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1. 发明申请

US20070276342A1 Devices and related methods for treating incontinence 审中-公开
标题翻译：用于治疗失禁的装置和相关方法
公开(公告)号：US20070276342A1
公开(公告)日：2007-11-29
申请号：US11729118
申请日：2007-03-28
申请人： Bryant Lin , Paul Wang , Joseph Knight , Stewart McCallum , Bertha Chen , Tatum Tarin
发明人： Bryant Lin , Paul Wang , Joseph Knight , Stewart McCallum , Bertha Chen , Tatum Tarin
IPC分类号： A61M27/00
CPC分类号： A61F2/004 , A61F2/0036 , A61F2/005 , A61F2/0054 , A61F2210/009
摘要： A device completely disposable within a bodily lumen of a patient and for controlling flow through the bodily lumen having a device body having a proximal end, a distal end and a device lumen within the device body extending from the proximal end to the distal end and a fixation element extending from the outer wall of device body adapted and configured to engage with the wall of the bodily lumen. The device body is adapted and configured to move from a position where the device lumen blocks flow through the bodily lumen to a position where the device lumen allows flow through the bodily lumen. In other configurations, there are one or more valves within the device lumen adapted and configured to move between a position to block flow through the bodily lumen and a position to allow flow through the bodily lumen. There is also a method for implanting a device within a body lumen by placing a device having a device body and fixation elements extending from the device body on a catheter and then dilating the body lumen such that the device body and the fixation elements may advance through the dilated body lumen without the fixation elements engaging the wall of the body lumen. Next, advancing the device to an implant site within the body lumen and then engaging the walls of the body lumen with the fixation elements.
摘要翻译：一种在患者的身体腔内完全一次性的装置，并且用于控制流过身体腔的流体，该装置主体具有从近端延伸到远端的装置主体内的近端，远端和装置腔，固定元件从装置主体的外壁延伸并且被配置为与身体管腔的壁接合。装置主体被适配和构造成从装置管腔阻止流过身体腔的位置移动到装置内腔允许流过身体腔的位置。在其他构造中，在装置内部有一个或多个阀，其适于和构造成在阻塞流过身体腔的流动的位置和允许流过身体腔的位置之间移动。还有一种通过将具有装置主体的装置和从装置主体延伸到导管上的固定元件放置在体腔内的方法，然后使体腔膨胀使得装置主体和固定元件可以前进扩张的体腔而没有固定元件与体腔的壁接合。接下来，将装置推进到体腔内的植入部位，然后使体腔的壁与固定元件接合。

2. 发明申请

US20050244448A1 Diagnosis and treatment of disorders of collagen and elastin metabolism 审中-公开
标题翻译：胶原蛋白和弹性蛋白代谢障碍的诊断和治疗
公开(公告)号：US20050244448A1
公开(公告)日：2005-11-03
申请号：US11082460
申请日：2005-03-16
申请人： Bertha Chen , Yan Wen , Mary Polan
发明人： Bertha Chen , Yan Wen , Mary Polan
IPC分类号： A61F13/00 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/136 , C12Q2600/158
摘要： This application discloses methods for diagnosing and treating SUI. The treatment methods are directed to inhibiting elastolysis in affected tissues and correcting imbalances in the expression of elastase enzymes and their inhibitors.
摘要翻译：本申请公开了用于诊断和治疗SUI的方法。治疗方法是针对抑制受损组织中的弹性分解和纠正弹性蛋白酶及其抑制剂表达的不平衡。

3. 发明授权

US06420119B1 Methods of diagnosing and treating urinary incontinence relating to collagen proteolysis in pelvic supporting tissue 失效
标题翻译：诊断和治疗与盆腔支持组织中的胶原蛋白水解有关的尿失禁的方法
公开(公告)号：US06420119B1
公开(公告)日：2002-07-16
申请号：US09689291
申请日：2000-10-11
申请人： Mary Lake Polan , Bertha Chen
发明人： Mary Lake Polan , Bertha Chen
IPC分类号： C12Q168
CPC分类号： A61K38/57 , C12Q1/6883 , C12Q2600/158
摘要： Methods are disclosed for diagnosing urinary incontinence or a predisposition to urinary incontinence in a subject by determining the ratio of expression levels of MMPs/TIMPs in pelvic supporting tissue of the subject and comparing the ratio to a predetermined indicator. A diagnostic kit is also disclosed. Methods are disclosed for treating urinary incontinence by reducing proteolysis of collagen in pelvic supporting tissue of the subject and for identifying therapeutic agents in in vitro screens.
摘要翻译：公开了通过确定受试者的骨盆支撑组织中MMPs / TIMP的表达水平的比例并将比率与预定指标进行比较来公开用于诊断受试者尿失禁或倾向性尿失禁的方法。还公开了诊断试剂盒。公开了通过减少受试者的骨盆支撑组织中的胶原蛋白的蛋白水解以及用于在体外筛选中鉴定治疗剂来治疗尿失禁的方法。

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