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1. 发明申请

US20130005040A1 Delivery of Biological Materials Into Cellular Organelles 审中-公开
标题翻译：将生物材料交付给细胞器
公开(公告)号：US20130005040A1
公开(公告)日：2013-01-03
申请号：US13456856
申请日：2012-04-26
申请人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12N15/89 , C12M1/00
CPC分类号： C12N15/85 , A01K2217/05 , C12N13/00 , C12N15/89
摘要： Systems, devices, and methods for delivering a biological material into an organelle of a cell are provided. In one aspect, for example, a method for introducing biological material into an organelle of a cell includes bringing into proximity a lance and a preselected biological material outside of a cell and charging the lance with a polarity and a charge sufficient to electrically associate the preselected biological material with a tip portion of the lance. The method also includes penetrating an outer portion of the cell with the lance and directing and inserting the lance into an organelle, discharging the lance to release at least a portion of the biological material into the organelle, and withdrawing the lance from the cell.
摘要翻译：提供了将生物材料递送到细胞的细胞器中的系统，装置和方法。在一个方面，例如，将生物材料引入细胞的细胞器中的方法包括将细胞附近的喷枪和预先选择的生物材料接近，并以足以使预选的电极相互关联的极性和电荷充入喷枪具有喷枪尖端部分的生物材料。该方法还包括用喷枪穿透细胞的外部部分并将喷枪引导并插入细胞器中，排出喷枪以将生物材料的至少一部分释放到细胞器中，并将细胞器从细胞中取出。

2. 发明申请

US20100323419A1 Methods and Devices for Charged Molecule Manipulation 审中-公开
标题翻译：电荷分子操作的方法和装置
公开(公告)号：US20100323419A1
公开(公告)日：2010-12-23
申请号：US12668369
申请日：2008-07-09
申请人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
发明人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
IPC分类号： C12N13/00 , C12M1/42
CPC分类号： C12N15/89 , C12M35/02
摘要： Systems and methods for manipulating molecular material are provided. In one aspect, for example, a method for manipulating molecular material may include positioning an uncharged needle structure in electrical proximity with a charged molecular material at a first locus in a liquid environment, charging the needle structure such that at least a portion of the charged molecular material becomes associated with the needle structure, moving the needle structure and the first locus relative to one another, and discharging the needle structure to disassociate the charged molecular material at a second locus.
摘要翻译：提供了操作分子材料的系统和方法。在一个方面，例如，用于操纵分子材料的方法可以包括在液体环境中的第一位置处将不带电的针结构定位成与电荷分子材料电接近，对针结构进行充电，使得至少一部分带电分子材料与针结构相关联，使针结构和第一轨迹相对移动，并且排出针结构以在第二位置分离带电分子材料。

3. 发明申请

US20100248343A1 Methods and Devices for Charged Molecule Manipulation 审中-公开
标题翻译：电荷分子操作的方法和装置
公开(公告)号：US20100248343A1
公开(公告)日：2010-09-30
申请号：US12816183
申请日：2010-06-15
申请人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
发明人： Quentin T. Aten , Larry L. Howell , Brian D. Jensen , Sandra Burnett
IPC分类号： C12M1/00
CPC分类号： C12N15/89 , C12M35/02
摘要： Devices and methods for constraining or holding a cell are provided. In one aspect, for example, a cellular constraint device is provided. Such a device can include a support surface and at least one constraining arm movably coupled to the support surface. The constraining arm has a first position in which the constraining arm is substantially parallel and substantially adjacent to the support surface. Additionally, at least a portion of the constraining arm is movable away from the support surface to a second position where the constraining arm is operable to constrain a single cell.
摘要翻译：提供了用于约束或保持单元的装置和方法。在一个方面，例如，提供了一种蜂窝约束装置。这种装置可以包括支撑表面和可移动地联接到支撑表面的至少一个约束臂。约束臂具有第一位置，其中约束臂基本上平行并且基本上邻近支撑表面。此外，约束臂的至少一部分可从支撑表面移动到第二位置，其中约束臂可操作以约束单个电池。

4. 发明授权

US06748818B2 High-performance fully-compliant micro-mechanisms for force/displacement amplification 失效
标题翻译：用于强制/位移放大的高性能完全兼容的微机构
公开(公告)号：US06748818B2
公开(公告)日：2004-06-15
申请号：US10144239
申请日：2002-05-13
申请人： Brian D. Jensen , Michael Farina , Katsuo Kurabayashi
发明人： Brian D. Jensen , Michael Farina , Katsuo Kurabayashi
IPC分类号： G05G100
CPC分类号： B81B3/0062 , B81B3/0037 , B81B2201/0235 , G01P15/00 , H01Q3/01 , H01Q9/14 , Y10T74/20006 , Y10T74/20207 , Y10T74/20305 , Y10T74/20329
摘要： A device for amplifying mechanical and geometrical advantage having a base structure, a first link member having a first end and a second end, and a first compliant flexural joint pivotally interconnects the first end of the first link member to the base structure. A second link member is also provided having a first end and a second end. A second compliant flexural joint pivotally interconnects the first end of the second link member to the base structure. Furthermore, a third link member is provided having a first end and a second end. A third compliant flexural joint pivotally interconnects the first end of the third link member to the second end of the first link member and a fourth compliant flexural joint pivotally interconnects the second end of the third link member to the second end of the second link member. The base structure, first link member, second link member, and third link member cooperate to define a four-bar linkage for receiving an input force and providing an amplified force or displacement output in response thereto.
摘要翻译：一种用于放大具有基座结构的机械和几何优点的装置，具有第一端和第二端的第一连杆构件以及第一柔性弯曲接头将第一连杆构件的第一端枢转地互连到基座结构。还提供了具有第一端和第二端的第二连杆构件。第二顺从弯曲接头将第二连杆构件的第一端枢转地互连到基部结构。此外，提供具有第一端和第二端的第三连杆构件。第三顺从弯曲接头将第三连杆构件的第一端枢转地互连到第一连杆构件的第二端，并且第四顺从弯曲接头将第三连杆构件的第二端枢转地互连到第二连杆构件的第二端。基座结构，第一连杆构件，第二连杆构件和第三连杆构件协作以限定用于接收输入力的四杆联动装置，并响应于此而提供放大的力或位移输出。

5. 发明申请

US20120295345A1 APPARATUSES AND RELATED METHODS FOR DELIVERING BIOLOGICAL MATERIAL INTO A CELL 审中-公开
标题翻译：用于将生物材料递送至细胞的装置和相关方法
公开(公告)号：US20120295345A1
公开(公告)日：2012-11-22
申请号：US13475401
申请日：2012-05-18
申请人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12N5/071 , C12M1/00 , C12N5/07 , C12N5/04 , C12N1/14 , C12N1/16
CPC分类号： C12N15/89 , A01K2217/05 , C12M35/00
摘要： Systems, devices, and methods for protecting a biological material during delivery into a biological structure are provided. In one aspect, for example, a device for protecting and delivering a preselected biological material into a biological structure can include a lance operable to maintain a charge capable of associating a biological material thereto and at least one protective region formed on or in the lance, where the protective region protects the biological material during delivery into a biological structure.
摘要翻译：提供了在递送到生物结构期间保护生物材料的系统，装置和方法。在一个方面，例如，用于保护并将预选生物材料输送到生物结构中的装置可以包括可操作以保持能够将生物材料与其缔合的电荷与形成在喷枪上或其中的至少一个保护区域的喷枪，其中保护区域在递送到生物结构期间保护生物材料。

6. 发明授权

US06424165B1 Electrostatic apparatus for measurement of microfracture strength 有权
$Electrostatic apparatus for measurement of microfracture strength$
标题翻译：用于测量微裂纹强度的静电设备
公开(公告)号：US06424165B1
公开(公告)日：2002-07-23
申请号：US09665980
申请日：2000-09-20
申请人： Maarten de Boer , Fernando Bitsie , Brian D. Jensen
发明人： Maarten de Boer , Fernando Bitsie , Brian D. Jensen
IPC分类号： G01R3102
CPC分类号： B81C99/005 , G01N3/38 , G01N2203/0005 , G01N2203/0023 , G01N2203/005 , G01N2203/0067 , G01N2203/0073 , G01N2203/0286
摘要： A new class of materials testing apparatus has been invented. Particularly suited to the measurement of fracture and fatigue properties in the extremely strong materials encountered in microelectromechanical systems, material strains well in excess of 1% can be applied pseudostatically, dynamically, or repetitively by these testers. There are no other practical methods to determine these material properties routinely in a process environment, and few alternatives in any circumstances.
摘要翻译：已经发明了一类新的材料测试仪器。特别适用于在微机电系统中遇到的非常强的材料中的断裂和疲劳性能的测量，超过1％的材料应变可以被这些测试仪伪造，动态地或重复地应用。在过程环境中常规地确定这些材料属性没有其他实际的方法，在任何情况下都没有替代方案。

7. 发明授权

US06215081B1 Bistable compliant mechanism 失效
标题翻译：双稳态机制
公开(公告)号：US06215081B1
公开(公告)日：2001-04-10
申请号：US09280916
申请日：1999-03-29
申请人： Brian D. Jensen , Larry L. Howell , Gregory M. Roach
发明人： Brian D. Jensen , Larry L. Howell , Gregory M. Roach
IPC分类号： H01H300
CPC分类号： H01H3/46 , H01H1/0036 , H01H2003/466
摘要： A compliant, bistable mechanism has a plurality of segments coupled end-to-end in a series to form a continuous chain of segments. The plurality of segments includes at least two rigid segments and at least one relatively flexible and resilient segment. Adjacent rigid segments are coupled by flexible joints or pin joints. The flexible and resilient segment is coupled to adjacent segments either fixedly or by pin joints. There are at least four pin joints, flexible joints, and/or flexible and resilient segments. The joints allow relative movement of the segments while the flexible and resilient segment resists movement and biases the segments. The segments move between first and second stable equilibrium positions. The segments have a pseudo-rigid-body model resembling a four-bar linkage. The segments and flexible joints may be integrally formed. First and second electrical contacts may be coupled to the segments to form an electrical connection as the segments move to one of the positions.
摘要翻译：顺应的双稳态机构具有多个段，其以一系列端对端地连接以形成连续的段链。多个段包括至少两个刚性段和至少一个相对柔性且弹性的段。相邻的刚性段通过柔性接头或销接头联接。柔性和弹性部分固定地或通过销接头联接到相邻的部分。有至少四个针接头，柔性接头和/或柔性和弹性段。接头允许片段的相对运动，而柔性和弹性片段抵抗运动并偏转片段。段在第一和第二稳定平衡位置之间移动。这些段具有类似于四连杆的伪刚体模型。节段和柔性接头可以一体形成。当所述段移动到所述位置中的一个时，第一和第二电触头可以联接到所述段以形成电连接。

8. 发明授权

US06211599B1 Microelectromechanical ratcheting apparatus 有权
公开(公告)号：US06211599B1
公开(公告)日：2001-04-03
申请号：US09366505
申请日：1999-08-03
申请人： Stephen M. Barnes , Samuel L. Miller , Brian D. Jensen , M. Steven Rodgers , Michael S. Burg
发明人： Stephen M. Barnes , Samuel L. Miller , Brian D. Jensen , M. Steven Rodgers , Michael S. Burg
IPC分类号： H02N100
CPC分类号： F16H31/005 , F03G7/06 , F16H31/007 , H02K7/07 , H02N1/008 , Y10T74/1529
摘要： A microelectromechanical (MEM) ratcheting apparatus is disclosed which includes an electrostatic or thermal actuator that drives a moveable member in the form of a ring gear, stage, or rack. Motion is effected by one or more reciprocating pawls driven by the actuator in a direction that is parallel to, in line with, or tangential to the path. The reciprocating pawls engage indexing elements (e.g. teeth or pins) on the moveable member to incrementally move the member along a curved or straight path with the ability to precisely control and determine the position of the moveable member. The MEM apparatus can be formed on a silicon substrate by conventional surface micromachining methods.

9. 发明申请

US20130177977A1 Systems and Devices for Restraining a Cell and Associated Methods 审中-公开
标题翻译：用于限制细胞和相关方法的系统和装置
公开(公告)号：US20130177977A1
公开(公告)日：2013-07-11
申请号：US13539184
申请日：2012-06-29
申请人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Walter Fazio , Jason Mathew Lund , Gregory H. Teichert , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12M1/12 , C12N15/89
CPC分类号： C12M25/00 , C12M23/12 , C12M35/00 , C12N15/89
摘要： Systems, devices, and methods for restraining a biological structure are provided. In one example, a biological structure restraining device can include a barrier structure, an opening defined in the barrier structure, and at least two contact points positioned adjacent to the opening and oriented to contact the biological structure, wherein the barrier structure and the opening are structurally positioned to receive the cell at the contact points. In another aspect, the device can also include a biological structure manipulator having a structure operable to press the biological structure against the contact points. In yet another aspect, the device can further include a biological structure injector having a structure operable to be inserted through the opening and into the biological structure, wherein the biological structure manipulator is operable to maintain the biological structure against the contact points as the biological structure injector is inserted into the biological structure.
摘要翻译：提供了用于抑制生物结构的系统，装置和方法。在一个实例中，生物结构抑制装置可以包括阻挡结构，限定在阻挡结构中的开口，以及至少两个位于邻近开口定位并接触生物结构的接触点，其中阻挡结构和开口是在结构上定位为在接触点处接收电池。在另一方面，该装置还可以包括生物结构操纵器，其具有可操作地抵抗接触点按压生物结构的结构。在另一方面，该装置还可以包括生物结构注射器，该生物结构注射器具有可操作地插入穿过开口并进入生物结构的结构，其中生物结构操纵器可操作以将生物结构保持抵抗接触点作为生物结构注射器插入生物结构。

10. 发明申请

US20120301960A1 Lance Device and Associated Methods for Delivering a Biological Material Into a Cell 审中-公开
标题翻译：喷枪装置和将生物材料递送到细胞中的相关方法
公开(公告)号：US20120301960A1
公开(公告)日：2012-11-29
申请号：US13480083
申请日：2012-05-24
申请人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
发明人： Quentin T. Aten , Sandra H. Burnett , Brian D. Jensen , Larry L. Howell
IPC分类号： C12M1/00 , C12N5/071
CPC分类号： C12N15/89 , C12M35/00
摘要： Systems, devices, and methods for delivering a biological material into a cell are provided. In one example, a lance device for introducing biological material into a cell and configured for use in a nanoinjection system including a microscope is provided. Such a device can include a lance having a tip region and a shaft region, wherein the lance is structurally configured to allow entry and movement of the tip region into the cell along an elongate axis of the tip region and along a focal plane of the microscope. In another example, the lance can be configured to allow substantially horizontal entry and movement of the tip region into the cell.
摘要翻译：提供了将生物材料递送到电池中的系统，装置和方法。在一个示例中，提供了用于将生物材料引入细胞并配置用于包括显微镜的纳米注射系统中的喷枪装置。这种装置可以包括具有尖端区域和轴区域的喷枪，其中喷枪在结构上构造成允许尖端区域沿着尖端区域的细长轴线并沿着显微镜的焦平面进入和移动到细胞中。在另一示例中，喷枪可以被配置为允许尖端区域基本上水平地进入和移动到电池中。

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