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1. 发明申请

US20100184998A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：US20100184998A1
公开(公告)日：2010-07-22
申请号：US12663998
申请日：2008-06-18
申请人： Beatriz Dominguez , Alan Dyke , William Hems , Christian Mathes , Anthony C. O'Sullivan , Gottfried Sedelmeier
发明人： Beatriz Dominguez , Alan Dyke , William Hems , Christian Mathes , Anthony C. O'Sullivan , Gottfried Sedelmeier
IPC分类号： C07C69/593 , C07C57/13 , C07D413/06 , C07C67/00 , C07D321/00
CPC分类号： C07C57/13 , C07C51/09 , C07C51/353 , C07C51/36 , C07C67/475 , C07C69/593 , C07C69/602 , C07D321/00
摘要： The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds.
摘要翻译：本发明涉及用于制备式（I）化合物的烯烃复分解方法，其是合成药学活性化合物的新型有用中间体。

2. 发明申请

US20060229473A1 Ligands 失效
标题翻译：配体
公开(公告)号：US20060229473A1
公开(公告)日：2006-10-12
申请号：US10560387
申请日：2004-06-08
申请人： Beatriz Dominguez , William Hems , Antonio Zanotti-Gerosa
发明人： Beatriz Dominguez , William Hems , Antonio Zanotti-Gerosa
IPC分类号： C07F15/00 , C07C209/10 , C07C27/00 , C07C45/67
CPC分类号： B01J31/2457 , B01J31/1608 , B01J2231/4211 , B01J2231/4261 , B01J2231/4283 , B01J2231/643 , B01J2231/645 , B01J2531/0263 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C39/42 , C07C47/55 , C07C49/813 , C07C63/72 , C07C69/76 , C07C205/12 , C07C231/18 , C07C2603/92 , C07F9/5027 , C07F9/65719 , C07F9/6581 , C07F15/0053 , C07C233/47 , C07C33/22 , C07C33/50
摘要： A substituted paracyclophane is described of formula (I) wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl, Z1, Z2 and Z3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or 1 and a+b+c+d+e+f=1 to 6. Preferably X1 and X2 are —(C2H4)— and a+b+c+d+e+f=1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions.
摘要翻译：描述了式（I）的取代的对环芳烷，其中X 1和X 2 2是包含2至4个碳原子的连接基团，Y 1，和Y 2选自氢，卤素，氧，氮，烷基，环烷基，芳基或杂芳基，Z 1，Z 2， SUP>和Z 3是用任选含有官能团a，b，c，d，e和f分别为0或1和a + b + c + d + e + f = 1的基团 X 1和X 2优选为 - （C 2 H 4 H 4） - 和 - + b + c + d + e + f = 1或2.取代的对环烷基提供过渡金属催化剂，其表现出对不对称反应的高活性和选择性。

3. 发明申请

US20050164296A1 Catalysts 失效
标题翻译：催化剂
公开(公告)号：US20050164296A1
公开(公告)日：2005-07-28
申请号：US10468340
申请日：2002-02-07
申请人： Antony Chesney , Graeme Bradford , William Hems
发明人： Antony Chesney , Graeme Bradford , William Hems
IPC分类号： B01J31/24 , B01J20/32 , B01J21/08 , B01J31/02 , B01J31/16 , B01J31/22 , B01J31/40 , B01J38/00 , C07F1/08 , C07F5/00 , C07F5/06 , C07F7/00 , C07F7/08 , C07F7/10 , C07F7/28 , C07F9/00 , C07F13/00 , C07F15/00 , C07F15/06 , C07F19/00 , G01N33/53 , B01J23/00 , G01N33/543
CPC分类号： B01J31/2414 , B01J20/3204 , B01J20/3219 , B01J20/3236 , B01J21/08 , B01J31/1633 , B01J31/2291 , B01J31/2295 , B01J2231/324 , B01J2231/4261 , B01J2231/52 , B01J2231/645 , B01J2531/16 , B01J2531/31 , B01J2531/46 , B01J2531/62 , B01J2531/72 , B01J2531/821 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/84
摘要： A tethered ligand comprising the reaction product of an organofunctional silica and a ligand containing a functional group capable of reaction with said organofunctional silica, wherein the organofunctional silica is prepared from an alkyl silicate and an organofunctional silane is described. A supported catalyst is also described comprising additionally a source of catalytically-active metal. Methods for preparing the tethered ligand and supported catalyst are provided and uses of the supported catalyst for performing asymmetric reactions are claimed. The catalysts are readily separable from the reaction mixtures and may be re-used if desired.
摘要翻译：描述了包含有机官能二氧化硅与含有能与所述有机官能二氧化硅反应的官能团的配体的反应产物的束缚配体，其中有机官能二氧化硅由硅酸烷基酯和有机官能硅烷制备。还描述了另外包含催化活性金属源的载体催化剂。提供制备束缚配体和负载催化剂的方法，并要求保护催化剂用于进行不对称反应的用途。催化剂容易与反应混合物分离，并且如果需要可以重新使用。

4. 发明授权

US06486337B2 Ruthenium-disphosphine complexes and their use as catalysts 有权
标题翻译：钌 - 配膦络合物及其用作催化剂
公开(公告)号：US06486337B2
公开(公告)日：2002-11-26
申请号：US09821222
申请日：2001-03-29
申请人： Mark Joseph Burk , William Hems , Antonio Zanotti-Gerosa
发明人： Mark Joseph Burk , William Hems , Antonio Zanotti-Gerosa
IPC分类号： C07F1500
CPC分类号： C07F15/0053
摘要： The present invention concerns novel complexes, suitable in particular for use as catalysts in the asymmetric hydrogenation of ketones, of formula 1 or a diastereoisomer thereof, wherein each Ar is an aromatic or heteroaromatic group of up to 20 atoms; X is halide or carboxylate; and R1, R2, R3, and R4 are independently hydrogen, aryl or alkyl, optionally linked or part of a ring.
摘要翻译：本发明涉及新型络合物，特别适用于式1或其非对映异构体的酮的不对称氢化中的催化剂，其中Ar是至多20个原子的芳族或杂芳族基团; X是卤素或羧酸酯; 并且R 1，R 2，R 3和R 4独立地为氢，芳基或烷基，任选地连接或部分环。

5. 发明申请

US20070066850A1 Catalysts 审中-公开
标题翻译：催化剂
公开(公告)号：US20070066850A1
公开(公告)日：2007-03-22
申请号：US10564902
申请日：2004-07-07
申请人： William Hems , Gabriela Grasa
发明人： William Hems , Gabriela Grasa
IPC分类号： C07C209/26 , C07F15/00 , C07F9/06 , C07F9/02
CPC分类号： C07D207/14 , C07F15/0053
摘要： Catalysts suitable for asymmetric hydrogenation reactions is described comprising the reaction product of a group (8) transition metal compound a chiral phosphine and a chiral diamine of formula (1) in which R1, R2 R3 or R4 are independently hydrogen, a saturated or unsaturated alkyl, or cycloalkyl group, an aryl group, a urethane or sulphonyl group and R5, R6, R7 or R8 are independently hydrogen, a saturated or unsaturated alkyl or cycloalkyl group, or an aryl group, at least one of R1, R2, R3 or R4 is hydrogen and A is a linking group comprising one or two substituted or unsubstituted carbon atoms.
摘要翻译：描述了适用于不对称氢化反应的催化剂，其包括（8）过渡金属化合物手性膦与式（1）的手性二胺的反应产物，其中R 1，R 2， R 3或R 4独立地是氢，饱和或不饱和的烷基或环烷基，芳基，氨基甲酸酯基或磺酰基，R 0 > 5，R 6，R 7或R 8独立地是氢，饱和或不饱和的烷基或环烷基，或芳基，R 1，R 2，R 3或R 4中的至少一个是氢和 A是包含一个或两个取代或未取代的碳原子的连接基团。

6. 发明申请

US20060135355A1 Nitrogen-containing ligands 审中-公开
标题翻译：含氮配体
公开(公告)号：US20060135355A1
公开(公告)日：2006-06-22
申请号：US10524550
申请日：2003-07-30
申请人： William Hems , Weiping Chen , Jianliang Xiao
发明人： William Hems , Weiping Chen , Jianliang Xiao
IPC分类号： B01J31/00
CPC分类号： C07C247/10 , B01J31/1616 , B01J31/1625 , B01J31/165 , B01J31/1658 , B01J31/1683 , B01J31/1805 , B01J2231/32 , B01J2231/326 , B01J2231/4211 , B01J2231/4261 , B01J2231/48 , B01J2231/50 , B01J2231/641 , B01J2231/643 , B01J2231/72 , B01J2231/74 , B01J2531/821 , B01J2531/824 , B01J2531/828 , C07B2200/07 , C07B2200/11 , C07C29/145 , C07C211/27 , C07C211/29 , C07C217/60 , C07C217/64 , C07C33/46
摘要： An immobilised nitrogen-containing ligand is described comprising the reaction product of a compound of formula (I) wherein R5, R6, R7 and R8 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group, an aryl group, a urethane group, a sulphonyl group or form an imine group, R1, R2, R3, and R4 are independently hydrogen, a saturated or unsaturated C1-C10 alkyl group or an aryl group and at least one of R1, R2, R3 and R4 is functionalised with a functional group, and a solid support having a site capable of reacting with said functional group. The nitrogen-containing ligand is useful for preparing immobilised catalysts for performing e.g. asymmetric catalysis.
摘要翻译：描述了一种固定化含氮配体，其包括式（I）化合物的反应产物，其中R 5，R 6，R 7，R 7， R 8独立地是氢，饱和或不饱和的C 1 -C 10烷基，芳基，氨基甲酸酯基，磺酰基或亚胺基，R 1， R 2，R 3和R 4独立地是氢，饱和或不饱和的C 1 -C 10烷基或芳基，并且在 R 1，R 2，R 3和R 4中的至少一个用官能团官能化，并且具有能够与所述官能团反应的位置的固体支持体。含氮配体可用于制备固定催化剂，用于进行例如不对称催化。

7. 发明申请

US20050272930A1 Process for the prepation of 3-hydroxy-(2-thienyl)propanamines 审中-公开
标题翻译： 3-羟基 - （2-噻吩基）丙胺的制备方法
公开(公告)号：US20050272930A1
公开(公告)日：2005-12-08
申请号：US10521799
申请日：2003-07-21
申请人： William Hems , Kai Rossen , Dietmar Reichert , Klaus Kohler , Juan Jose Almena Perea
发明人： William Hems , Kai Rossen , Dietmar Reichert , Klaus Kohler , Juan Jose Almena Perea
IPC分类号： C07D333/20 , C07D413/12 , C07D333/22
CPC分类号： C07D333/20
摘要： The present invention relates to a process for the preparation of compounds of the general formula (I) by catalytic enantioselective hydrogenation of the corresponding ketones. There are used inter alia ruthenium catalysts with chiral diamines and chiral biphosphines as ligands.
摘要翻译：本发明涉及通过相应酮的催化对映选择性氢化制备通式（I）的化合物的方法。尤其使用具有手性二胺和手性双膦作为配体的钌催化剂。

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