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1. 发明授权

US06750366B2 Microbial process for preparing pravastatin 失效
标题翻译：制备普伐他汀的微生物过程
公开(公告)号：US06750366B2
公开(公告)日：2004-06-15
申请号：US10011176
申请日：2001-12-05
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birinesik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birinesik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
IPC分类号： C07C6902
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I): from a compound of general formula (II): wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.
摘要翻译：本发明涉及一种制备式（I）化合物的新的微生物方法：由通式（II）的化合物：其中R代表碱金属或铵离子，通过浸没式培养可变形的模具在有氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物来将式（II）的化合物改性为6β-羟基化。该方法包括在含有可吸收的碳和氮源和矿物盐的营养培养基上培养能够将通式（II）的化合物6β-羟基化的高山被孢霉丝状菌种的菌株，并分离由发酵形成的产物肉汤，然后分离式（I）化合物并纯化。还公开了高山被孢霉的新型菌株。

2. 发明授权

US06696599B2 Microbial process for preparing pravastatin 失效
标题翻译：制备普伐他汀的微生物过程
公开(公告)号：US06696599B2
公开(公告)日：2004-02-24
申请号：US10437058
申请日：2003-05-14
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes Nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo Nee Igloy
IPC分类号： C07C6702
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.
摘要翻译：本发明涉及一种由通式（II）的化合物制备式（I）化合物的新的微生物方法，其中R代表碱金属或铵离子，通过浸没式培养能够提供6β 在需氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物来氢化式（II）化合物。该方法包括在含有可吸收的碳和氮源和矿物盐的营养培养基上培养能够将通式（II）的化合物6β-羟基化的高山被孢霉丝状菌种的菌株，并分离由发酵形成的产物肉汤，然后分离式（I）化合物并纯化。还公开了高山被孢霉的新型菌株。

3. 发明授权

US06682913B1 Microbial process for preparing pravastatin 失效
公开(公告)号：US06682913B1
公开(公告)日：2004-01-27
申请号：US09497805
申请日：2000-02-03
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Mozes nee Suto , Janso Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Bidlo nee Igloy
IPC分类号： C12P762
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6&bgr;-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6&bgr;-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

4. 发明申请

US20060281155A1 Microbial process for preparing pravastatin 审中-公开
公开(公告)号：US20060281155A1
公开(公告)日：2006-12-14
申请号：US11509662
申请日：2006-08-25
申请人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Suto , Janos Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Nee Igloy
发明人： Antonia Jekkel , Attila Konya , Istvan Barta , Eva Ilkoy , Gyorgy Somogyi , Gabor Ambrus , Gyula Horvath , Karoly Albrecht , Istvan Szabo , Julianna Suto , Janos Salat , Attila Andor , Laszlo Birincsik , Sandor Boros , Ildiko Lang , Margit Nee Igloy
IPC分类号： C12P7/62
CPC分类号： C12R1/645 , C12P7/62
摘要： The present invention relates to a new microbial process for the preparation of the compound formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged cultivation of a mold strain able to 6β-hydroxylate a compound of the Formula (II) in aerobic fermentation and by the separation and purification of the product of Formula (I) formed in the course of the bioconversion. The process comprises cultivating a strain of Mortierella maculata filamentous mold species that is able to 6β-hydroxylate a compound of the general Formula (II), on a nutrient medium containing assimilable carbon and nitrogen sources and mineral salts and separating the product formed from the fermentation broth, then isolating the compound of formula (I) and purifying the same. Novel strains of Mortierella maculata are also disclosed.

5. 发明申请

US20050124051A1 Hydroxylation of compactin to pravatatin by micromonospora 审中-公开
标题翻译：通过微单孢菌素将致密蛋白羟基化为普伐他汀
公开(公告)号：US20050124051A1
公开(公告)日：2005-06-09
申请号：US11014658
申请日：2004-12-16
申请人： Antonia Jekkel , Gabor Ambrus , Eva Ilkoy , Ildiko Horvath , Attila Konya , Istvan Szabo , Zsuzsanna Nagy , Gyula Horvath , Julia Mozes , Istvan Barta , Gyorgy Somogyi , Janos Salat , Sandor Boros
发明人： Antonia Jekkel , Gabor Ambrus , Eva Ilkoy , Ildiko Horvath , Attila Konya , Istvan Szabo , Zsuzsanna Nagy , Gyula Horvath , Julia Mozes , Istvan Barta , Gyorgy Somogyi , Janos Salat , Sandor Boros
IPC分类号： C12P7/62 , C07C69/30 , C12P1/04 , C12P7/42 , C12P17/06 , C12R1/29 , C12R1/31 , C12N1/21 , C12N9/18
CPC分类号： C12R1/29 , C12P7/42 , C12P17/06
摘要： The present invention relates to a new microbial process for the preparation of compound of formula (I) from a compound of general formula (II) wherein R stands for an alkali metal or ammonium ion, by the submerged culture of a strain which is able to 6β-hydroxylate the compound of formula (II) in aerobic fermentation and by the separation and purification of the product of formula (I) formed in the course of the biocoversion. The latter comprises the cultivation of a Micromonospora strain which is able to 6β-hydroxylate a compound of general formula (II)—wherein R is as defined above—at 25-32° C. on a nutrient medium containing available carbon—and nitrogen sources and mineral salts, thereafter feeding the substrate to be transformed into the developing culture, then hydroxilating the substrate until finishing of the bioconversion, then separating the compound of formula (I) from the culture broth and, if desired, purifying the same.
摘要翻译：本发明涉及一种由通式（II）化合物制备式（I）化合物的新型微生物方法，其中R代表碱金属或铵离子，通过浸没培养的能够在好氧发酵中通过分解和纯化在生物转化过程中形成的式（I）的产物，使式（II）化合物6β-羟化。后者包括培养微孢子虫菌株，其能够在含有可用碳源和氮源的营养培养基上在25-32℃下将通式（II）化合物（其中R如上定义）6β-羟基化然后将待转化的底物喂入显影培养物，然后将底物氢化，直到生物转化完成，然后从培养液中分离式（I）化合物，如果需要，将其纯化。

6. 发明授权

US06602865B1 Pyridazino(4,5-b)(1,5)oxazepinone, -thiazepinone and -diazepinone compounds 失效
标题翻译：哒嗪（4,5-b）（1,5）恶唑嗪酮，噻替酮和二氮杂酮化合物
公开(公告)号：US06602865B1
公开(公告)日：2003-08-05
申请号：US09439847
申请日：1999-11-15
申请人： Ferenc Andrasi , Agnes Angyal nee Pataky , Pal Berzsenyi , Sandor Boros , Laszlo Harsing , Katalin Horvath , Peter Matyus , Imre Moravcsik , Agnes Papp nee Behr , Antal Simay , Erzsebet Szabo nee Bagdy , Katalin Szabo nee Pusztai , Istvan Tarnawa , Ildiko Varga
发明人： Ferenc Andrasi , Agnes Angyal nee Pataky , Pal Berzsenyi , Sandor Boros , Laszlo Harsing , Katalin Horvath , Peter Matyus , Imre Moravcsik , Agnes Papp nee Behr , Antal Simay , Erzsebet Szabo nee Bagdy , Katalin Szabo nee Pusztai , Istvan Tarnawa , Ildiko Varga
IPC分类号： A61K3155
CPC分类号： C07D513/04 , A61K31/55 , A61K31/551 , A61K31/553 , A61K31/554
摘要： Pyridazino(4,5-b)(1,5)oxazepinone, thiazepinone and diazepinone compounds of formula(I) and their tautomers and the acid-addition salts of all these compounds show memory-enhancing and neuroprotective properties.
摘要翻译：式（I）的哒嗪（4,5-b）（1,5）恶唑酮，噻替酮和二氮杂酮化合物及其互变异构体和所有这些化合物的酸加成盐显示记忆增强和神经保护性质。

7. 发明授权

US5055125A Antidoted herbicide compositions and antidote compositions 失效
标题翻译：抗除草剂组合物和解毒剂组合物
公开(公告)号：US5055125A
公开(公告)日：1991-10-08
申请号：US507314
申请日：1990-04-10
申请人： Gyorgy Matolcsy , Antal Gimesi , Antalne Tombor , Barna Bordas , Janosne Benczik , Zoltan Kolonics , Csaba Soptei , Sandor Boros , Agota Kener , Denzso Sebok , Geza Szabo , Imre Varga
发明人： Gyorgy Matolcsy , Antal Gimesi , Antalne Tombor , Barna Bordas , Janosne Benczik , Zoltan Kolonics , Csaba Soptei , Sandor Boros , Agota Kener , Denzso Sebok , Geza Szabo , Imre Varga
IPC分类号： A01N25/14 , A01N25/32 , A01N37/22 , A01N43/76 , A01N47/10 , A01N47/12 , A01N47/24 , A01P13/00 , C07C233/88 , C07D263/04 , C07D263/52 , C07D295/21 , C07D487/04
CPC分类号： C07D263/04 , A01N25/32 , A01N47/12 , C07C233/88 , C07D263/52 , C07D295/21 , C07D487/04
摘要： Herbicidal compositions comprising a substituted thiolcarbamate derivative corresponding to the formula (I) wherein R.sub.1, R.sub.2 and R.sub.3 are selected independently from alkyl groups having 1 to 4 carbon atoms and/or a chloroacetanilide derivative corresponding to the formula (II) wherein R.sub.4 and R.sub.5 are hydrogen or alkyl group having 1 to 4 carbon atoms, identical or different, R.sub.6 is an alkoxyalkyl group corresponding to the formula --R.sub.7 --O--R.sub.8 in which R.sub.7 and R.sub.8 are selected from alkyl groups having 1 to 4 carbon atoms and, as an antidote, a thiocarbamic acid derivative corresponding to the formula (III) wherein R.sub.9 and R.sub.10 independently from each other are alkyl or alkenyl group having 1 to 4 carbon atoms, or R.sub.9 and R.sub.10 taken together with one or two nitrogen atoms form a heterocyclic group, which may contain one oxygen atom or they form a soiro-heterocyclic or condensated ring, which can be substituted with alkyl groups having 1 to 4 carbon atoms or an aryl group, R.sub.11 is an alkyl or alkenyl group having 1 to 3 carbon atoms or a benzyl group containing one or 2 substituents, carboxy methylene, 1-methylene naphtyl, acetophenon-(2)-yl-, carb-(.alpha.)naphthoxy-methylene, N-methylene o-benzoic acid sulphimide, N-isopropyl-N-phenylacetamidyl, N,N-disubstituted-2-acetamidyl group containing alkyl, alkylene groups having 1 to 3 carbon atoms, alkoxyalkyl, phenyl or dialkyl phenyl group.
摘要翻译：包含对应于式（I）的取代的硫代氨基甲酸酯衍生物的除草组合物，其中R 1，R 2和R 3独立地选自具有1至4个碳原子的烷基和/或对应于式（II）的氯代乙酰苯胺衍生物，其中R 4和R 5是氢或具有1〜4个碳原子的烷基相同或不同，R6是对应于式-R7-O-R8的烷氧基烷基，其中R 7和R 8选自具有1至4个碳原子的烷基，作为解毒剂，对应于式（III）的氨基甲酸衍生物，其中R 9和R 10彼此独立地为具有1至4个碳原子的烷基或烯基，或者R 9和R 10与一个或两个氮原子一起形成杂环基，其可以含有一个氧原子，或者它们形成可以被具有1至4个碳原子的烷基或芳基取代的单环或缩合的环，R 11是烷基或链烯基具有1至3个碳原子的苄基或含有一个或两个取代基的苄基，羧基亚甲基，1-亚甲基萘基，苯乙酮 - （2） - 基 - ，碳 - （α）萘氧基 - 亚甲基，N-亚甲基邻苯甲酸亚磺酰亚胺，N-异丙基-N-苯基乙酰胺基，含有N，N-二取代-2-乙酰氨基的烷基，具有1至3个碳原子的亚烷基，烷氧基烷基，苯基或二烷基苯基。

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