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    • 2. 发明授权
    • UV filter combinations comprising benzylidene malonates
    • US09764169B2
    • 2017-09-19
    • US13381965
    • 2010-06-29
    • Julie GrumelardThomas EhlisMarkus HanschMyriam Sohn
    • Julie GrumelardThomas EhlisMarkus HanschMyriam Sohn
    • A61Q17/04A61K8/37
    • A61Q17/04A61K8/37
    • Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone;(b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.
    • 3. 发明申请
    • UV FILTER COMBINATIONS COMPRISING BENZYLIDENE MALONATES
    • 紫外线过滤器组合包含苄基胆碱酯
    • US20120128611A1
    • 2012-05-24
    • US13381965
    • 2010-06-29
    • Julie GrumelardThomas EhlisPaul Adriaan Van Der SchaafMarkus HanschMyriam Sohn
    • Julie GrumelardThomas EhlisPaul Adriaan Van Der SchaafMarkus HanschMyriam Sohn
    • A61K8/37A61K8/49A61K8/58A61Q17/04
    • A61Q17/04A61K8/37
    • Disclosed is the use of a UV filter combination, comprising (a) a first UV filter selected from benzylidene malonates of formula (1), wherein R1 methyl; ethyl; propyl; or n-butyl; if R1 is methyl, then R is tert. butyl; formula (II); formula (III); a radical of formula (1a); or a radical of formula (1b); wherein R2 and R3, independently from each other are hydrogen; or methyl; R4 is methyl; ethyl; or n-propyl; R5 and R6 independently from each other are hydrogen; or C1-C3alkyl; if R1 is ethyl; propyl; or n-butyl, then R is isopropyl; and (b) a second UV filter selected from (b1) Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine; (b2) Butyl Methoxydibenzoylmethane; (b3)Diethylhexyl Butamido Triazone; (b4) Ethylhexyl Triazone; (b5) Diethylamino Hydroxy Benzoyl Hexyl Benzoate; (b6) Ethylhexyl Methoxycinnamate; (b7) Ethylhexyl Salicylate; (b8) Homosalate; (b9) Octocrylene; (b10) micronized Methylene Bis-Benzotriazolyl Tetramethylbutylphenol; (b11) Phenylbenzimidazole Sulfonic Acid; (b12) Titanium Dioxide; (b13) micronized Tris-Biphenyl Triazine; and (b14) micronized (2-{4-[2-(4-Diethylamino-2-hydroxy-benzoyl)-benzoyl]-piperazine-1-carbonyl}-phenyl)-(4-diethylamino-2-hydroxy-phenyl)-methanone; (b15) benzoicacid,4,4-[[3-[1,3,3,3-tetramethyl-1-[trimethylsilyl)oxy]-1-disiloxanyl]propyl]amino]-1,3,5-triazine-2,4-diyl]diimino]bis-, dibutyl ester wherein the UV filter combination comprises at least 2 UV filters of component (b1)-(b14); for the protection of human and animal hair and skin against UV radiation.
    • 公开了使用UV过滤器组合,其包含(a)选自式(1)的亚苄基丙二酸酯的第一UV过滤器,其中R 1甲基; 乙基; 丙基; 或正丁基; 如果R1是甲基,那么R是叔丁基。 丁基; 式(II); 式(III); 式(1a)的基团; 或式(1b)的基团; 其中R2和R3彼此独立地是氢; 或甲基; R4是甲基; 乙基; 或正丙基​​; R5和R6彼此独立地是氢; 或C 1 -C 3烷基; 如果R1是乙基; 丙基; 或正丁基,那么R是异丙基; 和(b)选自(b1)双 - 乙基己氧基苯酚甲氧基苯基三嗪的第二UV过滤器; (b2)丁基甲氧基二苯甲酰甲烷; (b3)丁酰己二酸二乙基己酯; (b4)乙基己基三嗪酮; (b5)二乙基氨基羟基苯甲酰己基苯甲酸酯; (b6)甲氧基肉桂酸乙基己酯; (b7)水杨酸乙基己酯; (b8)均质酸; (b9) (b10)微米亚甲基双苯并三唑基四甲基丁基苯酚; (b11)苯基苯并咪唑磺酸; (b12)二氧化钛; (b13)微粉化的三联苯三嗪; 和(b14)微粉化(2- {4- [2-(4-二乙基氨基-2-羟基 - 苯甲酰基) - 苯甲酰基] - 哌嗪-1-羰基} - 苯基) - (4-二乙基氨基-2-羟基 - 苯基) 甲酮 (b15)苯甲酸,4,4 - [[3- [1,3,3,3-四甲基-1- [三甲基甲硅烷基]氧基] -1-二硅氧烷基]丙基]氨基] -1,3,5-三嗪-2 ,4-二基]二亚氨基]双 - 二丁酯,其中UV滤光器组合包含至少2个组分(b1) - (b14)的UV滤光剂; 用于保护人和动物的头发和皮肤免受紫外线辐射。