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1. 发明授权

US09283160B2 Stabilization of cosmetic compositions 有权
标题翻译：化妆品组合物的稳定化
公开(公告)号：US09283160B2
公开(公告)日：2016-03-15
申请号：US13144113
申请日：2010-01-28
申请人： Bernd Herzog , Julie Grumelard
发明人： Bernd Herzog , Julie Grumelard
IPC分类号： A61Q17/04 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/49
CPC分类号： A61K8/494 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/496 , A61K8/4966 , A61K2800/52 , A61K2800/592 , A61Q17/04
摘要： Disclosed is the Use of UV absorbers selected from (a1) diphenylacrylates; and (a2) specific hydroxyphenyl triazines for stabilizing cosmetic compositions comprising an organic UV absorber selected from (b1) a specific benzophenone derivative, (b2) a specific benzotriazole derivative and (b3) a specific triazine derivative and UV filters selected from (c1) cinnamic acid derivatives; and (c2) dibenzoylmethane derivatives.
摘要翻译：公开了使用选自（a1）二苯基丙烯酸酯的UV吸收剂; 和（a2）用于稳定化妆品组合物的特定羟基苯基三嗪，其包含选自（b1）特定二苯甲酮衍生物，（b2）特定苯并三唑衍生物和（b3）特定三嗪衍生物的有机UV吸收剂和选自（c1）肉桂酸酸衍生物; 和（c2）二苯甲酰甲烷衍生物。

2. 发明申请

US20120093896A1 USE OF NANODISPERSIONS TO PROTECT WATER-SOLUBLE INGREDIENTS IN COSMETIC END FORMULATIONS 审中-公开
标题翻译：使用纳米尺寸来保护化妆品配方中的水溶性成分
公开(公告)号：US20120093896A1
公开(公告)日：2012-04-19
申请号：US12669972
申请日：2008-07-22
申请人： Sébastien Mongiat , Julie Grumelard , Werner Baschong , Bernd Herzog
发明人： Sébastien Mongiat , Julie Grumelard , Werner Baschong , Bernd Herzog
IPC分类号： A61K8/04 , A61K8/66 , A61K8/02 , A61Q19/00 , A61Q5/00 , A61K8/67 , A61Q1/12 , B82Y40/00 , B82Y99/00
CPC分类号： A61K8/676 , A61K8/04 , A61K8/345 , A61K8/375 , A61K8/4993 , A61K8/553 , A61K8/68 , A61K8/86 , A61K8/894 , A61K8/898 , A61K8/90 , A61K2800/413 , A61K2800/52 , A61K2800/522 , A61Q19/00 , B82Y5/00
摘要： The invention describes the use of a nanodispersion, which comprises: a) a membrane-forming molecule, b) a co-emulsifier, c) a lipophilic component, and d) a water-soluble ingredient sensitive to oxidation in cosmetic end formulations, the nanodispersion being obtainable by (α) mixing the components (a), (b) and (c) until a homogeneous liquid is obtained (so-called nanodispersion pre-phase), and (β) adding the water or aqueous phase (discontinuous phase) which contains the water-soluble ingredient and optionally the non-aqueous polar organic solvent to the liquid obtained in step (α). Component (d) is preferably ascorbic acid or vitamin C.
摘要翻译：本发明描述了纳米分散体的使用，其包括：a）成膜分子，b）共乳化剂，c）亲脂性组分，和d）在化妆品末端制剂中对氧化敏感的水溶性成分，通过（α）混合组分（a），（b）和（c）直到获得均匀的液体（所谓的纳米分散前相）和（＆bgr）加入水或水相（不连续的）可获得的纳米分散体相），其包含水溶性成分和任选的非水极性有机溶剂与步骤（α）中获得的液体。组分（d）优选为抗坏血酸或维生素C.

3. 发明申请

US20110305650A1 STABILIZATION OF COSMETIC COMPOSITIONS 有权
标题翻译：化妆品组合物的稳定性
公开(公告)号：US20110305650A1
公开(公告)日：2011-12-15
申请号：US13144113
申请日：2010-01-28
申请人： Bernd Herzog , Julie Grumelard
发明人： Bernd Herzog , Julie Grumelard
IPC分类号： A61K8/49 , A61Q17/02 , A61K8/37
CPC分类号： A61K8/494 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/411 , A61K8/496 , A61K8/4966 , A61K2800/52 , A61K2800/592 , A61Q17/04
摘要： Disclosed is the Use of UV absorbers selected from (a1) diphenylacrylates; and (a2) specific hydroxyphenyl triazines for stabilizing cosmetic compositions comprising an organic UV absorber selected from (b1) a specific benzophenone derivative, (b2) a specific benzotriazole derivative and (b3) a specific triazine derivative and UV filters selected from (c1) cinnamic acid derivatives; and (c2) dibenzoylmethane derivatives.
摘要翻译：公开了使用选自（a1）二苯基丙烯酸酯的UV吸收剂; 和（a2）用于稳定化妆品组合物的特定羟基苯基三嗪，其包含选自（b1）特定二苯甲酮衍生物，（b2）特定苯并三唑衍生物和（b3）特定三嗪衍生物的有机UV吸收剂和选自（c1）肉桂酸酸衍生物; 和（c2）二苯甲酰甲烷衍生物。

4. 发明授权

US09764169B2 UV filter combinations comprising benzylidene malonates 有权
公开(公告)号：US09764169B2
公开(公告)日：2017-09-19
申请号：US13381965
申请日：2010-06-29
申请人： Julie Grumelard , Thomas Ehlis , Markus Hansch , Myriam Sohn
发明人： Julie Grumelard , Thomas Ehlis , Markus Hansch , Myriam Sohn
IPC分类号： A61Q17/04 , A61K8/37
CPC分类号： A61Q17/04 , A61K8/37
摘要： Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone;(b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.

5. 发明授权

US08557820B2 Crystal modifications of transmission dyes 有权
标题翻译：透射染料的水晶修饰
公开(公告)号：US08557820B2
公开(公告)日：2013-10-15
申请号：US12597930
申请日：2008-04-28
申请人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
发明人： Martin Vogt , Stefan Müller , Julie Grumelard , Cyrille Deshayes , Holger Paul , Jürg Haase , Thomas Ehlis
IPC分类号： A61K31/497 , A61K8/00 , C07D241/04 , C07D295/00 , A61Q17/04
CPC分类号： C07D295/192 , A61K8/04 , A61K8/494 , A61K31/495 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K2300/00
摘要： Disclosed is the use of an aqueous dispersion comprising (a) a micronized sparingly soluble organic benzophenone derivative of formula (1), selected from the crystal modifications (B) and (C), wherein the crystal modification (B) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.70; and wherein the crystal modification (C) is characterized by a peak in the X-ray diffraction pattern at a d-spacing of about 7.06; and (b) a dispersing agent selected from anionic, non-ionic and amphoteric surfactants; for protecting the human skin from browning and skin aging. The new crystal modification (C) represents a thermodynamically stable compound of formula (1) at 25° C. This modification is therefore suitable in dispersions comprising micro-fine particles.
摘要翻译：公开了含有（a）选自晶体改性（B）和（C）的式（1）的微粉化的微溶有机二苯甲酮衍生物的水性分散体的用途，其中所述晶体改性（B）的特征在于峰在X-射线衍射图中，d-间距约为7.70; 并且其中所述晶体改性（C）的特征在于在约7.06的d间距处的X射线衍射图中的峰; 和（b）选自阴离子，非离子和两性表面活性剂的分散剂; 用于保护人体皮肤免受褐变和皮肤老化。新的结晶改性（C）在25℃下代表热力学稳定的式（1）化合物。因此，该修饰适用于包含微细颗粒的分散体。

6. 发明申请

US20100303746A1 GRINDING AIDES FOR MICRONIZED ORGANIC UV ABSORBERS 审中-公开
标题翻译：微波有机紫外线吸收剂研磨助剂
公开(公告)号：US20100303746A1
公开(公告)日：2010-12-02
申请号：US12744495
申请日：2008-11-20
申请人： Sebastien Mongiat , Julie Grumelard , Thomas Ehlis
发明人： Sebastien Mongiat , Julie Grumelard , Thomas Ehlis
IPC分类号： A61K8/49 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/494 , A61K2800/412
摘要： A method of preparing a composition, comprising (a) a micronised insoluble organic UV absorber, which method comprises grinding the insoluble organic UV absorber, in coarse particle form, in a grinding apparatus, in the presence of a grinding aid selected from the groups (b1) carboxylic acids and their salts; (b2) fatty acid esters (b3) alkyl phosphates or phosphoric acid esters; (b4) ethoxylated carboxylic acids or polyethyleneglycol (PEG) esters; (b5) fatty alcohol polyethyleneglycol (PEG) ethers of fatty alcohols; (b6) polyethylene/polypropylene -glycol ethers of saturated or unsaturated C4-C28 fatty acids; (b7) ethoxylated alkylphenols or ethoxylated alkylphenyl ethers; (b8) esters of polyol and mono-, di- or tri-glycerides; (b9) esters of fatty acids and saccharose; (b10) sorbitan mono- and di-esters of saturated and/or unsaturated C6-C22 fatty acids and ethylene oxide groups; and (b11) surfactants which are mainly acting as detergent or cleansing agents.
摘要翻译：一种制备组合物的方法，包括（a）微粉化的不溶性有机UV吸收剂，该方法包括在研磨装置中，在选自以下组的研磨助剂的存在下研磨粗颗粒形式的不溶性有机UV吸收剂（ b1）羧酸及其盐; （b2）脂肪酸酯（b3）磷酸烷基酯或磷酸酯; （b4）乙氧基化羧酸或聚乙二醇（PEG）酯; （b5）脂肪醇的脂肪醇聚乙二醇（PEG）醚; （b6）饱和或不饱和C4-C28脂肪酸的聚乙烯/聚丙二醇醚; （b7）乙氧基化烷基酚或乙氧基化烷基苯基醚; （b8）多元醇和甘油单酯，甘油二酯或甘油酯的酯; （b9）脂肪酸和蔗糖的酯; （b10）饱和和/或不饱和C6-C22脂肪酸和环氧乙烷基团的脱水山梨糖醇单酯和二酯; 和（b11）主要作为洗涤剂或清洁剂的表面活性剂。

7. 发明申请

US20100143274A1 USE OF AMINES AND AMIDES FOR THE STABILIZATION OF ORGANIC MICRONIZED UV ABSORBERS 审中-公开
标题翻译：用于有机微波紫外线吸收剂稳定化的氨基和氨基
公开(公告)号：US20100143274A1
公开(公告)日：2010-06-10
申请号：US12529573
申请日：2008-02-27
申请人： Cyrille Deshayes , Thomas Ehlis , Julie Grumelard
发明人： Cyrille Deshayes , Thomas Ehlis , Julie Grumelard
IPC分类号： A61K8/35 , A61Q17/04
CPC分类号： A61K8/41 , A61K8/35 , A61K8/494 , A61K2800/52 , A61Q17/04
摘要： Disclosed is the use of amines and amides for the stabilization of a cosmetic composition comprising: (a) an organic micronized UV absorber selected from a benzophenone derivative and (b) a dibenzoylmethane derivative. The use of the amines and amides results in the stabilization of the end-product formulations.
摘要翻译：公开了胺和酰胺用于稳定化妆品组合物的用途，包括：（a）选自二苯甲酮衍生物和（b）二苯甲酰甲烷衍生物的有机微粉化UV吸收剂。使用胺和酰胺导致最终产品配方的稳定化。

8. 发明申请

US20100129303A1 SUNSCREEN AND PERSONAL CARE COMPOSITIONS COMPRISING A RANDOM TERPOLYMER 审中-公开
标题翻译： SUNSCREEN和个人护理组合物包含随机的TERPOLYMER
公开(公告)号：US20100129303A1
公开(公告)日：2010-05-27
申请号：US12575631
申请日：2009-10-08
申请人： Olga V. Dueva-Koganov , Bingham S. Jaynes , Joseph A. Lupia , Arjan T. Termaten , Marcelles Van der Sluis , Marleen Suurmeijer , David Normington , Marcel Schnyder , Julie Grumelard , Myriam Sohn
发明人： Olga V. Dueva-Koganov , Bingham S. Jaynes , Joseph A. Lupia , Arjan T. Termaten , Marcelles Van der Sluis , Marleen Suurmeijer , David Normington , Marcel Schnyder , Julie Grumelard , Myriam Sohn
IPC分类号： A61K8/72 , A61Q17/04
CPC分类号： A61Q17/04 , A61K8/29 , A61K8/494 , A61K8/496 , A61K8/4966 , A61K8/8152 , A61K8/817 , A61K8/8182
摘要： Topically applicable, water-resistant cosmetic or dermatological compositions well suited for the UV-photoprotection of human skin and/or hair comprising an effective UV-photoprotecting amount of: (a) at least one UV screening agent from various classes and particularly effect mixtures thereof; and, (b) at least one random terpolymer; and, optionally, (c) other cosmetically acceptable ingredients. The various classes of UV-protecting compounds or UV sunscreens of special interest are selected from the groups b1 sparingly soluble micronized organic UV absorber, b2 Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, b3 at least one oil soluble organic UV absorber, b4 at least one inorganic UV absorber and b5 at least one water soluble UV absorber further defined herein.The present invention also relates to personal care compositions comprising at least one random terpolymer and other cosmetically acceptable ingredients.
摘要翻译：本发明适用于非常适合人皮肤和/或毛发的UV光保护的耐水化妆品或皮肤病学组合物，其包含有效的UV-光保护剂量：（a）至少一种来自各种类别的UV屏蔽剂，特别是其影响混合物 ; 和（b）至少一种无规三元共聚物; 和（c）其它美容上可接受的成分。各种类型的UV保护化合物或特别感兴趣的UV防晒剂选自b1微溶微粉化有机UV吸收剂，b2双 - 乙基己氧基苯酚甲氧基苯基三嗪，b3至少一种油溶性有机UV吸收剂，b4至少一种无机紫外线吸收剂和b5至少一种本文进一步限定的水溶性紫外线吸收剂。本发明还涉及包含至少一种无规三元共聚物和其它美容上可接受的成分的个人护理组合物。

9. 发明授权

US11458083B2 Cosmetic and/or dermatological composition containing a merocyanine derivative comprising specific polar groups consisting of hydroxyl- and ether-functionalities 有权
公开(公告)号：US11458083B2
公开(公告)日：2022-10-04
申请号：US14233603
申请日：2012-07-19
申请人： Herve Richard , Xavier Marat , Florence L'Alloret , Didier Candau , Julie Songeur-Geney , Julie Grumelard , Barbara Winkler , Dietmar Huglin
发明人： Herve Richard , Xavier Marat , Florence L'Alloret , Didier Candau , Julie Songeur-Geney , Julie Grumelard , Barbara Winkler , Dietmar Huglin
IPC分类号： A61K8/44 , A61K8/42 , A61K8/49 , A61Q17/04 , A61K8/41 , A61K8/34
摘要： The present invention relates to a cosmetic and/or dermatological composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its E,E-, E,Z- or Z,Z-geometrical isomer forms: comprising specific polar groups consisting of hydroxyl- and ether-functionalities. Another object of the present invention relates to a cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. Another object of the present invention relates to a cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined.

10. 发明申请

US20140294743A1 COSMETIC AND/OR DERMATOLOGICAL COMPOSITION CONTAINING A MEROCYANINE DERIVATIVE COMPRISING SPECIFIC POLAR GROUPS CONSISTING OF HYDROXYL- AND ETHER-FUNCTIONALITIES 审中-公开
标题翻译：含有包含羟基和其他功能的特定极性基团的梅毒衍生物的化妆和/或皮肤组合物
公开(公告)号：US20140294743A1
公开(公告)日：2014-10-02
申请号：US14233603
申请日：2012-07-19
申请人： Herve Richard , Xavier Marat , Florence L'Alloret , Didier Candau , Julie Songeur-Geney , Julie Grumelard , Barbara Winkler , Dietmar Huglin
发明人： Herve Richard , Xavier Marat , Florence L'Alloret , Didier Candau , Julie Songeur-Geney , Julie Grumelard , Barbara Winkler , Dietmar Huglin
IPC分类号： A61K8/44 , A61K8/34 , A61K8/42 , A61Q17/04 , A61K8/49
CPC分类号： A61K8/44 , A61K8/347 , A61K8/41 , A61K8/42 , A61K8/49 , A61K8/4926 , A61K8/4973 , A61Q17/04
摘要： The present invention relates to a cosmetic and/or dermatological composition comprising in a physiologically acceptable medium at least one merocyanine derivative of formula (1) or (2) and/or its E,E-, E,Z- or Z,Z-geometrical isomer forms: comprising specific polar groups consisting of hydroxyl- and ether-functionalities. Another object of the present invention relates to a cosmetic process for controlling and/or improving the darkening of the skin under exposure to UV radiation and the homogeneity of the colour of the complexion which comprises the application onto the skin of a cosmetic composition as above defined. Another object of the present invention relates to a cosmetic process for protecting the keratinic materials and particularly the skin against photo-ageing which comprises the application onto the keratinic material of a cosmetic composition as above defined.
摘要翻译：本发明涉及化妆品和/或皮肤病学组合物，其包含在生理学上可接受的介质中，至少一种式（1）或（2）的部花青衍生物和/或其E，E-，E，Z-或Z，Z- 几何异构体形式：包括由羟基和醚官能团组成的特定极性基团。本发明的另一个目的涉及一种用于控制和/或改善在暴露于紫外线辐射下的皮肤变暗的化妆方法和肤色的均匀性，其包括如上所述在化妆品组合物的皮肤上施用。本发明的另一个目的涉及一种用于保护角质化材料，特别是皮肤抵抗光老化的美容方法，其包括将上述应用于上述化妆品组合物的角蛋白材料。

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