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1. 发明申请

US20080208083A1 System and method to counter material deposition on devices in the urinary tract 审中-公开
标题翻译：用于对抗尿道器械上物质沉积的系统和方法
公开(公告)号：US20080208083A1
公开(公告)日：2008-08-28
申请号：US11796231
申请日：2007-04-27
申请人： Bryant Lin , Stewart McCallum , Tatum Tarin , Ross Venook
发明人： Bryant Lin , Stewart McCallum , Tatum Tarin , Ross Venook
IPC分类号： A61H1/00 , A61F7/12
CPC分类号： A61M27/008 , A61F2/82 , A61F2/90 , A61F2/94 , A61F2002/068
摘要： The invention relates to a device and method to counteract the deposition of material on devices that dwell in the urinary tract and which include an operably connected motion-inducing actuator. Counteracting material deposition includes impeding or preventing deposition as well as diminishing extant deposition. Deposition is counteracted by moving the device with the motion-inducing actuator; motion may include movement of the device with respect to its position within the urinary tract, as well as deformational or vibrational movement of the device. Embodiments of the device receive energy from a source either by physical or wireless connection. In some embodiments the motion-inducing actuator is integral with the structure of the device, in other embodiments the actuator is a separate structure. In still other embodiments, the device receives energy directly, without intervention of an actuator. In some of these latter embodiments, the device may include an energy focusing element.
摘要翻译：本发明涉及一种用于抵抗材料沉积在尿道中的装置上并且包括可操作地连接的运动诱导致动器的装置和方法。抵消材料沉积包括妨碍或防止沉积以及减少现存沉积。通过用运动诱导致动器移动装置来抵消沉积; 运动可以包括装置相对于其在尿道内的位置的运动，以及装置的变形或振动运动。设备的实施例通过物理或无线连接从源接收能量。在一些实施例中，运动诱导致动器与装置的结构是一体的，在其它实施例中，致动器是单独的结构。在其他实施例中，该设备直接接收能量，而不需要执行器的干预。在这些后面的实施例中的一些实施例中，该装置可以包括能量聚焦元件。

2. 发明申请

US20070276342A1 Devices and related methods for treating incontinence 审中-公开
标题翻译：用于治疗失禁的装置和相关方法
公开(公告)号：US20070276342A1
公开(公告)日：2007-11-29
申请号：US11729118
申请日：2007-03-28
申请人： Bryant Lin , Paul Wang , Joseph Knight , Stewart McCallum , Bertha Chen , Tatum Tarin
发明人： Bryant Lin , Paul Wang , Joseph Knight , Stewart McCallum , Bertha Chen , Tatum Tarin
IPC分类号： A61M27/00
CPC分类号： A61F2/004 , A61F2/0036 , A61F2/005 , A61F2/0054 , A61F2210/009
摘要： A device completely disposable within a bodily lumen of a patient and for controlling flow through the bodily lumen having a device body having a proximal end, a distal end and a device lumen within the device body extending from the proximal end to the distal end and a fixation element extending from the outer wall of device body adapted and configured to engage with the wall of the bodily lumen. The device body is adapted and configured to move from a position where the device lumen blocks flow through the bodily lumen to a position where the device lumen allows flow through the bodily lumen. In other configurations, there are one or more valves within the device lumen adapted and configured to move between a position to block flow through the bodily lumen and a position to allow flow through the bodily lumen. There is also a method for implanting a device within a body lumen by placing a device having a device body and fixation elements extending from the device body on a catheter and then dilating the body lumen such that the device body and the fixation elements may advance through the dilated body lumen without the fixation elements engaging the wall of the body lumen. Next, advancing the device to an implant site within the body lumen and then engaging the walls of the body lumen with the fixation elements.
摘要翻译：一种在患者的身体腔内完全一次性的装置，并且用于控制流过身体腔的流体，该装置主体具有从近端延伸到远端的装置主体内的近端，远端和装置腔，固定元件从装置主体的外壁延伸并且被配置为与身体管腔的壁接合。装置主体被适配和构造成从装置管腔阻止流过身体腔的位置移动到装置内腔允许流过身体腔的位置。在其他构造中，在装置内部有一个或多个阀，其适于和构造成在阻塞流过身体腔的流动的位置和允许流过身体腔的位置之间移动。还有一种通过将具有装置主体的装置和从装置主体延伸到导管上的固定元件放置在体腔内的方法，然后使体腔膨胀使得装置主体和固定元件可以前进扩张的体腔而没有固定元件与体腔的壁接合。接下来，将装置推进到体腔内的植入部位，然后使体腔的壁与固定元件接合。

3. 发明授权

US08642661B2 Pharmaceutical combinations of beta-3 adrenergic receptor agonists and muscarinic receptor antagonists 有权
标题翻译： β-3肾上腺素能受体激动剂和毒蕈碱受体拮抗剂的药物组合
公开(公告)号：US08642661B2
公开(公告)日：2014-02-04
申请号：US13196068
申请日：2011-08-02
申请人： Stephen Caltabiano , Eliot Ohlstein , Stewart McCallum
发明人： Stephen Caltabiano , Eliot Ohlstein , Stewart McCallum
IPC分类号： A01N33/02 , A61K31/135 , A01N33/00 , A61K31/13 , A61K31/16 , A01N43/04 , A61K31/70
CPC分类号： A61K31/137 , A61K31/216 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical combinations comprising a beta-3 adrenergic receptor agonist and a muscarinic receptor antagonist, and methods for their use are disclosed. Disclosed combinations include solabegron and oxybutynin. Methods of using the pharmaceutical combinations for the treatment of one or more symptoms associated with overactive bladder, for example, frequency of urgency, nocturia, and urinary incontinence, are also disclosed.
摘要翻译：公开了包含β-3肾上腺素能受体激动剂和毒蕈碱受体拮抗剂的药物组合及其使用方法。公开的组合包括溶胶酶和奥昔布宁。还公开了使用药物组合治疗与膀胱过度活动相关的一种或多种症状的方法，例如紧急频率，夜尿症和尿失禁。

4. 发明申请

US20120035118A1 PHARMACEUTICAL COMBINATIONS 有权
标题翻译：药物组合
公开(公告)号：US20120035118A1
公开(公告)日：2012-02-09
申请号：US13196068
申请日：2011-08-02
申请人： Stephen Caltabiano , Eliot Ohlstein , Stewart McCallum
发明人： Stephen Caltabiano , Eliot Ohlstein , Stewart McCallum
IPC分类号： A61K31/216 , A61K31/7024 , A61P13/00 , A61K31/196
CPC分类号： A61K31/137 , A61K31/216 , A61K45/06 , A61K2300/00
摘要： Pharmaceutical combinations comprising a beta-3 adrenergic receptor agonist and a muscarinic receptor antagonist, and methods for their use are disclosed. Disclosed combinations include solabegron and oxybutynin. Methods of using the pharmaceutical combinations for the treatment of one or more symptoms associated with overactive bladder, for example, frequency of urgency, nocturia, and urinary incontinence, are also disclosed.
摘要翻译：公开了包含β-3肾上腺素能受体激动剂和毒蕈碱受体拮抗剂的药物组合及其使用方法。公开的组合包括溶胶酶和奥昔布宁。还公开了使用药物组合治疗与膀胱过度活动相关的一种或多种症状的方法，例如紧急频率，夜尿症和尿失禁。

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