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    • 2. 发明申请
    • RECYCLABLE EXTRACTANT COMPOSITIONS
    • 可回收的提取物组合物
    • US20140094630A1
    • 2014-04-03
    • US14032328
    • 2013-09-20
    • DOUGLAS ROBERT ANTONBRUCE A. DINERSTEVEN D. DOIG
    • DOUGLAS ROBERT ANTONBRUCE A. DINERSTEVEN D. DOIG
    • C07C29/86
    • C07C29/86C12P7/04C12P7/16C12P21/06Y02E50/10
    • Provided herein are processes comprising providing a fermentation medium comprising a fermentable carbon source, a recombinant microorganism comprising an engineered butanol biosynthetic pathway, and butanol; contacting said fermentation medium with an extractant composition comprising an effective amount of antioxidant or antioxidant-like compound, whereby at least a portion of the butanol in the fermentation medium partitions into the extractant; recovering at least a portion of the butanol and extractant composition from the fermentation medium; recycling the extractant composition recovered in (c) one or more times in the fermentation medium; optionally adjusting the effective amount of antioxidant or antioxidant-like compound in the extractant composition, whereby the rate of oxidation or effect of oxidized products in the recycled extractant composition is substantially reduced and/or avoided such that the extractant composition may be recycled.
    • 本文提供的方法包括提供包含可发酵碳源的发酵培养基,包含工程丁醇生物合成途径的重组微生物和丁醇; 使所述发酵培养基与包含有效量的抗氧化剂或抗氧化剂样化合物的提取剂组合物接触,由此发酵培养基中的至少一部分丁醇分配到提取剂中; 从发酵培养基中回收至少一部分丁醇和提取剂组合物; 在(c)中回收的萃取剂组合物在发酵培养基中回收一次或多次; 任选地调节萃取剂组合物中抗氧化剂或抗氧化剂样化合物的有效量,从而大大降低和/或避免了再循环的萃取剂组合物中的氧化产物的氧化速率或氧化产物的影响,从而可以回收萃取剂组合物。