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1. 发明申请

US20080176812A1 Allele-specific silencing of disease genes 审中-公开
标题翻译：疾病基因的等位基因特异性沉默
公开(公告)号：US20080176812A1
公开(公告)日：2008-07-24
申请号：US11343366
申请日：2006-01-31
申请人： Beverly L. Davidson , Scott Harper , Pedro Gonzalez-Alegre , Victor Miller , Henry Paulson
发明人： Beverly L. Davidson , Scott Harper , Pedro Gonzalez-Alegre , Victor Miller , Henry Paulson
IPC分类号： A61K31/70 , C12N5/06 , C12N15/11 , C12N15/87 , A61P43/00 , C12Q1/68 , C12N15/00 , A01K67/027
CPC分类号： C12N15/1137 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12Y302/01031 , Y02A50/465
摘要： The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
摘要翻译：本发明涉及针对目标等位基因的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。

2. 发明申请

US20090105169A1 ALLELE-SPECIFIC SILENCING OF DISEASE GENES 审中-公开
标题翻译：疾病基因的特异性沉默
公开(公告)号：US20090105169A1
公开(公告)日：2009-04-23
申请号：US10522954
申请日：2003-05-26
申请人： Beverly L. Davidson , Victor Miller , Henry Paulson , Pedro Gonzalez-Alegre , Scott Harper
发明人： Beverly L. Davidson , Victor Miller , Henry Paulson , Pedro Gonzalez-Alegre , Scott Harper
IPC分类号： A61K31/7105 , C12N5/10 , A61P25/28 , C07H21/02
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N2310/111 , C12N2310/14 , C12N2310/53 , G01N2800/2835 , Y02A50/465
摘要： The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
摘要翻译：本发明涉及针对目标等位基因的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。

3. 发明申请

US20110244561A1 siRNA-MEDIATED GENE SILENCING 有权
标题翻译： siRNA介导的基因沉默
公开(公告)号：US20110244561A1
公开(公告)日：2011-10-06
申请号：US12952449
申请日：2010-11-23
申请人： Beverly L. Davidson , Henry Paulson , Victor Miller , Cynthia Gouvion
发明人： Beverly L. Davidson , Henry Paulson , Victor Miller , Cynthia Gouvion
IPC分类号： C12N5/10 , C07H21/04 , C12N15/63 , C12N1/00
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
摘要： The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
摘要翻译：本发明涉及针对目标等位基因的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。

4. 发明授权

US08329890B2 SiRNA-mediated gene silencing 有权
标题翻译： SiRNA介导的基因沉默
公开(公告)号：US08329890B2
公开(公告)日：2012-12-11
申请号：US12952449
申请日：2010-11-23
申请人： Beverly L. Davidson , Henry Paulson , Victor Miller , Cynthia Gouvion
发明人： Beverly L. Davidson , Henry Paulson , Victor Miller , Cynthia Gouvion
IPC分类号： C07H21/04
CPC分类号： C12N15/113 , A01K2217/05 , A61K38/00 , A61K48/00 , C12N15/111 , C12N15/1137 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2330/30 , C12N2799/021 , C12N2799/022 , C12Y302/01031 , Y02A50/465
摘要： The present invention is directed to small interfering RNA molecules (siRNA) targeted against an allele of interest, and methods of using these siRNA molecules.
摘要翻译：本发明涉及针对目标等位基因的小干扰RNA分子（siRNA）以及使用这些siRNA分子的方法。

5. 发明申请

US20070244057A1 Suppressing polyglutamine aggregation and toxicity 审中-公开
标题翻译：抑制聚谷氨酰胺聚集和毒性
公开(公告)号：US20070244057A1
公开(公告)日：2007-10-18
申请号：US11656048
申请日：2007-01-22
申请人： Henry Paulson , Victor Miller
发明人： Henry Paulson , Victor Miller
IPC分类号： A61K38/07 , A61K38/06 , A61P25/28 , C12N5/06 , C12N5/08 , C12N5/10
CPC分类号： A61K38/1703
摘要： It has been discovered that CHIP suppresses polyglutamine aggregation and toxicity in transfected cell lines, primary neurons and a novel zebrafish model of disease. Accordingly, certain embodiments of the present invention provide methods for decreasing the formation of an inclusion or aggregation of a protein or for increasing the solubility of a protein in a cell, comprising increasing the amount of C-terminal heat shock protein 70-interacting protein (CHIP) or a functional subunit of CHIP in the cell. Additionally, certain embodiments of the present invention provide methods for treating a subject that has a neurodegenerative disease or preventing a neurodegenerative disease in a subject, comprising administering to the subject a treatment effective to increase the amount of CHIP, or a functional subunit thereof, in cells of the subject.
摘要翻译：已经发现，CHIP抑制转染细胞系，原代神经元和新型斑马鱼疾病模型中的多聚谷氨酰胺聚集和毒性。因此，本发明的某些实施方案提供了减少蛋白质的包合物或聚集物的形成或增加蛋白质在细胞中的溶解度的方法，包括增加C末端热休克蛋白70相互作用蛋白质的量 CHIP）或细胞中CHIP的功能亚基。另外，本发明的某些实施方案提供了治疗患有神经变性疾病或预防受试者的神经变性疾病的受试者的方法，包括向受试者施用有效增加CHIP或其功能亚基的量的治疗，受试者的细胞。

6. 发明授权

US09387549B2 Adjustable clamping mechanism of a weld head with quick release insert 有权
标题翻译：具有快速释放插入件的焊头的可调夹紧机构
公开(公告)号：US09387549B2
公开(公告)日：2016-07-12
申请号：US13474947
申请日：2012-05-18
申请人： Jamil Snead , Victor Miller
发明人： Jamil Snead , Victor Miller
IPC分类号： B23K9/028 , B23K37/04 , B23K37/053
CPC分类号： B23K9/0286 , B23K37/0435 , B23K37/0533
摘要： Techniques, systems, and devices are described for a weld head that includes an adjustable clamping mechanism with a quick release insert. In one aspect, a weld head having an adjustable clamping mechanism for clamping a welding work piece includes a weld head containment structure having an opening that receives a welding work piece, a clamping member located inside the opening of the weld head containment structure and including a pivot joint for clamping the welding work piece to the weld head, a handle member connected to the clamping member at the pivot joint to rotate the clamping member when the handle member is moved, and an actuator coupled to the clamping member to enable the clamping member to pivot on the pivot joint to different clamping positions for clamping welding work pieces of different sizes.
摘要翻译：描述了一种用于焊头的技术，系统和设备，其包括具有快速释放插入件的可调夹紧机构。一方面，具有用于夹紧焊接工件的可调夹紧机构的焊头包括焊接头容纳结构，其具有接收焊接工件的开口，位于焊接头容纳结构的开口内部的夹紧构件，用于将焊接工件夹紧到焊接头的枢转接头，在枢转接头处连接到夹紧构件的手柄构件，以在手柄构件移动时旋转夹紧构件;以及致动器，其联接到夹紧构件以使夹紧构件在枢轴接头处枢转到不同的夹紧位置，用于夹紧不同尺寸的焊接工件。

7. 发明申请

US20110132877A1 INTEGRATED SHIELDING GAS AND MAGNETIC FIELD DEVICE FOR DEEP GROOVE WELDING 审中-公开
标题翻译：集成式屏蔽气体和用于深孔焊接的磁场装置
公开(公告)号：US20110132877A1
公开(公告)日：2011-06-09
申请号：US12954076
申请日：2010-11-24
申请人： Victor Miller , Lane Litke
发明人： Victor Miller , Lane Litke
IPC分类号： B23K9/16
CPC分类号： B23K9/0213 , B23K9/08 , B23K9/167 , B23K9/32
摘要： A welding system is provided which can weld in narrow gap thick walled work pieces, the welding system having a magnetic field unit which contains a magnetic coil, a magnetic field probe, and a shielding gas tube and nozzle. The unit having a shape and configuration which delivers the shielding gas and magnetic field close to the welding arc so as to provide for a shielded welding arc which is manipulated as desired by the magnetic field.
摘要翻译：提供一种焊接系统，其能够在窄间隙的厚壁工件中焊接，该焊接系统具有包含磁性线圈，磁场探针和保护气体管和喷嘴的磁场单元。该单元具有将保护气体和磁场传递到焊接电弧附近的形状和构造，以提供根据磁场所期望的屏蔽焊接电弧。

8. 发明授权

US07047074B2 Electromagnetic interference immune tissue invasive system 失效
公开(公告)号：US07047074B2
公开(公告)日：2006-05-16
申请号：US10077988
申请日：2002-02-19
申请人： Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
发明人： Patrick R. Connelly , Michael L. Weiner , Stuart G. MacDonald , Thomas H. Foster , Wilson Greatbatch , Victor Miller
IPC分类号： A61N1/362
CPC分类号： G01R33/285 , A61N1/056 , A61N1/086 , A61N1/3718 , A61N1/375 , G01R33/288
摘要： An electromagnetic immune tissue invasive system includes a primary device housing. The primary device housing having a control circuit therein. A shielding is formed around the primary device housing to shield the primary device housing and any circuits therein from electromagnetic interference. A lead system transmits and receives signals between the primary device housing. The lead system is either a fiber optic system or an electrically shielded electrical lead system.

9. 发明申请

US20050113876A1 Device and method for preventing magnetic-resonance imaging induced damage 失效
公开(公告)号：US20050113876A1
公开(公告)日：2005-05-26
申请号：US10795746
申请日：2004-03-08
申请人： Michael Weiner , Victor Miller , Patrick Connelly , Jeffrey Helfer
发明人： Michael Weiner , Victor Miller , Patrick Connelly , Jeffrey Helfer
IPC分类号： G01R33/28 , G01R33/48 , G01R33/54 , A61N1/375
CPC分类号： G01R33/285 , A61N1/086 , G01R33/288 , G01R33/4804 , Y10T428/24322 , Y10T428/24331
摘要： An electromagnetic shield has a first patterned or apertured layer having non-conductive materials and conductive material and a second patterned or apertured layer having non-conductive materials and conductive material. The conductive material may be a metal, a carbon composite, or a polymer composite. The non-conductive materials in the first patterned or apertured layer may be randomly located or located in a predetermined segmented pattern such that the non-conductive materials in the first patterned or apertured layer are located in a predetermined segmented pattern with respect to locations of the non-conductive materials in the second patterned or apertured layer.

10. 发明申请

US20210301589A1 CHILD SAFETY BARRIER SYSTEM 有权
公开(公告)号：US20210301589A1
公开(公告)日：2021-09-30
申请号：US16829931
申请日：2020-03-25
申请人： Victor Miller
发明人： Victor Miller
IPC分类号： E06B9/06 , E06B9/04
摘要： A child safety barrier system includes a plurality of elongated panel sections having a predetermined height and width. At least one support joint is connected between two of the plurality of panel sections to support the plurality of panels in a freestanding vertical orientation to form a panel assembly. A pair of telescoping anchors are positioned along each end of the panel assembly. Each of the telescoping anchors including a header assembly along the top end having an omnidirectional joint for positioning a malleable header block against the ceiling of a building in a plurality of different orientations.

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