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1. 发明授权

US06511496B1 Embolic protection device for use in interventional procedures 有权
标题翻译：用于介入手术的栓塞保护装置
公开(公告)号：US06511496B1
公开(公告)日：2003-01-28
申请号：US09659949
申请日：2000-09-12
申请人： Benjamin C. Huter , Scott J. Huter , Christopher L. Steadham
发明人： Benjamin C. Huter , Scott J. Huter , Christopher L. Steadham
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067
摘要： An intravascular filter device for capturing embolic particles entrained in blood flowing in an arterial vessel during an interventional procedure. The filter includes an expandable strut assembly and a filtering medium. Each strut is coated with an elastic polymer in order to minimize trauma to an arterial lumen upon deployment of the filter and to ensure secure adhesion of the filtering medium to the struts. Attached to the coating of the strut assembly is the filtering medium which is formed from a thin elastic polymer membrane containing a plurality of holes which allow blood to pass through filter while capturing embolic particles. The filtering medium is attached to the layer of polymeric material by laser welding, ultrasonic welding or adhesive bonding.
摘要翻译：一种血管内过滤器装置，用于捕获在介入手术期间夹带在动脉血管中流动的血液中的栓塞颗粒。过滤器包括可膨胀支柱组件和过滤介质。每个支柱涂覆有弹性聚合物，以便在部署过滤器时最小化对动脉腔的创伤，并确保过滤介质与支柱的牢固粘附。附着在支柱组件的涂层上的是由包含多个孔的薄弹性聚合物膜形成的过滤介质，其允许血液在捕获栓塞颗粒的同时通过过滤器。过滤介质通过激光焊接，超声波焊接或粘合剂粘结附着在聚合物材料层上。

2. 发明授权

US07425215B2 Delivery systems for embolic filter devices 有权
标题翻译：栓塞过滤装置的输送系统
公开(公告)号：US07425215B2
公开(公告)日：2008-09-16
申请号：US10385162
申请日：2003-03-10
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M25/0668
摘要： A delivery system for an expandable filter device includes a dual lumen delivery sheath which has a lumen for receiving the expandable filter device and a lumen for receiving a primary guide wire. The primary guide wire is utilized to place the delivery sheath and expandable filter into the desired region of the patient's vasculature via an over-the-wire or rapid-exchange arrangement. The delivery sheath can be protracted over the expandable filter device to allow the filter to be deployed within the patient's vasculature at the desired location. The delivery system can be embodied in an alternative design in which the primary guide wire extends through a guide wire lumen located in an obturator which forms part of the expandable filter device. Again, the primary guide wire is utilized to maneuver the filter device into the desired area via an over-the-wire arrangement. A slit extending longitudinally along the length of the sheath facilitates the removal of the guide wire and delivery sheath from the patient's vasculature.
摘要翻译：用于可膨胀过滤器装置的递送系统包括双腔输送护套，其具有用于接收可膨胀过滤器装置的内腔和用于接收主导丝的管腔。主引导线用于通过线上或快速交换布置将输送护套和可扩张过滤器放置在患者血管的期望区域中。输送护套可以延伸在可膨胀的过滤器装置上，以允许过滤器在病人的脉管系统中部署在期望的位置。输送系统可以以替代设计来体现，其中主导丝延伸穿过位于形成可膨胀过滤器装置的一部分的闭孔器中的导丝管腔。再次，主引导线用于通过线上布置来将过滤器装置操纵到期望的区域。沿鞘的长度纵向延伸的狭缝有助于从患者的脉管系统移除导丝和输送鞘。

3. 发明授权

US07252675B2 Embolic filtering devices 有权
标题翻译：栓塞过滤装置
公开(公告)号：US07252675B2
公开(公告)日：2007-08-07
申请号：US10260710
申请日：2002-09-30
申请人： Andy E. Denison , William J. Harrison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Steven T. Saville , Kent C. B. Stalker
发明人： Andy E. Denison , William J. Harrison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Steven T. Saville , Kent C. B. Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.
摘要翻译：用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架第二控制臂通过部分回路。部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

4. 发明授权

US07241304B2 Flexible and conformable embolic filtering devices 有权
标题翻译：灵活和适应性栓塞过滤装置
公开(公告)号：US07241304B2
公开(公告)日：2007-07-10
申请号：US10027915
申请日：2001-12-21
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter , John E. Papp
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter , John E. Papp
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/008
摘要： A self-expanding cage for use in conjunction with an embolic filtering device includes one or more circumferential members adapted to expand from an unexpanded position to a expanded position within the patient's body vessel. At least one proximal strut and at least one distal strut are attached to the circumferential member to form the basket. The circumferential member may include a plurality of bending regions which enhance the ability of the circumferential member to move between the unexpanded and expanded positions. The proximal and distal struts can be attached to one of the bending regions. When two or more circumferential members are utilized, each member may be connected by a connecting strut which may be connected at a bending region. The connecting strut can be a straight segment or may have a non-linear shape to provide additional flexibility. The expandable cage can be mounted to a elongated member, such as a guide wire, and can be either permanently mounted or rotatably mounted thereto.
摘要翻译：用于与栓塞过滤装置结合使用的自膨胀笼包括适于从未膨胀位置扩展到患者体内容器内的扩张位置的一个或多个周向构件。至少一个近端支柱和至少一个远端支柱附接到周向构件以形成篮。周向构件可以包括多个弯曲区域，这些弯曲区域增强了圆周构件在未膨胀和膨胀位置之间移动的能力。近端和远端支柱可以附接到一个弯曲区域。当使用两个或更多个周向构件时，每个构件可以通过可在弯曲区域处连接的连接支柱连接。连接支柱可以是直线段，或者可以具有非线性形状以提供额外的灵活性。可扩展的保持架可以安装到诸如导丝的细长构件上，并且可以永久地安装或可旋转地安装在其上。

5. 发明授权

US08845583B2 Embolic protection devices 有权
标题翻译：栓塞保护装置
公开(公告)号：US08845583B2
公开(公告)日：2014-09-30
申请号：US11651667
申请日：2007-01-10
申请人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
发明人： William J. Boyle , David H. Burkett , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , Arkady Kokish , Kent C. B. Stalker , Chicheng Wang , John D. Whitfield
IPC分类号： A61M29/00 , A61F2/01
CPC分类号： A61F2/013 , A61F2002/011 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/005 , A61F2230/0067 , A61F2230/008
摘要： An embolic protection device for use in a blood vessel when an interventional procedure is being performed in a stenosed or occluded region to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filtering assembly having a self-expanding strut assembly and a filter element attached thereto. In one embodiment, the filtering assembly is attached to the distal end of a guidewire and is deployed within the patient's vasculature as the guidewire is manipulated into the area of treatment. A restraining sheath placed over the filtering assembly in a coaxial arrangement maintains the filtering assembly in its collapsed position until it is ready to be deployed by the physician. Thereafter, the sheath can be retracted to expose the filtering assembly which will then self-expand within the patient's vasculature. Interventional devices can be delivered over the guidewire and any embolic debris created during the interventional procedure and released into the blood stream will enter the filtering assembly and be captured therein. Other embodiments include filtering assemblies attached to an outer tubular member and inner shaft member which apply axial force to the distal ends of the assembly to either expand or contract the struts as needed.
摘要翻译：一种用于血管中的栓塞保护装置，当在狭窄或闭塞区域进行介入手术以捕获可能在手术期间产生和释放到血流中的任何栓塞物质。该装置包括具有自扩张支柱组件和附接到其上的过滤元件的过滤组件。在一个实施例中，过滤组件附接到导丝的远端，并且当导线被操纵进入治疗区域时，其部署在患者的脉管系统内。以同轴布置放置在过滤组件上方的限制护套将过滤组件保持在其收缩位置，直到其准备好由医师部署。此后，护套可缩回以露出过滤组件，然后过滤组件将在患者的脉管系统内自我扩张。介入装置可以在导丝上传送，并且在介入手术期间产生的并释放到血流中的任何栓塞碎片将进入过滤组件并被捕获在其中。其他实施例包括附接到外部管状构件和内部轴构件的过滤构件，其向组件的远端施加轴向力，以根据需要来扩展或收缩支柱。

6. 发明授权

US08029530B2 Guide wire with embolic filtering attachment 有权
标题翻译：导丝与栓塞过滤附件
公开(公告)号：US08029530B2
公开(公告)日：2011-10-04
申请号：US12904001
申请日：2010-10-13
申请人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
发明人： Douglas H. Gesswein , Wayne E. Cornish , Scott J. Huter , Benjamin C. Huter , John E. Papp
IPC分类号： A61F2/01
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008
摘要： A separate deliverable embolic protection device filter that attaches to a helical coil at a distal end of a conventional guide, for use in a blood vessel when an interventional procedure is being performed to capture any embolic material which may be created and released into the bloodstream during the procedure. The device includes a filter assembly with a proximal end and a distal end, and a guide wire connector attached to the distal end of the filter assembly. The guide wire connector is able to couple with the helical coil of the guide wire. A restraining sheath placed over the filter assembly in a coaxial arrangement maintains the filter assembly in a collapsed position and delivers the filter assembly separately to the helical coil of the guide wire, and then the guide wire connector is joined to the helical coil. Alternatively, the guide wire can include a rotatable coil section forming a portion of the distal tip coil on the guide wire which is adapted to be coupled to the filter assembly. This arrangement allows the filter assembly to be rotatably mounted onto the guide wire.
摘要翻译：一种单独的可输送栓塞保护装置过滤器，其连接到常规引导件的远端处的螺旋线圈，用于血管中，当进行介入手术以捕获可能产生并释放到血流中的任何栓塞物质时步骤。该装置包括具有近端和远端的过滤器组件和连接到过滤器组件的远端的导丝连接器。导丝连接器能够与导丝的螺旋线圈耦合。以同轴布置放置在过滤器组件上方的限制护套将过滤器组件保持在折叠位置并将过滤器组件分别输送到导丝的螺旋线圈，然后导丝连接器连接到螺旋线圈。或者，引导线可以包括可旋转的线圈部分，其形成导丝上的远端尖端线圈的一部分，其适于联接到过滤器组件。这种布置允许过滤器组件可旋转地安装在导丝上。

7. 发明授权

US07976560B2 Embolic filtering devices 有权
标题翻译：栓塞过滤装置
公开(公告)号：US07976560B2
公开(公告)日：2011-07-12
申请号：US11654426
申请日：2007-01-17
申请人： Andy E. Denison , William J. Harrison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Steven T. Saville , Kent C. B. Stalker
发明人： Andy E. Denison , William J. Harrison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Steven T. Saville , Kent C. B. Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2002/015 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： An expandable frame for an embolic filtering device used to capture embolic debris in a body vessel includes a first half frame having a first control arm connected to a second control arm by a partial loop and a second half frame having a first control arm connected to a second control arm by a partial loop. The partial loops cooperatively form a composite loop for attachment of a filtering element which will expand in the body vessel to capture embolic debris entrained in the fluid of the vessel. The lengths and positioning of the first and second control arms of each half frame can be varied to create an expandable frame which conforms to the size and shape of the body vessel in which the filtering device is deployed. Additionally, the radius of the partial loops, along with the length of the arc of the partial loops, can be varied on each of the frames to create a composite filtering assembly that can easily adapt to the size and shape of the body vessel. Additionally, the control arms of the half frames can be disposed either proximally or distally of the composite loop to create a distinct filtering structure.
摘要翻译：用于捕获身体血管中的栓塞碎片的栓塞过滤装置的可膨胀框架包括：第一半框架，具有通过部分回路连接到第二控制臂的第一控制臂，以及具有连接到第二控制臂的第二控制臂的第二半框架第二控制臂通过部分回路。部分回路协同地形成用于附接过滤元件的复合回路，该过滤元件将在体内容器中膨胀以捕获携带在血管流体中的栓塞碎片。可以改变每个半框架的第一和第二控制臂的长度和定位，以便产生符合过滤装置展开的身体容器的尺寸和形状的可扩张框架。此外，部分回路的半径以及部分回路的圆弧的长度可以在每个框架上变化以产生可以容易地适应身体血管的尺寸和形状的复合过滤组件。此外，半框架的控制臂可以在复合环路的近侧或远端设置，以产生不同的过滤结构。

8. 发明授权

US07678128B2 Delivery and recovery sheaths for medical devices 失效
标题翻译：用于医疗器械的输送和恢复护套
公开(公告)号：US07678128B2
公开(公告)日：2010-03-16
申请号：US09897295
申请日：2001-06-29
申请人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C. B. Stalker
发明人： William J. Boyle , Andy E. Denison , Benjamin C. Huter , Scott J. Huter , John E. Papp , Charles R. Peterson , Kent C. B. Stalker
IPC分类号： A61M29/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/011 , A61F2002/018 , A61F2230/0006 , A61F2230/008
摘要： A deployment control system provides controlled deployment of an embolic protection device which may include a guide wire, an expandable filter attached to the guide wire near its distal end, and a restraining sheath that maintains the expanded filter in a collapsed position. The deployment control system includes a torque control device which allows the physician to torque the guide wire into the patient's anatomy and a mechanism for preventing the guide wire from buckling as the restraining sheath is being retracted to deploy the expandable filter. A recovery control system for recovering the embolic protection device includes an inner catheter which extends within a lumen of an outer recovery sheath in a coaxial arrangement. A distal portion of the inner catheter extends beyond another recovery sheath during advancement of the recovery system into the vasculature. The recovery sheath can be advanced over the inner catheter to collapse the expandable filter. The proximal ends of the inner catheter and recovery sheath include handle portions having snap mechanisms which hold the components together as the recovery system is being advanced into the patient's vasculature.
摘要翻译：部署控制系统提供栓塞保护装置的可控部署，该栓塞保护装置可以包括引导线，在其远端附近附接到导丝的可扩张过滤器，以及将扩张过滤器保持在折叠位置的限制护套。部署控制系统包括扭矩控制装置，该扭矩控制装置允许医师将导丝扭转到患者的解剖结构中，以及用于防止导线在收缩护套以展开可膨胀过滤器时弯曲的机构。用于回收栓塞保护装置的恢复控制系统包括在同轴布置中在外部恢复护套的内腔内延伸的内导管。在将回收系统推进脉管系统期间，内导管的远端部分延伸超过另一恢复护套。恢复护套可以在内导管上推进以使可膨胀过滤器折叠。内导管和恢复护套的近端包括手柄部分，其具有卡扣机构，当回收系统进入患者的脉管系统时，该部件将部件保持在一起。

9. 发明申请

US20090030445A1 DELIVERY SYSEMS FOR EMBOLIC FILTER DEVICES 审中-公开
标题翻译：用于嵌入式过滤装置的交付符号
公开(公告)号：US20090030445A1
公开(公告)日：2009-01-29
申请号：US12187129
申请日：2008-08-06
申请人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
发明人： William J. Boyle , Benjamin C. Huter , Scott J. Huter
IPC分类号： A61F2/01 , A61B17/00
CPC分类号： A61F2/013 , A61F2/95 , A61F2002/018 , A61F2230/0006 , A61F2230/0067 , A61F2230/008 , A61M25/0668
摘要： A delivery system for an expandable filter device includes a dual lumen delivery sheath which has a lumen for receiving the expandable filter device and a lumen for receiving a primary guide wire. The primary guide wire is utilized to place the delivery sheath and expandable filter into the desired region of the patient's vasculature via an over-the-wire or rapid-exchange arrangement. The delivery sheath can be protracted over the expandable filter device to allow the filter to be deployed within the patient's vasculature at the desired location. The delivery system can be embodied in an alternative design in which the primary guide wire extends through a guide wire lumen located in an obturator which forms part of the expandable filter device. Again, the primary guide wire is utilized to maneuver the filter device into the desired area via an over-the-wire arrangement. A slit extending longitudinally along the length of the sheath facilitates the removal of the guide wire and delivery sheath from the patient's vasculature.
摘要翻译：用于可膨胀过滤器装置的递送系统包括双腔输送护套，其具有用于接收可膨胀过滤器装置的内腔和用于接收主导丝的管腔。主引导线用于通过线上或快速交换布置将输送护套和可扩张过滤器放置在患者血管的期望区域中。输送护套可以延伸在可膨胀的过滤器装置上，以允许过滤器在病人的脉管系统中部署在期望的位置。输送系统可以以替代设计来体现，其中主导丝延伸穿过位于形成可膨胀过滤器装置的一部分的闭孔器中的导丝管腔。再次，主引导线用于通过线上布置来将过滤器装置操纵到期望的区域。沿鞘的长度纵向延伸的狭缝有助于从患者的脉管系统移除导丝和输送鞘。

10. 发明授权

US06575996B1 Filter device for embolic protection system 有权
标题翻译：用于栓塞保护系统的过滤装置
公开(公告)号：US06575996B1
公开(公告)日：2003-06-10
申请号：US09895784
申请日：2001-06-29
申请人： Andy Denison , Benjamin C. Huter , Scott J. Huter , John D. Whitfield
发明人： Andy Denison , Benjamin C. Huter , Scott J. Huter , John D. Whitfield
IPC分类号： A61M2900
CPC分类号： A61F2/013 , A61F2002/018 , A61F2230/005 , A61F2230/0067
摘要： A system for enabling the insertion and removal of an embolic protection device, for capturing and retaining embolic debris which may be created during the performance of a therapeutic interventional procedure in a stenosed or occluded region of a blood vessel. The system, in a version of an embodiment thereof, enables the device to expand upon deployment thereof so as to seal off the inner surface of a blood vessel, to inhibit the forming of a gap therein, for inhibiting embolic material from passing therethrough. The system, in another version of the embodiment thereof, enables the device to navigate through confined spaces in tortuous anatomy.
摘要翻译：一种能够插入和移除栓塞保护装置的系统，用于捕获和保留在血管的狭窄或阻塞区域中执行治疗介入手术期间可产生的栓塞碎片。该系统在其实施例的一个实施例中使装置能够在展开时扩张，以便密封血管的内表面，以阻止其中形成间隙，以阻止栓塞材料通过。该系统在其实施例的另一个版本中使得设备能够在弯曲的解剖结构中通过密闭的空间导航。

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