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1. 发明授权

US06988001B2 Hermetic component housing for photonic catheter 失效
公开(公告)号：US06988001B2
公开(公告)日：2006-01-17
申请号：US10283530
申请日：2002-10-30
申请人： Wilson Greatbatch , Michael L. Weiner
发明人： Wilson Greatbatch , Michael L. Weiner
IPC分类号： A61N1/362
CPC分类号： A61N1/056 , A61N1/0565
摘要： A hermetic component housing for use with a photonic catheter connected to a photonic pacemaker or other medical system designed for compatibility with Magnetic Resonance Imaging (MRI) procedures. The hermetic housing includes a housing body having a proximal end and a distal end. The body is formed with a hermetically sealed interior for carrying one or more electrical and/or optical components therein. The proximal end of the body is adapted to mount to a distal end of a photonic catheter carrying a fiber optic element or bundle. A hermetic terminal is provided to allow the fiber optic element or bundle to communicate with the body interior. The body can be adapted to mount (or function as) one or more electrodes designed for delivering or sensing electrical signals to body tissue, or it may be adapted to mount no electrodes. The component housing may be implemented by itself at the distal end of the photonic catheter, or it may be used in conjunction with other housings of like or different construction.

2. 发明授权

US5324643A Method of conferring resistance to retroviral infection 失效
标题翻译：赋予逆转录病毒感染抗性的方法
公开(公告)号：US5324643A
公开(公告)日：1994-06-28
申请号：US739718
申请日：1991-07-29
申请人： Wilson Greatbatch , John C. Sanford
发明人： Wilson Greatbatch , John C. Sanford
IPC分类号： A61K48/00 , C07K14/15 , C07K14/155 , C12N15/113 , C12N15/867 , C12N15/11 , C07H21/02 , C07H21/04 , C12N5/10
CPC分类号： C12N15/1131 , C07K14/005 , C12N15/1132 , C12N15/86 , A61K48/00 , C12N2740/13022 , C12N2740/13043 , C12N2740/15022 , C12N2740/16043
摘要： In accordance with the present invention, disclosed is a method of conferring, upon a host cell, resistance to retroviral infection by interfering with one or more of the infection processes including retroviral replication and assembly into infective viral particles. The method involves introducing a vector into a host cell, wherein the vector comprises a polynucleotide which directs transcription, within the host cell, of RNA which is a) complementary or homologous, depending on the target region, to a nucleic acid sequence within one or more regions of the genome of the retrovirus; and b) is effective in inhibiting retroviral replication and/or interfering with assembly into viral particles when the host cell is infected. Also disclosed is a method of treatment using cells upon which resistance to infection has been conferred.
摘要翻译：根据本发明，所公开的方法是通过干扰一种或多种包括逆转录病毒复制和组装在感染性病毒颗粒中的感染过程来赋予宿主细胞抗逆转录病毒感染的方法。所述方法包括将载体导入宿主细胞，其中所述载体包含多核苷酸，所述多核苷酸指导宿主细胞内的RNA，所述RNA是a）与取决于靶区域互补或同源的RNA与一个或多个核酸序列内的核酸序列逆转录病毒基因组的更多区域; 和b）当宿主细胞被感染时，有效地抑制逆转录病毒复制和/或干扰组装成病毒颗粒。还公开了使用其上赋予抗感染性的细胞的治疗方法。

3. 发明授权

US4385439A Method of making a lithium-iodine cell 失效
标题翻译：锂碘电池的制造方法
公开(公告)号：US4385439A
公开(公告)日：1983-05-31
申请号：US161058
申请日：1980-06-19
申请人： Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz, Jr. , Wilson Greatbatch
发明人： Ralph T. Mead , Frank W. Rudolph , Norbert W. Frenz, Jr. , Wilson Greatbatch
IPC分类号： H01M2/06 , H01M6/18 , H01M2/36
CPC分类号： H01M2/065 , H01M6/182 , Y10T29/49108 , Y10T29/4911
摘要： A lithium-iodine cell comprising a casing of electrically conducting material, an anode including a lithium element within the casing, an electrical conductor operatively connected to the lithium element and extending out from the casing, and a cathode comprising iodine-containing material in operative contact with both the casing and the lithium element. The anode electrical conductor is completely sealed from the rest of the cell, and the casing serves as the cathode current collector. The anode operative surface is provided with a coating of an organic electron donor material. The anode conductor is enclosed within the combination of an insulator element within the casing, an isolator element between the insulator and the conductor, and a ferrule having one end within the insulator and the other end extending from the casing. During assembly, the cathode material is introduced in heated form and a filling element is employed which serves to keep the edge of the casing open end clean to facilitate subsequent welding of a lid to the casing.
摘要翻译：一种锂 - 碘电池，包括导电材料的壳体，在壳体内包含锂元素的阳极，可操作地连接到锂元素并从壳体延伸出来的电导体，以及包含操作接触的含碘材料的阴极与壳体和锂元素。阳极电导体与电池的其余部分完全密封，并且壳体用作阴极集电器。阳极工作表面设置有有机电子给体材料的涂层。阳极导体封装在壳体内的绝缘体元件，绝缘体和导体之间的绝缘元件以及绝缘体内的一端和从壳体延伸的另一端的套圈之间。在组装期间，阴极材料以加热形式引入，并且使用填充元件，其用于保持壳体的边缘开口端清洁以便于将盖子随后焊接到壳体。

4. 发明授权

US4313438A Tissue growth control apparatus and method 失效
公开(公告)号：US4313438A
公开(公告)日：1982-02-02
申请号：US167752
申请日：1980-07-14
申请人： Wilson Greatbatch
发明人： Wilson Greatbatch
IPC分类号： A61B17/58 , A61F2/28 , A61N1/08 , A61N1/20 , A61N1/32 , A61N1/372 , A61N1/30
CPC分类号： A61B17/58 , A61N1/08 , A61N1/205 , A61N1/326 , A61N1/372 , A61F2002/2821
摘要： A method and apparatus for providing germicidal and healing treatment of tissue such as bone wherein an electrode of silver or like material is applied to a living tissue site to be healed, initially a direct voltage is applied to the electrode of a polarity driving the electrode as an anode to release silver ions to create a germicidal environment at the site, and thereafter a direct voltage of opposite polarity is applied to the electrode driving it as a cathode to stimulate healing of the tissue at the site. The apparatus is implanted in the body of a patient, and in one embodiment a battery is connected through a switch to the electrode and a reference electrode, the switch initially connecting the electrode as an anode and thereafter changeable by an external operator such as a magnet to connect the electrode as a cathode. In another embodiment, another electrode and an element cooperate with the treating electrode to form a galvanic couple with the treating electrode to create a germicidal environment and a predetermined time thereafter the arrangement changes to a biogalvanic couple with body fluid to cause healing of the tissue. In either embodiment a wave shaping circuit can be operatively associated with the treating electrode to facilitate external monitoring of the apparatus when implanted.

5. 发明授权

US4157720A Cardiac pacemaker 失效
标题翻译：心脏起搏器
公开(公告)号：US4157720A
公开(公告)日：1979-06-12
申请号：US833920
申请日：1977-09-16
申请人： Wilson Greatbatch
发明人： Wilson Greatbatch
IPC分类号： A61N1/375 , A61N1/04
CPC分类号： A61N1/375 , A61N1/3756
摘要： A cardiac pacemaker including a pulse generator and an electrical source such as a battery completely enveloped in a small size housing. An electrode operatively connected to the pulse generator has a helically-shaped portion extending outwardly from the housing in fixed relation thereto. The housing is of sufficiently small size to permit the pacemaker to be implanted in conjunction with a limited thoracotomy by turning the housing to rotatively insert the electrode into the heart tissue of the patient, i.e. into the myocardium. The housing can be of electrically conducting material, insulated from the electrode, and a portion of the housing can serve as an indifferent electrode.
摘要翻译：一种心脏起搏器，包括脉冲发生器和电源，例如完全包围在小尺寸壳体中的电池。可操作地连接到脉冲发生器的电极具有螺旋状部分，其从壳体以固定关系向外延伸。外壳的尺寸足够小以通过转动外壳将电极转移到患者的心脏组织，即心肌中，使起搏器能够与有限的开胸手术一起植入。壳体可以是导电材料，与电极绝缘，并且壳体的一部分可以用作无关电极。

6. 发明授权

US4105833A Lithium-bromine cell 失效
标题翻译：溴化锂电池
公开(公告)号：US4105833A
公开(公告)日：1978-08-08
申请号：US722653
申请日：1976-09-16
申请人： Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank W. Rudolph , Norbert W. Frenz
发明人： Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank W. Rudolph , Norbert W. Frenz
IPC分类号： H01M2/06 , H01M4/60 , H01M6/18 , H01M4/36
CPC分类号： H01M6/182 , H01M2/065 , H01M4/60 , H01M6/18
摘要： A lithium-bromine cell comprising a casing which can be of electrically conducting material and containing a lithium anode element from which a sealed conductor extends through the casing. A filling element which can be of electrically conducting material and which has a passage therethrough is fixed to the sealed casing with one end of the passage in communication with the interior of the casing and the other end externally exposed. Bromine is introduced through the passage to the interior of the casing into operative relationship with the lithium anode whereupon the passage is closed to complete the cell. The electrically conducting casing serves as a cathode current collector in operative contact with the bromine cathode, and after closing of the passage the electrically conducting filling element serves as an electrical terminal for the cell. An electrical potential difference exists between the terminal and the anode conductor during operation of the cell.
摘要翻译：一种锂 - 溴电池，其包括可以是导电材料并且包含锂阳极元件的壳体，密封导体从该锂阳极元件穿过壳体。可以是导电材料并且具有穿过其的通道的填充元件被固定到密封壳体，通道的一端与壳体的内部连通，另一端从外部暴露。通过通向壳体内部的通道将溴引入与锂阳极的操作关系，由此通道封闭以完成电池。导电壳体用作与溴阴极有效接触的阴极集电器，并且在通路关闭之后，导电填充元件用作电池的电端子。在电池工作期间，端子和阳极导体之间存在电位差。

7. 发明授权

US4058889A Method of making a lithium-bromine cell 失效
标题翻译：制造锂 - 溴电池的方法
公开(公告)号：US4058889A
公开(公告)日：1977-11-22
申请号：US708362
申请日：1976-07-26
申请人： Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank W. Rudolph , Norbert W. Frenz
发明人： Wilson Greatbatch , Ralph T. Mead , Robert L. McLean , Frank W. Rudolph , Norbert W. Frenz
IPC分类号： H01M2/06 , H01M4/60 , H01M6/18 , H01M6/00
CPC分类号： H01M6/182 , H01M2/06 , H01M4/60 , Y10T29/49115
摘要： A solid electrolyte primary cell comprising a lithium anode, a bromine cathode and a lithium bromide electrolyte. A solid lithium element operatively contacts the cathode material, and one form of cathode material is a charge transfer complex of an organic donor component material and bromine. The organic donor component material can be poly-2-vinyl pyridine. Another cathode material is liquid bromine. The surface of the lithium anode element which operatively contacts the cathode material can be provided with a coating of an organic electron donor component material. When the lithium anode operatively contacts the bromine cathode, a solid lithium bromide electrolyte begins to form at the interface and an electrical potential difference exists between conductors operatively connected to the anode and cathode.
摘要翻译：一种固体电解质原电池，其包含锂阳极，溴阴极和溴化锂电解质。固体锂元素可操作地接触阴极材料，并且一种形式的阴极材料是有机供体组分材料和溴的电荷转移络合物。有机供体组分材料可以是聚-2-乙烯基吡啶。另一种阴极材料是液态溴。可操作地接触阴极材料的锂阳极元件的表面可以提供有机电子给体组分材料的涂层。当锂阳极可操作地接触溴阴极时，固体溴化锂电解质开始在界面处形成，并且在可操作地连接到阳极和阴极的导体之间存在电势差。

8. 发明授权

US3981744A Enclosure for lithium-iodine cell and method of making the same 失效
标题翻译：锂碘电池外壳及其制作方法
公开(公告)号：US3981744A
公开(公告)日：1976-09-21
申请号：US513127
申请日：1974-10-08
申请人： Wilson Greatbatch , Ralph T. Mead
发明人： Wilson Greatbatch , Ralph T. Mead
IPC分类号： H01M2/00 , H01M6/18 , H01M4/36
CPC分类号： H01M2/00 , H01M6/182 , Y10T29/4911 , Y10T29/49114
摘要： An enclosure for a lithium-iodine cell including a first casing containing the cell components and a second casing containing the first casing. The first casing is disposed so that the lid thereof is adjacent the bottom of the second casing. Both casings are of a material which is non-reactive with iodine such as epoxy material. The first casing is encapsulated in a polyester material for electrical insulation and sealing against iodine migration. The second casing is placed in an hermetically sealed outer casing of metal, the second casing being spaced from the lid of the outer casing.
摘要翻译：一种用于锂碘电池的外壳，包括容纳电池组件的第一壳体和包含第一壳体的第二壳体。第一壳体被设置成使其盖子邻近第二壳体的底部。两种壳体都是与碘不反应的材料，例如环氧树脂材料。第一套被封装在聚酯材料中，用于电绝缘和密封以防碘迁移。第二壳体放置在密封的金属外壳中，第二壳体与外壳的盖隔开。

9. 发明申请

US20070217163A1 Implantable medical electronic device with amorphous metallic alloy enclosure 审中-公开
标题翻译：具有非晶金属合金外壳的植入式医疗电子设备
公开(公告)号：US20070217163A1
公开(公告)日：2007-09-20
申请号：US11376616
申请日：2006-03-15
申请人： Wilson Greatbatch , Jeffrey Deal
发明人： Wilson Greatbatch , Jeffrey Deal
IPC分类号： H05K7/20
CPC分类号： A61N1/375 , A61N1/37211 , A61N1/3787
摘要： An implantable device includes a device case comprising amorphous non-ferrous metal alloy material and having lower electrical conductivity than crystalline atomic structures comprising the same alloy constituents. The generation of eddy currents is thereby reduced and inductive charging and/or telemetry system operation can take place at higher frequencies with a resulting improvement in energy and data transfer efficiency.
摘要翻译：可植入装置包括包含无定形有色金属合金材料并且具有比包含相同合金成分的结晶原子结构更低导电性的装置壳体。从而降低了涡流的产生，并且可以在较高频率下进行感应充电和/或遥测系统操作，从而提高了能量和数据传输效率。

10. 发明授权

US07136701B2 Hybrid battery power source for implantable medical use 失效
标题翻译：用于植入式医疗用途的混合电池电源
公开(公告)号：US07136701B2
公开(公告)日：2006-11-14
申请号：US10727349
申请日：2003-12-03
申请人： Wilson Greatbatch , Jeffrey Deal
发明人： Wilson Greatbatch , Jeffrey Deal
IPC分类号： A61N1/40
CPC分类号： H01M16/00 , A61N1/08 , A61N1/378 , H01M6/16 , H01M6/5016 , H01M6/5033 , H01M10/052 , H01M10/0525 , H02J7/0054
摘要： A hybrid battery power source for implantable medical use provides a generally constant low internal resistance during discharge and avoids voltage delays of the type that develop as a result of run down-induced resistance increase in Li/SVO cells. The hybrid battery power source utilizes two batteries or cells, one being a primary cell of relatively high energy density and the other being a secondary cell of relatively low internal resistance that is rechargeable. The primary and secondary cells are connected in a parallel arrangement via a voltage boost/charge control circuit that is powered by the primary cell and adapted to charge the secondary cell while limiting charge/discharge excursions thereof in a manner that optimizes its output for high energy medical device use. The energy storage capacitors of the medical device in which the hybrid battery power source is situated are driven by the secondary cell. The primary cell is used to as an energy source for recharging the secondary cell.
摘要翻译：用于可植入医疗用途的混合电池电源在放电期间提供通常恒定的低内部电阻，并且避免由于Li / SVO电池的下降引起的电阻增加而发展的类型的电压延迟。混合电池电源使用两个电池或电池，一个是相对较高能量密度的主电池，另一个是可再充电的内阻相对较低的二次电池。主电池和次电池通过电压升压/充电控制电路以并联装置连接，该电压升压/充电控制电路由主电池供电并且适于对二次电池充电，同时以优化其高能量输出的方式限制充电/放电偏移医疗器械使用。混合电池电源所在的医疗装置的储能电容器由二次电池驱动。主电池用作再次充电二次电池的能量源。

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