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1. 发明申请

US20070161698A1 Modulators of CRTH2 Activity 审中-公开
标题翻译： CRTH2活性调节剂
公开(公告)号：US20070161698A1
公开(公告)日：2007-07-12
申请号：US11685542
申请日：2007-03-13
申请人： Yueh-Tyng Chien , G. Milne , Mark Currie , John Talley , Brian Cali , Barbara Chen , Craig Zimmerman , Jing Yang
发明人： Yueh-Tyng Chien , G. Milne , Mark Currie , John Talley , Brian Cali , Barbara Chen , Craig Zimmerman , Jing Yang
IPC分类号： A61K31/405
CPC分类号： A61K31/405
摘要： Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
摘要翻译：描述了CRTH2受体的调节剂及其在治疗各种疾病（包括哮喘）中的用途。

2. 发明申请

US20050234244A1 Synthesis of COX-2 and FAAH inhibitors 审中-公开
标题翻译： COX-2和FAAH抑制剂的合成
公开(公告)号：US20050234244A1
公开(公告)日：2005-10-20
申请号：US10979794
申请日：2004-11-01
申请人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Craig Zimmerman
发明人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Craig Zimmerman
IPC分类号： C07D209/18 , C07D209/26 , C07D209/28 , C07D409/06 , C07D43/02
CPC分类号： C07D209/18 , C07D209/26 , C07D209/28 , C07D409/06
摘要： Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.
摘要翻译：描述了制备有用的COX-2抑制剂和可用于这些方法的中间体的吲哚的方法。

3. 发明申请

US20050004200A1 Pyrazole compounds as integrin receptor antagonists derivatives 审中-公开
标题翻译：吡唑类化合物作为整合素受体拮抗剂衍生物
公开(公告)号：US20050004200A1
公开(公告)日：2005-01-06
申请号：US10741860
申请日：2003-12-19
申请人： Thomas Penning , Albert Khilevich , Barbara Chen , Preete Gandhi , Yaping Wang , Victoria Downs , Mark Boys , Mark Russell , Dale Spangler , Renee Huff
发明人： Thomas Penning , Albert Khilevich , Barbara Chen , Preete Gandhi , Yaping Wang , Victoria Downs , Mark Boys , Mark Russell , Dale Spangler , Renee Huff
IPC分类号： A61K31/415 , A61K31/416 , C07D401/14 , C07D405/14 , C07D471/04 , C07
CPC分类号： C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物以及选择性抑制或拮抗αVbeta3和/或αVβ5整联蛋白而不显着抑制αVβ6的方法整合素

4. 发明授权

US06455495B1 Methods and compositions for delivery of therapeutic agents to bone tissue employing conjugates of negatively charged peptide oligomers with therapeutic agents 有权
标题翻译：使用带负电荷的肽低聚物与治疗剂的缀合物将治疗剂递送至骨组织的方法和组合物
公开(公告)号：US06455495B1
公开(公告)日：2002-09-24
申请号：US09367516
申请日：1999-12-14
申请人： Leslie Orgel , Barbara Chen Fei Chu
发明人： Leslie Orgel , Barbara Chen Fei Chu
IPC分类号： A01N3718
CPC分类号： A61K47/645
摘要： The invention provides conjugates of negatively charged peptide oligomers with therapeutic agents, moieties capable of recruiting endogenous bone-affecting agents, or imaging agents, useful for delivering the agents to bone tissue or calcified masses, and the methods of use thereof. The negatively charged peptide oligomers bind strongly but reversibly to bone tissue and calcified masses with a controllable affinity and retention time on the tissue or mass.
摘要翻译：本发明提供带负电荷的肽低聚物与治疗剂，能够募集内源性骨影响剂的部分或可用于将药物递送至骨组织或钙化肿块的成像剂的缀合物及其使用方法。带负电荷的肽寡聚体强烈但可逆地结合骨组织和钙化质量，在组织或质量上具有可控的亲和力和保留时间。

5. 发明授权

US07960544B2 Useful indole compounds 失效
标题翻译：有用的吲哚化合物
公开(公告)号：US07960544B2
公开(公告)日：2011-06-14
申请号：US12097616
申请日：2006-12-18
申请人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
发明人： Wilmin Bartolini , Brian M. Cali , Barbara Chen , Yueh-Tyng Chien , Mark G. Currie , G. Todd Milne , James Philip Pearson , John Jeffrey Talley , Jane Yang , Craig Zimmerman , Charles Kim , Kevin Sprott , Timothy Barden , Regina Lundigran , Ara Mermerian
IPC分类号： C07D403/06 , C07D239/26 , C07D471/04 , C07D401/06 , C07D271/06 , C07D271/10 , C07D417/06 , C07D413/06 , C07D263/32 , C07D261/08
CPC分类号： C07D209/42 , C07D209/30 , C07D401/06 , C07D409/06 , C07D417/06
摘要： Indoles that have activity as inhibitors of FAAH are described as are indoles and indole derivatives that have activity as inhibitors of DAO.
摘要翻译：具有作为FAAH抑制剂的活性的吲哚被描述为具有作为DAO抑制剂的活性的吲哚和吲哚衍生物。

6. 发明申请

US20070166336A1 Stable and palatable oral liquid sumatriptan compositions 审中-公开
标题翻译：稳定可口的口服液舒马曲坦组合物
公开(公告)号：US20070166336A1
公开(公告)日：2007-07-19
申请号：US11637677
申请日：2006-12-13
申请人： David Delmarre , Ajit Narang , Kaidi Zhao , Meagan Weldele , Barbara Chen , Carlos-Julian Centeno , Danchen Gao
发明人： David Delmarre , Ajit Narang , Kaidi Zhao , Meagan Weldele , Barbara Chen , Carlos-Julian Centeno , Danchen Gao
IPC分类号： A61K31/405 , A61K9/00
CPC分类号： A61K9/0095 , A61K9/08 , A61K31/4045 , A61K31/405
摘要： The present invention is directed to improved oral liquid compositions that include sumatriptan, or a pharmaceutically acceptable salt or metabolite thereof, and a pharmaceutically acceptable carrier that includes a liquid portion of the composition. The compositions are substantially free of oxidation impurities. Typically, the compositions include a sweetening agent and a flavoring agent, or a bitterness-reducing agent and flavoring agent. Processes of preparing such compositions and methods of administering such compositions are also included.
摘要翻译：本发明涉及改进的口服液体组合物，其包括舒马曲坦或其药学上可接受的盐或代谢物，以及包括组合物的液体部分的药学上可接受的载体。组合物基本上不含氧化杂质。通常，组合物包括甜味剂和调味剂，或减少苦味剂和调味剂。还包括制备此类组合物的方法和施用此类组合物的方法。

7. 发明申请

US20050234030A1 Modulators of CRTH2, COX-2 and FAAH 审中-公开
标题翻译： CRTH2，COX-2和FAAH的调节剂
公开(公告)号：US20050234030A1
公开(公告)日：2005-10-20
申请号：US11028896
申请日：2005-01-03
申请人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Jing Yang , Craig Zimmerman
发明人： Wilmin Bartolini , Brian Cali , Barbara Chen , Yueh-Tyng Chien , Mark Currie , G. Milne , James Pearson , John Talley , Jing Yang , Craig Zimmerman
IPC分类号： A61K31/496 , A61K31/497 , A61K31/501 , A61K31/53 , A61K31/5377 , A61K31/541 , C07D209/18 , C07D209/26 , C07D209/28 , C07D401/06 , C07D405/06 , C07D409/06 , C07D413/02 , C07D417/02 , C07D43/02
CPC分类号： C07D209/18 , C07D209/26 , C07D209/28 , C07D401/06 , C07D405/06 , C07D409/06
摘要： Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.
摘要翻译：描述了作为一种或多种或CRTH2，COX-2和FAAH的调节剂的某些取代的吲哚。该化合物可用于治疗疼痛和/或炎症以及其它疾病。

8. 发明授权

US06900232B2 Cycloalkyl alkanoic acids as integrin receptor antagonists 失效
标题翻译：环烷基链烷酸作为整联蛋白受体拮抗剂
公开(公告)号：US06900232B2
公开(公告)日：2005-05-31
申请号：US09882186
申请日：2001-06-15
申请人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
发明人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D213/72
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译：本发明涉及由式I表示的一类化合物，其中A 1是下式的吡啶基，其任选被一个或多个选自下组的R 0选自羟基，烷基，烷氧基，烷氧基烷基，硫代烷基，卤代烷基，氰基，氨基烷基氨基，卤素，酰氨基，磺酰胺和-COR; 且R为羟基，烷氧基，烷基或氨基; 和其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α3β3和/或α / 5> 5＆lt; 5＆gt;整联蛋白。

9. 发明授权

US5683985A Oligonucleotide decoys and methods relating thereto 失效
标题翻译：寡核苷酸诱饵及其相关方法
公开(公告)号：US5683985A
公开(公告)日：1997-11-04
申请号：US122433
申请日：1993-09-22
申请人： Barbara Chen Fei Chu , Leslie Orgel
发明人： Barbara Chen Fei Chu , Leslie Orgel
IPC分类号： A61K31/70 , A61K31/7135 , A61P31/12 , A61P35/00 , C07H21/00 , C07H21/04 , C07H23/00 , C12N15/00 , C12N15/09 , A61K48/00
CPC分类号： C07H21/00
摘要： Improved DNA structures are disclosed which contain target sequences which bind to control proteins (such as the CREB protein). The structures of the present invention are stable to degradation, and are effective as decoys for control proteins, making it possible to modulate the transcriptional control normally exerted by such control proteins. In addition, there is provided a method to reversibly crosslink oligonucleotides to polypeptides which recognize the oligonucleotide sequence. This method involves synthesizing DNA structures as described above, wherein one or more phosphorothioate diester linkages are incorporated into the resulting oligonucleotide, allowing the phosphorothioate diester-containing oligonucleotide to bind to polypeptides which recognize the sequence of said oligonucleotide, then contacting the polypeptide-bound oligonucleotide with a transition metal reagent.
摘要翻译： PCT No.PCT / US92 / 03205 Sec。 371日期：1993年9月22日 102（e）日期1993年9月22日PCT 1992年4月17日提交PCT公开了包含与对照蛋白（例如CREB蛋白）结合的靶序列的改进的DNA结构。本发明的结构对降解是稳定的，并且作为对照蛋白质的诱饵是有效的，使得可以调节通常由这种对照蛋白产生的转录控制。此外，提供了将寡核苷酸可逆地交联以识别寡核苷酸序列的多肽的方法。该方法包括合成如上所述的DNA结构，其中将一种或多种硫代磷酸酯二酯键并入所得寡核苷酸中，使含硫代磷酸酯二酯的寡核苷酸与识别所述寡核苷酸序列的多肽结合，然后与多肽结合的寡核苷酸接触与过渡金属试剂。

10. 发明授权

US07205329B2 Modulators of CRTH2 activity 失效
标题翻译： CRTH2活性调节剂
公开(公告)号：US07205329B2
公开(公告)日：2007-04-17
申请号：US11183626
申请日：2005-07-18
申请人： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
发明人： Yueh-Tyng Chien , G. Todd Milne , Mark G. Currie , John Jeffrey Talley , Brian M. Cali , Barbara Chen , Craig Zimmerman , Jing Jing Yang
IPC分类号： A61K31/405 , C07D209/12
CPC分类号： C07D409/06 , C07D209/42
摘要： Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
摘要翻译：描述了CRTH2受体的调节剂及其在治疗各种疾病（包括哮喘）中的用途。

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