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1. 发明申请

US20060124846A1 Laser desorption ion source with ion guide coupling for ion mass spectroscopy 有权
标题翻译：激光解吸离子源与离子导向耦合离子质谱法
公开(公告)号：US20060124846A1
公开(公告)日：2006-06-15
申请号：US11317368
申请日：2005-12-22
申请人： Thomas Covey , Hassan Javaheri , Bradley Schneider
发明人： Thomas Covey , Hassan Javaheri , Bradley Schneider
IPC分类号： H01J49/00
CPC分类号： H01J49/063 , H01J49/164
摘要： A laser desorption ion source provides enhanced ion sampling efficiency and measurement sensitivity by using one or more ion guides to effectively capture ions in a plume emitted from the ion target and guide the ions through an aperture into a downstream vacuum chamber. In one configuration using two RF multipole ion guides, a first RF multipole ion guide disposed next to the ion target is selected to be sufficiently large to capture a substantial portion of the plume, while the second RF multipole ion guide disposed between the first multipole ion guide and the aperture has a smaller dimension to assist focusing of ions into the aperture. The first RF multipole ion guides the ions in the plume into the second RF multipole ion guide, which then focuses the ions so that they pass through the aperture into the downstream vacuum chamber.
摘要翻译：激光解吸离子源通过使用一个或多个离子引导件有效地捕获从离子靶发射的羽流中的离子并将离子引导通过孔进入下游真空室来提供增强的离子采样效率和测量灵敏度。在使用两个RF多极离子引导件的一种配置中，选择邻近离子靶设置的第一RF多极离子导向器足够大以捕获大部分羽流，而第二射频多极离子导向器设置在第一多极离子导向件和孔径具有较小的尺寸以辅助将离子聚焦到孔中。第一RF多极离子将羽流中的离子引导到第二射频多极离子导向器中，然后将离子聚焦以使它们通过孔进入下游真空室。

2. 发明申请

US20060169891A1 Method and apparatus for improved sensitivity in a mass spectrometer 有权
标题翻译：在质谱仪中提高灵敏度的方法和装置
公开(公告)号：US20060169891A1
公开(公告)日：2006-08-03
申请号：US11315788
申请日：2005-12-22
申请人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
发明人： Bruce Collings , Thomas Covey , Mircea Guna , Hassan Javaheri , Alexandre Loboda , Bradley Schneider , Bruce Thomson
IPC分类号： B01D59/44
CPC分类号： H01J49/067 , H01J49/063
摘要： In a mass spectrometer, ions from an ion source pass through an inlet aperture into a vacuum chamber for transmitting prior to mass analysis by the mass analyzer. The configuration of the inlet aperture forms a sonic orifice or sonic nozzle and with a predetermined vacuum chamber pressure, a supersonic free jet expansion is created in the vacuum chamber that entrains the ions within the barrel shock and Mach disc. Once formed, at least one ion guide with a predetermined cross-section to essentially radially confine the supersonic free jet expansion can focus the ions for transmission through the vacuum chamber. This effectively improves the ion transmission between the ion source and the mass analyzer.
摘要翻译：在质谱仪中，质子分析仪进行质量分析之前，离子源的离子通过入口孔进入真空室以进行传输。入口孔的构型形成声孔或声波喷嘴，并且在预定的真空室压力下，在真空室中产生超音速自由射流膨胀，该真空室将离子夹带在筒形冲击和马赫盘内。一旦形成，具有预定横截面以至基本上径向限制超音速自由射流膨胀的至少一个离子导向器可以将离子聚焦以透过真空室。这有效地改善离子源和质量分析器之间的离子传递。

3. 发明申请

US20120280120A1 METHOD AND SYSTEM FOR VACUUM DRIVEN MASS SPECTROMETER INTERFACE WITH ADJUSTABLE RESOLUTION AND SELECTIVITY 有权
标题翻译：具有可调分辨率和选择性的真空驱动质谱仪接口的方法和系统
公开(公告)号：US20120280120A1
公开(公告)日：2012-11-08
申请号：US13541414
申请日：2012-07-03
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J49/26 , H01J49/24
CPC分类号： H01J49/26 , G01N27/622 , H01J49/004 , H01J49/0404 , H01J49/0468 , H01J49/24
摘要： A mass spectrometer system and method of operating same are provided. The system comprises an ion conduit for receiving ions; a boundary member defining a curtain gas chamber containing the ion conduit; a curtain gas supply for providing a curtain gas to an inlet of the ion conduit to provide a gas flow into the conduit, and a curtain gas outflow out of a curtain gas chamber inlet; a mass spectrometer at least partially sealed to, and in fluid communication with, the conduit for receiving the ions from the conduit; a vacuum chamber surrounding the mass spectrometer operable to draw the gas flow including the ions through the conduit and into the vacuum chamber; and, a gas outlet for drawing a gas outflow from the gas flow located between the conduit and the mass spectrometer to increase the gas flow rate through the conduit.
摘要翻译：提供了质谱仪系统及其操作方法。该系统包括用于接收离子的离子导管; 限定包含离子导管的帘式气室的边界构件; 用于向离子管道的入口提供帘式气体以提供气体流入管道中的帘式气体供应，以及帘式气体从帘式气体室入口流出; 至少部分地密封并与导管流体连通的用于从导管接收离子的质谱仪; 围绕质谱仪的真空室可操作以将包括离子的气流通过导管抽入真空室; 以及气体出口，用于从位于导管和质谱仪之间的气流拉出气体流出，以增加通过导管的气体流速。

4. 发明申请

US20070187614A1 Radio frequency ion guide 有权
标题翻译：射频离子导向
公开(公告)号：US20070187614A1
公开(公告)日：2007-08-16
申请号：US11703756
申请日：2007-02-08
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J3/14
CPC分类号： H01J49/062
摘要： An ion guide with two or more ion focusing elements and a gas channeling sleeve is described. An ion transport space within the gas channeling sleeve is in fluid communication with a pumping port. A suction device is used to suction gas out of the ion transport space through the pumping port establishing a gas flow. Ions in the ion transport space are transported from an ion entry end to an ion exit end of the ion guide by the gas flow. Several examples include a multipole ion guide in which rods are used as ion focusing elements. The gas channeling sleeve is fitted about the rods. In another example, toroidal or ring shaped ion focusing elements are used as ion focusing elements. In another example, a set of ion focusing rings are mounted between insulators to form a cylinder with a gas impermeable side wall. The cylinder is itself used as the gas channeling sleeve.
摘要翻译：描述了具有两个或更多离子聚焦元件和气体导引套筒的离子导向器。气体通道套管内的离子传输空间与泵送口流体连通。抽吸装置用于通过建立气流的泵送端口将气体排出离子传输空间。离子传输空间中的离子通过气流从离子入口端输送到离子导向器的离子出口端。几个实例包括其中杆用作离子聚焦元件的多极离子导向器。气体通道套筒围绕杆安装。在另一示例中，使用环形或环形离子聚焦元件作为离子聚焦元件。在另一示例中，一组离子聚焦环安装在绝缘体之间以形成具有不透气侧壁的圆筒。气缸本身用作气体导引套筒。

5. 发明申请

US20060226354A1 Atmospheric pressure charged particle discriminator for mass spectrometry 有权
公开(公告)号：US20060226354A1
公开(公告)日：2006-10-12
申请号：US11447785
申请日：2006-06-06
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J49/00
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

6. 发明授权

US09425031B2 Method and system for providing a modifier to a curtain gas for a differential mobility spectrometer 有权
标题翻译：用于为差速迁移谱仪提供帘式气体的改性剂的方法和系统
公开(公告)号：US09425031B2
公开(公告)日：2016-08-23
申请号：US12472980
申请日：2009-05-27
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： H01J49/04 , H01J49/00 , G01N27/62
CPC分类号： H01J49/004 , G01N27/624
摘要： A system including a differential mobility spectrometer is described as is a method of operating the system including the differential mobility spectrometer. The method and system involve a) providing ions to the differential mobility spectrometer; b) providing a drift gas to an inlet of the differential mobility spectrometer; c) adjusting a meter to define a selected volumetric flow rate for supplying a modifier liquid to the drift gas; and, d) supplying an actual volumetric flow rate of the modifier liquid to the drift gas, wherein the actual volumetric flow rate is within a percentage deviation from the selected volumetric flow rate.
摘要翻译：描述了包括差动迁移谱仪的系统是包括差动迁移谱仪的系统的操作方法。该方法和系统包括：a）向差速迁移谱仪提供离子; b）向差动迁移谱仪的入口提供漂移气体; c）调节仪表以限定用于向漂移气体供应改性液体的选定体积流量; 以及d）将所述改性剂液体的实际体积流量提供给所述漂移气体，其中所述实际体积流量在与所选择的体积流量的百分比偏差之内。

7. 发明申请

US20090294648A1 METHOD AND SYSTEM FOR PROVIDING A MODIFIER TO A CURTAIN GAS FOR A DIFFERENTIAL MOBILITY SPECTROMETER 有权
标题翻译：用于提供差示运动光谱仪的曲面气体的改性剂的方法和系统
公开(公告)号：US20090294648A1
公开(公告)日：2009-12-03
申请号：US12472980
申请日：2009-05-27
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： B01D59/44 , H01J49/00
CPC分类号： H01J49/004 , G01N27/624
摘要： A system including a differential mobility spectrometer is described as is a method of operating the system including the differential mobility spectrometer. The method and system involve a) providing ions to the differential mobility spectrometer; b) providing a drift gas to an inlet of the differential mobility spectrometer; c) adjusting a meter to define a selected volumetric flow rate for supplying a modifier liquid to the drift gas; and, d) supplying an actual volumetric flow rate of the modifier liquid to the drift gas, wherein the actual volumetric flow rate is within a percentage deviation from the selected volumetric flow rate
摘要翻译：描述了包括差动迁移谱仪的系统是包括差动迁移谱仪的系统的操作方法。该方法和系统包括：a）向差速迁移谱仪提供离子; b）向差动迁移谱仪的入口提供漂移气体; c）调节仪表以限定用于向漂移气体供应改性液体的选定体积流量; 以及d）将所述改性液体的实际体积流量提供给所述漂移气体，其中所述实际体积流量与所选择的体积流量的偏差百分比

8. 发明申请

US20050285031A1 Method and system for high-throughput quantitation using laser desorption and multiple-reaction-monitoring 有权
标题翻译：使用激光解吸和多反应监测的高通量定量方法和系统
公开(公告)号：US20050285031A1
公开(公告)日：2005-12-29
申请号：US11173291
申请日：2005-06-30
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： B01D59/44 , H01J49/00 , H01J49/40
CPC分类号： H01J49/164 , H01J49/004 , H01J49/0481 , H01J49/4215
摘要： A mass spectrometry quantitation technique enables high-throughput quantitation of small molecules using a laser-desorption (e.g., MALDI) ion source coupled to a triple-quadrupole mass analyzer. The ions generated from the ion source are collisionally damped/cooled, and then quantitatively analyzed using the triple-quadrupole analyzer operated in the multiple-reaction-monitoring (MRM) mode. Significantly improved measurement throughput is obtained by applying the laser to each sample spot on the target for an irradiation duration significantly shorter than the time required to deplete the sample material in the sample spot. The irradiation duration may be set based on a determination of the MRM peak broadening caused by the ion optics. This allows significantly reduced widths of the MRM peaks while maintaining good signal to noise ratios and provides a significantly improved throughput of the quantitation analyses as well as improved reproducibility of the MRM peaks and reduced compound dependence of the MRM peak widths.
摘要翻译：使用耦合到三重四极杆质谱仪的激光解吸（例如MALDI）离子源，质谱定量技术可实现小分子的高通量定量。从离子源产生的离子被碰撞阻尼/冷却，然后使用在多反应监测（MRM）模式中操作的三重四极杆分析器进行定量分析。通过将激光施加到目标上的每个样品点上的照射时间显着短于在样品斑点中耗尽样品材料所需的时间，获得显着改善的测量通量。可以基于由离子光学器件引起的MRM峰扩展的确定来设定照射持续时间。这允许显着降低MRM峰的宽度，同时保持良好的信噪比，并且提供定量分析的显着改善的产量以及MRM峰的再现性以及MRM峰宽的复合依赖性。

9. 发明申请

US20060118715A1 Atmospheric pressure charged particle discriminator for mass spectrometry 审中-公开
标题翻译：用于质谱的大气压电荷粒子鉴别器
公开(公告)号：US20060118715A1
公开(公告)日：2006-06-08
申请号：US11330605
申请日：2006-01-12
申请人： Bradley Schneider , Thomas Covey
发明人： Bradley Schneider , Thomas Covey
IPC分类号： B01D59/44
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.
摘要翻译：用于执行质谱的装置和方法使用离子界面来提供在离子流进入真空室之前从大气压离子源（例如电喷雾源或MALDI源）从离子流中除去不期望的微粒的功能，质谱仪。离子界面包括具有孔的入口单元，其可以在离子源是电喷雾源时被加热用于对带电液滴进行脱溶剂;以及颗粒鉴别单元，孔设置在入口单元的孔的下游，并且在通向孔真空室。颗粒鉴别池产生气体动态和电场条件，其使得能够从离子流中分离不期望的带电粒子。

10. 发明授权

US07098452B2 Atmospheric pressure charged particle discriminator for mass spectrometry 有权
公开(公告)号：US07098452B2
公开(公告)日：2006-08-29
申请号：US10778424
申请日：2004-02-13
申请人： Bradley Schneider , Thomas R. Covey
发明人： Bradley Schneider , Thomas R. Covey
IPC分类号： H01J49/04
CPC分类号： H01J49/06 , H01J49/044
摘要： An apparatus and method for performing mass spectroscopy uses an ion interface to provide the function of removing undesirable particulates from an ion stream from an atmospheric pressure ion source, such as an electrospray source or a MALDI source, before the ion stream enters a vacuum chamber containing the mass spectrometer. The ion interface includes an entrance cell with a bore that may be heated for desolvating charged droplets when the ion source is an electrospray source, and a particle discrimination cell with a bore disposed downstream of the bore of the entrance cell and before an aperture leading to the vacuum chamber. The particle discrimination cell creates gas dynamic and electric field conditions that enables separation of undesirable charged particulates from the ion stream.

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