43 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/02 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/42 , C07D209/18 , C07D209/20
CPC分类号： C07D209/42 , C07D209/08 , C07D209/12 , Y10S514/927
摘要： New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen and the pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：新的式（I）的氨基丙醇化合物其中R是低级烷基，环烷基或烷硫基烷基，R1是氢或低级烷基，羟烷基，新戊酰氧基烷基，烷氧基烷基，烷氧基羰基，羧基或-CONR3R4，其中R3和R4可以是 R 2为低级烷基，羟基烷基，烷氧基烷基或新戊酰氧基烷基，或当R为烷硫基烷基或R 1为新戊酰氧基烷基时，R 2也可为氢及其药理学上可接受的盐; 在治疗或预防心脏和循环系统疾病方面非常有效。

8. 发明授权

US3976779A 1,2,3,4-Tetrahydro-carbazole compounds and .beta.-adrenergic compositions 失效
标题翻译： 1,2,3,4-四氢咔唑化合物和{62-肾上腺素能组合物
公开(公告)号：US3976779A
公开(公告)日：1976-08-24
申请号：US568743
申请日：1975-04-16
申请人： Herbert Leinert , Alfred Popelak , Kurt Stach , Wolfgang Bartsch , Karl Dietmann
发明人： Herbert Leinert , Alfred Popelak , Kurt Stach , Wolfgang Bartsch , Karl Dietmann
IPC分类号： C07D209/88 , A61K31/40
CPC分类号： C07D209/88
摘要： New 1,2,3,4-tetra-hydrocarbazole derivatives of the formula: ##SPC1##Wherein R.sup.1 is straight-chained or branched alkyl, and the pharmacologically compatible salts thereof, are markedly effective as inhibitors of adrogenic .beta.-receptors and thus useful for the treatment and prophylaxis of cardiac and circulatory diseases.
摘要翻译：新的具有下式的1,2,3,4-四烃基衍生物：

9. 发明授权

US4120963A Certain pyrido[3,4-b]indole-1-ones 失效
标题翻译：某些吡啶并[8,3-b {9吲哚-1-酮
公开(公告)号：US4120963A
公开(公告)日：1978-10-17
申请号：US798736
申请日：1977-05-19
申请人： Wolfgang Kampe , Martin Senn , Max Thiel , Wolfgang Bartsch , Karl Dietmann
发明人： Wolfgang Kampe , Martin Senn , Max Thiel , Wolfgang Bartsch , Karl Dietmann
IPC分类号： A61K31/435 , A61P25/02 , C07D471/04 , C07D471/14 , A61K31/44
CPC分类号： C07D471/04
摘要： New aminopropanol compounds of the formula ##STR1## wherein A is alkylene;B is sulfur or a valency bond;R is a straight-chained or branched lower alkyl; and the pharmacologically compatible salts thereof; are outstandingly effective adrenergic .beta.-receptor inhibitors and useful in the treatment or prophylaxis of circulatory diseases.
摘要翻译：新的式（I）的氨基丙醇化合物，其中A是亚烷基; B是硫或价键; R是直链或支链的低级烷基; 和其药理学上相容的盐; 是非常有效的肾上腺素能β受体抑制剂，可用于治疗或预防循环系统疾病。

10. 发明授权

US4076829A Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases 失效
标题翻译：用于治疗心脏和循环系统疾病的氨基丙醇化合物和组合物
公开(公告)号：US4076829A
公开(公告)日：1978-02-28
申请号：US626512
申请日：1975-10-28
申请人： Wolfgang Kampe , Kurt Stach , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
发明人： Wolfgang Kampe , Kurt Stach , Max Thiel , Wolfgang Bartsch , Karl Dietmann , Egon Roesch , Wolfgang Schaumann
IPC分类号： C07D209/43 , A61K31/40 , A61K31/403 , A61K31/404 , A61P25/02 , C07D209/08 , C07D209/12 , C07D209/32 , C07D209/42 , C07D209/14
CPC分类号： C07D209/42 , C07D209/08 , C07D209/12 , Y10S514/927
摘要： New aminopropanol compounds of the formula ##STR1## wherein R is lower alkyl, cycloalkyl or alkylthioalkyl,R.sub.1 is hydrogen or lower alkyl, hydroxyalkyl, pivaloyloxyalkyl, alkoxyalkyl, alkoxycarbonyl, carboxyl or --CONR.sub.3 R.sub.4, in which R.sub.3 and R.sub.4 which can be the same or different, represent hydrogen or lower alkyl, andR.sub.2 is lower alkyl, hydroxyalkyl, alkoxyalkyl or pivaloyloxyalkyl or, when R is alkylthioalkyl or R.sub.1 is pivaloyloxyalkyl, R.sub.2 can also be hydrogen andThe pharmacologically acceptable salts thereof; are outstandingly effective in the treatment or prophylaxis of cardiac and circulatory diseases.
摘要翻译：式（I）的新的氨基丙醇化合物其中R是低级烷基，环烷基或烷硫基烷基，R1是氢或低级烷基，羟基烷基，新戊酰氧基烷基，烷氧基烷基，烷氧基羰基，羧基或-CONR3R4，其中R3和R4可以是相同或不同，代表氢或低级烷基，R2是低级烷基，羟基烷基，烷氧基烷基或新戊酰氧基烷基，或当R是烷硫基烷基或R1是新戊酰氧基烷基时，R2也可以是氢，并且其药学上可接受的盐; 在治疗或预防心脏病和循环系统疾病方面具有突出优势。

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