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1. 发明申请

US20100184998A1 ORGANIC COMPOUNDS 审中-公开
标题翻译：有机化合物
公开(公告)号：US20100184998A1
公开(公告)日：2010-07-22
申请号：US12663998
申请日：2008-06-18
申请人： Beatriz Dominguez , Alan Dyke , William Hems , Christian Mathes , Anthony C. O'Sullivan , Gottfried Sedelmeier
发明人： Beatriz Dominguez , Alan Dyke , William Hems , Christian Mathes , Anthony C. O'Sullivan , Gottfried Sedelmeier
IPC分类号： C07C69/593 , C07C57/13 , C07D413/06 , C07C67/00 , C07D321/00
CPC分类号： C07C57/13 , C07C51/09 , C07C51/353 , C07C51/36 , C07C67/475 , C07C69/593 , C07C69/602 , C07D321/00
摘要： The present invention relates to olefin metathesis processes for the manufacture of a compound of the formula (I) which is a novel useful intermediate in the synthesis of pharmaceutically active compounds.
摘要翻译：本发明涉及用于制备式（I）化合物的烯烃复分解方法，其是合成药学活性化合物的新型有用中间体。

2. 发明申请

US20060229473A1 Ligands 失效
标题翻译：配体
公开(公告)号：US20060229473A1
公开(公告)日：2006-10-12
申请号：US10560387
申请日：2004-06-08
申请人： Beatriz Dominguez , William Hems , Antonio Zanotti-Gerosa
发明人： Beatriz Dominguez , William Hems , Antonio Zanotti-Gerosa
IPC分类号： C07F15/00 , C07C209/10 , C07C27/00 , C07C45/67
CPC分类号： B01J31/2457 , B01J31/1608 , B01J2231/4211 , B01J2231/4261 , B01J2231/4283 , B01J2231/643 , B01J2231/645 , B01J2531/0263 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C39/42 , C07C47/55 , C07C49/813 , C07C63/72 , C07C69/76 , C07C205/12 , C07C231/18 , C07C2603/92 , C07F9/5027 , C07F9/65719 , C07F9/6581 , C07F15/0053 , C07C233/47 , C07C33/22 , C07C33/50
摘要： A substituted paracyclophane is described of formula (I) wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl, Z1, Z2 and Z3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or 1 and a+b+c+d+e+f=1 to 6. Preferably X1 and X2 are —(C2H4)— and a+b+c+d+e+f=1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions.
摘要翻译：描述了式（I）的取代的对环芳烷，其中X 1和X 2 2是包含2至4个碳原子的连接基团，Y 1，和Y 2选自氢，卤素，氧，氮，烷基，环烷基，芳基或杂芳基，Z 1，Z 2， SUP>和Z 3是用任选含有官能团a，b，c，d，e和f分别为0或1和a + b + c + d + e + f = 1的基团 X 1和X 2优选为 - （C 2 H 4 H 4） - 和 - + b + c + d + e + f = 1或2.取代的对环烷基提供过渡金属催化剂，其表现出对不对称反应的高活性和选择性。

3. 发明授权

US07667075B2 Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis 有权
标题翻译：磺酰化二苯基乙二胺，其制备方法和用于转移氢化催化
公开(公告)号：US07667075B2
公开(公告)日：2010-02-23
申请号：US11719478
申请日：2005-11-01
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
IPC分类号： C07C311/21 , C07C311/16 , C07C311/03 , C07C303/38
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译：描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。手性二胺可用于制备适用于转移氢化反应的催化剂。

4. 发明授权

US08859815B2 Sulphonylated diphenylethylenediamines, method for their preparation and use in transfer hydrogenation catalysis 有权
标题翻译：磺酰化二苯基乙二胺，其制备方法和用于转移氢化催化
公开(公告)号：US08859815B2
公开(公告)日：2014-10-14
申请号：US13313889
申请日：2011-12-07
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
IPC分类号： C07C311/13 , C07C311/14 , C07C311/16 , C07C33/20 , C07C33/22 , C07C33/46 , C07C303/38 , B01J31/18 , C07C29/143 , C07C311/18
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译：描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。手性二胺可用于制备适用于转移氢化反应的催化剂。

5. 发明授权

US07256302B2 Substituted paracyclophane derivatives in asymmetric catalysis 失效
标题翻译：非对称催化中的取代对环芳烃衍生物
公开(公告)号：US07256302B2
公开(公告)日：2007-08-14
申请号：US10560387
申请日：2004-06-08
申请人： Beatriz Dominguez , William Patrick Hems , Antonio Zanotti-Gerosa
发明人： Beatriz Dominguez , William Patrick Hems , Antonio Zanotti-Gerosa
IPC分类号： C07F9/30
CPC分类号： B01J31/2457 , B01J31/1608 , B01J2231/4211 , B01J2231/4261 , B01J2231/4283 , B01J2231/643 , B01J2231/645 , B01J2531/0263 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , C07B53/00 , C07B2200/07 , C07C29/145 , C07C39/42 , C07C47/55 , C07C49/813 , C07C63/72 , C07C69/76 , C07C205/12 , C07C231/18 , C07C2603/92 , C07F9/5027 , C07F9/65719 , C07F9/6581 , C07F15/0053 , C07C233/47 , C07C33/22 , C07C33/50
摘要： A substituted paracyclophane is described of formula (I) wherein X1 and X2 are linking groups comprising between 2 to 4 carbon atoms, Y1 and Y2 are selected from the group consisting of hydrogen, halide, oxygen, nitrogen, alkyl, cycloalkyl, aryl or heteroaryl, Z1, Z2 and Z3 are substituting groups that optionally contain functional groups, a, b, c, d, e and f are 0 or 1 and a+b+c+d+e+f=1 to 6. Preferably X1 and X2 are —(C2H4)— and a+b+c+d+e+f=1 or 2. The substituted paracyclophane provides transition metal catalysts that demonstrate high activity and selectivity for asymmetric reactions
摘要翻译：描述了式（I）的取代的对环芳烷，其中X 1和X 2 2是包含2至4个碳原子的连接基团，Y 1，和Y 2选自氢，卤素，氧，氮，烷基，环烷基，芳基或杂芳基，Z 1，Z 2， SUP>和Z 3是用任选含有官能团a，b，c，d，e和f分别为0或1和a + b + c + d + e + f = 1的基团 X 1和X 2优选为 - （C 2 H 4 H 4） - 和 - + b + c + d + e + f = 1或2.取代的对环烷烷提供过渡金属催化剂，其表现出对不对称反应的高活性和选择性

6. 发明申请

US20090326274A1 Sulphonylated Diphenylethylenediamines, Method for Their Preparation and Use in Transfer Hydrogenation Catalysis 审中-公开
标题翻译：磺酰化二苯乙二胺，其制备方法及其在转移氢化催化中的应用
公开(公告)号：US20090326274A1
公开(公告)日：2009-12-31
申请号：US12493043
申请日：2009-06-26
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Alexandra Grasa , Jonathan Alan Medlock
IPC分类号： C07C45/61 , C07C211/01 , B01J31/02
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译：描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，Y 1，Y 2或Z中的至少一个是C 1 -C 10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。手性二胺可用于制备适用于转移氢化反应的催化剂。

7. 发明申请

US20070004943A1 Process for the production of a hydroxyalkyne by coupling reaction between acetaldehyde and a terminal alkyne 失效
标题翻译：通过乙醛和末端炔之间的偶联反应制备羟基亚氨基的方法
公开(公告)号：US20070004943A1
公开(公告)日：2007-01-04
申请号：US10553464
申请日：2004-04-15
申请人： Beatriz Dominguez
发明人： Beatriz Dominguez
IPC分类号： C07C33/04
CPC分类号： C07C29/42 , C07B2200/07 , C07C29/60 , C07C33/044 , C07C33/042
摘要： A process for performing, a coupling reaction between acetaldehyde and a terminal alkyne to yield a hydroxyalkyne is described comprising the steps of; (i) reacting without solvent, a terminal alkyne with a Lewis acidic metal salt in tile presence of a alkanolamine ligand and a cyclic amine base to form a metal-alkyne complex, and (ii) adding a solution of acetaldehyde to the metal-alkyne complex.
摘要翻译：描述了进行乙醛和末端炔烃之间的偶联反应以产生羟基亚氨基的方法，其包括以下步骤：（i）在不含溶剂的情况下使末端炔与路易斯酸性金属盐在链烷醇胺配体和环胺碱的存在下反应形成金属 - 炔炔络合物，和（ii）向乙炔加入乙醛溶液复杂。

8. 发明授权

US06180674B2 Unsaturated derivatives at the 4-position of 6-tert-butyl-1, 1- dimethylindane and their use in human and veterinary medicine and in cosmetics 失效
标题翻译： 6-叔丁基-1,1-二甲基茚满的4-位不饱和衍生物及其在人兽药和化妆品中的用途
公开(公告)号：US06180674B2
公开(公告)日：2001-01-30
申请号：US09158892
申请日：1998-09-23
申请人： Angel De Lera , Beatriz Dominguez
发明人： Angel De Lera , Beatriz Dominguez
IPC分类号： A61K3119
CPC分类号： C07D333/38 , A61K8/31 , A61K8/362 , A61K8/37 , A61K8/4926 , A61Q7/00 , A61Q19/00 , A61Q19/004 , C07C57/50 , C07C63/66 , C07C69/618 , C07C69/76
摘要： 6-tert-Butyl-1,1-dimethylindane derivatives which are unsaturated in the 4-position of formula: X represents: (i) either a radical of formula: and Y represents a radical of formula: (ii) or a radical of formula: and Y represents either a radical of formula (b) or a radical of formula: Z being —O—, —S— or R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6, p being 0, 1, 2 or 3, t being 0, 1 or 2, R2 represents H or lower alkyl, R3 represents H, lower alkyl or —COR7, R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, —OR8 or —N(r′)(r″), R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue or an amino acid residue, r′ and r″ represent H, lower alkyl, —COR7, aryl, a sugar residue or an amino acid residue or r′ and r″ form a heterocycle, and the salts of the compounds of formula (I). Use in the topical and systemic treatment of dermatological conditions, as well as in cosmetics.
摘要翻译：在式X中4-位不饱和的6-叔丁基-1,1-二甲基茚满衍生物表示：（i）下式的基团：Y表示式（ⅱ）的基团或基团并且Y表示式（b）的基团或式Z的基团是-O - ， - S-或R 1表示-CH 3， - （CH 2）p -OR 4， - （CH 2）p -OR 5或 - S（O）t-R6，p为0,1,2或3，t为0,1或2，R2为H或低级烷基，R3为H，低级烷基或-COR7，R4为H，低级烷基， -COR 7，芳基，芳烷基，单 - 或多羟基烷基或聚醚基，R 5表示H，低级烷基，-OR 8或-N（r'）（r“），R 6表示H或低级烷基，R 7表示低级烷基 R8代表H，烷基，烯基，炔基，芳基，芳烷基，单或多羟基烷基，糖残基或氨基酸残基，r'和r“代表H，低级烷基，-COR7，芳基，糖残基或氨基酸残基或r'和r“形成杂环，和式（I）化合物的盐。在局部和系统中使用 ic治疗皮肤病学条件，以及化妆品。

9. 发明申请

US20080081930A1 Sulphonylated Diphenylethylenediamines, Method For Their Preparation And Use In Transfer Hydrogenation Catalysis 有权
标题翻译：磺酰化二苯乙二胺，其制备方法和用于转移氢化催化
公开(公告)号：US20080081930A1
公开(公告)日：2008-04-03
申请号：US11719478
申请日：2005-11-01
申请人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Grasa , Jonathan Medlock
发明人： Beatriz Dominguez , Antonio Zanotti-Gerosa , Gabriela Grasa , Jonathan Medlock
IPC分类号： C07C49/15 , B01J31/12 , C07C311/16
CPC分类号： B01J31/1805 , B01J2231/643 , B01J2531/821 , B01J2531/822 , B01J2531/824 , B01J2531/827 , B01J2531/828 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07B2200/07 , C07C29/143 , C07C311/18 , C07C2602/10 , C07C33/46 , C07C33/22 , C07C35/32
摘要： A diamine of formula (I) is described, in which A is hydrogen or a saturated or unsaturated C1-C20 alkyl group or an aryl group; B is a substituted or unsubstituted C1-C20 alkyl, cycloalkyl, alkaryl, alkaryl or aryl group or an alkylamino group and at least one of X1, X2, Y1, Y2 or Z is a C1-C10 alkyl, cycloalkyl, alkaryl, aralkyl or alkoxy substituting group. The chiral diamine may be used to prepare catalysts suitable for use in transfer hydrogenation reactions.
摘要翻译：描述了式（I）的二胺，其中A是氢或饱和或不饱和的C 1 -C 20烷基或芳基; B是取代或未取代的C 1 -C 20烷基，环烷基，烷芳基，烷芳基或芳基或烷基氨基，X 1，X 2，或者Z是C1-C10烷基，环烷基，烷芳基，芳烷基或烷氧基取代基。手性二胺可用于制备适用于转移氢化反应的催化剂。

10. 发明授权

US06642273B2 Unsaturated derivatives at the 4-position of 6-tert-butyl-1,1-dimethylindane and their use in human and veterinary medicine and in cosmetics 失效
标题翻译： 6-叔丁基-1,1-二甲基茚满的4-位不饱和衍生物及其在人兽药和化妆品中的应用
公开(公告)号：US06642273B2
公开(公告)日：2003-11-04
申请号：US10214665
申请日：2002-08-09
申请人： Angel De Lera , Beatriz Dominguez
发明人： Angel De Lera , Beatriz Dominguez
IPC分类号： A61K3119
CPC分类号： C07D333/38 , A61K8/31 , A61K8/362 , A61K8/37 , A61K8/4926 , A61K8/4973 , A61K8/4986 , A61Q7/00 , A61Q19/00 , A61Q19/004 , C07C57/50 , C07C63/66 , C07C69/618 , C07C69/76 , Y10S977/801 , Y10S977/905 , Y10S977/906 , Y10S977/915
摘要： An unsaturated derivative at the 4-position of 6-tert-butyl-1,1-dimethylindane corresponding to the following formula: in which: X represents: a divalent radical of formula: and Y represents a divalent radical of following formula: R1 represents —CH3, —(CH2)p—OR4, —(CH2)p—COR5 or —S(O)t—R6, p being 0, 1, 2 or 3, t being 0, 1 or 2, R4 represents H, lower alkyl, —COR7, aryl, aralkyl, mono- or polyhydroxyalkyl, or a polyether radical, R5 represents H, lower alkyl, —OR8 or R6 represents H or lower alkyl, R7 represents lower alkyl, R8 represents H, alkyl, alkenyl, alkynyl, aryl, aralkyl, mono- or polyhydroxyalkyl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid, r′ and r″, which are identical or different, represent H, lower alkyl, —COR7, aryl, a sugar residue selected from the group consisting of residues deriving from glucose, galactose, mannose and glucuronic acid or an amino acid residue deriving from lysine, glycine and aspartic acid, or r′ and r″, taken together form a heterocycle selected from the group consisting of piperidino, morpholino, pyrrolidino and piperazino radical, the latter optionally being substituted in the 4-position by a C1-C6 alkyl radical or a mono- or polyhydroxyalkyl, and the salts of the compounds of formula (I), when R1 represents a carboxylic acid functional group, and the geometrical and optical isomers of the compounds of formula (I).
摘要翻译：对应于下式的6-叔丁基-1,1-二甲基茚的4-位的不饱和衍生物：其中：X表示：式的二价基团，Y表示下式的二价基团：R 1表示 -CH 3， - （CH 2）p -OR 4， - （CH 2）p-COR 5或-S（O）t -R 6，p为0,1,2或3，t为0,1或2，R 4表示H，低级烷基，-COR 7，芳基，芳烷基，单 - 或多羟基烷基或聚醚基，R 5表示H，低级烷基，-OR 8或R 6表示H或低级烷基，R 7表示低级烷基，R 8表示H，烷基，烯基，炔基芳基，芳烷基，单或多羟基烷基，选自葡萄糖，半乳糖，甘露糖和葡糖醛酸的残基或衍生自赖氨酸，甘氨酸和天冬氨酸的氨基酸残基的糖残基，r'和r“ ，其相同或不同，表示H，低级烷基，-COR 7，芳基，选自葡萄糖，半乳糖，甘露糖和葡萄糖的残基的糖残基衍生自赖氨酸，甘氨酸和天冬氨酸或r'和r“的氨基酸残基一起形成选自哌啶子基，吗啉代，吡咯烷子基和哌嗪基的杂环，后者任选被取代在当R1表示羧酸官能团时，通过C 1 -C 6烷基或单 - 或多羟基烷基的4-位和式（I）化合物的盐，以及式（I）化合物的几何和旋光异构体（一世）。

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