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1. 发明授权

US08847315B2 Complementary metal-oxide-semiconductor (CMOS) device and method 有权
标题翻译：互补金属氧化物半导体（CMOS）器件及方法
公开(公告)号：US08847315B2
公开(公告)日：2014-09-30
申请号：US13465064
申请日：2012-05-07
申请人： Bin Yang , Xia Li , Jun Yuan
发明人： Bin Yang , Xia Li , Jun Yuan
IPC分类号： H01L27/12 , H01L29/47 , H01L29/10 , H01L29/66 , H01L21/8238 , H01L21/84
CPC分类号： H01L21/823814 , H01L21/28026 , H01L21/823828 , H01L21/84 , H01L27/1203 , H01L27/1211 , H01L29/1054 , H01L29/165 , H01L29/42376 , H01L29/47 , H01L29/66545 , H01L29/66621 , H01L29/66628 , H01L29/66636 , H01L29/7834
摘要： A complementary metal-oxide-semiconductor (CMOS) device and methods of formation thereof are disclosed. In a particular embodiment, a CMOS device includes a silicon substrate, a dielectric insulator material on the silicon substrate, and an extension layer on the dielectric insulator material. The CMOS device further includes a gate in contact with a channel and in contact with an extension region. The CMOS device also includes a source in contact with the extension region and a drain in contact with the extension region. The extension region includes a first region in contact with the source and the gate and includes a second region in contact with the drain and the gate.
摘要翻译：公开了一种互补金属氧化物半导体（CMOS）器件及其形成方法。在特定实施例中，CMOS器件包括硅衬底，硅衬底上的介电绝缘体材料以及介电绝缘体材料上的延伸层。 CMOS器件还包括与沟道接触并与延伸区域接触的栅极。 CMOS器件还包括与延伸区域接触的源极和与延伸区域接触的漏极。延伸区域包括与源极和栅极接触的第一区域，并且包括与漏极和栅极接触的第二区域。

2. 发明申请

US20130292767A1 COMPLEMENTARY METAL-OXIDE-SEMICONDUCTOR (CMOS) DEVICE AND METHOD 有权
标题翻译：补充金属氧化物半导体（CMOS）器件及方法
公开(公告)号：US20130292767A1
公开(公告)日：2013-11-07
申请号：US13465064
申请日：2012-05-07
申请人： Bin Yang , Xia Li , Jun Yuan
发明人： Bin Yang , Xia Li , Jun Yuan
IPC分类号： H01L27/12 , H01L21/8238
CPC分类号： H01L21/823814 , H01L21/28026 , H01L21/823828 , H01L21/84 , H01L27/1203 , H01L27/1211 , H01L29/1054 , H01L29/165 , H01L29/42376 , H01L29/47 , H01L29/66545 , H01L29/66621 , H01L29/66628 , H01L29/66636 , H01L29/7834
摘要： A complementary metal-oxide-semiconductor (CMOS) device and methods of formation thereof are disclosed. In a particular embodiment, a CMOS device includes a silicon substrate, a dielectric insulator material on the silicon substrate, and an extension layer on the dielectric insulator material. The CMOS device further includes a gate in contact with a channel and in contact with an extension region. The CMOS device also includes a source in contact with the extension region and a drain in contact with the extension region. The extension region includes a first region in contact with the source and the gate and includes a second region in contact with the drain and the gate.
摘要翻译：公开了一种互补金属氧化物半导体（CMOS）器件及其形成方法。在特定实施例中，CMOS器件包括硅衬底，硅衬底上的介电绝缘体材料以及介电绝缘体材料上的延伸层。 CMOS器件还包括与沟道接触并与延伸区域接触的栅极。 CMOS器件还包括与延伸区域接触的源极和与延伸区域接触的漏极。延伸区域包括与源极和栅极接触的第一区域，并且包括与漏极和栅极接触的第二区域。

3. 发明授权

US09683019B2 Cyclic polypeptides for the treatment of heart failure 有权
公开(公告)号：US09683019B2
公开(公告)日：2017-06-20
申请号：US14963391
申请日：2015-12-09
申请人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Guimaraes
发明人： Frederic Zecri , Philipp Grosche , Kayo Yasoshima , Hongjuan Zhao , Jun Yuan , Aimee Richardson Usera , Changgang Lou , Aaron Kanter , Alexandra Marshall Bruce , Carla Guimaraes
IPC分类号： A61K38/12 , C07K7/64 , C07K16/46 , A61K45/06 , C07K14/47 , A61K47/48 , C07K14/765
CPC分类号： C07K14/47 , A61K38/12 , A61K38/1709 , A61K45/06 , A61K47/542 , A61K47/60 , A61K47/643 , A61K47/6811 , C07K7/64 , C07K14/765 , C07K16/461 , C07K2319/30 , C07K2319/31
摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

4. 发明授权

US09340582B2 Bioconjugates of synthetic apelin polypeptides 有权
标题翻译：合成apelin多肽的生物缀合物
公开(公告)号：US09340582B2
公开(公告)日：2016-05-17
申请号：US14336290
申请日：2014-07-21
申请人： Jun Yuan , Frederic Zecri , Philipp Grosche , Hongjuan Zhao , Eric Peters , Shari Lynn Caplan , Changgang Lou
发明人： Jun Yuan , Frederic Zecri , Philipp Grosche , Hongjuan Zhao , Eric Peters , Shari Lynn Caplan , Changgang Lou
IPC分类号： C07K14/47 , C07K7/08 , A61K47/48 , A61K45/06 , A61K38/10 , C07K16/00 , A61K39/395
CPC分类号： A61K38/10 , A61K38/00 , A61K45/06 , A61K47/542 , A61K47/643 , A61K47/68 , A61K47/6811 , C07K14/47 , C07K14/765 , C07K2319/30 , C07K2319/31
摘要： The invention provides a bioconjugates comprising a synthetic polypeptide of Formula I′ (SEQ ID NO: 1): or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein and a half-life extending moiety wherein the peptide and the half-life extending moiety are covalently linked or fuse, optionally via a linker. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the bioconjugates of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供包含式I'（SEQ ID NO：1）的合成多肽的生物缀合物或其酰胺，其酯或其盐，其中X 1，X 2，X 3，X 4，X 5，X 6，X 7，X 8，X 9 ，X10，X11，X12和X13在本文中定义并且半衰期延长部分，其中肽和半衰期延长部分任选地经由连接体共价连接或融合。多肽是APJ受体的激动剂。本发明还涉及本发明的生物缀合物的制备方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，布鲁加达综合征，室性心动过速，动脉粥样硬化，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（包括晒伤）和先兆子痫。本发明还提供药理活性剂和药物组合物的组合。

5. 发明授权

US09036570B2 Method and system for providing an uplink structure and improved channelization scheme in a wireless communication network 有权
标题翻译：在无线通信网络中提供上行链路结构和改进的信道化方案的方法和系统
公开(公告)号：US09036570B2
公开(公告)日：2015-05-19
申请号：US13264936
申请日：2010-04-16
申请人： Sophie Vrzic , Mo-Han Fong , DongSheng Yu , Robert Novak , Jun Yuan
发明人： Sophie Vrzic , Mo-Han Fong , DongSheng Yu , Robert Novak , Jun Yuan
IPC分类号： H04W4/00 , H04W72/00 , H04W36/38 , H04W72/04 , H04J13/16
CPC分类号： H04W36/385 , H04J13/16 , H04L5/0007 , H04L5/0037 , H04L5/0092 , H04W72/042 , H04W72/0453
摘要： A method and system are provided to perform channelization in a wireless communication network, wherein the wireless communication network including at least one base station that is communicatively coupled to at least one mobile terminal. A bandwidth of the wireless communication network is divided into a plurality of zones at the base station. Resource blocks are provided at the base station to receive data symbols transmitted in the wireless communication network. A plurality of resource blocks are combined at the base station to form a physical basic channel unit which are allocated to one of the plurality of zones at the base station. A permutation is performed on the physical basic channel unit to form a logical basic channel unit. A channel is provided to communicatively couple the base station and the mobile terminal so that the mobile terminal may send an access grant message and a user identification to the base station to transmit data in the logical basic channel unit.
摘要翻译：提供了一种在无线通信网络中执行信道化的方法和系统，其中所述无线通信网络包括通信地耦合到至少一个移动终端的至少一个基站。无线通信网络的带宽在基站被分成多个区域。在基站处提供资源块以接收在无线通信网络中发送的数据符号。在基站处组合多个资源块，以形成分配给基站的多个区域之一的物理基本信道单元。在物理基本信道单元上执行置换以形成逻辑基本信道单元。提供了一种通信来通信地耦合基站和移动终端，使得移动终端可以向基站发送接入许可消息和用户标识以在逻辑基本信道单元中发送数据。

6. 发明申请

US20150031604A1 CYCLIC POLYPEPTIDES FOR THE TREATMENT OF HEART FAILURE 有权
标题翻译：治疗心力衰竭的循环多糖
公开(公告)号：US20150031604A1
公开(公告)日：2015-01-29
申请号：US14336262
申请日：2014-07-21
申请人： Frederic ZECRI , Philipp GROSCHE , Kayo YASOSHIMA , Hongjuan ZHAO , Jun Yuan , Aimee Richardson USERA , Changgang LOU , Aaron KANTER , Alexandra Marshall BRUCE , Carla Giumaraes
发明人： Frederic ZECRI , Philipp GROSCHE , Kayo YASOSHIMA , Hongjuan ZHAO , Jun Yuan , Aimee Richardson USERA , Changgang LOU , Aaron KANTER , Alexandra Marshall BRUCE , Carla Giumaraes
IPC分类号： C07K7/64 , A61K38/12 , A61K45/06 , C07K16/46
CPC分类号： C07K14/47 , A61K38/12 , A61K38/1709 , A61K45/06 , A61K47/542 , A61K47/60 , A61K47/643 , A61K47/6811 , C07K7/64 , C07K14/765 , C07K16/461 , C07K2319/30 , C07K2319/31
摘要： The invention provides a cyclic polypeptide of Formula I (SEQ ID NO: 1): X1-R-X3-X4-L-S-X7-X8-X9-X10-X11-X12-X13 I or an amide, an ester or a salt thereof, or a bioconjugate thereof, wherein X1, X3, X4, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention or bioconjugates thereof, and their therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.
摘要翻译：本发明提供式I（SEQ ID NO：1）的环状多肽：X1-R-X3-X4-LS-X7-X8-X9-X10-X11-X12-X13I或酰胺，酯或盐或其生物缀合物，其中X1，X3，X4，X7，X8，X9，X10，X11，X12和X13在本文中定义。多肽是APJ受体的激动剂。本发明还涉及制备本发明多肽或其生物缀合物的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，心室心动过速，动脉粥样硬化，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，潴留，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（包括晒伤）和先兆子痫。本发明还提供药理活性剂和药物组合物的组合。

7. 发明授权

US08671395B1 Adaptive deadend avoidance in constrained simulation 有权
标题翻译：约束模拟中的自适应终止避免
公开(公告)号：US08671395B1
公开(公告)日：2014-03-11
申请号：US12879458
申请日：2010-09-10
申请人： Jun Yuan , Akok Jain , Manpreet Singh Reehal , Vinaya Kumar Singh
发明人： Jun Yuan , Akok Jain , Manpreet Singh Reehal , Vinaya Kumar Singh
IPC分类号： G06F9/44 , G06F9/455
CPC分类号： G06F17/5009 , G06F2217/06
摘要： The present disclosure relates to a method for avoiding deadends in a constrained simulation. The method may include analyzing a first deadend during a simulation and a first constraint of the simulation. The method may further include determining if the first constraint causes the first deadend. If the first constraint causes the first deadend, the method may also include defining a first lookahead constraint corresponding to the first constraint. The method may additionally include rerunning a first previous cycle in the simulation while adding the first lookahead constraint to the simulation.
摘要翻译：本公开涉及一种用于在受限模拟中避免死角的方法。该方法可以包括在模拟期间分析第一死区和模拟的第一约束。所述方法还可以包括确定所述第一约束是否引起所述第一死锁。如果第一约束导致第一个停止，则该方法还可以包括定义与第一约束相对应的第一前瞻约束。该方法可以另外包括在模拟中重新运行第一先前循环，同时将第一前视约束添加到模拟中。

8. 发明授权

US08649468B2 Micro-controller, processing method and device for power line carrier signal reception 有权
标题翻译：微控制器，电源线载波信号接收的处理方法和装置
公开(公告)号：US08649468B2
公开(公告)日：2014-02-11
申请号：US13609245
申请日：2012-09-10
申请人： Rui Wang , Song Pan , Jian Cui , Jun Yuan , Yajun Hu
发明人： Rui Wang , Song Pan , Jian Cui , Jun Yuan , Yajun Hu
IPC分类号： H04L27/06
CPC分类号： H04B3/542
摘要： The present invention provides a micro-controller, a processing method and device for power line carrier signal reception, where the method includes: an analog mixer mixes received power line carrier signals, an analog filter filters the mixed power line carrier signals, an analog-to-digital converter converts the filtered signals, a digital mixer mixes converted signals, a digital filter filters the mixed signals and a digital demodulator demodulates the filtered signals to obtain base band data. The present invention also provides a corresponding device and a micro-controller including the device. The technical solution of the present invention can modulate the carrier signals of any frequency to a fixed frequency through two-stage frequency mixing, so that demodulation of power line carrier signals with any frequency is possible.
摘要翻译：本发明提供了一种用于电力线载波信号接收的微控制器，处理方法和装置，其中所述方法包括：模拟混频器混合接收到的电力线载波信号，模拟滤波器对混合电力线载波信号进行滤波，数字转换器转换滤波后的信号，数字混频器混合转换的信号，数字滤波器对混合信号进行滤波，并且数字解调器解调滤波后的信号以获得基带数据。本发明还提供了包括该装置的相应装置和微控制器。本发明的技术方案可以通过两级混频将任何频率的载波信号调制到固定频率，从而可以对具有任何频率的电力线载波信号进行解调。

9. 发明授权

US08633193B2 Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds 失效
标题翻译：吡咯并吡啶，吡咯并嘧啶和相关的杂环化合物
公开(公告)号：US08633193B2
公开(公告)日：2014-01-21
申请号：US13014066
申请日：2011-01-26
申请人： Jun Yuan , Peter Hrnciar , Qin Guo , George D. Maynard
发明人： Jun Yuan , Peter Hrnciar , Qin Guo , George D. Maynard
IPC分类号： A61K31/519 , C07D487/04 , A61P37/00 , A61P37/06 , A61P11/06 , A61P17/06
CPC分类号： C07D471/04
摘要： Pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds analogues of the formula: wherein R, R2, R5, E, Z1, Z3, Z4, and Ar are defined herein. Such compounds are ligands of C5a receptors. Preferred pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds of the invention bind to C5a receptors with high affinity and exhibit neutral antagonist or inverse agonist activity at C5a receptors. The present invention also relates to pharmaceutical compositions comprising such compounds, and to the use of such compounds in treating a variety of inflammatory, cardiovascular, and immune system disorders. In addition, the present invention provides labeled pyrrolo-pyridine, pyrrolo-pyrimidine and related heterocyclic compounds, which are useful as probes for the localization of C5a receptors.
摘要翻译：吡咯并 - 吡啶，吡咯并 - 嘧啶和相关的杂环化合物，其分子式如下：其中R，R 2，R 5，E，Z 1，Z 3，Z 4和Ar如本文所定义。这些化合物是C5a受体的配体。本发明优选的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物以高亲和力结合C5a受体，并在C5a受体上表现出中性拮抗剂或反向激动剂活性。本发明还涉及包含这些化合物的药物组合物，以及这些化合物在治疗各种炎性，心血管和免疫系统疾病中的用途。此外，本发明提供了标记的吡咯并 - 吡啶，吡咯并 - 嘧啶和相关杂环化合物，其可用作C5a受体定位的探针。

10. 发明授权

US08629022B2 Asymmetric FET including sloped threshold voltage adjusting material layer and method of fabricating same 有权
标题翻译：包括倾斜阈值电压调节材料层的不对称FET及其制造方法
公开(公告)号：US08629022B2
公开(公告)日：2014-01-14
申请号：US13420730
申请日：2012-03-15
申请人： Dureseti Chidambarrao , Sunfei Fang , Yue Liang , Xiaojun Yu , Jun Yuan
发明人： Dureseti Chidambarrao , Sunfei Fang , Yue Liang , Xiaojun Yu , Jun Yuan
IPC分类号： H01L21/8234
CPC分类号： H01L27/092 , H01L21/823857 , H01L29/42368 , H01L29/513 , H01L29/517 , H01L29/66545 , H01L29/66583 , H01L29/78
摘要： A method of forming a semiconductor structure is provided. The method includes providing a structure including at least one dummy gate region located on a surface of a semiconductor substrate and a dielectric material layer located on sidewalls of the at least one dummy gate region. Next, a portion of the dummy gate region is removed exposing an underlying high k gate dielectric. A sloped threshold voltage adjusting material layer is then formed on an upper surface of the high k gate dielectric, and thereafter a gate conductor is formed atop the sloped threshold voltage adjusting material layer.
摘要翻译：提供一种形成半导体结构的方法。该方法包括提供包括位于半导体衬底的表面上的至少一个伪栅极区域和位于至少一个虚拟栅极区域的侧壁上的介电材料层的结构。接下来，去除暴露下面的高k栅极电介质的虚拟栅极区域的一部分。然后在高k栅极电介质的上表面上形成倾斜的阈值电压调节材料层，然后在倾斜的阈值电压调节材料层的顶部形成栅极导体。

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