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1. 发明授权

US06748818B2 High-performance fully-compliant micro-mechanisms for force/displacement amplification 失效
标题翻译：用于强制/位移放大的高性能完全兼容的微机构
公开(公告)号：US06748818B2
公开(公告)日：2004-06-15
申请号：US10144239
申请日：2002-05-13
申请人： Brian D. Jensen , Michael Farina , Katsuo Kurabayashi
发明人： Brian D. Jensen , Michael Farina , Katsuo Kurabayashi
IPC分类号： G05G100
CPC分类号： B81B3/0062 , B81B3/0037 , B81B2201/0235 , G01P15/00 , H01Q3/01 , H01Q9/14 , Y10T74/20006 , Y10T74/20207 , Y10T74/20305 , Y10T74/20329
摘要： A device for amplifying mechanical and geometrical advantage having a base structure, a first link member having a first end and a second end, and a first compliant flexural joint pivotally interconnects the first end of the first link member to the base structure. A second link member is also provided having a first end and a second end. A second compliant flexural joint pivotally interconnects the first end of the second link member to the base structure. Furthermore, a third link member is provided having a first end and a second end. A third compliant flexural joint pivotally interconnects the first end of the third link member to the second end of the first link member and a fourth compliant flexural joint pivotally interconnects the second end of the third link member to the second end of the second link member. The base structure, first link member, second link member, and third link member cooperate to define a four-bar linkage for receiving an input force and providing an amplified force or displacement output in response thereto.
摘要翻译：一种用于放大具有基座结构的机械和几何优点的装置，具有第一端和第二端的第一连杆构件以及第一柔性弯曲接头将第一连杆构件的第一端枢转地互连到基座结构。还提供了具有第一端和第二端的第二连杆构件。第二顺从弯曲接头将第二连杆构件的第一端枢转地互连到基部结构。此外，提供具有第一端和第二端的第三连杆构件。第三顺从弯曲接头将第三连杆构件的第一端枢转地互连到第一连杆构件的第二端，并且第四顺从弯曲接头将第三连杆构件的第二端枢转地互连到第二连杆构件的第二端。基座结构，第一连杆构件，第二连杆构件和第三连杆构件协作以限定用于接收输入力的四杆联动装置，并响应于此而提供放大的力或位移输出。

2. 发明申请

US20130005040A1 Delivery of Biological Materials Into Cellular Organelles 审中-公开
标题翻译：将生物材料交付给细胞器
公开(公告)号：US20130005040A1
公开(公告)日：2013-01-03
申请号：US13456856
申请日：2012-04-26
申请人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12N15/89 , C12M1/00
CPC分类号： C12N15/85 , A01K2217/05 , C12N13/00 , C12N15/89
摘要： Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.
摘要翻译：提供了将生物材料递送到细胞的细胞器中的系统，装置和方法。在一个方面，例如，将生物材料引入细胞的细胞器中的方法包括将细胞附近的喷枪和预先选择的生物材料接近，并以足以使预选的电极相互关联的极性和电荷充入喷枪具有喷枪尖端部分的生物材料。该方法还包括用喷枪穿透细胞的外部部分并将喷枪引导并插入细胞器中，排出喷枪以将生物材料的至少一部分释放到细胞器中，并将细胞器从细胞中取出。

3. 发明申请

US20100323419A1 Methods and Devices for Charged Molecule Manipulation 审中-公开
标题翻译：电荷分子操作的方法和装置
公开(公告)号：US20100323419A1
公开(公告)日：2010-12-23
申请号：US12668369
申请日：2008-07-09
申请人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
发明人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12N15/89 , C12M35/02
摘要： Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.
摘要翻译：提供了操作分子材料的系统和方法。在一个方面，例如，用于操纵分子材料的方法可以包括在液体环境中的第一位置处将不带电的针结构定位成与电荷分子材料电接近，对针结构进行充电，使得至少一部分带电分子材料与针结构相关联，使针结构和第一轨迹相对移动，并且排出针结构以在第二位置分离带电分子材料。

4. 发明申请

US20100248343A1 Methods and Devices for Charged Molecule Manipulation 审中-公开
标题翻译：电荷分子操作的方法和装置
公开(公告)号：US20100248343A1
公开(公告)日：2010-09-30
申请号：US12816183
申请日：2010-06-15
申请人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
发明人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
IPC分类号： C12M1/00
CPC分类号： C12N15/89 , C12M35/02
摘要： Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell.
摘要翻译：提供了用于约束或保持单元的装置和方法。在一个方面，例如，提供了一种蜂窝约束装置。这种装置可以包括支撑表面和可移动地联接到支撑表面的至少一个约束臂。约束臂具有第一位置，其中约束臂基本上平行并且基本上邻近支撑表面。此外，约束臂的至少一部分可从支撑表面移动到第二位置，其中约束臂可操作以约束单个电池。

5. 发明授权

US06567715B1 Method and system for automated on-chip material and structural certification of MEMS devices 有权
标题翻译： MEMS器件自动化芯片材料和结构认证的方法和系统
公开(公告)号：US06567715B1
公开(公告)日：2003-05-20
申请号：US09553989
申请日：2000-04-19
申请人： Michael B. Sinclair , Maarten P. DeBoer , Norman F. Smith , Brian D. Jensen , Samuel L. Miller
发明人： Michael B. Sinclair , Maarten P. DeBoer , Norman F. Smith , Brian D. Jensen , Samuel L. Miller
IPC分类号： G06F1900
CPC分类号： B81C99/005
摘要： A new approach toward MEMS quality control and materials characterization is provided by a combined test structure measurement and mechanical response modeling approach. Simple test structures are cofabricated with the MEMS devices being produced. These test structures are designed to isolate certain types of physical response, so that measurement of their behavior under applied stress can be easily interpreted as quality control and material properties information.
摘要翻译：通过组合的测试结构测量和机械响应建模方法提供了MEMS质量控制和材料表征的新方法。简单的测试结构与正在生产的MEMS器件共同构成。这些测试结构设计用于隔离某些类型的物理响应，从而可以轻易地将其在施加的应力下的行为测量解释为质量控制和材料属性信息。

6. 发明授权

US5180003A Dual fan cooling system 失效
标题翻译：双风扇冷却系统
公开(公告)号：US5180003A
公开(公告)日：1993-01-19
申请号：US838278
申请日：1992-01-14
申请人： Richard L. Kouzel , Aubery W. Penn , Brian D. Jensen , Paul A. Dicke
发明人： Richard L. Kouzel , Aubery W. Penn , Brian D. Jensen , Paul A. Dicke
IPC分类号： F01M11/10 , F01P5/02 , F04D25/16 , F04D29/58 , F25D1/00 , F28F13/12
CPC分类号： G06K19/07758 , F01P5/02 , F04D25/166 , F04D29/5826 , F01M11/10
摘要： Cooling systems are necessary to cool fluid circulated through an internal combustion engine so that engine temperatures can be controlled. The subject dual fan cooling system increases the air flow through a heat exchanger (40) by utilizing a primary fan and a secondary fan (50, 82). The primary fan (50) is located on one side of the heat exchanger (40) and pushes air through the heat exchanger (40) while the secondary fan (82) is located on the opposite side of the heat exchanger (40) and pulls air through the heat exchanger (40). The secondary fan (82) is rotatably mounted in a substantially concentric relation with the primary fan (50) to pull air through the heat exchanger (40) at the area (L) of lowest air flow. The secondary fan (82) also substantially eliminates the recirculation of air back through the heat exchanger (40). A shroud (86) encompasses the secondary fan (82) to substantially block air pushed through the heat exchanger (40) by the primary fan (50) from the secondary fan (82).
摘要翻译： PCT No.PCT / US90 / 00084 Sec。 371日期：1992年1月14日 102（e）日期1992年1月14日PCT 1990年1月4日PCT PCT。公开号WO90 / 07759 日期1990年7月12日。冷却系统是冷却通过内燃机循环的流体所必需的，以便控制发动机的温度。主体双风扇冷却系统通过利用主风扇和次风扇（50,82）增加通过热交换器（40）的空气流。主风扇（50）位于热交换器（40）的一侧，并且通过热交换器（40）推动空气，而次风扇（82）位于热交换器（40）的相对侧并拉动空气通过热交换器（40）。二次风扇82以与主风扇50大致同心的方式可旋转地安装，以便在最低空气流的区域（L）处将空气抽吸通过热交换器40。次级风扇82也基本上消除了通过热交换器40的空气再循环。护罩（86）包围二次风扇（82），以从第二风扇（82）基本阻挡主风扇（50）推动通过热交换器（40）的空气。

7. 发明申请

US20130177977A1 Systems and Devices for Restraining a Cell and Associated Methods 审中-公开
标题翻译：用于限制细胞和相关方法的系统和装置
公开(公告)号：US20130177977A1
公开(公告)日：2013-07-11
申请号：US13539184
申请日：2012-06-29
申请人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12M1/12 , C12N15/89
CPC分类号： C12M25/00 , C12M23/12 , C12M35/00 , C12N15/89
摘要： Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure.
摘要翻译：提供了用于抑制生物结构的系统，装置和方法。在一个实例中，生物结构抑制装置可以包括阻挡结构，限定在阻挡结构中的开口，以及至少两个位于邻近开口定位并接触生物结构的接触点，其中阻挡结构和开口是在结构上定位为在接触点处接收电池。在另一方面，该装置还可以包括生物结构操纵器，其具有可操作地抵抗接触点按压生物结构的结构。在另一方面，该装置还可以包括生物结构注射器，该生物结构注射器具有可操作地插入穿过开口并进入生物结构的结构，其中生物结构操纵器可操作以将生物结构保持抵抗接触点作为生物结构注射器插入生物结构。

8. 发明申请

US20120301960A1 Lance Device and Associated Methods for Delivering a Biological Material Into a Cell 审中-公开
标题翻译：喷枪装置和将生物材料递送到细胞中的相关方法
公开(公告)号：US20120301960A1
公开(公告)日：2012-11-29
申请号：US13480083
申请日：2012-05-24
申请人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12M1/00 , C12N5/071
CPC分类号： C12N15/89 , C12M35/00
摘要： Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.
摘要翻译：提供了将生物材料递送到电池中的系统，装置和方法。在一个示例中，提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。这种装置可以包括具有尖端区域和轴区域的喷枪，其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中。在另一示例中，喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。

9. 发明授权

US07075209B2 Compliant bistable micromechanism 失效
标题翻译：双稳态微机构
公开(公告)号：US07075209B2
公开(公告)日：2006-07-11
申请号：US10333302
申请日：2001-07-18
申请人： Larry L. Howell , Matthew Parkinson , Brian D. Jensen , Gregory M. Roach
发明人： Larry L. Howell , Matthew Parkinson , Brian D. Jensen , Gregory M. Roach
IPC分类号： H02N1/00 , G01P15/02
CPC分类号： H02N1/006 , B81C99/006 , F03G7/06 , H01H2001/0042
摘要： A method for designing and optimnizing compliant mechanisms is provided, in addition to bistable compliant mechanism designs. According to the method, a selected compliant structure may be modeled analytically, and the characteristics of the analytical model may be optimized. Multiple recursive optimization algorithms may be used, for example, to determine the general location of a global optimum, and then to determine the values of the analytical model characteristics that obtain the global optimum or a feasible configuration for the selected compliant structure. Geometric characteristics of the selected compliant structure may be derived from the values of the analytical model characteristics. Bistable compliant designs may have a shuttle disposed between a pair of base members. The shuttle (20) may be linked to the base members (22, 24) by a pair of legs (30, 32), via flexural pivots. The base members may have cantilevered mounting beams to create deformable mounts that receive and store potential energy. The stable configurations are those in which the stored potential energy is at a relative minimum.
摘要翻译：提供了一种用于设计和优化顺应机制的方法，以及双稳态机构设计。根据该方法，可以分析地对所选择的顺应性结构进行建模，并且可以优化分析模型的特性。可以使用多个递归优化算法，例如，以确定全局最优值的一般位置，然后确定获得所选顺应结构的全局最优值或可行配置的分析模型特征值。可以从分析模型特征的值导出所选顺应性结构的几何特征。双稳态兼容设计可以具有布置在一对基座构件之间的梭子。梭子（20）可以通过弯曲枢轴通过一对腿（30,32）连接到基部构件（22,24）。基部构件可以具有悬臂安装梁，以产生可接收和存储势能的可变形安装件。稳定的结构是其中存储的势能处于相对最小值的构型。

10. 发明授权

US4984850A Linear impact ripper apparatus 失效
标题翻译：线性破碎机
公开(公告)号：US4984850A
公开(公告)日：1991-01-15
申请号：US430544
申请日：1989-11-02
申请人： Brian D. Jensen
发明人： Brian D. Jensen
IPC分类号： E21B1/38 , B25D17/24 , B25D17/28 , E02F5/32 , E21B1/00 , E21B1/26 , E21C37/24
CPC分类号： E02F5/323 , B25D17/24 , B25D17/28
摘要： Impact rippers are useful, for example, in fracturing rock and other hard material which is to be excavated. Known systems using structures which mount the impact hammer and the linear ram within a single housing transmit vibrations into the mounting frame and are difficult to service and expensive to maintain. The subject linear impact ripper apparatus has an impact hammer having one end resiliently mounted to a mounting frame and another end slidably mounted on one of the linear ram and the tool holder. Thus, the disclosed linear impact ripper apparatus reduces vibrations transmitted to the mounting frame and has separate elements for ease of service and reduced maintenance cost and maintains the alignment between the separate parts of the structure. The arrangement allows the connection between the impact hammer and one of the linear ram and the tool holder to be sealed from atmosphere.
摘要翻译：冲击裂土器例如在压裂岩石和其他要被挖掘的硬质材料中是有用的。使用将冲击锤和线性冲头安装在单个壳体内的结构的已知系统将振动传递到安装框架中，并且难以维护并且维护成本高。主体线性冲击破碎装置具有冲击锤，其一端弹性地安装到安装框架，另一端可滑动地安装在线性压头和工具架之一上。因此，所公开的线性冲击破裂装置减少了传递到安装框架的振动，并且具有分开的元件，便于维修和降低维护成本，并且维持结构的分离部件之间的对准。该装置允许冲击锤与线性冲头和工具夹之一的连接与大气密封。

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