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1. 发明申请

US20130217583A1 MICROFLUIDIC DEVICES AND METHODS OF USE IN THE FORMATION AND CONTROL OF NANOREACTORS 有权
标题翻译：微流体装置及其在纳米复合材料的形成与控制中的应用
公开(公告)号：US20130217583A1
公开(公告)日：2013-08-22
申请号：US13759660
申请日：2013-02-05
申请人： Darren Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
发明人： Darren Link , Laurent Boitard , Jeffrey Branciforte , Yves Charles , Gilbert Feke , John Q. Lu , David Marran , Ahmadali Tabatabai , Michael Weiner , Wolfgang Hinz , Jonathan M. Rothberg
IPC分类号： C12Q1/68 , G01N33/543
CPC分类号： C12N15/1075 , B01F3/0807 , B01F13/0071 , B01F13/0076 , B01J19/0046 , B01J2219/00286 , B01J2219/00459 , B01J2219/00466 , B01J2219/00468 , B01J2219/00479 , B01J2219/005 , B01J2219/00576 , B01J2219/00599 , B01J2219/00702 , B01J2219/0072 , B01J2219/00743 , B01L3/5027 , B01L3/502715 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L3/502784 , B01L3/502792 , B01L3/565 , B01L7/52 , B01L2200/027 , B01L2200/0621 , B01L2200/0647 , B01L2200/0652 , B01L2200/0673 , B01L2300/0816 , B01L2300/0864 , B01L2300/0867 , B01L2300/0896 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/084 , B82Y5/00 , B82Y30/00 , C07K1/047 , C12Q1/6804 , C12Q1/6816 , C12Q1/6825 , C12Q1/6834 , C12Q1/686 , C12Q1/6869 , C12Q1/6874 , C12Q1/6876 , C12Q2525/161 , C12Q2561/119 , C12Q2563/103 , C12Q2563/107 , C12Q2563/159 , C12Q2565/537 , C12Q2565/629 , C12Q2600/16 , C40B30/04 , C40B40/04 , C40B50/08 , C40B60/08 , C40B60/12 , C40B70/00 , G01N21/6428 , G01N21/6445 , G01N21/6458 , G01N33/536 , G01N33/542 , G01N33/543 , G01N33/6845 , G01N33/6854 , G01N2500/10
摘要： The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays and combinatorial chemistry. Such methods can include labeling a library of compounds by emulsifying aqueous solutions of the compounds and aqueous solutions of unique liquid labels on a microfluidic device, which includes a plurality of electrically addressable, channel bearing fluidic modules integrally arranged on a microfabricated substrate such that a continuous channel is provided for flow of immiscible fluids, whereby each compound is labeled with a unique liquid label, pooling the labeled emulsions, coalescing the labeled emulsions with emulsions containing a specific cell or enzyme, thereby forming a nanoreactor, screening the nanoreactors for a desirable reaction between the contents of the nanoreactor, and decoding the liquid label, thereby identifying a single compound from a library of compounds.
摘要翻译：本发明提供了可用于进行高通量筛选测定和组合化学的新型微流体装置和方法。这样的方法可以包括通过将化合物的水溶液和独特的液体标签的水溶液乳化在微流体装置上来标记化合物文库，所述微流体装置包括整体地布置在微细加工的基底上的多个可电寻址的通道支承的流体模块，提供了用于不混溶流体流动的通道，由此每种化合物用独特的液体标记标记，汇集标记的乳液，将标记的乳液与含有特定细胞或酶的乳液聚结，从而形成纳米反应器，筛选纳米反应器以获得所需的反应在纳米反应器的内容物之间，并解码液体标签，从而从化合物文库鉴定单一化合物。

2. 发明申请

US20130210639A1 MICROFLUIDIC DEVICES 有权
标题翻译：微流体装置
公开(公告)号：US20130210639A1
公开(公告)日：2013-08-15
申请号：US13779943
申请日：2013-02-28
申请人： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
发明人： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
IPC分类号： C12N15/10 , C12Q1/68
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

3. 发明申请

US20130090248A1 SELECTION OF COMPARTMENTALISED SCREENING 有权
标题翻译：选择分层筛选
公开(公告)号：US20130090248A1
公开(公告)日：2013-04-11
申请号：US13629227
申请日：2012-09-27
申请人： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
发明人： Darren R. Link , Michael Weiner , David Marran , Jonathan M. Rothberg
IPC分类号： C12Q1/68
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

4. 发明申请

US20120176387A1 APPARATUS FOR THE DISPLAY OF EMBEDDED INFORMATION 审中-公开
标题翻译：显示嵌入信息的装置
公开(公告)号：US20120176387A1
公开(公告)日：2012-07-12
申请号：US13422017
申请日：2012-03-16
申请人： Michael Weiner
发明人： Michael Weiner
IPC分类号： G06T1/60
CPC分类号： G06K19/07703 , G06K17/00 , G06K19/04 , G06K19/06 , G06K19/07 , G09F21/02 , G09G2380/02
摘要： An apparatus for the electronic display of information, where the apparatus is a substrate incorporating a digital recording medium attached to or embedded within the substrate. The substrate further includes a flexible-substrate display located on an exposed surface of the substrate, where the display is a medium capable of selectively displaying one of at least two possible colors at each pixel location thereon in order to produce a substrate medium that may be modified in accordance with a user's selection.
摘要翻译：一种用于信息的电子显示的装置，其中装置是结合有附接到或嵌入在基板内的数字记录介质的基板。衬底还包括位于衬底的暴露表面上的柔性衬底显示器，其中显示器是能够在其上的每个像素位置处选择性地显示至少两种可能颜色之一的介质，以便产生可以是根据用户的选择进行修改。

5. 发明申请

US20080014589A1 Microfluidic devices and methods of use thereof 审中-公开
标题翻译：微流体装置及其使用方法
公开(公告)号：US20080014589A1
公开(公告)日：2008-01-17
申请号：US11803101
申请日：2007-05-11
申请人： Darren Link , Michael Weiner , David Marran , Jonathan Rothberg
发明人： Darren Link , Michael Weiner , David Marran , Jonathan Rothberg
IPC分类号： C12Q1/68 , B01D57/00 , B81B1/00 , C12N9/00 , G01N1/28 , G01N27/26 , G01N33/00 , G01N11/00 , C40B50/08 , C12P19/34 , C12Q1/00
CPC分类号： B01F3/0807 , B01F13/0062 , B01J19/0093 , B01L3/502715 , B01L3/502746 , B01L3/502784 , B01L3/565 , B01L7/525 , B01L9/527 , B01L2200/027 , B01L2200/0636 , B01L2200/0647 , B01L2200/0673 , B01L2200/10 , B01L2300/0636 , B01L2300/0816 , B01L2300/0861 , B01L2300/0864 , B01L2300/0867 , B01L2300/165 , B01L2400/0415 , B01L2400/0424 , B01L2400/0487 , B01L2400/086 , B03C5/005 , B03C5/026 , C12N15/1068 , C12N15/1086 , C12Q1/00 , C12Q1/6806 , C12Q1/6837 , C12Q1/6844 , C12Q1/6855 , C12Q1/6869 , C12Q1/6874 , C12Q2565/628 , C12Q2565/629 , G01N15/147 , G01N21/05 , G01N21/64 , G01N27/3275 , G01N35/08 , G01N2021/0346 , G01N2035/00237 , G01N2035/00326 , G01N2201/024 , Y10T137/87571 , Y10T137/87619 , Y10T137/87652 , C12Q2525/191 , C12Q2563/159 , C12Q2535/101 , C12Q2563/149 , C12Q2531/113
摘要： The present invention provides novel microfluidic substrates and methods that are useful for performing biological, chemical and diagnostic assays. The substrates can include a plurality of electrically addressable, channel bearing fluidic modules integrally arranged such that a continuous channel is provided for flow of immiscible fluids.
摘要翻译：本发明提供了可用于进行生物学，化学和诊断测定的新型微流体底物和方法。基板可以包括多个可电寻址的通道支承流体模块，其一体地布置成使得提供用于不混溶流体流动的连续通道。

6. 发明申请

US20060271444A1 Electronic sales and contracting method, system and program product 失效
标题翻译：电子销售和承包方式，系统和程序产品
公开(公告)号：US20060271444A1
公开(公告)日：2006-11-30
申请号：US11141281
申请日：2005-05-31
申请人： Aston Farquharson , Karen Faison , Jodie MacCrory , Michael Weiner
发明人： Aston Farquharson , Karen Faison , Jodie MacCrory , Michael Weiner
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0282 , G06Q30/0283 , G06Q30/04 , G06Q30/0601 , G06Q30/0609 , G06Q30/0631 , G06Q30/0635 , G06Q50/188
摘要： Under the present invention, a customer will login to a secure computer infrastructure and initially be polled and/or provide some input relating to an integrated IT solution that is desired. The customer can then make selections for hardware and/or software components desired for the integrated IT solution. The present invention will analyze the selections and verify whether each of the selected components is of similar quality to one another. If not, the customer can be alerted. The present invention will also make recommendations for services that best match the selected components. The integrated IT solution will then be finalized based on the components and services selected by the customer. Once the solution has been finalized, a corresponding contract(s) can be developed/generated, approved and executed within the secure computer infrastructure.
摘要翻译：在本发明中，客户将登录到安全的计算机基础设施，并且最初被轮询和/或提供与期望的集成IT解决方案相关的一些输入。然后，客户可以为集成IT解决方案所需的硬件和/或软件组件进行选择。本发明将分析选择并验证每个所选择的组件是否彼此具有相似的质量。如果没有，可以提醒客户。本发明还将针对与所选择的组件最匹配的服务提出建议。综合IT解决方案将根据客户选择的组件和服务进行定稿。解决方案一旦完成，就可以在安全的计算机基础架构内开发/生成，批准和执行相应的合同。

7. 发明申请

US20050266442A1 Immortalized human Tuberous Sclerosis null angiomyolipoma cell and method of use thereof 审中-公开
标题翻译：永生化人结节性硬化症无血管平滑肌脂肪瘤细胞及其使用方法
公开(公告)号：US20050266442A1
公开(公告)日：2005-12-01
申请号：US11090439
申请日：2005-03-25
申请人： Rachel Squillace , Michael Weiner
发明人： Rachel Squillace , Michael Weiner
IPC分类号： C12N5/077 , C12N5/09 , C12Q1/68 , C12N5/08
CPC分类号： C12N5/0658 , C12N5/0693 , C12N2503/02 , C12N2510/04 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158
摘要： Disclosed are immortailized cells and cell lines that do not express the Tuberous Sclerosis Complex(TSC)-2 gene. Also sisclosed are methods of detecting TSC-related disorders using differentially expressed genes.
摘要翻译：公开了不表达结核硬化综合征（TSC）-2基因的永生细胞和细胞系。还公开的是使用差异表达基因检测TSC相关疾病的方法。

8. 发明申请

US20050221270A1 Process for identifying and treating cells types within a living organism 失效
标题翻译：识别和处理活体内细胞类型的方法
公开(公告)号：US20050221270A1
公开(公告)日：2005-10-06
申请号：US10131361
申请日：2002-04-24
申请人： Patrick Connelly , Thomas Foster , Michael Weiner , Andrew Custer
发明人： Patrick Connelly , Thomas Foster , Michael Weiner , Andrew Custer
IPC分类号： A61B5/00 , A61B18/20 , A61K49/00 , C12Q1/00 , G01N33/569 , G01N33/574 , G01N33/58
CPC分类号： G01N33/574 , A61B5/0031 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61B5/14532 , A61B5/14557 , A61B5/1459 , A61B5/415 , A61B5/4839 , A61B5/6862 , A61B5/6876 , A61B18/20 , A61B2562/12 , A61K49/0004 , A61K49/0013 , A61K49/0047 , A61K49/0097 , G01N33/56966 , G01N33/58
摘要： A process for identifying and treating cells in a living organism. The cells are labeled, circulated within the organism, detected with an implanted detector, and then either isolated or ablated.
摘要翻译：识别和处理活体中细胞的方法。细胞被标记，在生物体内循环，用植入的检测器检测，然后分离或消融。

9. 发明申请

US20050187582A1 Fibrillation/tachycardia monitoring and preventive system and methodology 失效
标题翻译：心律失常监测及预防系统及方法
公开(公告)号：US20050187582A1
公开(公告)日：2005-08-25
申请号：US10783735
申请日：2004-02-20
申请人： Michael Weiner
发明人： Michael Weiner
IPC分类号： A61N1/362 , A61N1/365 , A61N1/39
CPC分类号： A61N1/3622 , A61N1/36542 , A61N1/3962
摘要： A cardiac assist device senses conditions of a heart and controls the generation of various electrical stimuli in response to sense conditions of the heart. The cardiac assist device generates a electrical pulse so as to defibrillate a fibrillated heart when the cardiac assist device determines from the sensed conditions a state of fibrillation. The cardiac assist device generates a chaos control electrical signal so as to bring a pre-fibrillated heart condition back into a normal beating condition when the cardiac assist device determines from the sensed conditions a pre-state of fibrillation. Lastly, the cardiac assist device generates an electrical enhancement signal that causes a threshold of pacing cells in the heart to be exceeded in response to a subthreshold stimulus when the cardiac assist device determines from the sensed conditions a subthreshold pacing signal.
摘要翻译：心脏辅助装置感测心脏的状况并响应于心脏的感觉状况来控制各种电刺激的产生。心脏辅助装置产生电脉冲，以便当心脏辅助装置根据感测到的状态确定原纤化状态时，使原纤化心脏去纤维化。心脏辅助装置产生混乱控制电信号，以便当心脏辅助装置根据感测到的状态确定原纤化状态时，使预纤维化的心脏状况恢复到正常的跳动状态。最后，当心脏辅助装置根据感测到的条件确定亚阈值起搏信号时，心脏辅助装置产生响应于亚阈值刺激而导致心脏中起搏细胞阈值的电增强信号。

10. 发明申请

US20050167595A1 Digital imaging assembly and methods thereof 失效
标题翻译：数字成像组件及其方法
公开(公告)号：US20050167595A1
公开(公告)日：2005-08-04
申请号：US10983053
申请日：2004-11-05
申请人： David Prelewitz , Robert Gray , Rolf Gerchberg , Michael Weiner
发明人： David Prelewitz , Robert Gray , Rolf Gerchberg , Michael Weiner
IPC分类号： G01J5/02 , G02B27/48 , G06K9/00 , G06K9/40
CPC分类号： G02B27/48
摘要： A coherent radiation imaging system that produces digital images with a reduced amount of speckle. Radiation from a long coherence length source is used to form an image of a sample. The output coherent wave is temporally divided into a plurality of wavelets. The spatial phase of each wavelet is then modulated a known and different amount. Each phase modulated wavelet illuminates the sample and is perturbed by its interaction with the sample. A spatial phase map of each perturbed wavelet is then created and converted to a sample image with an image reconstruction program. The plurality of sample images thus formed is statistically averaged to form a final averaged image. The high frequency speckle that is not optically resolvable tends to average to zero with continual statistical averaging, leaving only the optically resolvable lower frequency phase information.
摘要翻译：相干辐射成像系统，产生数量少的斑点数字图像。来自长相干长度源的辐射用于形成样品的图像。输出相干波在时间上分为多个小波。然后将每个小波的空间相位调制为已知且不同的量。每个相位调制小波照亮样品，并受到与样品的相互作用的干扰。然后创建每个扰动小波的空间相位图，并将其转换为具有图像重建程序的样本图像。如此形成的多个样本图像被统计学地平均以形成最终平均图像。不能光学解析的高频散斑趋向于平均为零，并且连续的统计平均，仅留下光学可分辨的较低频率相位信息。

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