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1. 发明申请

US20070231458A1 Spotting Device and Method for High Concentration Spot Deposition on Microarrays and Other Micorscale Devices 有权
标题翻译：用于高浓度点沉积在微阵列和其他微型设备上的检测装置和方法
公开(公告)号：US20070231458A1
公开(公告)日：2007-10-04
申请号：US11632086
申请日：2005-07-06
申请人： Bruce Gale , David Chang-Yen , David Myszka
发明人： Bruce Gale , David Chang-Yen , David Myszka
IPC分类号： B05C5/00 , B05D1/36 , B05D5/00 , B23P17/00 , G01N1/28
CPC分类号： B01J19/0046 , B01J2219/00353 , B01J2219/00367 , B01J2219/00369 , B01J2219/00371 , B01J2219/00497 , B01J2219/00527 , B01J2219/00536 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/00736 , B01J2219/00743 , B01L3/0293 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0822 , B01L2300/0877 , B01L2300/1827 , B01L2400/0415 , B01L2400/0487 , B82Y30/00 , C12M23/16 , C40B50/14 , C40B60/14 , G01N35/1002 , G01N35/1065 , G01N35/1074 , G01N2035/00158 , G01N2035/1034 , G01N2035/1039 , Y10T29/49
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray a slide, wafer, or other substrate. The spotter uses microfluidic conduits and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a substrate. Each orifice is part of a fluid pathways that includes an inlet and outlet conduit. When the spotter contacts a substrate a seal is formed between the orifices and the substrate.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在载玻片，晶片或其它基底的微阵列上。点样器使用微流体管道和孔口将蛋白质，其他生物分子或化学物质沉积在基底上的一个点上。每个孔是包括入口和出口导管的流体路径的一部分。当检测器接触基板时，在孔和基板之间形成密封。

2. 发明授权

US08210119B2 Spotting device and method for high concentration spot deposition on microarrays and other microscale devices 有权
标题翻译：用于微阵列和其他微量元件上的高浓度斑点沉积的点样装置和方法
公开(公告)号：US08210119B2
公开(公告)日：2012-07-03
申请号：US11632086
申请日：2005-07-06
申请人： Bruce Gale , David Chang-Yen , David Myszka
发明人： Bruce Gale , David Chang-Yen , David Myszka
IPC分类号： B05C1/06
CPC分类号： B01J19/0046 , B01J2219/00353 , B01J2219/00367 , B01J2219/00369 , B01J2219/00371 , B01J2219/00497 , B01J2219/00527 , B01J2219/00536 , B01J2219/00574 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00621 , B01J2219/00626 , B01J2219/00628 , B01J2219/0063 , B01J2219/00637 , B01J2219/00639 , B01J2219/00644 , B01J2219/00648 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00691 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01J2219/00731 , B01J2219/00734 , B01J2219/00736 , B01J2219/00743 , B01L3/0293 , B01L3/5027 , B01L3/502707 , B01L3/502715 , B01L3/50273 , B01L3/502761 , B01L2200/0647 , B01L2200/147 , B01L2300/0636 , B01L2300/0654 , B01L2300/0822 , B01L2300/0877 , B01L2300/1827 , B01L2400/0415 , B01L2400/0487 , B82Y30/00 , C12M23/16 , C40B50/14 , C40B60/14 , G01N35/1002 , G01N35/1065 , G01N35/1074 , G01N2035/00158 , G01N2035/1034 , G01N2035/1039 , Y10T29/49
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray a slide, wafer, or other substrate. The spotter uses microfluidic conduits and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a substrate. Each orifice is part of a fluid pathways that includes an inlet and outlet conduit. When the spotter contacts a substrate a seal is formed between the orifices and the substrate.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在载玻片，晶片或其它基底的微阵列上。点样器使用微流体管道和孔口将蛋白质，其他生物分子或化学物质沉积在基底上的一个点上。每个孔是包括入口和出口导管的流体路径的一部分。当检测器接触基板时，在孔和基板之间形成密封。

3. 发明申请

US20070231880A1 Microfluidic interface for highly parallel addressing of sensing arrays 有权
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：US20070231880A1
公开(公告)日：2007-10-04
申请号：US11241060
申请日：2005-09-30
申请人： David Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce Gale , David Myszka
发明人： David Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce Gale , David Myszka
IPC分类号： C12M3/00 , G01D15/02
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。点样器使用井，微流体管道和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。每个孔通过微管连接到两个孔。当检测器接触表面时，在孔和表面之间形成密封。相同或不同的物质可能流过每个孔口。任何数量的孔口都可以并入到一个定点器中。鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

4. 发明申请

US20100075860A1 MICROASSAY WITH INTERNAL REFERENCING 有权
标题翻译：微型内镜参考
公开(公告)号：US20100075860A1
公开(公告)日：2010-03-25
申请号：US12564448
申请日：2009-09-22
申请人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
发明人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
IPC分类号： C40B30/00 , C40B50/14 , C40B60/12
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：专用的微流体网络用于将物质沉积在传感器表面上。特别地，基于流动的微流体打印头用作将多个分析物递送到传感器用于同时分析的界面。此外，内部参考被并入传感器区域以提高灵敏度。

5. 发明授权

US08383059B2 Microfluidic interface for highly parallel addressing of sensing arrays 有权
标题翻译：用于感测阵列高度并行寻址的微流体接口
公开(公告)号：US08383059B2
公开(公告)日：2013-02-26
申请号：US11241060
申请日：2005-09-30
申请人： David A. Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce K. Gale , David Myszka
发明人： David A. Chang-Yen , Sriram Natarajan , Josh Eckman , Bruce K. Gale , David Myszka
IPC分类号： B01L3/00
CPC分类号： G01N33/553 , B01J19/0046 , B01L3/0293 , B01L3/5025 , B01L3/502715 , B01L3/50273 , B01L2200/021 , B01L2300/0636 , B01L2300/0819 , B01L2300/0822 , B01L2300/0877 , B01L2400/0487 , C12N15/1093 , G01N35/1074 , G01N2035/00158 , G01N2035/1039 , Y10T436/2575
摘要： Disclosed is a spotter device and methods for the formation of microassays, biochips, biosensors, and cell cultures. The spotter may be used to deposit highly concentrated spots of protein or other materials on a microarray slide, wafer, or other surface. It may also be used to perform various chemistry steps on the same spots. The spotter increases the surface density of substances at each spot by directing a flow the desired substance (or a solution thereof) over the spot area until surface saturation is accomplished. The spotter may be loaded by well plate handling equipment. The spotter uses wells, microfluidic conduits, and orifices to deposit proteins, other biomolecules, or chemicals on a spot on a separate surface. Each orifice is connected to two wells via microconduits. When the spotter contacts a surface, a seal is formed between the orifices and the surface. The same or different substances may be flowed across each orifice. Any number of orifices may be incorporated into a spotter. The spotter is particularly useful for depositing proteins in high concentrations on a surface, since the spotter may be placed on a surface for an extended period of time.
摘要翻译：公开了一种用于形成微量测定器，生物芯片，生物传感器和细胞培养物的检测器装置和方法。斑点斑块可用于将高度浓缩的蛋白质或其他材料的斑点沉积在微阵列载玻片，晶片或其它表面上。它也可以用于在同一点上执行各种化学步骤。点样器通过将所需物质（或其溶液）流过斑点区域直到达到表面饱和为止，增加每个斑点处物质的表面密度。识别器可以由井板处理设备装载。点样器使用井，微流体管道和孔口将蛋白质，其他生物分子或化学品沉积在单独表面上的一个点上。每个孔通过微管连接到两个孔。当检测器接触表面时，在孔和表面之间形成密封。相同或不同的物质可能流过每个孔口。任何数量的孔口都可以并入到一个定点器中。鉴定器对于在表面上沉积高浓度的蛋白质是特别有用的，因为可以将定位器放置在表面上较长时间。

6. 发明授权

US08211382B2 Microassay with internal referencing 有权
标题翻译：带有内部参考的Microassay
公开(公告)号：US08211382B2
公开(公告)日：2012-07-03
申请号：US12564448
申请日：2009-09-22
申请人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
发明人： David Myszka , Bruce Kent Gale , Joshua Wayne Eckman , Sriram Natarajan
IPC分类号： C40B30/00 , C40B60/12
CPC分类号： C40B60/12 , B01J2219/0036 , B01J2219/00385 , B01J2219/00527 , B01J2219/00596 , B01J2219/00702 , B01J2219/00725 , B01L3/0262 , B01L3/5027 , B01L2200/0689 , B01L2300/0819 , B01L2300/0877 , B01L2400/0487 , G01N33/54366
摘要： Specialized microfluidic networks are utilized to deposit substances on sensor surfaces. In particular, a flow-based microfluidic printhead is used as an interface to deliver multiple analytes to a sensor for simultaneous analysis. Furthermore, internal referencing is incorporated into sensor regions for improved sensitivity.
摘要翻译：专用的微流体网络用于将物质沉积在传感器表面上。特别地，基于流动的微流体打印头用作将多个分析物递送到传感器用于同时分析的界面。此外，内部参考被并入传感器区域以提高灵敏度。

7. 发明申请

US20050175999A1 Methods for determining binding affinities 审中-公开
标题翻译：确定结合亲和力的方法
公开(公告)号：US20050175999A1
公开(公告)日：2005-08-11
申请号：US10488371
申请日：2002-08-30
申请人： Scott Klakamp , David Myszka
发明人： Scott Klakamp , David Myszka
IPC分类号： G01N21/64 , C12Q1/68 , G01N21/27 , G01N33/15 , G01N33/48 , G01N33/50 , G01N33/53 , G01N33/543 , G01N33/557 , G01N33/566 , G06F19/00
CPC分类号： G01N33/54373 , G01N33/557
摘要： The present invention relates generally to methods for screening a plurality of ligands using a biosensor device. More particularly, the present invention relates to methods for screening a plurality of antibodies from complex solutions using a surface plasmon resonance device. The methods of this invention provide kinetic and equilibrium information for such screening assays. The present invention also relates to systems for determining kinetic rate constants for such screening assays.
摘要翻译：本发明一般涉及使用生物传感器装置筛选多个配体的方法。更具体地，本发明涉及使用表面等离子体共振装置从复合溶液中筛选多种抗体的方法。本发明的方法提供了用于这种筛选测定的动力学和平衡信息。本发明还涉及用于确定这种筛选测定的动力学速率常数的系统。

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