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1. 发明申请

US20060169891A1 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US20060169891A1
公开(公告)日：2006-08-03
申请号：US11315788
申请日：2005-12-22
申请人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
发明人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
IPC分类号： B01D59/44
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

2. 发明申请

US20060151692A1 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US20060151692A1
公开(公告)日：2006-07-13
申请号：US11032376
申请日：2005-01-10
申请人： Bruce Collings , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bruce Thomson
发明人： Bruce Collings , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bruce Thomson
IPC分类号： B01D59/44
CPC分类号： H01J49/04 , H01J49/062
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向限制超音速自由射流膨胀的离子导向器可将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

3. 发明授权

US07259371B2 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US07259371B2
公开(公告)日：2007-08-21
申请号：US11315788
申请日：2005-12-22
申请人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
发明人： Bruce A. Collings , Thomas R. Covey , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bradley B. Schneider , Bruce A. Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

4. 发明授权

US07256395B2 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US07256395B2
公开(公告)日：2007-08-14
申请号：US11032376
申请日：2005-01-10
申请人： Bruce A. Collings , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bruce A. Thomson
发明人： Bruce A. Collings , Mircea Guna , Hassan Javaheri , Alexandre V. Loboda , Bruce A. Thomson
IPC分类号： H01J49/00
CPC分类号： H01J49/04 , H01J49/062
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, an ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以基本上径向地限制超音速自由射流膨胀的离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

5. 发明授权

US08309914B2 Method of operating a linear ion trap to provide low pressure short time high amplitude excitation with pulsed pressure 有权
标题翻译：操作线性离子阱以提供具有脉冲压力的低压短时间高振幅激励的方法
公开(公告)号：US08309914B2
公开(公告)日：2012-11-13
申请号：US12359526
申请日：2009-01-26
申请人： Mircea Guna , Yves Le Blanc , Bruce Collings
发明人： Mircea Guna , Yves Le Blanc , Bruce Collings
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/426 , H01J49/0063 , H01J49/24
摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10−4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non-steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6×10−5 Torr to about 5×10−4 Torr for a first elevated-pressure duration; and f) within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.
摘要翻译：描述了在离子阱中分离离子的方法。这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的工作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供至少10％的离子阱内的工作压力的非稳态压力增加，以提高离子中的压力在第一升高压力持续时间内，在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获变化的第一升高压力; 和f）在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留碎片的离子阱内的母离子。激发时间间隔和第一升高压力时间基本上在时间上重叠。

6. 发明申请

US20130181125A1 METHOD AND SYSTEM FOR INCREASING THE DYNAMIC RANGE OF ION DETECTORS 审中-公开
标题翻译：用于增加离子检测器动态范围的方法和系统
公开(公告)号：US20130181125A1
公开(公告)日：2013-07-18
申请号：US13817189
申请日：2011-08-18
申请人： Mircea Guna , Bruce Collings
发明人： Mircea Guna , Bruce Collings
IPC分类号： H01J49/00 , H01J49/06
CPC分类号： H01J49/0031 , H01J49/025 , H01J49/06 , H01J49/061
摘要： A mass spectrometer system can include a mass analyzer operable to mass transmit streams of ions to a detector in a mass dependent fashion for measurement of ion flux intensity. An ion attenuator can be located in the extraction region between the mass analyzer and detector, downstream of the mass analyzer, and can be operable to provide selective attenuation of the ion beam by attenuating ion flux intensity also in mass dependent fashion. Higher concentration ions can be selected and attenuated, while other lower concentration ions can be left unattenuated. Different ions can be attenuated to different degrees. Locating the ion attenuator downstream of the mass analyzer so that the ion beam is already mass differentiated when attenuated can avoid mass discriminatory effects associated with ion beam attenuators. Selective attenuation of only certain ions but not others can extend the dynamic range of the detector without necessarily sacrificing detector sensitivity.
摘要翻译：质谱仪系统可以包括质量分析器，其可以质量传递离子流到检测器以质量依赖的方式来测量离子通量强度。离子衰减器可以位于质量分析器和检测器之间的质量分析器下游的提取区域中，并且可以通过以质量依赖的方式衰减离子通量强度来操作来提供离子束的选择性衰减。可以选择和减弱更高浓度的离子，而其他低浓度离子可以保持不衰减。不同的离子可以衰减到不同的程度。将离子衰减器定位在质量分析仪的下游，以便当衰减时离子束已经被质量分化，可以避免与离子束衰减器相关的质量差异影响。只有某些离子而不是其他离子的选择性衰减可以扩展检测器的动态范围，而不必牺牲检测器灵敏度。

7. 发明授权

US08237109B2 Methods for fragmenting ions in a linear ion trap 有权
标题翻译：线性离子阱中离子的分离方法
公开(公告)号：US08237109B2
公开(公告)日：2012-08-07
申请号：US12359621
申请日：2009-01-26
申请人： Mircea Guna , Bruce Collings
发明人： Mircea Guna , Bruce Collings
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/005 , H01J49/063 , H01J49/4225
摘要： Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5×10−4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.
摘要翻译：描述了保留在离子阱中的分离离子的方法。在各种实施方案中，使用小于约5×10-4乇的中性碰撞气体的非稳定状态压力和小于约500mV（峰对地）的激发振幅来分离大于约 80％的碎片效率。在各种实施例中，离子激发的持续时间大于约25ms。

8. 发明申请

US20090194686A1 METHODS FOR FRAGMENTING IONS IN A LINEAR ION TRAP 有权
标题翻译：用于在线性离子阱中去除离子的方法
公开(公告)号：US20090194686A1
公开(公告)日：2009-08-06
申请号：US12359621
申请日：2009-01-26
申请人： Mircea Guna , Bruce Collings
发明人： Mircea Guna , Bruce Collings
IPC分类号： B01D59/44
CPC分类号： H01J49/005 , H01J49/063 , H01J49/4225
摘要： Methods for fragmenting ions retained in an ion trap are described. In various embodiments, a non-steady-state pressure of a neutral collision gas of less than about 5×10−4 Torr and an excitation amplitude of less than about 500 mV (peak to ground) is used to fragment ions with greater than about 80% fragmentation efficiency. In various embodiments, duration of ion excitation is greater than about 25 ms.
摘要翻译：描述了保留在离子阱中的分离离子的方法。在各种实施方案中，使用小于约5×10-4乇的中性碰撞气体的非稳定状态压力和小于约500mV（峰对地）的激发振幅用于将大于约80％碎片效率。在各种实施例中，离子激发的持续时间大于约25ms。

9. 发明申请

US20090194684A1 METHOD OF OPERATING A LINEAR ION TRAP TO PROVIDE LOW PRESSURE SHORT TIME HIGH AMPLITUDE EXCITATION WITH PULSED PRESSURE 有权
标题翻译：操作线性离子阱的方法提供低压短时间高倍数激发与脉冲压力
公开(公告)号：US20090194684A1
公开(公告)日：2009-08-06
申请号：US12359526
申请日：2009-01-26
申请人： Mircea Guna , Yves Le Blanc , Bruce Collings
发明人： Mircea Guna , Yves Le Blanc , Bruce Collings
IPC分类号： B01D59/44
CPC分类号： H01J49/426 , H01J49/0063 , H01J49/24
摘要： Methods for fragmenting ions in an ion trap are described. These methods involve a) selecting parent ions for fragmentation; b) retaining the parent ions within the ion trap for a retention time interval, the ion trap having an operating pressure of less than about 1×10-4 Torr; c) providing a RF trapping voltage to the ion trap to provide a Mathieu stability parameter q at an excitement level during an excitement time interval within the retention time interval; d) providing a resonant excitation voltage to the ion trap during the excitement time interval to excite and fragment the parent ions; e) providing a non-steady-state pressure increase of at least 10% of the operating pressure within the ion trap by delivering a neutral gas into the ion trap for at least a portion of the retention time interval to raise the pressure in the ion trap to a varying first elevated-pressure in the range between about 6×10-5 Torr to about 5×10-4 Torr for a first elevated-pressure duration; and f within the retention time interval and after the excitement time interval, terminating the resonant excitation voltage and changing the RF trapping voltage applied to the ion trap to reduce the Mathieu stability parameter q to a hold level less than the excitement level to retain fragments of the parent ions within the ion trap. The excitation time interval and the first elevated-pressure duration substantially overlap in time.
摘要翻译：描述了在离子阱中分离离子的方法。这些方法包括：a）选择亲本离子进行碎裂; b）将母离子保留在离子阱内保持时间间隔，离子阱具有小于约1×10-4乇的操作压力; c）向离子阱提供RF捕获电压，以在保持时间间隔内的兴奋时间间隔期间以兴奋水平提供Mathieu稳定性参数q; d）在兴奋时间间隔期间向离子阱提供共振激发电压以激发和分裂母体离子; e）通过将中性气体输送到离子阱中至少保留时间间隔的一部分来提供至少10％的离子阱内的工作压力的非稳态压力增加，以提高离子中的压力在第一升高的压力持续时间内在约6×10 -5 Torr至约5×10 -4 Torr之间的范围内捕获到变化的第一升高压力; 和f在保持时间间隔内和在兴奋时间间隔之后，终止谐振激励电压并改变施加到离子阱的RF捕获电压，以将Mathieu稳定性参数q降低到小于兴奋水平的保持水平以保留离子阱内的母离子。激发时间间隔和第一升高压力时间基本上在时间上重叠。

10. 发明授权

US09324554B2 Methods and systems for providing a substantially quadrupole field with significant hexapole and octapole components 有权
标题翻译：用于提供具有显着的六极和八极组分的基本四极场的方法和系统
公开(公告)号：US09324554B2
公开(公告)日：2016-04-26
申请号：US13818570
申请日：2011-08-25
申请人： Mircea Guna
发明人： Mircea Guna
IPC分类号： H01J49/42
CPC分类号： H01J49/4285 , H01J49/422 , H01J49/4225
摘要： A system and method involving processing ions in a linear ion trap are provided, involving a two-dimensional asymmetric substantially quadrupole field having a hexapole and octopole component.
摘要翻译：提供了涉及在线性离子阱中处理离子的系统和方法，涉及具有六极和八极分量的二维不对称基本四极场。

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