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1. 发明申请

US20050124051A1 Hydroxylation of compactin to pravatatin by micromonospora 审中-公开
标题翻译：通过微单孢菌素将致密蛋白羟基化为普伐他汀
公开(公告)号：US20050124051A1
公开(公告)日：2005-06-09
申请号：US11014658
申请日：2004-12-16
申请人： Antonia Jekkel , Gabor Ambrus , Eva Ilkoy , Ildiko Horvath , Attila Konya , Istvan Szabo , Zsuzsanna Nagy , Gyula Horvath , Julia Mozes , Istvan Barta , Gyorgy Somogyi , Janos Salat , Sandor Boros
发明人： Antonia Jekkel , Gabor Ambrus , Eva Ilkoy , Ildiko Horvath , Attila Konya , Istvan Szabo , Zsuzsanna Nagy , Gyula Horvath , Julia Mozes , Istvan Barta , Gyorgy Somogyi , Janos Salat , Sandor Boros
IPC分类号： C12P7/62 , C07C69/30 , C12P1/04 , C12P7/42 , C12P17/06 , C12R1/29 , C12R1/31 , C12N1/21 , C12N9/18
CPC分类号： C12R1/29 , C12P7/42 , C12P17/06
摘要： The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6β-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the biocoversion. The latter comprises the cultivation of a Micromonospora strain which is able to 6β-hydroxylate a compound of general formula (II)—wherein R is as defined above—at 25-32° C. on a nutrient medium containing available carbon—and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.
摘要翻译：本发明涉及一种由通式（II）化合物制备式（I）化合物的新型微生物方法，其中R代表碱金属或铵离子，通过浸没培养的能够在好氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物，使式（II）化合物6β-羟化。后者包括培养微孢子虫菌株，其能够在含有可用碳源和氮源的营养培养基上在25-32℃下将通式（II）化合物（其中R如上定义）6β-羟基化然后将待转化的底物喂入显影培养物，然后将底物氢化，直到生物转化完成，然后从培养液中分离式（I）化合物，如果需要，将其纯化。

2. 发明申请

US20060281155A1 Microbial process for preparing pravastatin 审中-公开
公开(公告)号：US20060281155A1
公开(公告)日：2006-12-14
申请号：US11509662
申请日：2006-08-25
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Suto , Janos Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Suto , Janos Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Nee Igloy
IPC分类号： C12P7/62
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6β-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6β-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

3. 发明授权

US06696599B2 Microbial process for preparing pravastatin 失效
标题翻译：制备普伐他汀的微生物过程
公开(公告)号：US06696599B2
公开(公告)日：2004-02-24
申请号：US10437058
申请日：2003-05-14
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
IPC分类号： C07C6702
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.
摘要翻译：本发明涉及一种由通式（II）的化合物制备式（I）化合物的新的微生物方法，其中R代表碱金属或铵离子，通过浸没式培养能够提供6β 在需氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物来氢化式（II）化合物。该方法包括在含有可吸收的碳和氮源和矿物盐的营养培养基上培养能够将通式（II）的化合物6β-羟基化的高山被孢霉丝状菌种的菌株，并分离由发酵形成的产物肉汤，然后分离式（I）化合物并纯化。还公开了高山被孢霉的新型菌株。

4. 发明授权

US06750366B2 Microbial process for preparing pravastatin 失效
标题翻译：制备普伐他汀的微生物过程
公开(公告)号：US06750366B2
公开(公告)日：2004-06-15
申请号：US10011176
申请日：2001-12-05
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birinesik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birinesik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
IPC分类号： C07C6902
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I): from a compound of general formula (II): wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.
摘要翻译：本发明涉及一种制备式（I）化合物的新的微生物方法：由通式（II）的化合物：其中R代表碱金属或铵离子，通过浸没式培养可变形的模具在有氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物来将式（II）的化合物改性为6β-羟基化。该方法包括在含有可吸收的碳和氮源和矿物盐的营养培养基上培养能够将通式（II）的化合物6β-羟基化的高山被孢霉丝状菌种的菌株，并分离由发酵形成的产物肉汤，然后分离式（I）化合物并纯化。还公开了高山被孢霉的新型菌株。

5. 发明授权

US06682913B1 Microbial process for preparing pravastatin 失效
公开(公告)号：US06682913B1
公开(公告)日：2004-01-27
申请号：US09497805
申请日：2000-02-03
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo nee Igloy
IPC分类号： C12P762
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

6. 发明申请

US20060223150A1 Process for the isolation and purification of mevinolin 审中-公开
标题翻译：米维林分离纯化方法
公开(公告)号：US20060223150A1
公开(公告)日：2006-10-05
申请号：US10842221
申请日：2004-05-10
申请人： Vilmos Keri , Eva Ilkoy , Irma Hogye , Antonia Jekkel , Ilonu Bagdi , Gabor Ambrus , Attila Jakab , Attilla Andor , Lajos Deak , Istvan Szabo , Janos Balint , Zsuzsanna Scheidl , Etelka Deli , Gyula Horvath , Csaba Szabo , Ildiko Lang , Imre Szekely , Imre Moravcsik , Vera Kovacs , Szabolcs Matyas , Zsuasanna Sztaray , Laszlo Eszenyi
发明人： Vilmos Keri , Eva Ilkoy , Irma Hogye , Antonia Jekkel , Ilonu Bagdi , Gabor Ambrus , Attila Jakab , Attilla Andor , Lajos Deak , Istvan Szabo , Janos Balint , Zsuzsanna Scheidl , Etelka Deli , Gyula Horvath , Csaba Szabo , Ildiko Lang , Imre Szekely , Imre Moravcsik , Vera Kovacs , Szabolcs Matyas , Zsuasanna Sztaray , Laszlo Eszenyi
IPC分类号： C12P17/00 , C12N1/16
CPC分类号： C12P17/06
摘要： In a process for preparing mevinolin by fermentation of a biomass in a fermentation liquor, which includes dissolving mevinolin from the biomass into the fermentation liquor, and separating the biomass from the fermentation liquor to obtain a separated fermentation liquor, separating the mevinolin from the separated fermentation liquor, and recovering the end product, the improvement which comprises carrying out the dissolving at a pH between about 7.5 and about 10, and the separating of the mevinolin is carried out at a pH between about 4.5 and about 1.
摘要翻译：在发酵液中通过发酵生物质来制备美维林的方法，其包括将生物质中的美维林溶解于发酵液中，并将生物质与发酵液分离以获得分离的发酵液，从分离的发酵液中分离出美维林液体并回收最终产物，其改进包括在pH约7.5至约10之间进行溶解，并且在约4.5至约1之间的pH下进行甲维林的分离。

7. 发明授权

US5403728A Microbial process for preparing mevinolin by a strain of aspergillus 失效
标题翻译：用曲霉菌制备美维林的微生物过程
公开(公告)号：US5403728A
公开(公告)日：1995-04-04
申请号：US77364
申请日：1993-06-17
申请人： Antonia Jekkel , Eva Ilkoy , Istvan M. Szabo , Gabor Ambrus , Attila Andor , Ilona Varga , Imre Moravcsik , Istvan Szabo , Janos Erdei , Kalman Polya , Andras Kiss , Laszlo Cseke , Karoly Nagy , Mihaly Kaszas , Lajos Kiss , Istvan Magyi , Edit Halasz , Gyorgy Santha
发明人： Antonia Jekkel , Eva Ilkoy , Istvan M. Szabo , Gabor Ambrus , Attila Andor , Ilona Varga , Imre Moravcsik , Istvan Szabo , Janos Erdei , Kalman Polya , Andras Kiss , Laszlo Cseke , Karoly Nagy , Mihaly Kaszas , Lajos Kiss , Istvan Magyi , Edit Halasz , Gyorgy Santha
IPC分类号： C07D309/30 , C12P7/62 , C12P17/06 , C12P7/00 , C12P7/02
CPC分类号： C12R1/66 , C07D309/30 , C12P17/06 , C12P7/62
摘要： The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.
摘要翻译：本发明涉及一种制备β，δ-二羟基-7- [1,2,6,7,8,8a-六氢-2,6-二甲基-8-（2-甲基 - 丁酰氧基） - 萘-1 - 基] - 庚酸δ-内酯和β，二羟基-7- [1,2,6,7,8,8a-六氢-2,6-二甲基-8-（2-甲基丁酰氧基） - 萘醌-1-基] - 庚酸，通过将生物合成上述化合物的不完全真菌菌株的浸没培养物的需氧发酵在含有（II）的营养培养基中的含氧培养基中，可利用的碳源和氮源以及矿物盐，并且通过分离式（I）的产物，其包括培养产生上述式（I）和/或（I）的化合物的新的黑曲霉菌种的菌株， II），在25℃至30℃的温度范围内，如果需要，分离由发酵液形成的产物，然后以式（I）的内酯形式分离，如果需要，将其纯化一样。

8. 发明授权

US07668109B2 Method for determining mobile terminal performance in a running wireless network 有权
标题翻译：确定运行无线网络中移动终端性能的方法
公开(公告)号：US07668109B2
公开(公告)日：2010-02-23
申请号：US10597333
申请日：2004-01-30
申请人： Andras Veres , Istvan Szabo , Tamas Borsos
发明人： Andras Veres , Istvan Szabo , Tamas Borsos
IPC分类号： H04L1/00
CPC分类号： H04W24/08 , H04W88/02
摘要： In a second variation, the system, which is configured to determine the performance of a mobile terminal within a wireless communications network, may comprise a first message receiving unit for receiving messages transmitted via the communications network associated with user transactions, a second message receiving unit for receiving messages transmitted via the communications network associated with mobile terminal type information, a correlating unit for correlating data within the received user transaction messages with data within the mobile terminal type information messages, and a derivation unit for deriving one or more performance indicators by mobile terminal type information from the correlated data.
摘要翻译：在第二变型中，被配置为确定无线通信网络内的移动终端的性能的系统可以包括用于接收经由与用户事务相关联的通信网络发送的消息的第一消息接收单元，第二消息接收单元用于接收经由与移动终端类型信息相关联的通信网络发送的消息;相关单元，用于将所接收的用户交易消息内的数据与移动终端类型信息消息内的数据相关联;以及导出单元，用于通过移动终端获取一个或多个性能指标来自相关数据的终端类型信息。

9. 发明申请

US20070105544A1 Method for determining mobile terminal performance in a running wireless network 有权
标题翻译：确定运行无线网络中移动终端性能的方法
公开(公告)号：US20070105544A1
公开(公告)日：2007-05-10
申请号：US10597333
申请日：2004-01-30
申请人： Andras Veres , Istvan Szabo , Tamas Borsos
发明人： Andras Veres , Istvan Szabo , Tamas Borsos
IPC分类号： H04Q7/20
CPC分类号： H04W24/08 , H04W88/02
摘要： A technique for determining the performance of a mobile terminal within a communications network is disclosed. The technique receives messages associated with one or more user transactions and messages associated with mobile terminal type information. The data within the received user transaction messages is then correlated with data associated with the mobile terminal type information messages. Various performance indicators may then be derived by mobile terminal type information from the correlated data. The invention may be practiced in context with the benchmarking of mobile terminal types on an application level.
摘要翻译：公开了一种用于确定通信网络内的移动终端的性能的技术。该技术接收与一个或多个用户事务相关联的消息和与移动终端类型信息相关联的消息。接收到的用户事务消息中的数据然后与与移动终端类型信息消息相关联的数据相关。然后可以通过来自相关数据的移动终端类型信息来导出各种性能指标。本发明可以在应用级别的移动终端类型的基准测试的背景下实践。

10. 发明申请

US20110082329A1 Modification of Sperm Motility and Its Storage Shelf Time 审中-公开
标题翻译：精子运动修复及其储存时间
公开(公告)号：US20110082329A1
公开(公告)日：2011-04-07
申请号：US12922563
申请日：2009-04-09
申请人： Istvan Szabo
发明人： Istvan Szabo
IPC分类号： A61D19/02 , A01N1/02 , C01G51/08 , C01G53/09
CPC分类号： A01N1/0226 , A61K33/24
摘要： The invention relates to a composition for increasing sperm motility at low metal ion concentration and/or decreasing sperm motility at high metal ion concentration, wherein said composition comprises one or more metal ion selected from Co2+ and Ni2+ or compounds thereof as an active ingredient either alone or in combination with a physiologically acceptable carrier and optionally auxiliary ingredients.The invention includes the use of the above metal ions or compounds thereof for the preparation of a composition for increasing sperm motility in low concentration and decreasing sperm motility in high concentration, and the use of such compositions.
摘要翻译：本发明涉及一种用于增加低金属离子浓度下精子活力和/或在高金属离子浓度下降低精子运动性的组合物，其中所述组合物包含一种或多种选自Co 2+和Ni 2+的金属离子或其化合物作为单独的活性成分或与生理上可接受的载体和任选的辅助成分组合。本发明包括使用上述金属离子或其化合物来制备用于增加低浓度精子活力和降低高浓度精子活力的组合物，以及使用这些组合物。

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