专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5431860A Complex mixing device for dispersion of gases in liquid 失效
标题翻译：用于液体中气体分散的复合混合装置
公开(公告)号：US5431860A
公开(公告)日：1995-07-11
申请号：US234459
申请日：1994-04-28
申请人： Laszlo Kozma , Sandor Kovats , Bela Makadi , Laszlo Cseke , Sandor Pusztai , Mihaly Kaszas , Gyorgy Santha , Istvan Bartho , Karoly Zalai , Gyula Beszedics , Gabriella Kordik , Karoly Gergely , Miklos Feder
发明人： Laszlo Kozma , Sandor Kovats , Bela Makadi , Laszlo Cseke , Sandor Pusztai , Mihaly Kaszas , Gyorgy Santha , Istvan Bartho , Karoly Zalai , Gyula Beszedics , Gabriella Kordik , Karoly Gergely , Miklos Feder
IPC分类号： B01F3/04 , B01F7/00
CPC分类号： B01F3/04836 , B01F3/04531 , B01F7/00341 , B01F7/00633
摘要： A mixing device, especially for a fermenter, capable of dispersing gas in a broth therein, in which a number of propeller mixers are provided on a vertically extending shaft. The lower propeller mixer is a gas dispersing mixer having a hollow hub and open channels on the blades extending from this hub and tapering outwardly. At least one intermediate propeller mixer has some blades shorter than others and of reverse flow direction, some blades having baffle bars on trail edges thereof. The upper propeller mixer has the longer blades without channels and flow modifying elements.
摘要翻译：特别是用于发酵罐的混合装置，其能够将气体分散在其中，其中在垂直延伸的轴上设置有多个螺旋桨混合器。下部螺旋桨混合器是具有中空轮毂的气体分散混合器，并且在该叶片上的开口通道从该轮毂延伸并向外逐渐变细。至少一个中间螺旋桨混合器具有比其他叶片更短并且具有反向流动方向的一些叶片，一些叶片在其尾部边缘上具有挡板。上部螺旋桨混合器具有较长的叶片，没有通道和流动修改元件。

2. 发明授权

US5403728A Microbial process for preparing mevinolin by a strain of aspergillus 失效
标题翻译：用曲霉菌制备美维林的微生物过程
公开(公告)号：US5403728A
公开(公告)日：1995-04-04
申请号：US77364
申请日：1993-06-17
申请人： Antonia Jekkel , Eva Ilkoy , Istvan M. Szabo , Gabor Ambrus , Attila Andor , Ilona Varga , Imre Moravcsik , Istvan Szabo , Janos Erdei , Kalman Polya , Andras Kiss , Laszlo Cseke , Karoly Nagy , Mihaly Kaszas , Lajos Kiss , Istvan Magyi , Edit Halasz , Gyorgy Santha
发明人： Antonia Jekkel , Eva Ilkoy , Istvan M. Szabo , Gabor Ambrus , Attila Andor , Ilona Varga , Imre Moravcsik , Istvan Szabo , Janos Erdei , Kalman Polya , Andras Kiss , Laszlo Cseke , Karoly Nagy , Mihaly Kaszas , Lajos Kiss , Istvan Magyi , Edit Halasz , Gyorgy Santha
IPC分类号： C07D309/30 , C12P7/62 , C12P17/06 , C12P7/00 , C12P7/02
CPC分类号： C12R1/66 , C07D309/30 , C12P17/06 , C12P7/62
摘要： The invention refers to a new microbial process for preparing .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methyl-butyryloxy)-naphthalen-1-yl]-heptanoic acid .delta.-lactone of formula (I) and .beta.,.delta.-dihydroxy-7-[1,2,6,7,8,8a-hexahydro-2.6-dimethyl-8-(2-methylbutyryloxy)-naphtalen-1-yl]-heptanoic acid of formula (II), ##STR1## by the aerobic fermentation of the submerged culture of an imperfect fungus strain biosynthesizing the above compounds, in a nutrient medium containing utilizable carbon and nitrogen sources as well as mineral salts, and by isolating the product of formula (I), which comprises cultivating a strain of the new Aspergillus obscurus fungus species producing the above compound(s) of formulas (I) and/or (II), in a temperature range of 25.degree. to 30.degree. C. and, if desired, separating the product(s) formed from the fermentation broth, then isolating it in the lactone form of formula (I) and, if desired, purifying the same.
摘要翻译：本发明涉及一种制备β，δ-二羟基-7- [1,2,6,7,8,8a-六氢-2,6-二甲基-8-（2-甲基 - 丁酰氧基） - 萘-1 - 基] - 庚酸δ-内酯和β，二羟基-7- [1,2,6,7,8,8a-六氢-2,6-二甲基-8-（2-甲基丁酰氧基） - 萘醌-1-基] - 庚酸，通过将生物合成上述化合物的不完全真菌菌株的浸没培养物的需氧发酵在含有（II）的营养培养基中的含氧培养基中，可利用的碳源和氮源以及矿物盐，并且通过分离式（I）的产物，其包括培养产生上述式（I）和/或（I）的化合物的新的黑曲霉菌种的菌株， II），在25℃至30℃的温度范围内，如果需要，分离由发酵液形成的产物，然后以式（I）的内酯形式分离，如果需要，将其纯化一样。

3. 发明授权

US5312567A Complex mixer for dispersion of gases in liquid 失效
标题翻译：用于液体中气体分散的复合混合器
公开(公告)号：US5312567A
公开(公告)日：1994-05-17
申请号：US930515
申请日：1992-09-25
申请人： Laszlo Kozma , Sandor Kovats , Bela Makadi , Laszlo Cseke , Sandor Pusztai , Mihaly Kaszas , Gyorgy Santha , Istvan Bartho , Karoly Zalai , Gyula Beszedics , Gabriella Kordik , Karoly Gergely , Miklos Feder
发明人： Laszlo Kozma , Sandor Kovats , Bela Makadi , Laszlo Cseke , Sandor Pusztai , Mihaly Kaszas , Gyorgy Santha , Istvan Bartho , Karoly Zalai , Gyula Beszedics , Gabriella Kordik , Karoly Gergely , Miklos Feder
IPC分类号： B01F3/04 , B01F7/00 , C12M1/00
CPC分类号： B01F3/04836 , B01F3/04531 , B01F7/00366 , B01F2003/04673 , B01F7/00341 , B01F7/00633
摘要： Complex mixing system with stages consisting of propeller mixers of high diameter ratio, where the blades are provided with flow modifying elements, whereby the energy proportions spent on dispersion of the amount of gas injected into the reactor, homogenization of the multi-phase mixtures, suspension of solid particles, etc. and the properties corresponding to the rheological properties of the gas-liquid mixtures and to the special requirements of the processes can be ensured even in extreme cases. Open channels (5) opposite to the direction of rotation are on the blades (4) of the dispersing stage (2a) of the propeller mixers (2) fixed to a common shaft, where the channels (5) are interconnected with gas inlet (7). The angle of incidence of a certain part of the blades (4) of mixing stages (2b, 2d) used for homogenization and suspension is of opposite direction and the length is shorter and/or the angle of incidence is smaller than those of the other blades. Baffle bars (8) are on the trailing end of the blades on a certain part (2c) of the propeller mixers used similarly for homogenization and suspension, and/or auxiliary blades (12) at an angle of max. 20.degree. to the blade wings are arranged above or below the trailing end of the blades (FIG. 1 and 6).
摘要翻译：复杂混合系统，其阶段由高直径比的螺旋桨混合器组成，其中叶片具有流动修饰元件，由此在分散注入反应器的气体的量上花费的能量比例，多相混合物的混合物，悬浮液的固体颗粒等，并且即使在极端情况下也可以确保与气体 - 液体混合物的流变性质相对应的特性以及工艺的特殊要求。与旋转方向相反的开放通道（5）位于固定到公共轴上的螺旋桨混合器（2）的分散台（2a）的叶片（4）上，其中通道（5）与气体入口 7）。用于均质化和悬浮的混合阶段（2b，2d）的一部分叶片（4）的入射角与反方向相反，长度较短和/或入射角小于其他刀片。挡板（8）位于螺旋桨混合器的特定部分（2c）上的叶片的后端，类似于均匀化和悬浮使用的螺旋桨混合器，和/或辅助叶片（12）以最大角度。叶片翼的20°设置在叶片尾端的上方或下方（图1和图6）。

4. 发明授权

US4584135A Process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth 失效
标题翻译：从发酵液制备土霉素 - 硅酸钙复合盐的方法
公开(公告)号：US4584135A
公开(公告)日：1986-04-22
申请号：US537293
申请日：1983-09-29
申请人： Janos Balint , Laszlo Cseke , Ferenc Fabian , Lajos Kun , Miklos Szarvas
发明人： Janos Balint , Laszlo Cseke , Ferenc Fabian , Lajos Kun , Miklos Szarvas
IPC分类号： C12P29/00 , C07C103/26
CPC分类号： C12P29/00
摘要： The invention relates to a process for the preparation of an oxytetracycline-calcium silicate complex salt from fermentation broth.By the process according to the invention the valuable antibiotic oxytetracycline may be separated from the fermentation broth in an easy manner. The complex obtained according to (a) contains up to 50% of antibiotic and is suitable for the processing in the pharmaceutical industry while the product according to (b) contains 10 to 20% of antibiotic and may be used as fodder additive directly.
摘要翻译：本发明涉及从发酵液制备土霉素 - 硅酸钙复合盐的方法。通过根据本发明的方法，可以容易地将有价值的抗生素土霉素与发酵液分离。根据（a）获得的复合物含有高达50％的抗生素，适用于制药工业的加工，而根据（b）的产品含有10-20％的抗生素，可直接用作饲料添加剂。

5. 发明授权

US4579686A Process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride 失效
标题翻译：制备易流动（可流动）盐酸土霉素的方法
公开(公告)号：US4579686A
公开(公告)日：1986-04-01
申请号：US606348
申请日：1984-05-02
申请人： Miklos Szarvas , Eva Horvath nee Feher , Laszlo Cseke , Janos Balint , Ferenc Fabian , Lajos Kun
发明人： Miklos Szarvas , Eva Horvath nee Feher , Laszlo Cseke , Janos Balint , Ferenc Fabian , Lajos Kun
IPC分类号： C07C237/26 , C07C67/00 , C07C231/00 , C07C233/00 , C07C103/26
CPC分类号： C07C233/00
摘要： The invention relates to a new process for the preparation of easy-flowing (flowable) oxytetracyclin hydrochloride. According to the process of the invention, the crude, dry or filter-wet oxytetracyclin hydrochloride consisting of needle-shaped crystals is boiled with an organic solvent forming an azeotropic mixture with water, optionally a part of the solvent is distilled off in a form of an azeotropic mixture, then the mixture is cooled and the precipitated oxytetracyclin hydrochloride consisting of spherical crystals is separated and dried.Oxytetracyclin hydrochloride exists in two various crystal forms, the one of which is needle-shaped, while the other one consists of orthorhombic sheets. The crystals of this latter form are capable of forming spherical particles by coalescence. The crystal form consisting of spherical particles is much more useful for the pharmaceutical industry.By means of the new process easy-flowing (flowable) oxytetracyclin hydrochloride can be prepared in a favorable yield and with a high purity from the crude hydrochloride product consisting of needle-shaped crystals.
摘要翻译：本发明涉及一种制备易流动（可流动的）盐酸四环素的新方法。根据本发明的方法，将由针状结晶组成的粗制，干燥或过滤湿润的土霉素盐酸盐与有机溶剂一起沸腾，与水形成共沸混合物，任选地，一部分溶剂以共沸混合物，然后将混合物冷却，分离并干燥沉淀的由球形晶体组成的盐酸四环素盐酸盐。盐酸四环素以两种不同的晶体形式存在，其中一种是针状，另一种由斜方片组成。后一种形式的晶体能够通过聚结形成球形颗粒。由球形颗粒组成的晶体形式对于制药工业来说更为有用。通过新方法，易于流动（可流动）的盐酸土霉素可以从由针状晶体组成的粗盐酸盐产物以有利的产率和高纯度制备。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式