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1. 发明申请

US20070276342A1 Devices and related methods for treating incontinence 审中-公开
标题翻译：用于治疗失禁的装置和相关方法
公开(公告)号：US20070276342A1
公开(公告)日：2007-11-29
申请号：US11729118
申请日：2007-03-28
申请人： Bryant Lin , Paul Wang , Joseph Knight , Stewart McCallum , Bertha Chen , Tatum Tarin
发明人： Bryant Lin , Paul Wang , Joseph Knight , Stewart McCallum , Bertha Chen , Tatum Tarin
IPC分类号： A61M27/00
CPC分类号： A61F2/004 , A61F2/0036 , A61F2/005 , A61F2/0054 , A61F2210/009
摘要： A device completely disposable within a bodily lumen of a patient and for controlling flow through the bodily lumen having a device body having a proximal end, a distal end and a device lumen within the device body extending from the proximal end to the distal end and a fixation element extending from the outer wall of device body adapted and configured to engage with the wall of the bodily lumen. The device body is adapted and configured to move from a position where the device lumen blocks flow through the bodily lumen to a position where the device lumen allows flow through the bodily lumen. In other configurations, there are one or more valves within the device lumen adapted and configured to move between a position to block flow through the bodily lumen and a position to allow flow through the bodily lumen. There is also a method for implanting a device within a body lumen by placing a device having a device body and fixation elements extending from the device body on a catheter and then dilating the body lumen such that the device body and the fixation elements may advance through the dilated body lumen without the fixation elements engaging the wall of the body lumen. Next, advancing the device to an implant site within the body lumen and then engaging the walls of the body lumen with the fixation elements.
摘要翻译：一种在患者的身体腔内完全一次性的装置，并且用于控制流过身体腔的流体，该装置主体具有从近端延伸到远端的装置主体内的近端，远端和装置腔，固定元件从装置主体的外壁延伸并且被配置为与身体管腔的壁接合。装置主体被适配和构造成从装置管腔阻止流过身体腔的位置移动到装置内腔允许流过身体腔的位置。在其他构造中，在装置内部有一个或多个阀，其适于和构造成在阻塞流过身体腔的流动的位置和允许流过身体腔的位置之间移动。还有一种通过将具有装置主体的装置和从装置主体延伸到导管上的固定元件放置在体腔内的方法，然后使体腔膨胀使得装置主体和固定元件可以前进扩张的体腔而没有固定元件与体腔的壁接合。接下来，将装置推进到体腔内的植入部位，然后使体腔的壁与固定元件接合。

2. 发明申请

US20070249946A1 Non-invasive cardiac monitor and methods of using continuously recorded cardiac data 有权
标题翻译：非侵入性心脏监测器和使用连续记录的心脏数据的方法
公开(公告)号：US20070249946A1
公开(公告)日：2007-10-25
申请号：US11703428
申请日：2007-02-06
申请人： Uday Kumar , Kit Au-Yeung , John White , Joseph Knight
发明人： Uday Kumar , Kit Au-Yeung , John White , Joseph Knight
IPC分类号： A61B5/0402
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G06F19/00 , G16H10/60 , G16H15/00 , G16H40/63
摘要： Embodiments of the invention provide methods of obtaining continuous cardiac information from a mammal. First, attach a self-contained, wearable, portable continuous cardiac monitor to the mammal to create a chamber containing electrodes used to detect cardiac signals from the mammal. Next, continuously detect without analyzing the cardiac signals from the mammal for at least 24 hours. Next, store information related to substantially all detected cardiac signals in the cardiac monitor.
摘要翻译：本发明的实施方案提供从哺乳动物获得连续心脏信息的方法。首先，向哺乳动物附上一个独立的，可携带的便携式连续心脏监测器，以产生含有用于检测来自哺乳动物的心脏信号的电极的腔室。接下来，连续检测不分析来自哺乳动物的心脏信号至少24小时。接下来，在心脏监视器中存储与基本上所有检测到的心脏信号相关的信息。

3. 发明申请

US20070255153A1 Non-invasive cardiac monitor and methods of using continuously recorded cardiac data 有权
标题翻译：非侵入性心脏监测器和使用连续记录的心脏数据的方法
公开(公告)号：US20070255153A1
公开(公告)日：2007-11-01
申请号：US11703311
申请日：2007-02-06
申请人： Uday Kumar , Joseph Knight , Kit Au-Yeung , John White
发明人： Uday Kumar , Joseph Knight , Kit Au-Yeung , John White
IPC分类号： A61B5/04
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G06F19/00 , G16H10/60 , G16H15/00 , G16H40/63
摘要： One embodiment of the invention is a cardiac monitor having a housing; a plurality of electrodes within and extending from the housing; a state machine within the housing configured to digitialize and store in memory signals from the plurality of electrodes; a sealing surface and an adhesive on the sealing surface configured to form a watertight perimeter around the plurality of electrodes when the housing is affixed to a mammal. Another embodiment of the invention provides a continuous cardiac monitor having a housing; a surface on the housing adapted to be sealably engaged to a mammal; an adhesive on the surface that is adapted to remain affixed to the mammal for at least 7 days; at least two electrodes within the housing positioned to detect a cardiac information of the mammal while the surface is sealably engaged to the mammal; an electronic memory within the housing wherein, the electronic memory is sized to store at least 24 hours of continuous cardiac information; and wiring within the housing connecting the electronic memory to the electrodes.
摘要翻译：本发明的一个实施例是具有外壳的心脏监护仪; 在所述壳体内并从所述壳体延伸的多个电极; 所述壳体内的状态机被配置为对来自所述多个电极的存储器信号进行数字化和存储; 所述密封表面和所述密封表面上的粘合剂被构造成当所述壳体固定到哺乳动物时在所述多个电极周围形成水密周界。本发明的另一个实施例提供一种具有壳体的连续心脏监测器; 适于与哺乳动物密封地接合的壳体上的表面; 表面上的粘合剂适于保持固定在哺乳动物上至少7天; 所述壳体内的至少两个电极定位成在所述表面与所述哺乳动物密封地接合时检测哺乳动物的心脏信息; 所述壳体内的电子存储器，其中，所述电子存储器的尺寸设置为存储至少24小时的连续心脏信息; 以及在将电子存储器连接到电极的壳体内的布线。

4. 发明申请

US20050288533A1 PROCESSES FOR THE PREPARATION OF HIGHER MOLECULAR WEIGHT SATURATED KETONES 有权
标题翻译：制备高分子量饱和酮的方法
公开(公告)号：US20050288533A1
公开(公告)日：2005-12-29
申请号：US10877339
申请日：2004-06-25
申请人： Scott Barnicki , Jennifer McCusker-Orth , Joseph Knight , Jerry Miller
发明人： Scott Barnicki , Jennifer McCusker-Orth , Joseph Knight , Jerry Miller
IPC分类号： C07C45/68 , C07C45/73
CPC分类号： C07C45/73
摘要： Continuous single-step processes for producing higher molecular weight ketones are disclosed that involve a liquid-phase crossed condensation of an aldehyde with a ketone in the presence of a hydrogenation catalyst and a small amount of a catalyst comprising a concentrated hydroxide or alkoxide of an alkali-metal (from Group 1 or Group IA of the Periodic Table of the Elements) or alkali-earth metal (from Group 2, or Group IIA of the Periodic Table of the Elements), wherein the amount of water provided to the reaction mixture, or reaction zone, is relatively low, with respect to the total initial weight of the reaction mixture. The reaction may be carried out in the absence of solubilizing agents or phase transfer agents. The product mixture is largely free of by-products resulting from further condensation reactions of the desired ketone product or intermediates, and free of the self-condensation products of the reactant aldehyde, that are afterward difficult to remove from the reaction mixture.
摘要翻译：公开了用于生产较高分子量酮的连续单步方法，其涉及在氢化催化剂和少量含有碱金属氢氧化物或醇盐的催化剂存在下，醛与酮的液相交联缩合金属（来自元素周期表的第1族或第IA族）或碱土金属（来自元素周期表的第2族或IIA族），其中提供给反应混合物的水的量，或反应区相对于反应混合物的总初始重量相对较低。反应可以在不存在增溶剂或相转移剂的情况下进行。产物混合物基本上不含所需酮产物或中间体的进一步缩合反应产生的副产物，并且不含反应物醛的自缩合产物，其后难以从反应混合物中除去。

5. 发明申请

US20060105023A1 Treatment of neurological disorders with nicotine 审中-公开
标题翻译：用尼古丁治疗神经障碍
公开(公告)号：US20060105023A1
公开(公告)日：2006-05-18
申请号：US11319898
申请日：2005-12-27
申请人： Joseph Knight
发明人： Joseph Knight
IPC分类号： A61K31/4439 , A61K47/00
CPC分类号： A23L2/52 , A23L2/72 , A61K31/4439
摘要： Neurological disorders, such as migraine and addiction to smoking tobacco, are treated by the administration of an effective amount of nicotine, preferably in a water solution of nicotine processed to diminish the odor, taste, and smell of nicotine.
摘要翻译：通过施用有效量的尼古丁，优选在加工的尼古丁水溶液中来治疗诸如偏头痛和吸烟成瘾的神经障碍，以减少尼古丁的气味，味道和气味。

6. 发明申请

US20060271167A1 Vascular prosthesis 有权
公开(公告)号：US20060271167A1
公开(公告)日：2006-11-30
申请号：US10561929
申请日：2004-06-28
申请人： Joseph Knight
发明人： Joseph Knight
IPC分类号： A61F2/24 , A61F2/06
CPC分类号： A61F2/2412 , A61F2/06 , A61F2/24 , A61F2002/061
摘要： The subject invention concerns vascular prosthetic devices and methods for ascending aorta and/or valve replacement in humans and animals. In one embodiment, a device of the invention includes a vessel-like structure having a first end adapted for surgical attachment to a left ventricle, a second end adapted for surgical attachment to an aorta, and, interposed between the first and second ends, a sinus portion configured in the shape of the sinuses of Valsalva in a human aortic valve.

7. 发明申请

US20070225611A1 Non-invasive cardiac monitor and methods of using continuously recorded cardiac data 有权
标题翻译：非侵入性心脏监测器和使用连续记录的心脏数据的方法
公开(公告)号：US20070225611A1
公开(公告)日：2007-09-27
申请号：US11703335
申请日：2007-02-06
申请人： Uday Kumar , Joseph Knight , Kit Au-Yeung , John White
发明人： Uday Kumar , Joseph Knight , Kit Au-Yeung , John White
IPC分类号： A61B5/04
CPC分类号： A61B5/02438 , A61B5/0006 , A61B5/0408 , A61B5/0432 , A61B5/04325 , A61B5/411 , A61B5/6833 , A61B2560/0412 , A61B2560/0468 , G06F19/00 , G16H10/60 , G16H15/00 , G16H40/63
摘要： Embodiments of the present invention provide a method of analyzing cardiac information by collecting a plurality of self-contained, wearable, portable cardiac monitors each of the cardiac monitors electronically storing at least 24 hours of continuously detected and unanalyzed cardiac signals from a mammal. Next, retrieving cardiac information stored in each of the plurality of self-contained portable cardiac monitors. Next, forwarding retrieved cardiac information.
摘要翻译：本发明的实施例提供了一种通过收集多个独立的，可穿戴的便携式心脏监测器来分析心脏信息的方法，每个心脏监测器电子地存储来自哺乳动物的至少24小时的连续检测和未分析的心脏信号。接下来，检索存储在多个独立式便携式心脏监测器中的每一个中的心脏信息。接下来，转发所检索的心脏信息。

8. 发明授权

US4997651A Pharmaceutical formulations 失效
公开(公告)号：US4997651A
公开(公告)日：1991-03-05
申请号：US273227
申请日：1988-11-18
申请人： Stephen W. Poole , Timothy P. Stanley , Geoffrey Divall , Terence W. Packham , Joseph Knight
发明人： Stephen W. Poole , Timothy P. Stanley , Geoffrey Divall , Terence W. Packham , Joseph Knight
IPC分类号： A61K9/08 , A61K9/00 , A61K9/14 , A61K31/185 , A61K31/195 , A61K47/00 , A61K47/08 , A61K47/10 , A61K47/12 , A61K47/32 , A61P35/00 , C07B63/00 , C07C229/00 , C07C229/34 , C07C229/36 , C07C229/42
CPC分类号： A61K9/19 , A61K31/195 , A61K47/10 , A61K47/12 , A61K47/32 , A61K9/0019
摘要： The present invention relates to a new two-component pharmaceutical formulation of melphalan in which the two components comprise(a) freeze-dried mephalan hydrochloride and(b) a solvent-diluent comprising a citrate, propylene glycol and ethanol.Substantially pure melphalan, substantially pure melphalan hydrochloride and methods for preparing them are also described.

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