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1. 发明公开

US20240241202A1 MAGNETIC RESONANCE IMAGING APPARATUS AND CHEMICAL-SHIFT PEAK DETECTION METHOD 审中-公开
公开(公告)号：US20240241202A1
公开(公告)日：2024-07-18
申请号：US18391962
申请日：2023-12-21
申请人： CANON MEDICAL SYSTEMS CORPORATION
发明人： Sotaro TAKI , Sadanori TOMIHA , Masao YUI
IPC分类号： G01R33/56 , G01R33/48 , G01R33/565
CPC分类号： G01R33/5601 , G01R33/4804 , G01R33/56563
摘要： An MRI apparatus according to one embodiment includes processing circuitry that obtains information about a contrast agent containing substances with different chemical shifts, and determines, based on the information, a frequency band related to decrease in a MR signal due to the chemical shifts; and sequence control circuitry that acquires, before contrast enhancement using the contrast agent, a first MR signal group in the frequency band by CEST imaging under different saturation pulse conditions, and acquires, after contrast enhancement using the contrast agent, a second MR signal group in the frequency band by CEST imaging under different saturation pulse conditions. The processing circuitry calculates a difference between a first Z-spectrum generated based on the first MR signal group and a second Z-spectrum generated based on the second MR signal group, and detects, from the difference, peaks indicating the decrease in the MR signal due to the chemical shifts of the substances.

2. 发明授权

US11707634B2 Real-time methods for magnetic resonance spectra acquisition 有权
公开(公告)号：US11707634B2
公开(公告)日：2023-07-25
申请号：US17019263
申请日：2020-09-13
申请人： Olena Ibragimova , Ilgiz Ibragimov
发明人： Olena Ibragimova , Ilgiz Ibragimov
IPC分类号： G01R33/60 , A61N2/00 , A61B34/30 , A61N2/06 , A61B5/055 , A61F2/82 , A61F7/00 , A61K33/24 , A61K31/714 , A61B18/06 , G01R33/36 , G01R33/38 , A61N7/02 , G01R33/28 , G01R33/32 , G01N24/10 , G01N24/12 , G01N24/14 , H01F1/047 , A61B90/00 , G01R33/383 , G01R33/3873 , G01R33/48 , H01F1/055 , H03F3/54 , G01R33/30 , G01R33/563 , G01R33/465 , A61B18/18 , A61B17/32 , A61B18/00 , H01F41/02 , A61K33/243
CPC分类号： A61N2/002 , A61B5/055 , A61B18/06 , A61B34/30 , A61B90/37 , A61F2/82 , A61F7/00 , A61K31/714 , A61K33/24 , A61N2/06 , A61N7/02 , G01N24/10 , G01N24/12 , G01N24/14 , G01R33/282 , G01R33/285 , G01R33/307 , G01R33/32 , G01R33/3621 , G01R33/3802 , G01R33/383 , G01R33/3808 , G01R33/3873 , G01R33/4804 , G01R33/56308 , G01R33/60 , H01F1/047 , H01F1/0557 , H03F3/54 , A61B18/1815 , A61B2017/320069 , A61B2018/00577 , A61B2018/00994 , A61B2090/374 , A61F2007/009 , A61F2007/0089 , A61F2250/0001 , A61K33/243 , G01R33/323 , G01R33/465 , G01R33/48 , H01F41/0273
摘要： The invention pertains to advances in real-time methods in nuclear magnetic resonance by offering a new dual-frequency dynamic nuclear polarization (DNP) method that uses a microwave beam to polarize the spins of electrons and concomitantly act as a NMR transmitter.

3. 发明授权

US10610317B2 Image-guided therapy of a tissue 有权
公开(公告)号：US10610317B2
公开(公告)日：2020-04-07
申请号：US14717738
申请日：2015-05-20
申请人： MONTERIS MEDICAL CORPORATION
发明人： Richard Tyc , Salman Qureshi , Mark Andrew Grant , Luis Filipe Silva Fernandes , Daniel Prazeres Carreira , John Schellhorn
IPC分类号： A61B17/00 , A61B34/20 , A61B34/30 , A61B90/14 , A61B90/00 , A61B34/00 , A61B90/10 , A61B90/11 , A61B18/22 , A61B5/055 , A61B5/01 , A61B5/00 , A61B18/02 , A61B18/06 , A61B18/14 , A61B18/18 , A61B18/28 , A61N5/06 , A61N7/02 , G01R33/28 , G01R33/48 , A61B34/10 , A61B18/20 , A61B17/34 , A61B18/00
CPC分类号： A61B34/71 , A61B5/015 , A61B5/055 , A61B5/4839 , A61B5/742 , A61B5/746 , A61B18/02 , A61B18/0206 , A61B18/06 , A61B18/148 , A61B18/1492 , A61B18/1815 , A61B18/22 , A61B18/28 , A61B90/10 , A61B90/11 , A61N5/0601 , A61N5/062 , A61N7/022 , G01R33/285 , G01R33/4804 , A61B34/20 , A61B34/25 , A61B90/14 , A61B2017/00017 , A61B2017/00911 , A61B2017/3407 , A61B2018/00017 , A61B2018/00023 , A61B2018/00446 , A61B2018/00577 , A61B2018/00642 , A61B2018/00702 , A61B2018/00791 , A61B2018/00994 , A61B2018/0212 , A61B2018/0293 , A61B2018/1807 , A61B2018/1861 , A61B2018/20351 , A61B2018/2211 , A61B2018/2261 , A61B2034/107 , A61B2034/2068 , A61B2034/301 , A61B2090/061 , A61B2090/374
摘要： Image-guided therapy of a tissue can utilize magnetic resonance imaging (MRI) or another medical imaging device to guide an instrument within the tissue. A workstation can actuate movement of the instrument, and can actuate energy emission and/or cooling of the instrument to effect treatment to the tissue. The workstation and/or an operator of the workstation can be located outside a vicinity of an MRI device or other medical imaging device, and drive means for positioning the instrument can be located within the vicinity of the MRI device or the other medical imaging device. The instrument can be an MRI compatible laser probe that provides thermal therapy to, e.g., a tissue in a brain of a patient.

4. 发明授权

US10076249B2 Proton density and T1 weighted zero TE MR thermometry 有权
公开(公告)号：US10076249B2
公开(公告)日：2018-09-18
申请号：US14817450
申请日：2015-08-04
申请人： GENERAL ELECTRIC COMPANY
发明人： Silke Maria Lechner-Greite , Florian Wiesinger , Desmond Teck Beng Yeo , Matthew Richard Tarasek
IPC分类号： A61B5/00 , A61B5/01 , G01R33/48 , G01R33/56 , A61B18/18 , A61B18/00 , A61B18/02 , A61B18/04
CPC分类号： A61B5/015 , A61B5/055 , A61B5/4836 , A61B5/7214 , A61B5/7285 , A61B18/02 , A61B18/04 , A61B18/1815 , A61B2018/00577 , A61B2018/00791 , G01R33/4804 , G01R33/4814 , G01R33/4816 , G01R33/5602
摘要： A system and method for tracking temperature changes in tissue and bone is disclosed. In one aspect, the temperature changes are tracked simultaneously with high spatial encoding and temporal efficiency. The method is robust in terms of B0 and chemical shift off-resonance, as well as insensitive to eddy currents for accurate temperature mapping. Zero TE (ZTE) based MR thermometry is utilized herein to extract temperature changes from proton density and T1 weighted images. Additionally, T1 signal contamination is corrected for by calibrating T1 and B0 by using a variable flip angle method to achieve temperature mapping in bone, aqueous and adipose tissue simultaneously.

5. 发明申请

US20180210050A1 SYSTEM AND METHOD FOR CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) MAGNETIC RESONANCE FINGERPRINTING 审中-公开
公开(公告)号：US20180210050A1
公开(公告)日：2018-07-26
申请号：US15874961
申请日：2018-01-19
申请人： The General Hospital Corporation
发明人： Matthew Rosen , Christian T. Farrar , Ouri Cohen , Shuning Huang
IPC分类号： G01R33/50 , G01R33/48
CPC分类号： G01R33/50 , G01R33/4804 , G01R33/4824 , G01R33/5605
摘要： A system and method of use includes (a) directing a magnetic resonance (MR) system to perform a pulse sequences block in which radio frequency (RF) energy is applied to the subject to substantially saturate magnetization corresponding to an exchangeable proton. The method includes (b), following step (a), acquiring data from the subject with the MR system and (c) repeating step (a) a plurality of times where parameters of the pulse sequence sub-block differ in at least some pulse sequence sub-blocks by at least an amount of RF energy applied to saturate the magnetization. The method further includes (d), after each repetition of step (a), repeating step (b) to acquire data representing signal evolutions from the subject. Additionally, the method includes (e) comparing the signal evolutions with a dictionary database comprising a plurality of different signal evolution templates to determine quantitative chemical exchange or exchangeable proton information of the subject.

6. 发明申请

US20180164393A1 PH-WEIGHTED MRI USING FAST AMINE CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) IMAGING 审中-公开
公开(公告)号：US20180164393A1
公开(公告)日：2018-06-14
申请号：US15577664
申请日：2016-05-27
申请人： The Regents of the University of California
发明人： Benjamin Ellingson , Robert Harris
IPC分类号： G01R33/56 , A61B5/055 , G01N33/48 , G01R33/48 , G01N24/08
CPC分类号： G01R33/5605 , A61B5/055 , G01N24/08 , G01N33/48 , G01R33/4616 , G01R33/4804 , G01R33/4838 , G01R33/5616 , G01R33/56509 , G01R33/56563
摘要： A pH-weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) method and system are provided that works by indirectly measuring the NMR signal from amine protons found on the backbones of amino acids and other metabolites, which resonate at a frequency of +2.8-3.2 ppm with respect to bulk water protons. The technique uses a modified magnetization transfer radiofrequency saturation pulse for the generation of image contrast. A train of three 100 ms Gaussian pulses at high amplitude (6 uT) or Sinc3 pulses are played at a particular frequency off-resonance from bulk water prior to a fast echo planar imaging (EPI) readout, with one full image acquired at each offset frequency. This non-invasive pH-weighted MRI technique does not require exogenous contrast agents and can be used in preclinical investigations and clinical monitoring in patients with malignant glioma, stroke, and other ailments.

7. 发明申请

US20180117186A1 MAGNETIC PARTICLES FOR USE IN MAGNETIC RESONANCE IMAGING THERMOMETRY 审中-公开
公开(公告)号：US20180117186A1
公开(公告)日：2018-05-03
申请号：US15801215
申请日：2017-11-01
申请人： The Regents of the University of Colorado, a body Corporate
发明人： Robert Camley , Zbigniew Celinski , Janusz H. Hankiewicz
IPC分类号： A61K49/18 , A61B5/055 , A61B5/01 , G01R33/56 , G01R33/48
CPC分类号： A61K49/1824 , A61B5/01 , A61B5/055 , A61K49/1818 , G01R33/4804 , G01R33/5601
摘要： The present invention provides doped ferrite particles or metallic compounds or alloys, which can be used as temperature-dependent sensors in magnetic resonance imaging. In certain embodiments, these particles have a Curie temperature near that of living animals, allowing one to obtain spatial maps of temperature useful for thermal medical procedures or diagnostics. In other embodiments, one can use the methods and materials of the present invention to obtain spatial temperature maps of materials and non-living objects, such as tires or polymers. This method allows for a non-invasive determination of internal body temperature with a resolution of about 1° C.

8. 发明申请

US20180074141A1 Magnetic Resonance Tomography with Slow Temperature Variation Compensation 审中-公开
公开(公告)号：US20180074141A1
公开(公告)日：2018-03-15
申请号：US15698146
申请日：2017-09-07
申请人： Rudi Baumgartl , Andrew Dewdney
发明人： Rudi Baumgartl , Andrew Dewdney
IPC分类号： G01R33/389 , G01R33/31 , G01R33/48 , G06F19/00
CPC分类号： G01R33/389 , G01K13/00 , G01R33/31 , G01R33/4804 , G01R33/583 , G16H40/40
摘要： A magnetic resonance tomography system has a frequency control device for temperature compensation, a temperature sensor, and a high frequency generator. A system frequency of the magnetic resonance tomography system has a temperature dependence on a temperature. An output frequency of an output signal from the high frequency generator is dependent on a value of a digital frequency variable, and a synthesis signal with the system frequency is generated dependent on the output signal. A temperature change is detected using the temperature sensor, a temperature-time function of the temperature is determined using the temperature change that has been detected, a time is determined at which a change in the digital frequency variables in the least significant bit brings about a change in the frequency of the synthesis signal that corresponds with a change in the system frequency due to a temperature, according to the interpolated temperature-time function, and the digital frequency variable in the least significant bit is changed at the specified time.

9. 发明授权

US09808176B2 Method and magnetic resonance system for magnetic resonance thermometry 有权
公开(公告)号：US09808176B2
公开(公告)日：2017-11-07
申请号：US14220427
申请日：2014-03-20
申请人： Patrick Gross
发明人： Patrick Gross
IPC分类号： G01R33/48 , A61B5/055 , A61B5/01
CPC分类号： A61B5/055 , A61B5/01 , G01R33/48 , G01R33/4804
摘要： In magnetic resonance (MR) thermometry, first and second magnetic resonance data that are acquired sequentially, from which a phase shift is determined between a measurement phase and a reference phase. In a first region of an examined person, the measurement phase is determined from the second magnetic resonance data and the reference phase is determined from the first magnetic resonance data. In a second region of the examined person, both the reference phase and measurement phase are determined from the second magnetic resonance data. Techniques for reference-based magnetic resonance thermometry and reference-free magnetic resonance thermometry can be applied.

10. 发明申请

US20170011255A1 FIELD-INVARIANT QUANTITATIVE MAGNETIC-RESONANCE SIGNATURES 有权
标题翻译：场不变量子磁共振信号
公开(公告)号：US20170011255A1
公开(公告)日：2017-01-12
申请号：US15089571
申请日：2016-04-03
申请人： Tesla Health, Inc
发明人： Jeffrey Howard Kaditz , Andrew Gettings Stevens
IPC分类号： G06K9/00
CPC分类号： G01R33/48 , G01N24/08 , G01R33/448 , G01R33/465 , G01R33/4804 , G01R33/56358
摘要： A system that determines an invariant magnetic-resonance (MR) signature of a biological sample is disclosed. During operation, the system determines a magnetic-resonance (MR) model of voxels in a biological sample based on differences between MR signals associated with the voxels in multiple scans and simulated MR signals. The MR signals are measured or captured by an MR scanner in the system during multiple MR scans, and based on scanning instructions, and the simulated MR signals for the biological sample are generated using the MR model and the scanning instructions. Moreover, the system iteratively modifies the scanning instructions (including a magnetic-field strength and/or a pulse sequence) in the MR scans based on the differences until a convergence criterion is achieved. Then, the system stores, in memory, an identifier of the biological sample and a magnetic-field-strength-invariant MR signature of the biological sample that is associated with the MR model.
摘要翻译：公开了一种确定生物样品的不变磁共振（MR）签名的系统。在操作期间，系统基于与多个扫描中的体素相关联的MR信号与模拟的MR信号之间的差异来确定生物样本中的体素的磁共振（MR）模型。在多次MR扫描期间，并且基于扫描指令，由系统中的MR扫描仪测量或捕获MR信号，并且使用MR模型和扫描指令生成生物样品的模拟MR信号。此外，系统基于差异迭代地修改MR扫描中的扫描指令（包括磁场强度和/或脉冲序列），直到达到收敛标准。然后，系统在存储器中存储生物样品的标识符和与MR模型相关联的生物样品的磁场强度不变的MR特征。

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